Squalene/phytoene synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytoene synthase, putative

Species:

Leishmania mexicana

UniProt:

E9ATD5_LEIMU

TriTrypDb:

LmxM.36.3560

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATD5

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.355
CLV_NRD_NRD_1	25	27	PF00675	0.528
CLV_NRD_NRD_1	266	268	PF00675	0.263
CLV_NRD_NRD_1	314	316	PF00675	0.321
CLV_NRD_NRD_1	388	390	PF00675	0.688
CLV_NRD_NRD_1	77	79	PF00675	0.329
CLV_PCSK_KEX2_1	128	130	PF00082	0.238
CLV_PCSK_KEX2_1	25	27	PF00082	0.464
CLV_PCSK_KEX2_1	314	316	PF00082	0.321
CLV_PCSK_KEX2_1	340	342	PF00082	0.311
CLV_PCSK_KEX2_1	390	392	PF00082	0.596
CLV_PCSK_KEX2_1	77	79	PF00082	0.329
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.261
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.311
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.554
CLV_PCSK_SKI1_1	114	118	PF00082	0.235
CLV_PCSK_SKI1_1	162	166	PF00082	0.306
CLV_PCSK_SKI1_1	267	271	PF00082	0.282
CLV_PCSK_SKI1_1	286	290	PF00082	0.292
DEG_APCC_DBOX_1	266	274	PF00400	0.261
DEG_Nend_UBRbox_1	1	4	PF02207	0.517
DOC_CYCLIN_RxL_1	262	272	PF00134	0.299
DOC_MAPK_gen_1	229	236	PF00069	0.238
DOC_MAPK_gen_1	262	271	PF00069	0.292
DOC_MAPK_gen_1	92	100	PF00069	0.366
DOC_PP1_RVXF_1	112	119	PF00149	0.238
DOC_PP1_RVXF_1	231	237	PF00149	0.296
DOC_PP1_RVXF_1	265	272	PF00149	0.292
DOC_USP7_MATH_1	258	262	PF00917	0.325
DOC_USP7_MATH_1	41	45	PF00917	0.478
LIG_14-3-3_CanoR_1	162	171	PF00244	0.238
LIG_14-3-3_CanoR_1	233	239	PF00244	0.296
LIG_14-3-3_CanoR_1	94	98	PF00244	0.337
LIG_14-3-3_CterR_2	389	392	PF00244	0.621
LIG_BRCT_BRCA1_1	319	323	PF00533	0.396
LIG_EH1_1	270	278	PF00400	0.296
LIG_eIF4E_1	191	197	PF01652	0.238
LIG_FHA_1	205	211	PF00498	0.259
LIG_FXI_DFP_1	56	60	PF00024	0.313
LIG_LIR_Gen_1	183	193	PF02991	0.292
LIG_LIR_Gen_1	345	354	PF02991	0.364
LIG_LIR_Gen_1	46	56	PF02991	0.308
LIG_LIR_Gen_1	58	66	PF02991	0.304
LIG_LIR_Nem_3	183	188	PF02991	0.238
LIG_LIR_Nem_3	21	27	PF02991	0.450
LIG_LIR_Nem_3	301	307	PF02991	0.276
LIG_LIR_Nem_3	334	338	PF02991	0.341
LIG_LIR_Nem_3	343	347	PF02991	0.307
LIG_LIR_Nem_3	46	52	PF02991	0.375
LIG_LIR_Nem_3	58	62	PF02991	0.272
LIG_LIR_Nem_3	79	83	PF02991	0.260
LIG_LIR_Nem_3	8	13	PF02991	0.449
LIG_MYND_1	141	145	PF01753	0.238
LIG_Pex14_2	160	164	PF04695	0.238
LIG_Pex14_2	188	192	PF04695	0.292
LIG_PTB_Apo_2	327	334	PF02174	0.361
LIG_PTB_Apo_2	361	368	PF02174	0.434
LIG_Rb_pABgroove_1	176	184	PF01858	0.238
LIG_SH2_CRK	10	14	PF00017	0.457
LIG_SH2_CRK	231	235	PF00017	0.238
LIG_SH2_GRB2like	304	307	PF00017	0.261
LIG_SH2_GRB2like	362	365	PF00017	0.439
LIG_SH2_PTP2	49	52	PF00017	0.362
LIG_SH2_STAP1	304	308	PF00017	0.261
LIG_SH2_STAT3	71	74	PF00017	0.375
LIG_SH2_STAT5	191	194	PF00017	0.238
LIG_SH2_STAT5	308	311	PF00017	0.261
LIG_SH2_STAT5	362	365	PF00017	0.439
LIG_SH2_STAT5	49	52	PF00017	0.308
LIG_SH3_3	139	145	PF00018	0.238
LIG_SUMO_SIM_par_1	195	200	PF11976	0.261
LIG_SUMO_SIM_par_1	96	102	PF11976	0.341
LIG_TYR_ITIM	47	52	PF00017	0.368
LIG_UBA3_1	270	278	PF00899	0.292
MOD_CK2_1	192	198	PF00069	0.261
MOD_CK2_1	93	99	PF00069	0.364
MOD_GlcNHglycan	29	33	PF01048	0.530
MOD_GlcNHglycan	319	322	PF01048	0.412
MOD_GlcNHglycan	355	359	PF01048	0.448
MOD_GlcNHglycan	377	380	PF01048	0.552
MOD_GlcNHglycan	381	384	PF01048	0.600
MOD_GlcNHglycan	43	46	PF01048	0.496
MOD_GSK3_1	130	137	PF00069	0.254
MOD_GSK3_1	37	44	PF00069	0.581
MOD_GSK3_1	375	382	PF00069	0.644
MOD_LATS_1	373	379	PF00433	0.430
MOD_N-GLC_1	317	322	PF02516	0.233
MOD_N-GLC_1	363	368	PF02516	0.406
MOD_N-GLC_2	222	224	PF02516	0.292
MOD_NEK2_1	106	111	PF00069	0.150
MOD_NEK2_1	136	141	PF00069	0.238
MOD_NEK2_1	192	197	PF00069	0.247
MOD_NEK2_1	234	239	PF00069	0.300
MOD_NEK2_1	317	322	PF00069	0.304
MOD_NEK2_1	86	91	PF00069	0.374
MOD_PIKK_1	384	390	PF00454	0.542
MOD_PIKK_1	99	105	PF00454	0.434
MOD_PK_1	346	352	PF00069	0.341
MOD_PKA_2	215	221	PF00069	0.317
MOD_PKA_2	369	375	PF00069	0.392
MOD_PKA_2	93	99	PF00069	0.343
MOD_Plk_1	197	203	PF00069	0.342
MOD_Plk_1	317	323	PF00069	0.261
MOD_Plk_1	363	369	PF00069	0.415
MOD_Plk_4	192	198	PF00069	0.261
MOD_SUMO_for_1	202	205	PF00179	0.261
MOD_SUMO_for_1	277	280	PF00179	0.261
MOD_SUMO_for_1	50	53	PF00179	0.305
TRG_ENDOCYTIC_2	10	13	PF00928	0.454
TRG_ENDOCYTIC_2	189	192	PF00928	0.238
TRG_ENDOCYTIC_2	231	234	PF00928	0.238
TRG_ENDOCYTIC_2	308	311	PF00928	0.261
TRG_ENDOCYTIC_2	347	350	PF00928	0.360
TRG_ENDOCYTIC_2	49	52	PF00928	0.308
TRG_ENDOCYTIC_2	80	83	PF00928	0.255
TRG_ER_diArg_1	168	171	PF00400	0.261
TRG_ER_diArg_1	24	26	PF00400	0.505
TRG_ER_diArg_1	76	78	PF00400	0.341
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3G5	Trypanosomatidae	74%	68%
A0A422N197	Trypanosoma rangeli	64%	100%
A2AIL4	Mus musculus	25%	100%
A4HPM3	Leishmania braziliensis	94%	100%
A4ID42	Leishmania infantum	98%	100%
A7YVD7	Bos taurus	26%	100%
D0A8J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	71%
D3ZN43	Rattus norvegicus	24%	100%
Q330K2	Homo sapiens	25%	100%
Q4Q162	Leishmania major	97%	100%
V5B709	Trypanosoma cruzi	74%	84%