Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATE8_LEIMU

TriTrypDb:

LmxM.36.3670

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.433
CLV_NRD_NRD_1	151	153	PF00675	0.441
CLV_NRD_NRD_1	178	180	PF00675	0.419
CLV_NRD_NRD_1	185	187	PF00675	0.440
CLV_NRD_NRD_1	218	220	PF00675	0.523
CLV_NRD_NRD_1	337	339	PF00675	0.750
CLV_NRD_NRD_1	50	52	PF00675	0.713
CLV_NRD_NRD_1	58	60	PF00675	0.686
CLV_PCSK_KEX2_1	129	131	PF00082	0.455
CLV_PCSK_KEX2_1	137	139	PF00082	0.444
CLV_PCSK_KEX2_1	151	153	PF00082	0.441
CLV_PCSK_KEX2_1	218	220	PF00082	0.523
CLV_PCSK_KEX2_1	50	52	PF00082	0.697
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.455
CLV_PCSK_SKI1_1	129	133	PF00082	0.485
CLV_PCSK_SKI1_1	179	183	PF00082	0.434
DEG_APCC_DBOX_1	32	40	PF00400	0.667
DEG_MDM2_SWIB_1	48	55	PF02201	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DEG_SPOP_SBC_1	89	93	PF00917	0.727
DOC_MAPK_gen_1	186	192	PF00069	0.454
DOC_MAPK_gen_1	19	26	PF00069	0.722
DOC_PP1_RVXF_1	114	120	PF00149	0.553
DOC_PP1_RVXF_1	64	71	PF00149	0.681
DOC_PP2B_LxvP_1	271	274	PF13499	0.602
DOC_USP7_MATH_1	274	278	PF00917	0.603
DOC_USP7_MATH_1	291	295	PF00917	0.517
DOC_USP7_MATH_1	89	93	PF00917	0.727
DOC_USP7_UBL2_3	187	191	PF12436	0.453
DOC_USP7_UBL2_3	56	60	PF12436	0.698
DOC_WW_Pin1_4	110	115	PF00397	0.562
DOC_WW_Pin1_4	123	128	PF00397	0.490
DOC_WW_Pin1_4	261	266	PF00397	0.615
LIG_14-3-3_CanoR_1	116	120	PF00244	0.508
LIG_14-3-3_CanoR_1	130	134	PF00244	0.454
LIG_14-3-3_CanoR_1	218	226	PF00244	0.536
LIG_APCC_ABBAyCdc20_2	151	157	PF00400	0.461
LIG_BRCT_BRCA1_1	7	11	PF00533	0.607
LIG_DCNL_PONY_1	1	4	PF03556	0.524
LIG_FHA_1	130	136	PF00498	0.569
LIG_FHA_1	97	103	PF00498	0.526
LIG_FHA_2	107	113	PF00498	0.726
LIG_FHA_2	206	212	PF00498	0.505
LIG_FHA_2	91	97	PF00498	0.765
LIG_LIR_Gen_1	121	128	PF02991	0.621
LIG_LIR_Gen_1	167	175	PF02991	0.325
LIG_LIR_Gen_1	247	256	PF02991	0.708
LIG_LIR_Nem_3	118	122	PF02991	0.567
LIG_LIR_Nem_3	132	136	PF02991	0.462
LIG_LIR_Nem_3	145	149	PF02991	0.445
LIG_LIR_Nem_3	167	171	PF02991	0.343
LIG_LIR_Nem_3	247	253	PF02991	0.601
LIG_LIR_Nem_3	299	305	PF02991	0.583
LIG_MLH1_MIPbox_1	7	11	PF16413	0.438
LIG_PCNA_yPIPBox_3	19	27	PF02747	0.467
LIG_Pex14_1	146	150	PF04695	0.473
LIG_Pex14_2	48	52	PF04695	0.447
LIG_Pex14_2	70	74	PF04695	0.676
LIG_SH2_CRK	136	140	PF00017	0.511
LIG_SH2_CRK	250	254	PF00017	0.643
LIG_SH2_GRB2like	163	166	PF00017	0.505
LIG_SH2_SRC	155	158	PF00017	0.492
LIG_SH2_STAT3	120	123	PF00017	0.694
LIG_SH2_STAT3	163	166	PF00017	0.505
LIG_SH2_STAT5	163	166	PF00017	0.505
LIG_SH2_STAT5	250	253	PF00017	0.760
LIG_SH3_3	95	101	PF00018	0.771
LIG_TRAF2_1	209	212	PF00917	0.519
LIG_TYR_ITIM	248	253	PF00017	0.630
LIG_UBA3_1	292	300	PF00899	0.589
LIG_ULM_U2AF65_1	179	184	PF00076	0.426
LIG_WRC_WIRS_1	45	50	PF05994	0.435
MOD_CDC14_SPxK_1	126	129	PF00782	0.491
MOD_CDK_SPxK_1	110	116	PF00069	0.559
MOD_CDK_SPxK_1	123	129	PF00069	0.486
MOD_CDK_SPxxK_3	123	130	PF00069	0.525
MOD_CK1_1	249	255	PF00069	0.640
MOD_CK1_1	85	91	PF00069	0.704
MOD_CK2_1	106	112	PF00069	0.617
MOD_CK2_1	205	211	PF00069	0.501
MOD_CK2_1	291	297	PF00069	0.605
MOD_CK2_1	91	97	PF00069	0.755
MOD_GlcNHglycan	13	16	PF01048	0.592
MOD_GlcNHglycan	157	161	PF01048	0.554
MOD_GlcNHglycan	289	292	PF01048	0.587
MOD_GlcNHglycan	30	33	PF01048	0.741
MOD_GlcNHglycan	84	87	PF01048	0.800
MOD_GSK3_1	106	113	PF00069	0.567
MOD_GSK3_1	287	294	PF00069	0.605
MOD_GSK3_1	305	312	PF00069	0.584
MOD_GSK3_1	85	92	PF00069	0.737
MOD_GSK3_1	96	103	PF00069	0.635
MOD_N-GLC_1	164	169	PF02516	0.475
MOD_NEK2_1	10	15	PF00069	0.589
MOD_NEK2_1	106	111	PF00069	0.462
MOD_NEK2_1	238	243	PF00069	0.648
MOD_NEK2_1	27	32	PF00069	0.581
MOD_NEK2_1	279	284	PF00069	0.711
MOD_NEK2_2	5	10	PF00069	0.430
MOD_PIKK_1	309	315	PF00454	0.629
MOD_PKA_1	129	135	PF00069	0.494
MOD_PKA_2	115	121	PF00069	0.515
MOD_PKA_2	129	135	PF00069	0.455
MOD_PKA_2	217	223	PF00069	0.528
MOD_PKA_2	279	285	PF00069	0.747
MOD_PKB_1	307	315	PF00069	0.638
MOD_Plk_1	164	170	PF00069	0.474
MOD_Plk_1	192	198	PF00069	0.510
MOD_Plk_1	246	252	PF00069	0.597
MOD_Plk_4	115	121	PF00069	0.526
MOD_Plk_4	192	198	PF00069	0.510
MOD_Plk_4	238	244	PF00069	0.646
MOD_Plk_4	5	11	PF00069	0.498
MOD_ProDKin_1	110	116	PF00069	0.559
MOD_ProDKin_1	123	129	PF00069	0.486
MOD_ProDKin_1	261	267	PF00069	0.616
MOD_SUMO_rev_2	294	301	PF00179	0.670
MOD_SUMO_rev_2	58	68	PF00179	0.755
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.670
TRG_ENDOCYTIC_2	136	139	PF00928	0.472
TRG_ENDOCYTIC_2	150	153	PF00928	0.461
TRG_ENDOCYTIC_2	155	158	PF00928	0.351
TRG_ENDOCYTIC_2	201	204	PF00928	0.451
TRG_ENDOCYTIC_2	250	253	PF00928	0.643
TRG_ER_diArg_1	136	138	PF00400	0.440
TRG_ER_diArg_1	150	152	PF00400	0.432
TRG_ER_diArg_1	306	309	PF00400	0.620
TRG_ER_diArg_1	50	52	PF00400	0.739
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T7	Leptomonas seymouri	77%	100%
A0A1X0P4T0	Trypanosomatidae	79%	98%
A0A3S7XBA9	Leishmania donovani	94%	100%
A4HPN4	Leishmania braziliensis	86%	100%
A4ID30	Leishmania infantum	94%	100%
D0A8H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
Q4Q149	Leishmania major	92%	100%
V5BIQ3	Trypanosoma cruzi	78%	95%