Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATD9_LEIMU

TriTrypDb:

LmxM.36.3600

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.281
CLV_NRD_NRD_1	162	164	PF00675	0.295
CLV_NRD_NRD_1	19	21	PF00675	0.501
CLV_NRD_NRD_1	339	341	PF00675	0.743
CLV_NRD_NRD_1	436	438	PF00675	0.406
CLV_PCSK_KEX2_1	162	164	PF00082	0.295
CLV_PCSK_KEX2_1	19	21	PF00082	0.466
CLV_PCSK_KEX2_1	304	306	PF00082	0.577
CLV_PCSK_KEX2_1	339	341	PF00082	0.753
CLV_PCSK_KEX2_1	425	427	PF00082	0.478
CLV_PCSK_KEX2_1	65	67	PF00082	0.717
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.577
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.500
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.723
CLV_PCSK_PC7_1	61	67	PF00082	0.640
CLV_PCSK_SKI1_1	265	269	PF00082	0.303
CLV_PCSK_SKI1_1	352	356	PF00082	0.599
CLV_PCSK_SKI1_1	366	370	PF00082	0.501
CLV_PCSK_SKI1_1	448	452	PF00082	0.326
CLV_PCSK_SKI1_1	65	69	PF00082	0.756
DEG_APCC_DBOX_1	152	160	PF00400	0.410
DEG_SCF_FBW7_1	320	327	PF00400	0.545
DEG_SCF_FBW7_2	137	143	PF00400	0.356
DEG_SPOP_SBC_1	232	236	PF00917	0.525
DEG_SPOP_SBC_1	52	56	PF00917	0.517
DOC_CKS1_1	137	142	PF01111	0.397
DOC_CKS1_1	433	438	PF01111	0.412
DOC_MAPK_gen_1	19	25	PF00069	0.505
DOC_MAPK_gen_1	437	443	PF00069	0.458
DOC_MAPK_RevD_3	150	163	PF00069	0.257
DOC_PP1_RVXF_1	161	168	PF00149	0.282
DOC_PP1_SILK_1	352	357	PF00149	0.455
DOC_PP2B_LxvP_1	23	26	PF13499	0.454
DOC_PP2B_LxvP_1	278	281	PF13499	0.468
DOC_PP4_FxxP_1	113	116	PF00568	0.535
DOC_USP7_MATH_1	116	120	PF00917	0.481
DOC_USP7_MATH_1	220	224	PF00917	0.452
DOC_USP7_MATH_1	232	236	PF00917	0.580
DOC_USP7_MATH_1	284	288	PF00917	0.664
DOC_USP7_MATH_1	350	354	PF00917	0.680
DOC_USP7_MATH_1	388	392	PF00917	0.453
DOC_USP7_MATH_1	52	56	PF00917	0.563
DOC_USP7_UBL2_3	444	448	PF12436	0.463
DOC_USP7_UBL2_3	5	9	PF12436	0.384
DOC_WW_Pin1_4	136	141	PF00397	0.386
DOC_WW_Pin1_4	265	270	PF00397	0.363
DOC_WW_Pin1_4	320	325	PF00397	0.671
DOC_WW_Pin1_4	333	338	PF00397	0.615
DOC_WW_Pin1_4	432	437	PF00397	0.414
DOC_WW_Pin1_4	98	103	PF00397	0.491
LIG_14-3-3_CanoR_1	134	138	PF00244	0.435
LIG_14-3-3_CanoR_1	251	259	PF00244	0.364
LIG_14-3-3_CanoR_1	339	347	PF00244	0.774
LIG_Actin_WH2_2	206	224	PF00022	0.480
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	29	33	PF00533	0.494
LIG_CSL_BTD_1	137	140	PF09270	0.455
LIG_FHA_1	216	222	PF00498	0.554
LIG_FHA_1	238	244	PF00498	0.496
LIG_FHA_1	323	329	PF00498	0.693
LIG_FHA_1	411	417	PF00498	0.427
LIG_FHA_1	467	473	PF00498	0.509
LIG_FHA_2	137	143	PF00498	0.569
LIG_FHA_2	156	162	PF00498	0.260
LIG_FHA_2	206	212	PF00498	0.374
LIG_FHA_2	242	248	PF00498	0.334
LIG_FHA_2	261	267	PF00498	0.354
LIG_GBD_Chelix_1	80	88	PF00786	0.564
LIG_LIR_Apic_2	111	116	PF02991	0.566
LIG_LIR_Apic_2	268	274	PF02991	0.377
LIG_LIR_Gen_1	34	44	PF02991	0.410
LIG_LIR_Gen_1	4	15	PF02991	0.436
LIG_LIR_Gen_1	455	464	PF02991	0.414
LIG_LIR_Nem_3	183	187	PF02991	0.383
LIG_LIR_Nem_3	30	36	PF02991	0.468
LIG_LIR_Nem_3	4	10	PF02991	0.448
LIG_NRBOX	177	183	PF00104	0.333
LIG_NRBOX	313	319	PF00104	0.460
LIG_PCNA_yPIPBox_3	193	207	PF02747	0.344
LIG_PDZ_Class_2	469	474	PF00595	0.523
LIG_SH2_NCK_1	397	401	PF00017	0.370
LIG_SH2_SRC	397	400	PF00017	0.413
LIG_SH2_SRC	46	49	PF00017	0.582
LIG_SH2_STAT5	410	413	PF00017	0.396
LIG_SH3_3	266	272	PF00018	0.457
LIG_SH3_3	278	284	PF00018	0.367
LIG_SH3_3	343	349	PF00018	0.644
LIG_SUMO_SIM_par_1	204	211	PF11976	0.435
LIG_SUMO_SIM_par_1	239	245	PF11976	0.473
LIG_TRAF2_1	108	111	PF00917	0.590
LIG_TRAF2_1	158	161	PF00917	0.390
LIG_TRAF2_1	224	227	PF00917	0.298
LIG_TRAF2_1	331	334	PF00917	0.568
LIG_UBA3_1	416	425	PF00899	0.418
MOD_CDC14_SPxK_1	336	339	PF00782	0.558
MOD_CDK_SPK_2	432	437	PF00069	0.414
MOD_CDK_SPxK_1	320	326	PF00069	0.649
MOD_CDK_SPxK_1	333	339	PF00069	0.667
MOD_CDK_SPxK_1	432	438	PF00069	0.412
MOD_CDK_SPxxK_3	333	340	PF00069	0.566
MOD_CK1_1	215	221	PF00069	0.521
MOD_CK1_1	231	237	PF00069	0.423
MOD_CK1_1	27	33	PF00069	0.476
MOD_CK1_1	287	293	PF00069	0.662
MOD_CK1_1	91	97	PF00069	0.534
MOD_CK1_1	98	104	PF00069	0.472
MOD_CK2_1	155	161	PF00069	0.446
MOD_CK2_1	328	334	PF00069	0.564
MOD_CMANNOS	430	433	PF00535	0.527
MOD_GlcNHglycan	118	121	PF01048	0.468
MOD_GlcNHglycan	13	16	PF01048	0.587
MOD_GlcNHglycan	222	225	PF01048	0.486
MOD_GlcNHglycan	230	233	PF01048	0.617
MOD_GlcNHglycan	236	239	PF01048	0.607
MOD_GlcNHglycan	253	256	PF01048	0.214
MOD_GlcNHglycan	330	333	PF01048	0.580
MOD_GlcNHglycan	361	364	PF01048	0.560
MOD_GlcNHglycan	383	386	PF01048	0.584
MOD_GlcNHglycan	75	78	PF01048	0.711
MOD_GlcNHglycan	97	100	PF01048	0.547
MOD_GSK3_1	228	235	PF00069	0.474
MOD_GSK3_1	237	244	PF00069	0.510
MOD_GSK3_1	27	34	PF00069	0.510
MOD_GSK3_1	318	325	PF00069	0.718
MOD_GSK3_1	350	357	PF00069	0.745
MOD_GSK3_1	91	98	PF00069	0.536
MOD_NEK2_1	241	246	PF00069	0.311
MOD_NEK2_1	318	323	PF00069	0.482
MOD_NEK2_1	88	93	PF00069	0.553
MOD_NEK2_2	410	415	PF00069	0.432
MOD_OFUCOSY	408	414	PF10250	0.441
MOD_PIKK_1	295	301	PF00454	0.723
MOD_PIKK_1	338	344	PF00454	0.574
MOD_PIKK_1	369	375	PF00454	0.566
MOD_PIKK_1	388	394	PF00454	0.327
MOD_PIKK_1	46	52	PF00454	0.516
MOD_PIKK_1	53	59	PF00454	0.636
MOD_PIKK_1	91	97	PF00454	0.643
MOD_PKA_2	133	139	PF00069	0.438
MOD_PKA_2	338	344	PF00069	0.745
MOD_PKA_2	359	365	PF00069	0.613
MOD_Plk_1	241	247	PF00069	0.428
MOD_Plk_1	3	9	PF00069	0.517
MOD_Plk_2-3	242	248	PF00069	0.377
MOD_Plk_4	133	139	PF00069	0.442
MOD_Plk_4	245	251	PF00069	0.540
MOD_Plk_4	287	293	PF00069	0.610
MOD_ProDKin_1	136	142	PF00069	0.391
MOD_ProDKin_1	265	271	PF00069	0.361
MOD_ProDKin_1	320	326	PF00069	0.673
MOD_ProDKin_1	333	339	PF00069	0.618
MOD_ProDKin_1	432	438	PF00069	0.412
MOD_ProDKin_1	98	104	PF00069	0.488
MOD_SUMO_for_1	67	70	PF00179	0.629
MOD_SUMO_rev_2	298	306	PF00179	0.579
TRG_ENDOCYTIC_2	169	172	PF00928	0.418
TRG_ENDOCYTIC_2	36	39	PF00928	0.478
TRG_ER_diArg_1	162	164	PF00400	0.510
TRG_NES_CRM1_1	192	204	PF08389	0.504
TRG_NLS_Bipartite_1	425	441	PF00514	0.380
TRG_NLS_MonoExtC_3	64	70	PF00514	0.714
TRG_NLS_MonoExtN_4	434	441	PF00514	0.357
TRG_NLS_MonoExtN_4	62	69	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I528	Leptomonas seymouri	50%	98%
A0A1X0P3J4	Trypanosomatidae	27%	100%
A0A3R7M2K8	Trypanosoma rangeli	26%	100%
A0A3S7XBB1	Leishmania donovani	89%	100%
A4HPM7	Leishmania braziliensis	74%	100%
D0A8J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AHX7	Leishmania infantum	89%	100%
Q4Q158	Leishmania major	88%	100%
V5BML3	Trypanosoma cruzi	26%	100%