Putative signal recognition particle receptor like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle receptor like protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATD6_LEIMU

TriTrypDb:

LmxM.36.3570

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0005785	signal recognition particle receptor complex	3	10
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0016020	membrane	2	3
GO:0031090	organelle membrane	3	3
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	1

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Expansion

Sequence features

E9ATD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATD6

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005047	signal recognition particle binding	4	10
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.290
CLV_NRD_NRD_1	25	27	PF00675	0.451
CLV_NRD_NRD_1	374	376	PF00675	0.424
CLV_NRD_NRD_1	530	532	PF00675	0.294
CLV_PCSK_KEX2_1	203	205	PF00082	0.355
CLV_PCSK_KEX2_1	231	233	PF00082	0.381
CLV_PCSK_KEX2_1	25	27	PF00082	0.465
CLV_PCSK_KEX2_1	277	279	PF00082	0.545
CLV_PCSK_KEX2_1	353	355	PF00082	0.412
CLV_PCSK_KEX2_1	374	376	PF00082	0.411

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q5	Leptomonas seymouri	76%	99%
A0A0S4JKS8	Bodo saltans	56%	100%
A0A1X0P3D4	Trypanosomatidae	63%	100%
A0A3R7RBB0	Trypanosoma rangeli	60%	100%
A0A3S7XBC9	Leishmania donovani	95%	100%
A4HPM4	Leishmania braziliensis	87%	99%
A4ID41	Leishmania infantum	95%	100%
D0A8J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
P08240	Homo sapiens	37%	95%
Q4Q161	Leishmania major	93%	100%

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