Nudix hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase 3, putative

Species:

Leishmania mexicana

UniProt:

E9ATE7_LEIMU

TriTrypDb:

LmxM.36.3660

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATE7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016462	pyrophosphatase activity	5	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0047631	ADP-ribose diphosphatase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.355
CLV_PCSK_KEX2_1	128	130	PF00082	0.355
CLV_PCSK_KEX2_1	251	253	PF00082	0.438
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.438
CLV_PCSK_SKI1_1	240	244	PF00082	0.451
DEG_APCC_DBOX_1	61	69	PF00400	0.438
DOC_ANK_TNKS_1	205	212	PF00023	0.383
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.355
DOC_PP2B_LxvP_1	232	235	PF13499	0.418
DOC_PP2B_LxvP_1	8	11	PF13499	0.404
DOC_PP4_FxxP_1	22	25	PF00568	0.432
DOC_PP4_FxxP_1	34	37	PF00568	0.394
DOC_SPAK_OSR1_1	133	137	PF12202	0.367
DOC_USP7_MATH_1	144	148	PF00917	0.461
DOC_USP7_MATH_1	25	29	PF00917	0.448
DOC_WW_Pin1_4	101	106	PF00397	0.501
DOC_WW_Pin1_4	109	114	PF00397	0.463
DOC_WW_Pin1_4	16	21	PF00397	0.677
DOC_WW_Pin1_4	185	190	PF00397	0.371
LIG_14-3-3_CanoR_1	128	137	PF00244	0.418
LIG_14-3-3_CanoR_1	51	57	PF00244	0.311
LIG_14-3-3_CanoR_1	99	105	PF00244	0.520
LIG_Actin_WH2_2	37	53	PF00022	0.357
LIG_Actin_WH2_2	58	74	PF00022	0.516
LIG_BRCT_BRCA1_1	130	134	PF00533	0.445
LIG_BRCT_BRCA1_1	18	22	PF00533	0.438
LIG_Clathr_ClatBox_1	204	208	PF01394	0.445
LIG_Dynein_DLC8_1	49	55	PF01221	0.318
LIG_FHA_1	173	179	PF00498	0.316
LIG_FHA_2	266	272	PF00498	0.419
LIG_FHA_2	61	67	PF00498	0.544
LIG_LIR_Apic_2	19	25	PF02991	0.434
LIG_LIR_Gen_1	131	141	PF02991	0.304
LIG_LIR_Nem_3	131	137	PF02991	0.304
LIG_PCNA_yPIPBox_3	43	57	PF02747	0.334
LIG_SH2_CRK	141	145	PF00017	0.291
LIG_SH2_STAT5	267	270	PF00017	0.430
LIG_SH2_STAT5	60	63	PF00017	0.492
LIG_SH2_STAT5	81	84	PF00017	0.459
LIG_SH3_3	14	20	PF00018	0.582
LIG_SH3_3	4	10	PF00018	0.587
LIG_SUMO_SIM_anti_2	227	233	PF11976	0.313
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.524
LIG_SUMO_SIM_par_1	13	19	PF11976	0.433
LIG_SUMO_SIM_par_1	183	188	PF11976	0.358
LIG_TRAF2_2	219	224	PF00917	0.313
LIG_TRFH_1	6	10	PF08558	0.401
LIG_UBA3_1	232	240	PF00899	0.332
LIG_WRC_WIRS_1	266	271	PF05994	0.432
MOD_CK2_1	104	110	PF00069	0.570
MOD_CK2_1	265	271	PF00069	0.467
MOD_CK2_1	60	66	PF00069	0.533
MOD_GlcNHglycan	106	109	PF01048	0.575
MOD_GlcNHglycan	240	243	PF01048	0.470
MOD_GlcNHglycan	68	71	PF01048	0.455
MOD_GlcNHglycan	83	86	PF01048	0.494
MOD_GSK3_1	185	192	PF00069	0.390
MOD_GSK3_1	234	241	PF00069	0.355
MOD_GSK3_1	52	59	PF00069	0.554
MOD_GSK3_1	77	84	PF00069	0.440
MOD_GSK3_1	97	104	PF00069	0.522
MOD_NEK2_1	15	20	PF00069	0.561
MOD_NEK2_1	197	202	PF00069	0.298
MOD_NEK2_1	50	55	PF00069	0.570
MOD_NEK2_1	56	61	PF00069	0.536
MOD_NEK2_1	71	76	PF00069	0.519
MOD_NEK2_1	79	84	PF00069	0.523
MOD_NEK2_2	25	30	PF00069	0.447
MOD_NEK2_2	52	57	PF00069	0.308
MOD_PIKK_1	35	41	PF00454	0.394
MOD_PIKK_1	50	56	PF00454	0.471
MOD_PKA_1	128	134	PF00069	0.445
MOD_PKA_2	127	133	PF00069	0.451
MOD_PKA_2	50	56	PF00069	0.312
MOD_PKA_2	98	104	PF00069	0.466
MOD_Plk_4	265	271	PF00069	0.372
MOD_Plk_4	45	51	PF00069	0.626
MOD_Plk_4	56	62	PF00069	0.467
MOD_ProDKin_1	101	107	PF00069	0.503
MOD_ProDKin_1	109	115	PF00069	0.460
MOD_ProDKin_1	16	22	PF00069	0.678
MOD_ProDKin_1	185	191	PF00069	0.371
MOD_SUMO_rev_2	237	242	PF00179	0.331
TRG_DiLeu_BaEn_2	172	178	PF01217	0.445
TRG_ENDOCYTIC_2	267	270	PF00928	0.372
TRG_ER_diArg_1	127	129	PF00400	0.355
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P576	Leptomonas seymouri	64%	100%
A0A0S4JQK4	Bodo saltans	40%	100%
A0A1X0P4G7	Trypanosomatidae	42%	100%
A0A3S7XBB4	Leishmania donovani	94%	100%
A0A422N1K2	Trypanosoma rangeli	43%	100%
A4HPN3	Leishmania braziliensis	85%	100%
A4ID31	Leishmania infantum	95%	100%
D0A8I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q150	Leishmania major	93%	100%
Q5RCY2	Pongo abelii	33%	100%
Q6AY63	Rattus norvegicus	34%	100%
Q9JKX6	Mus musculus	31%	100%
Q9UKK9	Homo sapiens	34%	100%
V5B9P3	Trypanosoma cruzi	47%	100%