NIPSNAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NIPSNAP, putative

Species:

Leishmania mexicana

UniProt:

E9ATC5_LEIMU

TriTrypDb:

LmxM.36.3460

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	80	82	PF00675	0.334
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DOC_CKS1_1	174	179	PF01111	0.590
DOC_MAPK_gen_1	165	175	PF00069	0.546
DOC_PP2B_PxIxI_1	45	51	PF00149	0.463
DOC_WW_Pin1_4	128	133	PF00397	0.585
DOC_WW_Pin1_4	173	178	PF00397	0.594
LIG_14-3-3_CanoR_1	190	196	PF00244	0.521
LIG_APCC_ABBA_1	130	135	PF00400	0.632
LIG_DCNL_PONY_1	1	4	PF03556	0.626
LIG_FHA_1	146	152	PF00498	0.619
LIG_FHA_1	174	180	PF00498	0.660
LIG_FHA_1	21	27	PF00498	0.502
LIG_FHA_1	54	60	PF00498	0.530
LIG_LIR_Apic_2	93	97	PF02991	0.516
LIG_LIR_Gen_1	148	153	PF02991	0.604
LIG_LIR_Gen_1	157	164	PF02991	0.449
LIG_LIR_Gen_1	29	39	PF02991	0.473
LIG_LIR_Nem_3	121	127	PF02991	0.581
LIG_LIR_Nem_3	148	152	PF02991	0.569
LIG_LIR_Nem_3	157	163	PF02991	0.468
LIG_LIR_Nem_3	29	34	PF02991	0.473
LIG_Pex14_1	90	94	PF04695	0.448
LIG_SH2_CRK	124	128	PF00017	0.583
LIG_SH2_GRB2like	71	74	PF00017	0.516
LIG_SH2_PTP2	160	163	PF00017	0.643
LIG_SH2_PTP2	65	68	PF00017	0.495
LIG_SH2_PTP2	94	97	PF00017	0.495
LIG_SH2_STAT3	126	129	PF00017	0.644
LIG_SH2_STAT3	41	44	PF00017	0.495
LIG_SH2_STAT5	126	129	PF00017	0.587
LIG_SH2_STAT5	160	163	PF00017	0.631
LIG_SH2_STAT5	24	27	PF00017	0.516
LIG_SH2_STAT5	65	68	PF00017	0.495
LIG_SH2_STAT5	94	97	PF00017	0.516
LIG_SH3_1	40	46	PF00018	0.516
LIG_SH3_3	171	177	PF00018	0.656
LIG_SH3_3	22	28	PF00018	0.597
LIG_SH3_3	40	46	PF00018	0.396
LIG_WRC_WIRS_1	31	36	PF05994	0.377
MOD_CDC14_SPxK_1	131	134	PF00782	0.632
MOD_CDK_SPxK_1	128	134	PF00069	0.575
MOD_CK1_1	11	17	PF00069	0.434
MOD_CK1_1	120	126	PF00069	0.659
MOD_CK1_1	139	145	PF00069	0.628
MOD_GlcNHglycan	13	16	PF01048	0.566
MOD_GlcNHglycan	137	141	PF01048	0.664
MOD_GSK3_1	101	108	PF00069	0.453
MOD_GSK3_1	175	182	PF00069	0.596
MOD_N-GLC_1	117	122	PF02516	0.609
MOD_NEK2_1	101	106	PF00069	0.348
MOD_NEK2_1	145	150	PF00069	0.548
MOD_NEK2_1	179	184	PF00069	0.600
MOD_PIKK_1	118	124	PF00454	0.708
MOD_PKA_2	189	195	PF00069	0.530
MOD_Plk_4	105	111	PF00069	0.425
MOD_ProDKin_1	128	134	PF00069	0.584
MOD_ProDKin_1	173	179	PF00069	0.594
MOD_SUMO_rev_2	155	161	PF00179	0.559
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.184
TRG_ENDOCYTIC_2	124	127	PF00928	0.587
TRG_ENDOCYTIC_2	160	163	PF00928	0.581
TRG_ENDOCYTIC_2	31	34	PF00928	0.305
TRG_ENDOCYTIC_2	65	68	PF00928	0.351
TRG_ENDOCYTIC_2	71	74	PF00928	0.411
TRG_ER_diArg_1	45	48	PF00400	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX6	Leptomonas seymouri	71%	100%
A0A1X0P390	Trypanosomatidae	54%	100%
A0A3S7XB71	Leishmania donovani	98%	100%
A0A422NA85	Trypanosoma rangeli	51%	100%
A4HPL3	Leishmania braziliensis	92%	100%
A4ID51	Leishmania infantum	98%	100%
Q4Q172	Leishmania major	96%	100%