WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATE4_LEIMU

TriTrypDb:

LmxM.36.3650

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ATE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATE4

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.567
CLV_PCSK_KEX2_1	316	318	PF00082	0.574
CLV_PCSK_SKI1_1	174	178	PF00082	0.276
CLV_PCSK_SKI1_1	29	33	PF00082	0.598
DEG_APCC_DBOX_1	28	36	PF00400	0.586
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DEG_SCF_FBW7_1	94	101	PF00400	0.529
DOC_CYCLIN_RxL_1	363	376	PF00134	0.573
DOC_MAPK_gen_1	180	188	PF00069	0.562
DOC_MAPK_gen_1	316	325	PF00069	0.530
DOC_MAPK_gen_1	368	374	PF00069	0.474
DOC_MAPK_MEF2A_6	180	188	PF00069	0.562
DOC_PP1_RVXF_1	172	179	PF00149	0.476
DOC_PP2B_LxvP_1	332	335	PF13499	0.517
DOC_USP7_MATH_1	232	236	PF00917	0.462
DOC_USP7_MATH_1	288	292	PF00917	0.427
DOC_USP7_MATH_1	336	340	PF00917	0.442
DOC_USP7_MATH_1	344	348	PF00917	0.377
DOC_WW_Pin1_4	135	140	PF00397	0.416
DOC_WW_Pin1_4	180	185	PF00397	0.581
DOC_WW_Pin1_4	20	25	PF00397	0.612
DOC_WW_Pin1_4	271	276	PF00397	0.508
DOC_WW_Pin1_4	94	99	PF00397	0.533
LIG_14-3-3_CanoR_1	10	14	PF00244	0.606
LIG_14-3-3_CanoR_1	317	323	PF00244	0.582
LIG_14-3-3_CanoR_1	363	367	PF00244	0.478
LIG_14-3-3_CanoR_1	45	53	PF00244	0.529
LIG_Actin_WH2_2	1	16	PF00022	0.578
LIG_BRCT_BRCA1_1	14	18	PF00533	0.654
LIG_deltaCOP1_diTrp_1	171	178	PF00928	0.476
LIG_FHA_1	148	154	PF00498	0.451
LIG_FHA_1	155	161	PF00498	0.417
LIG_FHA_1	168	174	PF00498	0.426
LIG_FHA_1	235	241	PF00498	0.465
LIG_FHA_1	249	255	PF00498	0.608
LIG_FHA_1	293	299	PF00498	0.389
LIG_FHA_1	304	310	PF00498	0.400
LIG_FHA_1	365	371	PF00498	0.453
LIG_FHA_1	54	60	PF00498	0.510
LIG_FHA_1	86	92	PF00498	0.509
LIG_FHA_2	189	195	PF00498	0.496
LIG_LIR_Gen_1	170	179	PF02991	0.476
LIG_LIR_Gen_1	321	329	PF02991	0.484
LIG_LIR_Nem_3	170	175	PF02991	0.481
LIG_LIR_Nem_3	225	230	PF02991	0.448
LIG_LIR_Nem_3	321	325	PF02991	0.530
LIG_NRBOX	31	37	PF00104	0.581
LIG_NRBOX	387	393	PF00104	0.549
LIG_Pex14_2	322	326	PF04695	0.468
LIG_SH2_CRK	227	231	PF00017	0.523
LIG_SH2_SRC	111	114	PF00017	0.566
LIG_SH2_STAP1	128	132	PF00017	0.510
LIG_SH2_STAP1	366	370	PF00017	0.455
LIG_SH2_STAT5	11	14	PF00017	0.601
LIG_SH2_STAT5	111	114	PF00017	0.526
LIG_SH2_STAT5	143	146	PF00017	0.479
LIG_SH2_STAT5	273	276	PF00017	0.528
LIG_SH2_STAT5	300	303	PF00017	0.551
LIG_SH2_STAT5	366	369	PF00017	0.467
LIG_SH3_3	298	304	PF00018	0.474
LIG_SH3_3	353	359	PF00018	0.433
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.410
LIG_SUMO_SIM_par_1	150	159	PF11976	0.416
LIG_SUMO_SIM_par_1	228	235	PF11976	0.475
LIG_SUMO_SIM_par_1	291	299	PF11976	0.393
LIG_SUMO_SIM_par_1	55	63	PF11976	0.406
LIG_WRC_WIRS_1	374	379	PF05994	0.546
MOD_CDK_SPxxK_3	135	142	PF00069	0.505
MOD_CK1_1	206	212	PF00069	0.509
MOD_CK1_1	225	231	PF00069	0.218
MOD_CK1_1	234	240	PF00069	0.543
MOD_CK1_1	247	253	PF00069	0.614
MOD_CK1_1	348	354	PF00069	0.472
MOD_CK1_1	89	95	PF00069	0.537
MOD_CK2_1	211	217	PF00069	0.476
MOD_CK2_1	286	292	PF00069	0.379
MOD_GlcNHglycan	14	17	PF01048	0.650
MOD_GlcNHglycan	227	230	PF01048	0.483
MOD_GlcNHglycan	234	237	PF01048	0.525
MOD_GlcNHglycan	25	28	PF01048	0.411
MOD_GlcNHglycan	288	291	PF01048	0.396
MOD_GlcNHglycan	90	94	PF01048	0.500
MOD_GSK3_1	113	120	PF00069	0.465
MOD_GSK3_1	143	150	PF00069	0.433
MOD_GSK3_1	151	158	PF00069	0.470
MOD_GSK3_1	211	218	PF00069	0.478
MOD_GSK3_1	231	238	PF00069	0.191
MOD_GSK3_1	244	251	PF00069	0.565
MOD_GSK3_1	288	295	PF00069	0.431
MOD_GSK3_1	344	351	PF00069	0.469
MOD_GSK3_1	358	365	PF00069	0.392
MOD_GSK3_1	40	47	PF00069	0.584
MOD_GSK3_1	85	92	PF00069	0.548
MOD_GSK3_1	94	101	PF00069	0.472
MOD_N-GLC_1	248	253	PF02516	0.697
MOD_NEK2_1	102	107	PF00069	0.517
MOD_NEK2_1	133	138	PF00069	0.490
MOD_NEK2_1	203	208	PF00069	0.448
MOD_NEK2_1	215	220	PF00069	0.391
MOD_NEK2_1	222	227	PF00069	0.257
MOD_NEK2_1	31	36	PF00069	0.497
MOD_PIKK_1	281	287	PF00454	0.432
MOD_PK_1	45	51	PF00069	0.556
MOD_PKA_2	362	368	PF00069	0.480
MOD_PKA_2	44	50	PF00069	0.586
MOD_PKA_2	9	15	PF00069	0.596
MOD_PKB_1	316	324	PF00069	0.676
MOD_Plk_1	211	217	PF00069	0.494
MOD_Plk_1	222	228	PF00069	0.348
MOD_Plk_1	281	287	PF00069	0.444
MOD_Plk_1	292	298	PF00069	0.355
MOD_Plk_4	151	157	PF00069	0.399
MOD_Plk_4	203	209	PF00069	0.496
MOD_Plk_4	222	228	PF00069	0.267
MOD_Plk_4	235	241	PF00069	0.462
MOD_Plk_4	296	302	PF00069	0.421
MOD_Plk_4	31	37	PF00069	0.475
MOD_Plk_4	336	342	PF00069	0.469
MOD_Plk_4	348	354	PF00069	0.352
MOD_Plk_4	373	379	PF00069	0.548
MOD_Plk_4	73	79	PF00069	0.664
MOD_Plk_4	98	104	PF00069	0.523
MOD_ProDKin_1	135	141	PF00069	0.413
MOD_ProDKin_1	180	186	PF00069	0.581
MOD_ProDKin_1	20	26	PF00069	0.606
MOD_ProDKin_1	271	277	PF00069	0.504
MOD_ProDKin_1	94	100	PF00069	0.531
MOD_SUMO_rev_2	136	144	PF00179	0.488
MOD_SUMO_rev_2	158	163	PF00179	0.543
TRG_DiLeu_BaEn_1	262	267	PF01217	0.274
TRG_ENDOCYTIC_2	227	230	PF00928	0.532
TRG_ER_diArg_1	243	246	PF00400	0.302
TRG_ER_diArg_1	316	318	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ1	Leptomonas seymouri	79%	100%
A0A0S4JCI3	Bodo saltans	29%	71%
A0A1X0P3H5	Trypanosomatidae	49%	100%
A0A3S7XBC0	Leishmania donovani	96%	100%
A0A422MYE0	Trypanosoma rangeli	47%	100%
A4HPN2	Leishmania braziliensis	93%	100%
A4ID34	Leishmania infantum	96%	100%
D0A8I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q153	Leishmania major	95%	100%
V5B728	Trypanosoma cruzi	49%	100%