F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ATE0_LEIMU

TriTrypDb:

LmxM.36.3610

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.346
CLV_C14_Caspase3-7	429	433	PF00656	0.564
CLV_C14_Caspase3-7	479	483	PF00656	0.530
CLV_NRD_NRD_1	350	352	PF00675	0.666
CLV_PCSK_KEX2_1	16	18	PF00082	0.540
CLV_PCSK_KEX2_1	349	351	PF00082	0.707
CLV_PCSK_KEX2_1	43	45	PF00082	0.600
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.540
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.620
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.544
CLV_PCSK_SKI1_1	131	135	PF00082	0.554
CLV_PCSK_SKI1_1	177	181	PF00082	0.637
CLV_PCSK_SKI1_1	287	291	PF00082	0.455
CLV_PCSK_SKI1_1	394	398	PF00082	0.587
DEG_Nend_UBRbox_2	1	3	PF02207	0.511
DEG_ODPH_VHL_1	58	69	PF01847	0.483
DEG_SPOP_SBC_1	513	517	PF00917	0.424
DOC_MAPK_FxFP_2	118	121	PF00069	0.442
DOC_MAPK_gen_1	136	144	PF00069	0.475
DOC_MAPK_gen_1	16	22	PF00069	0.442
DOC_MAPK_gen_1	72	80	PF00069	0.504
DOC_MAPK_MEF2A_6	72	80	PF00069	0.504
DOC_PP1_RVXF_1	175	182	PF00149	0.440
DOC_PP1_RVXF_1	42	49	PF00149	0.500
DOC_PP2B_LxvP_1	494	497	PF13499	0.575
DOC_PP2B_LxvP_1	58	61	PF13499	0.458
DOC_PP4_FxxP_1	118	121	PF00568	0.442
DOC_USP7_MATH_1	119	123	PF00917	0.503
DOC_USP7_MATH_1	232	236	PF00917	0.498
DOC_USP7_MATH_1	460	464	PF00917	0.517
DOC_WW_Pin1_4	162	167	PF00397	0.374
DOC_WW_Pin1_4	320	325	PF00397	0.438
LIG_14-3-3_CanoR_1	287	297	PF00244	0.372
LIG_14-3-3_CanoR_1	301	306	PF00244	0.477
LIG_14-3-3_CanoR_1	340	345	PF00244	0.456
LIG_14-3-3_CanoR_1	350	359	PF00244	0.386
LIG_14-3-3_CanoR_1	380	384	PF00244	0.426
LIG_14-3-3_CanoR_1	420	426	PF00244	0.496
LIG_AP2alpha_2	231	233	PF02296	0.536
LIG_AP2alpha_2	469	471	PF02296	0.534
LIG_BRCT_BRCA1_1	33	37	PF00533	0.461
LIG_eIF4E_1	95	101	PF01652	0.496
LIG_FHA_1	181	187	PF00498	0.385
LIG_FHA_1	2	8	PF00498	0.485
LIG_FHA_1	351	357	PF00498	0.417
LIG_FHA_1	380	386	PF00498	0.421
LIG_FHA_1	403	409	PF00498	0.462
LIG_FHA_1	425	431	PF00498	0.486
LIG_FHA_1	472	478	PF00498	0.527
LIG_FHA_1	84	90	PF00498	0.490
LIG_FHA_1	96	102	PF00498	0.370
LIG_FHA_2	13	19	PF00498	0.445
LIG_FHA_2	193	199	PF00498	0.512
LIG_FHA_2	499	505	PF00498	0.551
LIG_LIR_Apic_2	160	166	PF02991	0.410
LIG_LIR_Apic_2	319	324	PF02991	0.473
LIG_LIR_Gen_1	329	339	PF02991	0.373
LIG_LIR_Gen_1	405	413	PF02991	0.453
LIG_LIR_Gen_1	507	514	PF02991	0.397
LIG_LIR_Gen_1	53	61	PF02991	0.499
LIG_LIR_Nem_3	265	271	PF02991	0.392
LIG_LIR_Nem_3	34	40	PF02991	0.476
LIG_LIR_Nem_3	382	386	PF02991	0.396
LIG_LIR_Nem_3	405	410	PF02991	0.456
LIG_LIR_Nem_3	436	441	PF02991	0.555
LIG_LIR_Nem_3	499	503	PF02991	0.455
LIG_LIR_Nem_3	507	511	PF02991	0.411
LIG_LIR_Nem_3	53	58	PF02991	0.504
LIG_SH2_CRK	321	325	PF00017	0.470
LIG_SH2_CRK	97	101	PF00017	0.503
LIG_SH2_NCK_1	163	167	PF00017	0.468
LIG_SH2_NCK_1	206	210	PF00017	0.587
LIG_SH2_PTP2	55	58	PF00017	0.498
LIG_SH2_STAP1	97	101	PF00017	0.413
LIG_SH2_STAT5	13	16	PF00017	0.483
LIG_SH2_STAT5	260	263	PF00017	0.421
LIG_SH2_STAT5	383	386	PF00017	0.406
LIG_SH2_STAT5	416	419	PF00017	0.526
LIG_SH2_STAT5	45	48	PF00017	0.508
LIG_SH2_STAT5	453	456	PF00017	0.515
LIG_SH2_STAT5	55	58	PF00017	0.498
LIG_SH2_STAT5	95	98	PF00017	0.401
LIG_SH3_3	224	230	PF00018	0.384
LIG_SH3_3	250	256	PF00018	0.484
LIG_SUMO_SIM_anti_2	4	12	PF11976	0.480
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.364
LIG_SUMO_SIM_par_1	393	401	PF11976	0.425
LIG_SUMO_SIM_par_1	4	12	PF11976	0.471
LIG_SUMO_SIM_par_1	76	82	PF11976	0.457
LIG_TRAF2_1	39	42	PF00917	0.493
LIG_WRC_WIRS_1	452	457	PF05994	0.518
MOD_CK1_1	12	18	PF00069	0.483
MOD_CK1_1	207	213	PF00069	0.466
MOD_CK1_1	23	29	PF00069	0.487
MOD_CK1_1	234	240	PF00069	0.470
MOD_CK1_1	241	247	PF00069	0.452
MOD_CK1_1	304	310	PF00069	0.424
MOD_CK1_1	36	42	PF00069	0.485
MOD_CK1_1	367	373	PF00069	0.461
MOD_CK1_1	379	385	PF00069	0.390
MOD_CK1_1	400	406	PF00069	0.454
MOD_CK1_1	424	430	PF00069	0.530
MOD_CK2_1	12	18	PF00069	0.541
MOD_CK2_1	232	238	PF00069	0.449
MOD_CK2_1	320	326	PF00069	0.419
MOD_CK2_1	36	42	PF00069	0.447
MOD_CK2_1	498	504	PF00069	0.506
MOD_GlcNHglycan	127	130	PF01048	0.645
MOD_GlcNHglycan	206	209	PF01048	0.715
MOD_GlcNHglycan	214	217	PF01048	0.717
MOD_GlcNHglycan	22	25	PF01048	0.646
MOD_GlcNHglycan	240	243	PF01048	0.715
MOD_GlcNHglycan	264	267	PF01048	0.672
MOD_GlcNHglycan	276	279	PF01048	0.542
MOD_GlcNHglycan	478	481	PF01048	0.711
MOD_GlcNHglycan	522	525	PF01048	0.387
MOD_GlcNHglycan	81	84	PF01048	0.744
MOD_GSK3_1	232	239	PF00069	0.551
MOD_GSK3_1	300	307	PF00069	0.432
MOD_GSK3_1	396	403	PF00069	0.393
MOD_GSK3_1	424	431	PF00069	0.417
MOD_GSK3_1	471	478	PF00069	0.550
MOD_GSK3_1	514	521	PF00069	0.376
MOD_GSK3_1	79	86	PF00069	0.454
MOD_NEK2_1	180	185	PF00069	0.366
MOD_NEK2_1	20	25	PF00069	0.448
MOD_NEK2_1	217	222	PF00069	0.420
MOD_NEK2_1	248	253	PF00069	0.537
MOD_NEK2_1	261	266	PF00069	0.386
MOD_NEK2_1	273	278	PF00069	0.345
MOD_NEK2_1	288	293	PF00069	0.398
MOD_NEK2_1	305	310	PF00069	0.450
MOD_NEK2_1	312	317	PF00069	0.437
MOD_NEK2_1	402	407	PF00069	0.458
MOD_NEK2_1	471	476	PF00069	0.455
MOD_NEK2_1	518	523	PF00069	0.376
MOD_NEK2_1	79	84	PF00069	0.479
MOD_NEK2_1	9	14	PF00069	0.543
MOD_NEK2_2	182	187	PF00069	0.431
MOD_PIKK_1	59	65	PF00454	0.495
MOD_PIKK_1	95	101	PF00454	0.496
MOD_PK_1	406	412	PF00069	0.468
MOD_PKA_1	350	356	PF00069	0.438
MOD_PKA_2	300	306	PF00069	0.494
MOD_PKA_2	350	356	PF00069	0.493
MOD_PKA_2	379	385	PF00069	0.413
MOD_PKA_2	411	417	PF00069	0.475
MOD_Plk_1	192	198	PF00069	0.467
MOD_Plk_1	400	406	PF00069	0.416
MOD_Plk_4	120	126	PF00069	0.507
MOD_Plk_4	3	9	PF00069	0.483
MOD_Plk_4	33	39	PF00069	0.447
MOD_Plk_4	342	348	PF00069	0.431
MOD_Plk_4	379	385	PF00069	0.404
MOD_Plk_4	421	427	PF00069	0.528
MOD_Plk_4	504	510	PF00069	0.317
MOD_Plk_4	514	520	PF00069	0.376
MOD_ProDKin_1	162	168	PF00069	0.372
MOD_ProDKin_1	320	326	PF00069	0.442
TRG_DiLeu_BaEn_1	42	47	PF01217	0.462
TRG_DiLeu_BaEn_1	73	78	PF01217	0.449
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.254
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.454
TRG_ENDOCYTIC_2	331	334	PF00928	0.398
TRG_ENDOCYTIC_2	55	58	PF00928	0.498
TRG_ENDOCYTIC_2	97	100	PF00928	0.437
TRG_ER_diArg_1	350	352	PF00400	0.393
TRG_ER_diArg_1	538	541	PF00400	0.533
TRG_NES_CRM1_1	146	160	PF08389	0.379
TRG_NLS_MonoExtN_4	348	353	PF00514	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ9	Leptomonas seymouri	61%	98%
A0A1X0P3D8	Trypanosomatidae	28%	100%
A0A3S7XB84	Leishmania donovani	89%	100%
A4HPM8	Leishmania braziliensis	82%	100%
A4ID38	Leishmania infantum	89%	100%
Q4Q157	Leishmania major	91%	100%