Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATB4_LEIMU

TriTrypDb:

LmxM.36.3350

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATB4

PDB structure(s): 7aih_Aa , 7am2_Aa , 7ane_Aa

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.550
CLV_NRD_NRD_1	160	162	PF00675	0.417
CLV_NRD_NRD_1	177	179	PF00675	0.476
CLV_PCSK_KEX2_1	17	19	PF00082	0.649
CLV_PCSK_KEX2_1	177	179	PF00082	0.451
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.649
CLV_PCSK_SKI1_1	55	59	PF00082	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DOC_CKS1_1	48	53	PF01111	0.409
DOC_MAPK_gen_1	52	62	PF00069	0.530
DOC_USP7_MATH_1	129	133	PF00917	0.463
DOC_USP7_UBL2_3	170	174	PF12436	0.496
DOC_WW_Pin1_4	47	52	PF00397	0.472
DOC_WW_Pin1_4	60	65	PF00397	0.508
DOC_WW_Pin1_4	89	94	PF00397	0.447
LIG_14-3-3_CanoR_1	189	193	PF00244	0.627
LIG_14-3-3_CanoR_1	3	11	PF00244	0.637
LIG_14-3-3_CanoR_1	82	91	PF00244	0.461
LIG_BRCT_BRCA1_1	91	95	PF00533	0.446
LIG_CaM_IQ_9	2	18	PF13499	0.683
LIG_DCNL_PONY_1	1	4	PF03556	0.531
LIG_FHA_1	3	9	PF00498	0.693
LIG_FHA_1	54	60	PF00498	0.550
LIG_FHA_1	67	73	PF00498	0.660
LIG_FHA_1	86	92	PF00498	0.442
LIG_FHA_2	131	137	PF00498	0.453
LIG_FHA_2	68	74	PF00498	0.629
LIG_LIR_Nem_3	26	31	PF02991	0.489
LIG_LIR_Nem_3	92	98	PF02991	0.431
LIG_PTB_Apo_2	30	37	PF02174	0.472
LIG_SH2_CRK	28	32	PF00017	0.576
LIG_SH2_GRB2like	138	141	PF00017	0.391
LIG_SH2_SRC	138	141	PF00017	0.391
LIG_SH2_STAT5	138	141	PF00017	0.417
LIG_SH2_STAT5	49	52	PF00017	0.377
LIG_SH3_1	58	64	PF00018	0.570
LIG_SH3_3	104	110	PF00018	0.505
LIG_SH3_3	45	51	PF00018	0.479
LIG_SH3_3	58	64	PF00018	0.540
LIG_TYR_ITSM	24	31	PF00017	0.599
MOD_CDK_SPK_2	47	52	PF00069	0.472
MOD_CDK_SPxK_1	47	53	PF00069	0.468
MOD_CDK_SPxxK_3	89	96	PF00069	0.397
MOD_CK1_1	108	114	PF00069	0.491
MOD_CK1_1	47	53	PF00069	0.450
MOD_CK1_1	83	89	PF00069	0.506
MOD_CK2_1	67	73	PF00069	0.627
MOD_GSK3_1	148	155	PF00069	0.485
MOD_GSK3_1	183	190	PF00069	0.633
MOD_GSK3_1	80	87	PF00069	0.479
MOD_N-GLC_1	130	135	PF02516	0.565
MOD_N-GLC_1	153	158	PF02516	0.528
MOD_N-GLC_1	80	85	PF02516	0.403
MOD_NEK2_1	2	7	PF00069	0.682
MOD_NEK2_1	44	49	PF00069	0.476
MOD_NEK2_1	84	89	PF00069	0.490
MOD_NEK2_2	188	193	PF00069	0.629
MOD_PIKK_1	155	161	PF00454	0.530
MOD_PIKK_1	2	8	PF00454	0.668
MOD_PKA_2	188	194	PF00069	0.646
MOD_PKA_2	2	8	PF00069	0.633
MOD_Plk_1	130	136	PF00069	0.556
MOD_Plk_1	148	154	PF00069	0.413
MOD_Plk_1	53	59	PF00069	0.542
MOD_Plk_1	80	86	PF00069	0.391
MOD_Plk_4	130	136	PF00069	0.497
MOD_Plk_4	188	194	PF00069	0.633
MOD_Plk_4	44	50	PF00069	0.511
MOD_ProDKin_1	47	53	PF00069	0.468
MOD_ProDKin_1	60	66	PF00069	0.513
MOD_ProDKin_1	89	95	PF00069	0.444
MOD_SUMO_rev_2	125	130	PF00179	0.448
TRG_ENDOCYTIC_2	28	31	PF00928	0.605
TRG_ER_diArg_1	177	179	PF00400	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXS2	Leptomonas seymouri	83%	100%
A0A0S4JKW3	Bodo saltans	48%	84%
A0A1X0P3E4	Trypanosomatidae	68%	100%
A0A3S5H832	Leishmania donovani	96%	100%
A0A422NVM1	Trypanosoma rangeli	71%	100%
A4HPK2	Leishmania braziliensis	92%	100%
A4ID62	Leishmania infantum	96%	100%
D0A8L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
Q4Q183	Leishmania major	94%	100%