Short chain dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase-like protein

Species:

Leishmania mexicana

UniProt:

E9ATC0_LEIMU

TriTrypDb:

LmxM.36.3410

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

E9ATC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATC0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	320	322	PF00675	0.547
CLV_NRD_NRD_1	368	370	PF00675	0.606
CLV_NRD_NRD_1	95	97	PF00675	0.324
CLV_PCSK_KEX2_1	320	322	PF00082	0.547
CLV_PCSK_KEX2_1	368	370	PF00082	0.571
CLV_PCSK_KEX2_1	95	97	PF00082	0.329
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.571
CLV_PCSK_PC7_1	91	97	PF00082	0.345
CLV_PCSK_SKI1_1	306	310	PF00082	0.612
CLV_PCSK_SKI1_1	356	360	PF00082	0.498
CLV_PCSK_SKI1_1	75	79	PF00082	0.310
DEG_APCC_DBOX_1	355	363	PF00400	0.372
DEG_APCC_DBOX_1	368	376	PF00400	0.332
DEG_APCC_DBOX_1	74	82	PF00400	0.357
DEG_Nend_UBRbox_2	1	3	PF02207	0.343
DEG_SPOP_SBC_1	344	348	PF00917	0.211
DEG_SPOP_SBC_1	65	69	PF00917	0.345
DOC_CKS1_1	3	8	PF01111	0.328
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.330
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.262
DOC_MAPK_MEF2A_6	284	293	PF00069	0.230
DOC_PP1_SILK_1	262	267	PF00149	0.304
DOC_PP2B_LxvP_1	11	14	PF13499	0.327
DOC_PP2B_LxvP_1	188	191	PF13499	0.262
DOC_USP7_MATH_1	65	69	PF00917	0.345
DOC_USP7_MATH_1	71	75	PF00917	0.264
DOC_USP7_UBL2_3	59	63	PF12436	0.348
DOC_WW_Pin1_4	2	7	PF00397	0.333
DOC_WW_Pin1_4	244	249	PF00397	0.321
DOC_WW_Pin1_4	321	326	PF00397	0.411
LIG_14-3-3_CanoR_1	172	181	PF00244	0.321
LIG_14-3-3_CanoR_1	266	276	PF00244	0.230
LIG_14-3-3_CanoR_1	290	294	PF00244	0.283
LIG_14-3-3_CanoR_1	369	373	PF00244	0.368
LIG_Actin_WH2_1	250	268	PF00022	0.286
LIG_Actin_WH2_2	128	145	PF00022	0.244
LIG_Actin_WH2_2	253	268	PF00022	0.286
LIG_CtBP_PxDLS_1	118	123	PF00389	0.399
LIG_FHA_1	168	174	PF00498	0.237
LIG_FHA_1	23	29	PF00498	0.327
LIG_FHA_1	358	364	PF00498	0.331
LIG_LIR_Gen_1	175	181	PF02991	0.321
LIG_LIR_Gen_1	210	221	PF02991	0.321
LIG_LIR_Nem_3	175	180	PF02991	0.309
LIG_LIR_Nem_3	210	216	PF02991	0.263
LIG_MAD2	306	314	PF02301	0.364
LIG_NRBOX	77	83	PF00104	0.345
LIG_PTB_Apo_2	219	226	PF02174	0.328
LIG_PTB_Phospho_1	219	225	PF10480	0.283
LIG_SH2_CRK	177	181	PF00017	0.309
LIG_SH2_CRK	94	98	PF00017	0.561
LIG_SH2_STAP1	177	181	PF00017	0.321
LIG_SH2_STAT5	159	162	PF00017	0.286
LIG_SH2_STAT5	177	180	PF00017	0.127
LIG_SH2_STAT5	194	197	PF00017	0.235
LIG_SH2_STAT5	225	228	PF00017	0.237
LIG_SH2_STAT5	269	272	PF00017	0.230
LIG_SH2_STAT5	298	301	PF00017	0.230
LIG_SH3_3	3	9	PF00018	0.334
LIG_SUMO_SIM_anti_2	131	136	PF11976	0.286
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.231
LIG_TRFH_1	353	357	PF08558	0.299
LIG_TYR_ITIM	192	197	PF00017	0.286
LIG_UBA3_1	362	370	PF00899	0.368
MOD_CDC14_SPxK_1	247	250	PF00782	0.321
MOD_CDK_SPK_2	5	10	PF00069	0.325
MOD_CDK_SPxK_1	244	250	PF00069	0.321
MOD_CK1_1	175	181	PF00069	0.200
MOD_CK1_1	23	29	PF00069	0.327
MOD_CK1_1	244	250	PF00069	0.321
MOD_CK1_1	267	273	PF00069	0.230
MOD_CK1_1	371	377	PF00069	0.340
MOD_CK1_1	64	70	PF00069	0.491
MOD_CK2_1	125	131	PF00069	0.262
MOD_CK2_1	162	168	PF00069	0.321
MOD_GlcNHglycan	114	117	PF01048	0.279
MOD_GlcNHglycan	266	269	PF01048	0.430
MOD_GlcNHglycan	347	350	PF01048	0.432
MOD_GlcNHglycan	63	66	PF01048	0.664
MOD_GSK3_1	108	115	PF00069	0.272
MOD_GSK3_1	18	25	PF00069	0.329
MOD_GSK3_1	237	244	PF00069	0.268
MOD_GSK3_1	260	267	PF00069	0.243
MOD_GSK3_1	298	305	PF00069	0.264
MOD_GSK3_1	59	66	PF00069	0.540
MOD_LATS_1	304	310	PF00433	0.410
MOD_N-GLC_1	241	246	PF02516	0.504
MOD_NEK2_1	125	130	PF00069	0.262
MOD_NEK2_1	20	25	PF00069	0.375
MOD_NEK2_1	345	350	PF00069	0.377
MOD_PIKK_1	237	243	PF00454	0.304
MOD_PKA_1	368	374	PF00069	0.323
MOD_PKA_2	289	295	PF00069	0.283
MOD_PKA_2	368	374	PF00069	0.366
MOD_Plk_1	175	181	PF00069	0.189
MOD_Plk_4	260	266	PF00069	0.262
MOD_ProDKin_1	2	8	PF00069	0.330
MOD_ProDKin_1	244	250	PF00069	0.321
MOD_ProDKin_1	321	327	PF00069	0.408
MOD_SUMO_rev_2	305	315	PF00179	0.434
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.230
TRG_ENDOCYTIC_2	177	180	PF00928	0.299
TRG_ENDOCYTIC_2	194	197	PF00928	0.155
TRG_ENDOCYTIC_2	94	97	PF00928	0.538
TRG_ER_diArg_1	353	356	PF00400	0.328
TRG_ER_diArg_1	94	96	PF00400	0.521
TRG_ER_diArg_1	99	102	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	306	311	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L3	Leptomonas seymouri	73%	100%
A0A140FAN3	Pinus massoniana	31%	100%
A0A1X0P3I1	Trypanosomatidae	58%	100%
A0A3S5IS03	Trypanosoma rangeli	55%	100%
A0A3S7XB64	Leishmania donovani	95%	100%
A3LXZ3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	24%	100%
A4HPK8	Leishmania braziliensis	86%	100%
A4ID56	Leishmania infantum	95%	100%
A5DND6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5JYX5	Caenorhabditis elegans	28%	100%
A7LB60	Arachis hypogaea	28%	100%
D0A8K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P0DKC5	Arabidopsis thaliana	30%	100%
P0DKC6	Arabidopsis thaliana	30%	100%
P50172	Mus musculus	27%	100%
P54554	Bacillus subtilis (strain 168)	28%	100%
P9WGP8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WGP9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q0VFE7	Xenopus tropicalis	33%	100%
Q3T0R4	Bos taurus	30%	100%
Q4JK73	Macaca fascicularis	28%	100%
Q4Q177	Leishmania major	86%	100%
Q556J2	Dictyostelium discoideum	25%	100%
Q566S6	Danio rerio	29%	100%
Q5BL28	Danio rerio	28%	100%
Q5M875	Rattus norvegicus	25%	100%
Q5R6U1	Pongo abelii	30%	100%
Q5RJY4	Rattus norvegicus	31%	100%
Q6AYS8	Rattus norvegicus	30%	100%
Q6BIG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	100%
Q6IAN0	Homo sapiens	30%	100%
Q6QLL4	Cavia porcellus	28%	100%
Q7Q732	Anopheles gambiae	28%	100%
Q7RZR2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q7SYS6	Xenopus laevis	26%	100%
Q7T2D1	Danio rerio	28%	100%
Q7Z5P4	Homo sapiens	23%	100%
Q8LKV5	Sesamum indicum	28%	100%
Q8NBQ5	Homo sapiens	28%	100%
Q8T197	Dictyostelium discoideum	29%	100%
Q99J47	Mus musculus	31%	100%
Q9EQ06	Mus musculus	30%	100%
Q9LUE4	Arabidopsis thaliana	30%	100%
Q9STY8	Arabidopsis thaliana	28%	100%
Q9Y140	Drosophila melanogaster	26%	100%
Q9Y394	Homo sapiens	24%	100%
V5BS47	Trypanosoma cruzi	56%	100%