Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain, putative

Species:

Leishmania mexicana

UniProt:

E9ATB5_LEIMU

TriTrypDb:

LmxM.36.3360

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATB5

PDB structure(s): 5fea_A , 5fea_B

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0070577	lysine-acetylated histone binding	4	1
GO:0140030	modification-dependent protein binding	3	1
GO:0140033	acetylation-dependent protein binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.677
CLV_NRD_NRD_1	183	185	PF00675	0.557
CLV_NRD_NRD_1	202	204	PF00675	0.445
CLV_PCSK_FUR_1	143	147	PF00082	0.601
CLV_PCSK_KEX2_1	145	147	PF00082	0.665
CLV_PCSK_KEX2_1	183	185	PF00082	0.581
CLV_PCSK_KEX2_1	202	204	PF00082	0.552
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.659
CLV_PCSK_SKI1_1	138	142	PF00082	0.578
CLV_PCSK_SKI1_1	91	95	PF00082	0.269
DEG_APCC_DBOX_1	137	145	PF00400	0.591
DEG_APCC_DBOX_1	36	44	PF00400	0.603
DEG_APCC_DBOX_1	90	98	PF00400	0.269
DOC_PP4_FxxP_1	66	69	PF00568	0.269
DOC_WW_Pin1_4	83	88	PF00397	0.362
LIG_14-3-3_CanoR_1	153	157	PF00244	0.601
LIG_14-3-3_CanoR_1	164	170	PF00244	0.586
LIG_14-3-3_CanoR_1	37	41	PF00244	0.710
LIG_14-3-3_CterR_2	220	223	PF00244	0.689
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BIR_III_4	7	11	PF00653	0.579
LIG_BRCT_BRCA1_1	62	66	PF00533	0.287
LIG_CtBP_PxDLS_1	87	91	PF00389	0.269
LIG_deltaCOP1_diTrp_1	114	123	PF00928	0.303
LIG_FHA_1	191	197	PF00498	0.642
LIG_FHA_2	153	159	PF00498	0.651
LIG_FHA_2	186	192	PF00498	0.606
LIG_FHA_2	40	46	PF00498	0.621
LIG_FHA_2	77	83	PF00498	0.414
LIG_LIR_Apic_2	63	69	PF02991	0.269
LIG_LIR_Gen_1	48	57	PF02991	0.514
LIG_LIR_Gen_1	79	88	PF02991	0.337
LIG_LIR_Nem_3	13	18	PF02991	0.538
LIG_LIR_Nem_3	160	166	PF02991	0.644
LIG_LIR_Nem_3	48	53	PF02991	0.540
LIG_LIR_Nem_3	76	81	PF02991	0.367
LIG_SH2_CRK	50	54	PF00017	0.530
LIG_SH2_CRK	81	85	PF00017	0.303
LIG_SH2_STAP1	103	107	PF00017	0.413
LIG_SH2_STAT3	14	17	PF00017	0.585
LIG_SH2_STAT5	18	21	PF00017	0.478
LIG_SH2_STAT5	181	184	PF00017	0.544
LIG_SH3_3	81	87	PF00018	0.331
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.329
LIG_TRAF2_1	155	158	PF00917	0.686
LIG_TRAF2_1	168	171	PF00917	0.591
LIG_TRAF2_1	58	61	PF00917	0.167
LIG_TYR_ITSM	77	84	PF00017	0.337
LIG_UBA3_1	93	99	PF00899	0.413
MOD_CK1_1	39	45	PF00069	0.622
MOD_CK1_1	86	92	PF00069	0.279
MOD_CK2_1	152	158	PF00069	0.640
MOD_CK2_1	165	171	PF00069	0.474
MOD_CK2_1	186	192	PF00069	0.683
MOD_CK2_1	39	45	PF00069	0.623
MOD_CK2_1	55	61	PF00069	0.381
MOD_GlcNHglycan	138	141	PF01048	0.644
MOD_GSK3_1	125	132	PF00069	0.433
MOD_GSK3_1	186	193	PF00069	0.576
MOD_GSK3_1	214	221	PF00069	0.683
MOD_GSK3_1	55	62	PF00069	0.524
MOD_N-GLC_1	214	219	PF02516	0.675
MOD_PKA_2	152	158	PF00069	0.604
MOD_PKA_2	36	42	PF00069	0.693
MOD_Plk_1	59	65	PF00069	0.401
MOD_Plk_2-3	186	192	PF00069	0.683
MOD_Plk_2-3	76	82	PF00069	0.337
MOD_Plk_4	125	131	PF00069	0.428
MOD_Plk_4	60	66	PF00069	0.413
MOD_ProDKin_1	83	89	PF00069	0.362
TRG_DiLeu_BaEn_1	111	116	PF01217	0.362
TRG_ENDOCYTIC_2	50	53	PF00928	0.496
TRG_ENDOCYTIC_2	80	83	PF00928	0.269
TRG_ER_diArg_1	143	146	PF00400	0.711
TRG_ER_diArg_1	182	184	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4L2	Leptomonas seymouri	87%	100%
A0A0S4JKA2	Bodo saltans	36%	96%
A0A1X0P378	Trypanosomatidae	43%	100%
A0A3S7XB61	Leishmania donovani	100%	100%
A0A422NVK9	Trypanosoma rangeli	46%	100%
A4HPK3	Leishmania braziliensis	96%	100%
A4ID61	Leishmania infantum	100%	100%
D0A8L1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q182	Leishmania major	99%	100%
V5B6X9	Trypanosoma cruzi	44%	100%