Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ATE2_LEIMU

TriTrypDb:

LmxM.36.3630

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ATE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.488
CLV_C14_Caspase3-7	253	257	PF00656	0.693
CLV_NRD_NRD_1	108	110	PF00675	0.389
CLV_NRD_NRD_1	113	115	PF00675	0.389
CLV_NRD_NRD_1	134	136	PF00675	0.394
CLV_NRD_NRD_1	198	200	PF00675	0.564
CLV_NRD_NRD_1	247	249	PF00675	0.507
CLV_PCSK_FUR_1	109	113	PF00082	0.372
CLV_PCSK_KEX2_1	110	112	PF00082	0.404
CLV_PCSK_KEX2_1	113	115	PF00082	0.398
CLV_PCSK_KEX2_1	134	136	PF00082	0.394
CLV_PCSK_KEX2_1	198	200	PF00082	0.510
CLV_PCSK_KEX2_1	247	249	PF00082	0.507
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.375
CLV_PCSK_PC7_1	109	115	PF00082	0.338
CLV_PCSK_SKI1_1	113	117	PF00082	0.461
CLV_PCSK_SKI1_1	3	7	PF00082	0.667
CLV_PCSK_SKI1_1	83	87	PF00082	0.454
DEG_SPOP_SBC_1	14	18	PF00917	0.460
DEG_SPOP_SBC_1	251	255	PF00917	0.641
DEG_SPOP_SBC_1	270	274	PF00917	0.599
DOC_MAPK_gen_1	132	141	PF00069	0.587
DOC_MAPK_HePTP_8	80	92	PF00069	0.332
DOC_MAPK_MEF2A_6	83	92	PF00069	0.332
DOC_PP2B_LxvP_1	293	296	PF13499	0.560
DOC_PP4_FxxP_1	292	295	PF00568	0.619
DOC_USP7_MATH_1	222	226	PF00917	0.600
DOC_USP7_MATH_1	69	73	PF00917	0.505
DOC_USP7_MATH_1	81	85	PF00917	0.345
DOC_USP7_UBL2_3	116	120	PF12436	0.602
DOC_WW_Pin1_4	232	237	PF00397	0.603
DOC_WW_Pin1_4	280	285	PF00397	0.726
LIG_BRCT_BRCA1_1	226	230	PF00533	0.603
LIG_deltaCOP1_diTrp_1	231	239	PF00928	0.644
LIG_deltaCOP1_diTrp_1	40	47	PF00928	0.388
LIG_FHA_1	43	49	PF00498	0.421
LIG_FHA_1	75	81	PF00498	0.469
LIG_FHA_2	15	21	PF00498	0.490
LIG_FHA_2	270	276	PF00498	0.733
LIG_LIR_Apic_2	231	236	PF02991	0.595
LIG_LIR_Apic_2	291	295	PF02991	0.593
LIG_LIR_Gen_1	259	269	PF02991	0.600
LIG_LIR_Nem_3	255	261	PF02991	0.692
LIG_PCNA_yPIPBox_3	167	177	PF02747	0.622
LIG_Pex14_2	226	230	PF04695	0.603
LIG_SH2_CRK	287	291	PF00017	0.683
LIG_SH2_GRB2like	258	261	PF00017	0.633
LIG_SH2_STAP1	214	218	PF00017	0.764
LIG_SH2_STAP1	261	265	PF00017	0.638
LIG_SH2_STAT5	59	62	PF00017	0.416
LIG_SH3_3	237	243	PF00018	0.718
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.332
LIG_TRAF2_1	115	118	PF00917	0.627
LIG_TRAF2_1	148	151	PF00917	0.509
LIG_WW_1	284	287	PF00397	0.678
MOD_CK1_1	18	24	PF00069	0.438
MOD_CK1_1	180	186	PF00069	0.667
MOD_CK1_1	188	194	PF00069	0.675
MOD_CK1_1	235	241	PF00069	0.628
MOD_CK1_1	62	68	PF00069	0.484
MOD_CK1_1	70	76	PF00069	0.451
MOD_CK2_1	222	228	PF00069	0.743
MOD_CK2_1	269	275	PF00069	0.732
MOD_GlcNHglycan	182	185	PF01048	0.511
MOD_GlcNHglycan	190	193	PF01048	0.521
MOD_GlcNHglycan	31	34	PF01048	0.499
MOD_GSK3_1	12	19	PF00069	0.493
MOD_GSK3_1	222	229	PF00069	0.733
MOD_GSK3_1	29	36	PF00069	0.299
MOD_GSK3_1	59	66	PF00069	0.456
MOD_GSK3_1	69	76	PF00069	0.438
MOD_N-GLC_1	177	182	PF02516	0.354
MOD_N-GLC_1	259	264	PF02516	0.436
MOD_N-GLC_1	70	75	PF02516	0.706
MOD_NEK2_1	13	18	PF00069	0.501
MOD_NEK2_1	190	195	PF00069	0.692
MOD_PIKK_1	185	191	PF00454	0.723
MOD_PIKK_1	59	65	PF00454	0.420
MOD_Plk_1	177	183	PF00069	0.539
MOD_Plk_1	81	87	PF00069	0.391
MOD_Plk_4	235	241	PF00069	0.628
MOD_Plk_4	264	270	PF00069	0.721
MOD_Plk_4	288	294	PF00069	0.588
MOD_Plk_4	74	80	PF00069	0.486
MOD_Plk_4	81	87	PF00069	0.381
MOD_ProDKin_1	232	238	PF00069	0.603
MOD_ProDKin_1	280	286	PF00069	0.724
MOD_SUMO_for_1	115	118	PF00179	0.595
MOD_SUMO_rev_2	117	122	PF00179	0.603
TRG_ENDOCYTIC_2	261	264	PF00928	0.685
TRG_ENDOCYTIC_2	287	290	PF00928	0.687
TRG_ER_diArg_1	108	111	PF00400	0.582
TRG_ER_diArg_1	112	114	PF00400	0.605
TRG_ER_diArg_1	246	248	PF00400	0.733
TRG_NLS_MonoCore_2	108	113	PF00514	0.535
TRG_NLS_MonoExtC_3	108	113	PF00514	0.603
TRG_NLS_MonoExtN_4	109	114	PF00514	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJD1	Leishmania donovani	84%	100%
A4HPN0	Leishmania braziliensis	54%	97%
A4ID36	Leishmania infantum	84%	100%
Q4Q155	Leishmania major	79%	98%