UPF0652 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UPF0652 protein

Gene product:

Protein of unknown function (DUF2009), putative

Species:

Leishmania mexicana

UniProt:

E9ATD7_LEIMU

TriTrypDb:

LmxM.36.3580

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.268
CLV_NRD_NRD_1	168	170	PF00675	0.212
CLV_NRD_NRD_1	191	193	PF00675	0.229
CLV_NRD_NRD_1	221	223	PF00675	0.328
CLV_NRD_NRD_1	98	100	PF00675	0.234
CLV_PCSK_FUR_1	99	103	PF00082	0.234
CLV_PCSK_KEX2_1	101	103	PF00082	0.234
CLV_PCSK_KEX2_1	168	170	PF00082	0.398
CLV_PCSK_KEX2_1	221	223	PF00082	0.328
CLV_PCSK_KEX2_1	98	100	PF00082	0.234
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.234
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.299
CLV_PCSK_SKI1_1	273	277	PF00082	0.255
CLV_PCSK_SKI1_1	358	362	PF00082	0.367
CLV_PCSK_SKI1_1	371	375	PF00082	0.371
CLV_PCSK_SKI1_1	398	402	PF00082	0.213
CLV_PCSK_SKI1_1	421	425	PF00082	0.268
CLV_PCSK_SKI1_1	70	74	PF00082	0.351
CLV_PCSK_SKI1_1	82	86	PF00082	0.245
CLV_Separin_Metazoa	160	164	PF03568	0.134
CLV_Separin_Metazoa	95	99	PF03568	0.379
DEG_APCC_DBOX_1	14	22	PF00400	0.234
DOC_CDC14_PxL_1	353	361	PF14671	0.299
DOC_CDC14_PxL_1	391	399	PF14671	0.379
DOC_CYCLIN_yClb1_LxF_4	344	350	PF00134	0.234
DOC_MAPK_DCC_7	341	349	PF00069	0.249
DOC_MAPK_gen_1	15	22	PF00069	0.428
DOC_MAPK_HePTP_8	338	350	PF00069	0.249
DOC_MAPK_HePTP_8	49	61	PF00069	0.134
DOC_MAPK_MEF2A_6	15	22	PF00069	0.294
DOC_MAPK_MEF2A_6	326	335	PF00069	0.364
DOC_MAPK_MEF2A_6	341	350	PF00069	0.177
DOC_MAPK_MEF2A_6	43	51	PF00069	0.170
DOC_MAPK_MEF2A_6	52	61	PF00069	0.299
DOC_MAPK_NFAT4_5	15	23	PF00069	0.249
DOC_PP2B_LxvP_1	137	140	PF13499	0.254
DOC_PP4_FxxP_1	37	40	PF00568	0.381
DOC_USP7_MATH_1	132	136	PF00917	0.246
DOC_USP7_MATH_1	147	151	PF00917	0.389
DOC_USP7_MATH_1	62	66	PF00917	0.286
DOC_USP7_UBL2_3	170	174	PF12436	0.134
LIG_14-3-3_CanoR_1	215	221	PF00244	0.330
LIG_14-3-3_CanoR_1	305	310	PF00244	0.244
LIG_14-3-3_CanoR_1	438	445	PF00244	0.234
LIG_BIR_III_2	66	70	PF00653	0.379
LIG_BRCT_BRCA1_1	224	228	PF00533	0.379
LIG_BRCT_BRCA1_1	416	420	PF00533	0.234
LIG_CaM_IQ_9	116	131	PF13499	0.268
LIG_Clathr_ClatBox_1	347	351	PF01394	0.234
LIG_EH_1	103	107	PF12763	0.249
LIG_eIF4E_1	260	266	PF01652	0.328
LIG_FHA_1	134	140	PF00498	0.341
LIG_FHA_1	162	168	PF00498	0.385
LIG_FHA_1	212	218	PF00498	0.379
LIG_FHA_1	29	35	PF00498	0.234
LIG_FHA_2	153	159	PF00498	0.324
LIG_FHA_2	9	15	PF00498	0.339
LIG_LIR_Apic_2	35	40	PF02991	0.379
LIG_LIR_Gen_1	204	212	PF02991	0.208
LIG_LIR_Gen_1	225	236	PF02991	0.178
LIG_LIR_Gen_1	351	360	PF02991	0.213
LIG_LIR_Gen_1	407	416	PF02991	0.236
LIG_LIR_Gen_1	53	62	PF02991	0.293
LIG_LIR_Nem_3	111	115	PF02991	0.271
LIG_LIR_Nem_3	204	210	PF02991	0.323
LIG_LIR_Nem_3	225	231	PF02991	0.270
LIG_LIR_Nem_3	351	356	PF02991	0.234
LIG_LIR_Nem_3	390	394	PF02991	0.302
LIG_LIR_Nem_3	403	408	PF02991	0.196
LIG_LIR_Nem_3	461	466	PF02991	0.254
LIG_LIR_Nem_3	53	57	PF02991	0.326
LIG_LYPXL_yS_3	394	397	PF13949	0.328
LIG_MLH1_MIPbox_1	416	420	PF16413	0.234
LIG_MYND_3	87	91	PF01753	0.379
LIG_NRBOX	396	402	PF00104	0.379
LIG_PCNA_PIPBox_1	272	281	PF02747	0.268
LIG_PCNA_PIPBox_1	413	422	PF02747	0.268
LIG_PCNA_yPIPBox_3	168	182	PF02747	0.353
LIG_Pex14_2	420	424	PF04695	0.248
LIG_REV1ctd_RIR_1	417	425	PF16727	0.248
LIG_SH2_CRK	207	211	PF00017	0.375
LIG_SH2_CRK	353	357	PF00017	0.234
LIG_SH2_GRB2like	391	394	PF00017	0.299
LIG_SH2_NCK_1	353	357	PF00017	0.213
LIG_SH2_STAP1	237	241	PF00017	0.328
LIG_SH2_STAP1	30	34	PF00017	0.234
LIG_SH2_STAP1	408	412	PF00017	0.233
LIG_SH2_STAP1	455	459	PF00017	0.234
LIG_SH2_STAT5	166	169	PF00017	0.247
LIG_SH2_STAT5	260	263	PF00017	0.249
LIG_SH2_STAT5	294	297	PF00017	0.325
LIG_SH2_STAT5	30	33	PF00017	0.234
LIG_SH2_STAT5	353	356	PF00017	0.234
LIG_SH2_STAT5	372	375	PF00017	0.379
LIG_SH3_3	340	346	PF00018	0.249
LIG_SH3_4	361	368	PF00018	0.299
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.299
LIG_SxIP_EBH_1	352	362	PF03271	0.234
LIG_UBA3_1	115	124	PF00899	0.334
LIG_UBA3_1	412	421	PF00899	0.332
LIG_UBA3_1	93	101	PF00899	0.249
LIG_WRC_WIRS_1	206	211	PF05994	0.379
MOD_CK1_1	230	236	PF00069	0.282
MOD_CK1_1	253	259	PF00069	0.334
MOD_CK1_1	28	34	PF00069	0.234
MOD_CK2_1	177	183	PF00069	0.356
MOD_CK2_1	404	410	PF00069	0.328
MOD_CK2_1	8	14	PF00069	0.245
MOD_GlcNHglycan	307	310	PF01048	0.328
MOD_GlcNHglycan	425	429	PF01048	0.248
MOD_GlcNHglycan	440	443	PF01048	0.234
MOD_GSK3_1	305	312	PF00069	0.286
MOD_GSK3_1	400	407	PF00069	0.258
MOD_GSK3_1	68	75	PF00069	0.282
MOD_N-GLC_2	444	446	PF02516	0.282
MOD_NEK2_1	1	6	PF00069	0.380
MOD_NEK2_1	250	255	PF00069	0.379
MOD_NEK2_1	400	405	PF00069	0.268
MOD_NEK2_1	458	463	PF00069	0.234
MOD_NEK2_2	147	152	PF00069	0.389
MOD_NEK2_2	216	221	PF00069	0.299
MOD_NEK2_2	237	242	PF00069	0.269
MOD_PIKK_1	1	7	PF00454	0.372
MOD_PKA_2	320	326	PF00069	0.297
MOD_PKA_2	437	443	PF00069	0.234
MOD_PKA_2	8	14	PF00069	0.241
MOD_Plk_4	133	139	PF00069	0.294
MOD_Plk_4	177	183	PF00069	0.364
MOD_Plk_4	205	211	PF00069	0.406
MOD_Plk_4	261	267	PF00069	0.271
MOD_Plk_4	351	357	PF00069	0.213
MOD_Plk_4	72	78	PF00069	0.408
MOD_Plk_4	82	88	PF00069	0.301
MOD_SUMO_rev_2	75	84	PF00179	0.299
TRG_DiLeu_BaEn_1	111	116	PF01217	0.293
TRG_DiLeu_BaEn_1	283	288	PF01217	0.249
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.379
TRG_ENDOCYTIC_2	207	210	PF00928	0.375
TRG_ENDOCYTIC_2	313	316	PF00928	0.320
TRG_ENDOCYTIC_2	353	356	PF00928	0.234
TRG_ENDOCYTIC_2	394	397	PF00928	0.292
TRG_ENDOCYTIC_2	408	411	PF00928	0.189
TRG_ENDOCYTIC_2	455	458	PF00928	0.234
TRG_ER_diArg_1	220	222	PF00400	0.350
TRG_ER_diArg_1	97	99	PF00400	0.249
TRG_NES_CRM1_1	16	29	PF08389	0.249
TRG_NES_CRM1_1	53	66	PF08389	0.379
TRG_NLS_MonoExtC_3	167	173	PF00514	0.178
TRG_NLS_MonoExtC_3	450	456	PF00514	0.379
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P579	Leptomonas seymouri	80%	100%
A0A0N1IK28	Leptomonas seymouri	31%	95%
A0A0S4JK69	Bodo saltans	45%	93%
A0A1X0P4E6	Trypanosomatidae	58%	100%
A0A1X0P522	Trypanosomatidae	30%	96%
A0A3R7KQ87	Trypanosoma rangeli	58%	100%
A0A3S7X9T8	Leishmania donovani	30%	95%
A0A3S7XBA3	Leishmania donovani	96%	100%
A0A422NK56	Trypanosoma rangeli	31%	96%
A4HN88	Leishmania braziliensis	32%	100%
A4HPM5	Leishmania braziliensis	91%	100%
A4IBV6	Leishmania infantum	30%	95%
A4ID40	Leishmania infantum	96%	100%
C9ZYQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
D0A8J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AFP3	Leishmania major	30%	100%
E9B6U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	95%
Q10301	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	95%
Q4Q160	Leishmania major	96%	100%
Q54BM8	Dictyostelium discoideum	36%	69%
Q9USN2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
V5BS87	Trypanosoma cruzi	58%	93%
V5C2P9	Trypanosoma cruzi	31%	96%