SH2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania mexicana

UniProt:

E9ATC8_LEIMU

TriTrypDb:

LmxM.36.3490

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATC8

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	18
GO:0032886	regulation of microtubule-based process	4	18
GO:0050789	regulation of biological process	2	18
GO:0050794	regulation of cellular process	3	18
GO:0060632	regulation of microtubule-based movement	5	18
GO:0065007	biological regulation	1	18

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.507
CLV_NRD_NRD_1	235	237	PF00675	0.237
CLV_NRD_NRD_1	262	264	PF00675	0.250
CLV_PCSK_KEX2_1	262	264	PF00082	0.257
CLV_PCSK_KEX2_1	303	305	PF00082	0.478
CLV_PCSK_KEX2_1	64	66	PF00082	0.487
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.470
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.492
CLV_PCSK_SKI1_1	122	126	PF00082	0.436
CLV_PCSK_SKI1_1	141	145	PF00082	0.229
CLV_PCSK_SKI1_1	186	190	PF00082	0.367
CLV_PCSK_SKI1_1	19	23	PF00082	0.520
CLV_PCSK_SKI1_1	287	291	PF00082	0.269
CLV_PCSK_SKI1_1	304	308	PF00082	0.740
CLV_PCSK_SKI1_1	325	329	PF00082	0.519
CLV_PCSK_SKI1_1	69	73	PF00082	0.381
DEG_SPOP_SBC_1	24	28	PF00917	0.574
DEG_SPOP_SBC_1	294	298	PF00917	0.511
DOC_CYCLIN_RxL_1	183	192	PF00134	0.349
DOC_MAPK_gen_1	223	233	PF00069	0.446
DOC_MAPK_gen_1	64	72	PF00069	0.385
DOC_MAPK_MEF2A_6	226	233	PF00069	0.444
DOC_MAPK_MEF2A_6	64	72	PF00069	0.337
DOC_USP7_MATH_1	239	243	PF00917	0.483
DOC_USP7_MATH_1	24	28	PF00917	0.681
DOC_USP7_MATH_1	293	297	PF00917	0.615
DOC_USP7_MATH_1	44	48	PF00917	0.617
DOC_USP7_UBL2_3	228	232	PF12436	0.451
DOC_WW_Pin1_4	28	33	PF00397	0.667
DOC_WW_Pin1_4	312	317	PF00397	0.513
DOC_WW_Pin1_4	37	42	PF00397	0.664
LIG_14-3-3_CanoR_1	141	148	PF00244	0.439
LIG_14-3-3_CanoR_1	304	310	PF00244	0.531
LIG_EH1_1	65	73	PF00400	0.491
LIG_eIF4E_1	183	189	PF01652	0.335
LIG_FHA_1	142	148	PF00498	0.260
LIG_FHA_1	176	182	PF00498	0.451
LIG_FHA_1	20	26	PF00498	0.703
LIG_FHA_1	283	289	PF00498	0.417
LIG_FHA_1	319	325	PF00498	0.601
LIG_FHA_1	49	55	PF00498	0.553
LIG_FHA_2	151	157	PF00498	0.433
LIG_FHA_2	165	171	PF00498	0.524
LIG_LIR_Gen_1	115	124	PF02991	0.448
LIG_LIR_Gen_1	146	155	PF02991	0.524
LIG_LIR_LC3C_4	177	182	PF02991	0.464
LIG_LIR_Nem_3	115	121	PF02991	0.418
LIG_LIR_Nem_3	146	151	PF02991	0.459
LIG_LIR_Nem_3	264	269	PF02991	0.449
LIG_PCNA_PIPBox_1	111	120	PF02747	0.326
LIG_PCNA_yPIPBox_3	109	118	PF02747	0.535
LIG_SH2_CRK	110	114	PF00017	0.418
LIG_SH2_CRK	118	122	PF00017	0.454
LIG_SH2_CRK	148	152	PF00017	0.341
LIG_SH2_STAT3	249	252	PF00017	0.448
LIG_SH2_STAT5	166	169	PF00017	0.612
LIG_SH2_STAT5	220	223	PF00017	0.516
LIG_SH3_2	326	331	PF14604	0.539
LIG_SH3_3	323	329	PF00018	0.534
LIG_SH3_3	35	41	PF00018	0.759
LIG_TRAF2_1	27	30	PF00917	0.555
LIG_TRAF2_1	74	77	PF00917	0.510
LIG_UBA3_1	113	122	PF00899	0.273
MOD_CDK_SPK_2	28	33	PF00069	0.517
MOD_CK1_1	150	156	PF00069	0.400
MOD_CK1_1	28	34	PF00069	0.730
MOD_CK1_1	282	288	PF00069	0.576
MOD_CK1_1	297	303	PF00069	0.655
MOD_CK1_1	308	314	PF00069	0.733
MOD_CK1_1	315	321	PF00069	0.726
MOD_CK1_1	47	53	PF00069	0.431
MOD_CK2_1	164	170	PF00069	0.536
MOD_CK2_1	23	29	PF00069	0.580
MOD_CK2_1	295	301	PF00069	0.555
MOD_CK2_1	71	77	PF00069	0.336
MOD_Cter_Amidation	301	304	PF01082	0.466
MOD_GlcNHglycan	310	313	PF01048	0.766
MOD_GlcNHglycan	73	76	PF01048	0.375
MOD_GSK3_1	143	150	PF00069	0.501
MOD_GSK3_1	19	26	PF00069	0.602
MOD_GSK3_1	293	300	PF00069	0.646
MOD_GSK3_1	304	311	PF00069	0.736
MOD_GSK3_1	44	51	PF00069	0.649
MOD_NEK2_1	143	148	PF00069	0.432
MOD_NEK2_1	213	218	PF00069	0.471
MOD_NEK2_1	305	310	PF00069	0.733
MOD_NEK2_1	71	76	PF00069	0.430
MOD_Plk_1	13	19	PF00069	0.499
MOD_Plk_1	175	181	PF00069	0.511
MOD_Plk_1	213	219	PF00069	0.490
MOD_Plk_2-3	13	19	PF00069	0.533
MOD_Plk_4	143	149	PF00069	0.484
MOD_Plk_4	50	56	PF00069	0.605
MOD_Plk_4	77	83	PF00069	0.383
MOD_ProDKin_1	28	34	PF00069	0.667
MOD_ProDKin_1	312	318	PF00069	0.512
MOD_ProDKin_1	37	43	PF00069	0.666
MOD_SUMO_rev_2	190	195	PF00179	0.503
MOD_SUMO_rev_2	296	305	PF00179	0.447
TRG_DiLeu_BaEn_1	176	181	PF01217	0.423
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.409
TRG_ENDOCYTIC_2	110	113	PF00928	0.398
TRG_ENDOCYTIC_2	118	121	PF00928	0.408
TRG_ENDOCYTIC_2	148	151	PF00928	0.520
TRG_ENDOCYTIC_2	256	259	PF00928	0.472
TRG_ENDOCYTIC_2	266	269	PF00928	0.422
TRG_ER_diArg_1	245	248	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K9	Leptomonas seymouri	60%	100%
A0A0S4JE13	Bodo saltans	41%	100%
A0A0S4JHQ4	Bodo saltans	41%	100%
A0A0S4JRV9	Bodo saltans	23%	100%
A0A1X0P4D1	Trypanosomatidae	42%	100%
A0A3Q8IRH9	Leishmania donovani	22%	100%
A0A3R7NWF2	Trypanosoma rangeli	26%	100%
A0A3S7XB90	Leishmania donovani	91%	100%
A0A422MZF7	Trypanosoma rangeli	44%	100%
A4HPL6	Leishmania braziliensis	78%	100%
A4ID48	Leishmania infantum	91%	100%
A4IDM9	Leishmania infantum	22%	100%
D0A8J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q169	Leishmania major	90%	100%
V5B520	Trypanosoma cruzi	24%	100%
V5B6Z0	Trypanosoma cruzi	42%	100%