CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATC2_LEIMU

TriTrypDb:

LmxM.36.3430

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	298	304	PF00089	0.531
CLV_NRD_NRD_1	176	178	PF00675	0.354
CLV_NRD_NRD_1	219	221	PF00675	0.292
CLV_NRD_NRD_1	41	43	PF00675	0.455
CLV_NRD_NRD_1	565	567	PF00675	0.438
CLV_NRD_NRD_1	576	578	PF00675	0.560
CLV_NRD_NRD_1	635	637	PF00675	0.666
CLV_NRD_NRD_1	662	664	PF00675	0.550
CLV_NRD_NRD_1	693	695	PF00675	0.659
CLV_NRD_NRD_1	93	95	PF00675	0.371
CLV_PCSK_KEX2_1	176	178	PF00082	0.354
CLV_PCSK_KEX2_1	219	221	PF00082	0.292
CLV_PCSK_KEX2_1	41	43	PF00082	0.455
CLV_PCSK_KEX2_1	565	567	PF00082	0.467
CLV_PCSK_KEX2_1	578	580	PF00082	0.495
CLV_PCSK_KEX2_1	635	637	PF00082	0.751
CLV_PCSK_KEX2_1	653	655	PF00082	0.459
CLV_PCSK_KEX2_1	661	663	PF00082	0.606
CLV_PCSK_KEX2_1	693	695	PF00082	0.659
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.529
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.504
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.665
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.659
CLV_PCSK_SKI1_1	151	155	PF00082	0.351
CLV_PCSK_SKI1_1	219	223	PF00082	0.292
CLV_PCSK_SKI1_1	331	335	PF00082	0.583
CLV_PCSK_SKI1_1	45	49	PF00082	0.350
CLV_PCSK_SKI1_1	52	56	PF00082	0.413
CLV_PCSK_SKI1_1	578	582	PF00082	0.604
CLV_PCSK_SKI1_1	654	658	PF00082	0.647
CLV_PCSK_SKI1_1	745	749	PF00082	0.468
CLV_Separin_Metazoa	216	220	PF03568	0.292
DEG_APCC_DBOX_1	159	167	PF00400	0.357
DEG_APCC_DBOX_1	604	612	PF00400	0.503
DEG_SPOP_SBC_1	339	343	PF00917	0.629
DEG_SPOP_SBC_1	383	387	PF00917	0.772
DEG_SPOP_SBC_1	401	405	PF00917	0.468
DOC_ANK_TNKS_1	294	301	PF00023	0.466
DOC_ANK_TNKS_1	597	604	PF00023	0.524
DOC_CYCLIN_RxL_1	216	226	PF00134	0.287
DOC_CYCLIN_RxL_1	41	49	PF00134	0.348
DOC_MAPK_DCC_7	131	139	PF00069	0.351
DOC_MAPK_gen_1	176	187	PF00069	0.350
DOC_MAPK_gen_1	235	245	PF00069	0.351
DOC_MAPK_gen_1	50	57	PF00069	0.436
DOC_MAPK_gen_1	572	582	PF00069	0.449
DOC_MAPK_gen_1	605	612	PF00069	0.497
DOC_MAPK_gen_1	635	645	PF00069	0.600
DOC_MAPK_HePTP_8	633	645	PF00069	0.593
DOC_MAPK_MEF2A_6	131	139	PF00069	0.351
DOC_MAPK_MEF2A_6	235	243	PF00069	0.351
DOC_MAPK_MEF2A_6	367	374	PF00069	0.620
DOC_MAPK_MEF2A_6	605	612	PF00069	0.500
DOC_MAPK_MEF2A_6	636	645	PF00069	0.600
DOC_PP1_RVXF_1	218	225	PF00149	0.291
DOC_PP1_RVXF_1	246	252	PF00149	0.351
DOC_PP2B_LxvP_1	503	506	PF13499	0.434
DOC_SPAK_OSR1_1	568	572	PF12202	0.280
DOC_SPAK_OSR1_1	71	75	PF12202	0.332
DOC_USP7_MATH_1	110	114	PF00917	0.257
DOC_USP7_MATH_1	27	31	PF00917	0.459
DOC_USP7_MATH_1	289	293	PF00917	0.282
DOC_USP7_MATH_1	310	314	PF00917	0.593
DOC_USP7_MATH_1	350	354	PF00917	0.590
DOC_USP7_MATH_1	402	406	PF00917	0.642
DOC_USP7_MATH_1	433	437	PF00917	0.496
DOC_USP7_MATH_1	446	450	PF00917	0.663
DOC_USP7_MATH_1	482	486	PF00917	0.476
DOC_USP7_MATH_1	535	539	PF00917	0.609
DOC_USP7_MATH_1	671	675	PF00917	0.656
DOC_USP7_MATH_1	703	707	PF00917	0.646
DOC_USP7_MATH_1	777	781	PF00917	0.571
DOC_USP7_UBL2_3	693	697	PF12436	0.644
DOC_USP7_UBL2_3	745	749	PF12436	0.490
DOC_WW_Pin1_4	10	15	PF00397	0.494
DOC_WW_Pin1_4	113	118	PF00397	0.460
DOC_WW_Pin1_4	137	142	PF00397	0.343
DOC_WW_Pin1_4	300	305	PF00397	0.591
DOC_WW_Pin1_4	340	345	PF00397	0.584
DOC_WW_Pin1_4	346	351	PF00397	0.601
DOC_WW_Pin1_4	413	418	PF00397	0.675
DOC_WW_Pin1_4	431	436	PF00397	0.572
DOC_WW_Pin1_4	687	692	PF00397	0.646
LIG_14-3-3_CanoR_1	180	184	PF00244	0.335
LIG_14-3-3_CanoR_1	323	329	PF00244	0.592
LIG_14-3-3_CanoR_1	635	643	PF00244	0.482
LIG_14-3-3_CanoR_1	675	681	PF00244	0.548
LIG_14-3-3_CanoR_1	784	793	PF00244	0.478
LIG_14-3-3_CanoR_1	92	102	PF00244	0.530
LIG_Actin_WH2_2	188	206	PF00022	0.351
LIG_APCC_ABBA_1	54	59	PF00400	0.415
LIG_BIR_II_1	1	5	PF00653	0.517
LIG_CaM_NSCaTE_8	676	683	PF13499	0.581
LIG_FHA_1	180	186	PF00498	0.351
LIG_FHA_1	340	346	PF00498	0.625
LIG_FHA_1	377	383	PF00498	0.644
LIG_FHA_1	456	462	PF00498	0.631
LIG_FHA_1	541	547	PF00498	0.488
LIG_FHA_1	640	646	PF00498	0.627
LIG_FHA_1	675	681	PF00498	0.501
LIG_FHA_2	11	17	PF00498	0.558
LIG_FHA_2	505	511	PF00498	0.567
LIG_FHA_2	722	728	PF00498	0.477
LIG_Integrin_RGD_1	295	297	PF01839	0.319
LIG_LIR_Gen_1	46	56	PF02991	0.315
LIG_LIR_Gen_1	581	591	PF02991	0.473
LIG_LIR_Gen_1	679	686	PF02991	0.573
LIG_LIR_Gen_1	89	97	PF02991	0.412
LIG_LIR_Nem_3	231	237	PF02991	0.350
LIG_LIR_Nem_3	46	51	PF02991	0.307
LIG_LIR_Nem_3	581	586	PF02991	0.461
LIG_LIR_Nem_3	624	629	PF02991	0.463
LIG_LIR_Nem_3	67	73	PF02991	0.319
LIG_LIR_Nem_3	679	684	PF02991	0.557
LIG_LIR_Nem_3	740	746	PF02991	0.477
LIG_LIR_Nem_3	89	93	PF02991	0.411
LIG_LYPXL_yS_3	214	217	PF13949	0.292
LIG_MYND_1	520	524	PF01753	0.594
LIG_Pex14_1	17	21	PF04695	0.478
LIG_Pex14_1	494	498	PF04695	0.369
LIG_Pex14_2	224	228	PF04695	0.292
LIG_Pex14_2	515	519	PF04695	0.557
LIG_SH2_CRK	429	433	PF00017	0.741
LIG_SH2_CRK	583	587	PF00017	0.457
LIG_SH2_CRK	70	74	PF00017	0.322
LIG_SH2_CRK	744	748	PF00017	0.478
LIG_SH2_CRK	90	94	PF00017	0.244
LIG_SH2_NCK_1	583	587	PF00017	0.457
LIG_SH2_SRC	264	267	PF00017	0.193
LIG_SH2_SRC	600	603	PF00017	0.514
LIG_SH2_STAP1	21	25	PF00017	0.464
LIG_SH2_STAT5	183	186	PF00017	0.287
LIG_SH2_STAT5	264	267	PF00017	0.357
LIG_SH2_STAT5	489	492	PF00017	0.485
LIG_SH2_STAT5	600	603	PF00017	0.514
LIG_SH2_STAT5	785	788	PF00017	0.483
LIG_SH3_3	209	215	PF00018	0.357
LIG_SH3_3	233	239	PF00018	0.292
LIG_SH3_3	279	285	PF00018	0.424
LIG_SH3_3	312	318	PF00018	0.639
LIG_SH3_3	414	420	PF00018	0.476
LIG_SH3_3	429	435	PF00018	0.606
LIG_SH3_3	536	542	PF00018	0.529
LIG_SH3_3	607	613	PF00018	0.513
LIG_SH3_3	638	644	PF00018	0.601
LIG_SH3_3	706	712	PF00018	0.667
LIG_SUMO_SIM_par_1	393	398	PF11976	0.480
LIG_SUMO_SIM_par_1	472	477	PF11976	0.503
LIG_TYR_ITIM	212	217	PF00017	0.351
LIG_TYR_ITIM	68	73	PF00017	0.317
LIG_TYR_ITSM	579	586	PF00017	0.427
MOD_CDC14_SPxK_1	690	693	PF00782	0.622
MOD_CDK_SPxK_1	687	693	PF00069	0.613
MOD_CDK_SPxxK_3	113	120	PF00069	0.393
MOD_CDK_SPxxK_3	431	438	PF00069	0.617
MOD_CDK_SPxxK_3	687	694	PF00069	0.617
MOD_CK1_1	113	119	PF00069	0.459
MOD_CK1_1	327	333	PF00069	0.559
MOD_CK1_1	338	344	PF00069	0.682
MOD_CK1_1	346	352	PF00069	0.642
MOD_CK1_1	376	382	PF00069	0.641
MOD_CK1_1	386	392	PF00069	0.619
MOD_CK1_1	400	406	PF00069	0.518
MOD_CK1_1	434	440	PF00069	0.647
MOD_CK1_1	449	455	PF00069	0.549
MOD_CK1_1	525	531	PF00069	0.681
MOD_CK1_1	615	621	PF00069	0.604
MOD_CK1_1	664	670	PF00069	0.620
MOD_CK1_1	674	680	PF00069	0.631
MOD_CK1_1	696	702	PF00069	0.596
MOD_CK1_1	780	786	PF00069	0.616
MOD_CK2_1	34	40	PF00069	0.461
MOD_CK2_1	401	407	PF00069	0.755
MOD_CK2_1	445	451	PF00069	0.664
MOD_GlcNHglycan	1	4	PF01048	0.611
MOD_GlcNHglycan	112	115	PF01048	0.274
MOD_GlcNHglycan	230	233	PF01048	0.351
MOD_GlcNHglycan	252	255	PF01048	0.292
MOD_GlcNHglycan	278	281	PF01048	0.434
MOD_GlcNHglycan	30	33	PF01048	0.502
MOD_GlcNHglycan	375	378	PF01048	0.610
MOD_GlcNHglycan	388	391	PF01048	0.591
MOD_GlcNHglycan	404	407	PF01048	0.628
MOD_GlcNHglycan	429	432	PF01048	0.559
MOD_GlcNHglycan	439	443	PF01048	0.649
MOD_GlcNHglycan	486	489	PF01048	0.439
MOD_GlcNHglycan	509	515	PF01048	0.618
MOD_GlcNHglycan	657	660	PF01048	0.599
MOD_GlcNHglycan	663	666	PF01048	0.624
MOD_GlcNHglycan	703	706	PF01048	0.619
MOD_GSK3_1	162	169	PF00069	0.334
MOD_GSK3_1	250	257	PF00069	0.292
MOD_GSK3_1	270	277	PF00069	0.171
MOD_GSK3_1	335	342	PF00069	0.529
MOD_GSK3_1	344	351	PF00069	0.581
MOD_GSK3_1	382	389	PF00069	0.613
MOD_GSK3_1	397	404	PF00069	0.507
MOD_GSK3_1	427	434	PF00069	0.678
MOD_GSK3_1	438	445	PF00069	0.664
MOD_GSK3_1	518	525	PF00069	0.581
MOD_GSK3_1	612	619	PF00069	0.504
MOD_GSK3_1	631	638	PF00069	0.487
MOD_GSK3_1	685	692	PF00069	0.567
MOD_GSK3_1	693	700	PF00069	0.743
MOD_GSK3_1	760	767	PF00069	0.450
MOD_GSK3_1	780	787	PF00069	0.499
MOD_N-GLC_1	324	329	PF02516	0.487
MOD_N-GLC_1	615	620	PF02516	0.651
MOD_N-GLC_2	720	722	PF02516	0.534
MOD_NEK2_1	166	171	PF00069	0.313
MOD_NEK2_1	274	279	PF00069	0.459
MOD_NEK2_1	382	387	PF00069	0.724
MOD_NEK2_1	395	400	PF00069	0.554
MOD_NEK2_1	649	654	PF00069	0.765
MOD_NEK2_2	676	681	PF00069	0.576
MOD_PIKK_1	523	529	PF00454	0.601
MOD_PKA_1	578	584	PF00069	0.416
MOD_PKA_1	635	641	PF00069	0.647
MOD_PKA_1	661	667	PF00069	0.502
MOD_PKA_1	693	699	PF00069	0.608
MOD_PKA_2	179	185	PF00069	0.335
MOD_PKA_2	316	322	PF00069	0.725
MOD_PKA_2	449	455	PF00069	0.557
MOD_PKA_2	571	577	PF00069	0.497
MOD_PKA_2	578	584	PF00069	0.542
MOD_PKA_2	634	640	PF00069	0.634
MOD_PKA_2	661	667	PF00069	0.578
MOD_PKA_2	671	677	PF00069	0.661
MOD_PKA_2	693	699	PF00069	0.696
MOD_PKA_2	93	99	PF00069	0.554
MOD_Plk_1	289	295	PF00069	0.280
MOD_Plk_1	324	330	PF00069	0.512
MOD_Plk_1	395	401	PF00069	0.578
MOD_Plk_2-3	723	729	PF00069	0.590
MOD_Plk_4	179	185	PF00069	0.356
MOD_Plk_4	310	316	PF00069	0.622
MOD_Plk_4	324	330	PF00069	0.602
MOD_Plk_4	332	338	PF00069	0.578
MOD_Plk_4	518	524	PF00069	0.644
MOD_Plk_4	578	584	PF00069	0.608
MOD_Plk_4	676	682	PF00069	0.572
MOD_ProDKin_1	10	16	PF00069	0.480
MOD_ProDKin_1	113	119	PF00069	0.459
MOD_ProDKin_1	137	143	PF00069	0.343
MOD_ProDKin_1	300	306	PF00069	0.594
MOD_ProDKin_1	340	346	PF00069	0.584
MOD_ProDKin_1	348	354	PF00069	0.601
MOD_ProDKin_1	413	419	PF00069	0.667
MOD_ProDKin_1	431	437	PF00069	0.572
MOD_ProDKin_1	687	693	PF00069	0.650
MOD_SUMO_for_1	249	252	PF00179	0.351
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.351
TRG_ENDOCYTIC_2	214	217	PF00928	0.340
TRG_ENDOCYTIC_2	429	432	PF00928	0.744
TRG_ENDOCYTIC_2	583	586	PF00928	0.466
TRG_ENDOCYTIC_2	70	73	PF00928	0.318
TRG_ENDOCYTIC_2	744	747	PF00928	0.421
TRG_ENDOCYTIC_2	90	93	PF00928	0.249
TRG_ER_diArg_1	176	178	PF00400	0.352
TRG_ER_diArg_1	218	220	PF00400	0.292
TRG_ER_diArg_1	565	568	PF00400	0.441
TRG_ER_diArg_1	576	579	PF00400	0.423
TRG_NLS_Bipartite_1	565	581	PF00514	0.428
TRG_NLS_MonoCore_2	659	664	PF00514	0.498
TRG_NLS_MonoExtC_3	660	666	PF00514	0.502
TRG_NLS_MonoExtC_3	692	697	PF00514	0.655
TRG_NLS_MonoExtN_4	575	581	PF00514	0.458
TRG_NLS_MonoExtN_4	660	665	PF00514	0.502
TRG_NLS_MonoExtN_4	691	698	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	568	573	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P689	Leptomonas seymouri	50%	97%
A0A1X0P424	Trypanosomatidae	35%	100%
A0A3S7XBD6	Leishmania donovani	88%	100%
A4HPL0	Leishmania braziliensis	66%	97%
A4ID54	Leishmania infantum	88%	100%
Q4Q175	Leishmania major	86%	100%