DUF1619 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1619), putative

Species:

Leishmania mexicana

UniProt:

E9ATE6_LEIMU

TriTrypDb:

LmxM.36.3657

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATE6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0030030	cell projection organization	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.262
CLV_C14_Caspase3-7	281	285	PF00656	0.365
CLV_C14_Caspase3-7	33	37	PF00656	0.495
CLV_NRD_NRD_1	104	106	PF00675	0.321
CLV_NRD_NRD_1	182	184	PF00675	0.365
CLV_PCSK_KEX2_1	101	103	PF00082	0.319
CLV_PCSK_KEX2_1	182	184	PF00082	0.319
CLV_PCSK_KEX2_1	395	397	PF00082	0.477
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.355
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.242
CLV_PCSK_SKI1_1	106	110	PF00082	0.361
CLV_PCSK_SKI1_1	168	172	PF00082	0.141
CLV_PCSK_SKI1_1	344	348	PF00082	0.253
CLV_PCSK_SKI1_1	72	76	PF00082	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DEG_SPOP_SBC_1	274	278	PF00917	0.275
DEG_SPOP_SBC_1	30	34	PF00917	0.270
DOC_CKS1_1	148	153	PF01111	0.228
DOC_MAPK_FxFP_2	16	19	PF00069	0.449
DOC_MAPK_MEF2A_6	483	492	PF00069	0.274
DOC_PP1_RVXF_1	201	208	PF00149	0.220
DOC_PP1_RVXF_1	542	548	PF00149	0.382
DOC_PP4_FxxP_1	136	139	PF00568	0.218
DOC_PP4_FxxP_1	16	19	PF00568	0.449
DOC_PP4_FxxP_1	187	190	PF00568	0.310
DOC_PP4_FxxP_1	380	383	PF00568	0.280
DOC_PP4_FxxP_1	515	518	PF00568	0.263
DOC_USP7_MATH_1	274	278	PF00917	0.262
DOC_USP7_MATH_1	334	338	PF00917	0.282
DOC_USP7_MATH_1	578	582	PF00917	0.351
DOC_WW_Pin1_4	147	152	PF00397	0.177
DOC_WW_Pin1_4	175	180	PF00397	0.343
DOC_WW_Pin1_4	31	36	PF00397	0.414
DOC_WW_Pin1_4	347	352	PF00397	0.245
DOC_WW_Pin1_4	39	44	PF00397	0.332
DOC_WW_Pin1_4	469	474	PF00397	0.320
DOC_WW_Pin1_4	514	519	PF00397	0.410
DOC_WW_Pin1_4	82	87	PF00397	0.356
LIG_14-3-3_CanoR_1	242	248	PF00244	0.302
LIG_14-3-3_CanoR_1	396	400	PF00244	0.415
LIG_14-3-3_CanoR_1	580	584	PF00244	0.397
LIG_14-3-3_CanoR_1	72	78	PF00244	0.402
LIG_14-3-3_CanoR_1	96	101	PF00244	0.369
LIG_FHA_1	150	156	PF00498	0.382
LIG_FHA_1	252	258	PF00498	0.308
LIG_FHA_1	423	429	PF00498	0.312
LIG_FHA_1	457	463	PF00498	0.419
LIG_FHA_1	487	493	PF00498	0.386
LIG_FHA_1	51	57	PF00498	0.275
LIG_FHA_1	520	526	PF00498	0.452
LIG_FHA_1	540	546	PF00498	0.187
LIG_FHA_2	107	113	PF00498	0.329
LIG_FHA_2	148	154	PF00498	0.313
LIG_FHA_2	190	196	PF00498	0.365
LIG_FHA_2	279	285	PF00498	0.373
LIG_FHA_2	440	446	PF00498	0.477
LIG_KLC1_Yacidic_2	107	112	PF13176	0.341
LIG_LIR_Apic_2	13	19	PF02991	0.450
LIG_LIR_Apic_2	377	383	PF02991	0.335
LIG_LIR_Apic_2	76	80	PF02991	0.357
LIG_LIR_Apic_2	81	86	PF02991	0.406
LIG_LIR_Apic_2	89	93	PF02991	0.329
LIG_LIR_Gen_1	26	35	PF02991	0.437
LIG_LIR_Gen_1	276	285	PF02991	0.292
LIG_LIR_Gen_1	458	467	PF02991	0.273
LIG_LIR_Gen_1	537	545	PF02991	0.425
LIG_LIR_Nem_3	130	136	PF02991	0.205
LIG_LIR_Nem_3	178	184	PF02991	0.295
LIG_LIR_Nem_3	249	253	PF02991	0.270
LIG_LIR_Nem_3	26	30	PF02991	0.386
LIG_LIR_Nem_3	276	282	PF02991	0.261
LIG_LIR_Nem_3	458	464	PF02991	0.294
LIG_LIR_Nem_3	475	481	PF02991	0.344
LIG_LIR_Nem_3	537	541	PF02991	0.344
LIG_LIR_Nem_3	546	550	PF02991	0.286
LIG_LIR_Nem_3	573	579	PF02991	0.429
LIG_LIR_Nem_3	84	90	PF02991	0.314
LIG_LYPXL_yS_3	18	21	PF13949	0.518
LIG_MAD2	561	569	PF02301	0.494
LIG_MYND_1	566	570	PF01753	0.457
LIG_NRBOX	1	7	PF00104	0.598
LIG_Pex14_2	331	335	PF04695	0.235
LIG_Pex14_2	543	547	PF04695	0.288
LIG_SH2_CRK	118	122	PF00017	0.365
LIG_SH2_CRK	181	185	PF00017	0.262
LIG_SH2_CRK	232	236	PF00017	0.310
LIG_SH2_CRK	279	283	PF00017	0.261
LIG_SH2_CRK	494	498	PF00017	0.269
LIG_SH2_CRK	538	542	PF00017	0.222
LIG_SH2_CRK	83	87	PF00017	0.397
LIG_SH2_CRK	90	94	PF00017	0.325
LIG_SH2_GRB2like	232	235	PF00017	0.275
LIG_SH2_NCK_1	279	283	PF00017	0.262
LIG_SH2_NCK_1	83	87	PF00017	0.262
LIG_SH2_PTP2	172	175	PF00017	0.262
LIG_SH2_PTP2	326	329	PF00017	0.262
LIG_SH2_STAT3	481	484	PF00017	0.380
LIG_SH2_STAT3	505	508	PF00017	0.444
LIG_SH2_STAT5	110	113	PF00017	0.282
LIG_SH2_STAT5	135	138	PF00017	0.310
LIG_SH2_STAT5	172	175	PF00017	0.369
LIG_SH2_STAT5	326	329	PF00017	0.255
LIG_SH2_STAT5	353	356	PF00017	0.259
LIG_SH2_STAT5	44	47	PF00017	0.338
LIG_SH2_STAT5	77	80	PF00017	0.314
LIG_SH2_STAT5	87	90	PF00017	0.211
LIG_SH3_3	139	145	PF00018	0.232
LIG_SH3_3	148	154	PF00018	0.255
LIG_SH3_3	160	166	PF00018	0.368
LIG_SH3_3	18	24	PF00018	0.395
LIG_SH3_3	560	566	PF00018	0.459
LIG_SH3_5	86	90	PF00018	0.365
LIG_SUMO_SIM_par_1	152	158	PF11976	0.244
LIG_SUMO_SIM_par_1	291	296	PF11976	0.225
LIG_SUMO_SIM_par_1	7	14	PF11976	0.552
LIG_TYR_ITIM	170	175	PF00017	0.141
LIG_TYR_ITIM	492	497	PF00017	0.247
LIG_TYR_ITIM	536	541	PF00017	0.225
LIG_WRC_WIRS_1	520	525	PF05994	0.298
MOD_CDK_SPxxK_3	175	182	PF00069	0.262
MOD_CDK_SPxxK_3	31	38	PF00069	0.514
MOD_CK1_1	194	200	PF00069	0.388
MOD_CK1_1	300	306	PF00069	0.329
MOD_CK1_1	402	408	PF00069	0.342
MOD_CK1_1	422	428	PF00069	0.187
MOD_CK1_1	460	466	PF00069	0.340
MOD_CK1_1	474	480	PF00069	0.403
MOD_CK1_1	486	492	PF00069	0.425
MOD_CK1_1	554	560	PF00069	0.562
MOD_CK2_1	106	112	PF00069	0.369
MOD_CK2_1	147	153	PF00069	0.326
MOD_CK2_1	243	249	PF00069	0.373
MOD_CK2_1	299	305	PF00069	0.341
MOD_GlcNHglycan	13	16	PF01048	0.585
MOD_GlcNHglycan	175	178	PF01048	0.407
MOD_GlcNHglycan	198	201	PF01048	0.358
MOD_GlcNHglycan	259	263	PF01048	0.187
MOD_GlcNHglycan	305	308	PF01048	0.365
MOD_GlcNHglycan	354	357	PF01048	0.294
MOD_GlcNHglycan	360	363	PF01048	0.383
MOD_GlcNHglycan	369	373	PF01048	0.263
MOD_GlcNHglycan	377	380	PF01048	0.220
MOD_GlcNHglycan	405	408	PF01048	0.327
MOD_GlcNHglycan	464	467	PF01048	0.387
MOD_GlcNHglycan	474	477	PF01048	0.428
MOD_GlcNHglycan	68	72	PF01048	0.319
MOD_GSK3_1	123	130	PF00069	0.363
MOD_GSK3_1	149	156	PF00069	0.183
MOD_GSK3_1	173	180	PF00069	0.407
MOD_GSK3_1	207	214	PF00069	0.357
MOD_GSK3_1	264	271	PF00069	0.343
MOD_GSK3_1	274	281	PF00069	0.346
MOD_GSK3_1	299	306	PF00069	0.285
MOD_GSK3_1	334	341	PF00069	0.313
MOD_GSK3_1	395	402	PF00069	0.379
MOD_GSK3_1	452	459	PF00069	0.317
MOD_GSK3_1	465	472	PF00069	0.404
MOD_GSK3_1	479	486	PF00069	0.331
MOD_GSK3_1	539	546	PF00069	0.361
MOD_N-GLC_1	243	248	PF02516	0.314
MOD_N-GLC_1	303	308	PF02516	0.237
MOD_N-GLC_1	314	319	PF02516	0.193
MOD_N-GLC_1	338	343	PF02516	0.341
MOD_N-GLC_1	412	417	PF02516	0.453
MOD_N-GLC_1	433	438	PF02516	0.458
MOD_N-GLC_1	455	460	PF02516	0.313
MOD_N-GLC_1	486	491	PF02516	0.436
MOD_N-GLC_1	526	531	PF02516	0.425
MOD_NEK2_1	207	212	PF00069	0.346
MOD_NEK2_1	237	242	PF00069	0.298
MOD_NEK2_1	257	262	PF00069	0.159
MOD_NEK2_1	299	304	PF00069	0.302
MOD_NEK2_1	314	319	PF00069	0.232
MOD_NEK2_1	388	393	PF00069	0.461
MOD_NEK2_1	399	404	PF00069	0.320
MOD_NEK2_1	543	548	PF00069	0.318
MOD_NEK2_1	571	576	PF00069	0.442
MOD_NEK2_1	579	584	PF00069	0.465
MOD_NEK2_1	9	14	PF00069	0.585
MOD_PIKK_1	155	161	PF00454	0.262
MOD_PIKK_1	551	557	PF00454	0.453
MOD_PKA_1	395	401	PF00069	0.354
MOD_PKA_2	375	381	PF00069	0.359
MOD_PKA_2	395	401	PF00069	0.206
MOD_PKA_2	579	585	PF00069	0.667
MOD_PKA_2	95	101	PF00069	0.380
MOD_Plk_1	106	112	PF00069	0.321
MOD_Plk_1	243	249	PF00069	0.141
MOD_Plk_1	314	320	PF00069	0.262
MOD_Plk_1	338	344	PF00069	0.296
MOD_Plk_1	368	374	PF00069	0.427
MOD_Plk_1	433	439	PF00069	0.381
MOD_Plk_1	456	462	PF00069	0.308
MOD_Plk_1	486	492	PF00069	0.439
MOD_Plk_1	571	577	PF00069	0.409
MOD_Plk_4	106	112	PF00069	0.335
MOD_Plk_4	268	274	PF00069	0.324
MOD_Plk_4	360	366	PF00069	0.365
MOD_Plk_4	395	401	PF00069	0.411
MOD_Plk_4	439	445	PF00069	0.527
MOD_Plk_4	457	463	PF00069	0.208
MOD_Plk_4	554	560	PF00069	0.516
MOD_Plk_4	571	577	PF00069	0.324
MOD_ProDKin_1	147	153	PF00069	0.177
MOD_ProDKin_1	175	181	PF00069	0.343
MOD_ProDKin_1	31	37	PF00069	0.414
MOD_ProDKin_1	347	353	PF00069	0.245
MOD_ProDKin_1	39	45	PF00069	0.326
MOD_ProDKin_1	469	475	PF00069	0.324
MOD_ProDKin_1	514	520	PF00069	0.418
MOD_ProDKin_1	82	88	PF00069	0.356
MOD_SUMO_rev_2	107	115	PF00179	0.433
MOD_SUMO_rev_2	283	287	PF00179	0.262
TRG_DiLeu_BaEn_1	305	310	PF01217	0.341
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.262
TRG_ENDOCYTIC_2	118	121	PF00928	0.362
TRG_ENDOCYTIC_2	133	136	PF00928	0.228
TRG_ENDOCYTIC_2	172	175	PF00928	0.438
TRG_ENDOCYTIC_2	18	21	PF00928	0.495
TRG_ENDOCYTIC_2	181	184	PF00928	0.353
TRG_ENDOCYTIC_2	232	235	PF00928	0.275
TRG_ENDOCYTIC_2	279	282	PF00928	0.261
TRG_ENDOCYTIC_2	326	329	PF00928	0.365
TRG_ENDOCYTIC_2	494	497	PF00928	0.337
TRG_ENDOCYTIC_2	538	541	PF00928	0.347
TRG_ER_diArg_1	181	183	PF00400	0.365
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2E7	Leptomonas seymouri	59%	100%
A0A0S4J6N9	Bodo saltans	33%	82%
A0A1X0P3E6	Trypanosomatidae	39%	99%
A0A3Q8IJL4	Leishmania donovani	90%	100%
A0A3R7KNL3	Trypanosoma rangeli	37%	91%
A4ID32	Leishmania infantum	91%	100%
D0A8I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q151	Leishmania major	89%	100%
Q8R2Q6	Mus musculus	25%	98%
V5DNN8	Trypanosoma cruzi	40%	100%