Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATA9_LEIMU

TriTrypDb:

LmxM.36.3300

Length:

821

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ATA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.398
CLV_NRD_NRD_1	122	124	PF00675	0.810
CLV_NRD_NRD_1	276	278	PF00675	0.696
CLV_NRD_NRD_1	403	405	PF00675	0.459
CLV_NRD_NRD_1	439	441	PF00675	0.454
CLV_NRD_NRD_1	47	49	PF00675	0.670
CLV_NRD_NRD_1	513	515	PF00675	0.489
CLV_NRD_NRD_1	524	526	PF00675	0.470
CLV_NRD_NRD_1	540	542	PF00675	0.423
CLV_NRD_NRD_1	577	579	PF00675	0.507
CLV_NRD_NRD_1	587	589	PF00675	0.480
CLV_NRD_NRD_1	607	609	PF00675	0.398
CLV_NRD_NRD_1	629	631	PF00675	0.485
CLV_NRD_NRD_1	658	660	PF00675	0.424
CLV_NRD_NRD_1	678	680	PF00675	0.364
CLV_NRD_NRD_1	740	742	PF00675	0.438
CLV_NRD_NRD_1	776	778	PF00675	0.627
CLV_NRD_NRD_1	98	100	PF00675	0.582
CLV_PCSK_FUR_1	538	542	PF00082	0.565
CLV_PCSK_FUR_1	585	589	PF00082	0.566
CLV_PCSK_KEX2_1	239	241	PF00082	0.822
CLV_PCSK_KEX2_1	276	278	PF00082	0.702
CLV_PCSK_KEX2_1	403	405	PF00082	0.442
CLV_PCSK_KEX2_1	439	441	PF00082	0.424
CLV_PCSK_KEX2_1	47	49	PF00082	0.670
CLV_PCSK_KEX2_1	513	515	PF00082	0.519
CLV_PCSK_KEX2_1	523	525	PF00082	0.445
CLV_PCSK_KEX2_1	540	542	PF00082	0.448
CLV_PCSK_KEX2_1	577	579	PF00082	0.507
CLV_PCSK_KEX2_1	587	589	PF00082	0.480
CLV_PCSK_KEX2_1	606	608	PF00082	0.421
CLV_PCSK_KEX2_1	629	631	PF00082	0.504
CLV_PCSK_KEX2_1	658	660	PF00082	0.499
CLV_PCSK_KEX2_1	678	680	PF00082	0.371
CLV_PCSK_KEX2_1	740	742	PF00082	0.452
CLV_PCSK_KEX2_1	776	778	PF00082	0.589
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.563
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.594
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.589
CLV_PCSK_SKI1_1	298	302	PF00082	0.421
CLV_PCSK_SKI1_1	331	335	PF00082	0.520
CLV_PCSK_SKI1_1	471	475	PF00082	0.471
CLV_PCSK_SKI1_1	610	614	PF00082	0.603
CLV_PCSK_SKI1_1	629	633	PF00082	0.360
CLV_PCSK_SKI1_1	659	663	PF00082	0.587
CLV_PCSK_SKI1_1	732	736	PF00082	0.432
DEG_APCC_DBOX_1	427	435	PF00400	0.248
DEG_COP1_1	68	76	PF00400	0.584
DOC_CKS1_1	272	277	PF01111	0.657
DOC_CKS1_1	278	283	PF01111	0.570
DOC_CYCLIN_RxL_1	295	302	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.581
DOC_MAPK_gen_1	610	619	PF00069	0.443
DOC_MAPK_HePTP_8	491	503	PF00069	0.327
DOC_MAPK_MEF2A_6	494	503	PF00069	0.329
DOC_MAPK_RevD_3	427	440	PF00069	0.240
DOC_PP2B_LxvP_1	301	304	PF13499	0.461
DOC_PP2B_PxIxI_1	346	352	PF00149	0.324
DOC_USP7_MATH_1	122	126	PF00917	0.661
DOC_USP7_MATH_1	128	132	PF00917	0.612
DOC_USP7_MATH_1	166	170	PF00917	0.673
DOC_USP7_MATH_1	183	187	PF00917	0.551
DOC_USP7_MATH_1	245	249	PF00917	0.741
DOC_USP7_UBL2_3	30	34	PF12436	0.588
DOC_USP7_UBL2_3	606	610	PF12436	0.525
DOC_WW_Pin1_4	114	119	PF00397	0.587
DOC_WW_Pin1_4	124	129	PF00397	0.643
DOC_WW_Pin1_4	142	147	PF00397	0.749
DOC_WW_Pin1_4	154	159	PF00397	0.620
DOC_WW_Pin1_4	162	167	PF00397	0.621
DOC_WW_Pin1_4	173	178	PF00397	0.694
DOC_WW_Pin1_4	212	217	PF00397	0.635
DOC_WW_Pin1_4	241	246	PF00397	0.616
DOC_WW_Pin1_4	264	269	PF00397	0.687
DOC_WW_Pin1_4	271	276	PF00397	0.635
DOC_WW_Pin1_4	277	282	PF00397	0.570
DOC_WW_Pin1_4	343	348	PF00397	0.602
DOC_WW_Pin1_4	350	355	PF00397	0.252
DOC_WW_Pin1_4	363	368	PF00397	0.357
LIG_14-3-3_CanoR_1	10	17	PF00244	0.522
LIG_14-3-3_CanoR_1	150	158	PF00244	0.574
LIG_14-3-3_CanoR_1	184	191	PF00244	0.785
LIG_14-3-3_CanoR_1	221	226	PF00244	0.783
LIG_14-3-3_CanoR_1	264	268	PF00244	0.770
LIG_14-3-3_CanoR_1	331	340	PF00244	0.461
LIG_14-3-3_CanoR_1	387	395	PF00244	0.346
LIG_14-3-3_CanoR_1	710	716	PF00244	0.488
LIG_14-3-3_CanoR_1	732	739	PF00244	0.551
LIG_14-3-3_CanoR_1	814	820	PF00244	0.601
LIG_Actin_WH2_2	308	326	PF00022	0.449
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_deltaCOP1_diTrp_1	736	745	PF00928	0.407
LIG_EH1_1	767	775	PF00400	0.488
LIG_eIF4E_1	768	774	PF01652	0.257
LIG_FHA_1	291	297	PF00498	0.543
LIG_FHA_1	332	338	PF00498	0.297
LIG_FHA_1	474	480	PF00498	0.516
LIG_FHA_1	55	61	PF00498	0.545
LIG_FHA_1	591	597	PF00498	0.583
LIG_FHA_1	750	756	PF00498	0.406
LIG_FHA_2	364	370	PF00498	0.334
LIG_FHA_2	415	421	PF00498	0.490
LIG_FHA_2	712	718	PF00498	0.611
LIG_FHA_2	767	773	PF00498	0.433
LIG_FHA_2	78	84	PF00498	0.519
LIG_LIR_Gen_1	420	430	PF02991	0.362
LIG_LIR_Gen_1	752	761	PF02991	0.405
LIG_LIR_Gen_1	763	771	PF02991	0.334
LIG_LIR_LC3C_4	433	436	PF02991	0.226
LIG_LIR_Nem_3	12	17	PF02991	0.708
LIG_LIR_Nem_3	37	42	PF02991	0.479
LIG_LIR_Nem_3	420	425	PF02991	0.368
LIG_LIR_Nem_3	752	756	PF02991	0.418
LIG_LIR_Nem_3	763	767	PF02991	0.324
LIG_MAD2	295	303	PF02301	0.496
LIG_NRBOX	296	302	PF00104	0.394
LIG_Pex14_2	318	322	PF04695	0.463
LIG_SH2_CRK	14	18	PF00017	0.695
LIG_SH2_CRK	422	426	PF00017	0.437
LIG_SH2_CRK	438	442	PF00017	0.452
LIG_SH2_CRK	753	757	PF00017	0.476
LIG_SH2_NCK_1	768	772	PF00017	0.249
LIG_SH2_STAP1	307	311	PF00017	0.480
LIG_SH2_STAT3	545	548	PF00017	0.395
LIG_SH2_STAT5	35	38	PF00017	0.635
LIG_SH2_STAT5	406	409	PF00017	0.502
LIG_SH2_STAT5	641	644	PF00017	0.512
LIG_SH2_STAT5	768	771	PF00017	0.243
LIG_SH3_2	272	277	PF14604	0.725
LIG_SH3_3	145	151	PF00018	0.750
LIG_SH3_3	17	23	PF00018	0.534
LIG_SH3_3	196	202	PF00018	0.620
LIG_SH3_3	269	275	PF00018	0.607
LIG_SUMO_SIM_anti_2	769	775	PF11976	0.431
LIG_SUMO_SIM_par_1	769	775	PF11976	0.431
LIG_TRAF2_1	136	139	PF00917	0.629
LIG_TRAF2_1	168	171	PF00917	0.672
LIG_TRAF2_1	388	391	PF00917	0.366
LIG_TRAF2_1	517	520	PF00917	0.533
LIG_TRAF2_1	601	604	PF00917	0.579
LIG_TRAF2_1	706	709	PF00917	0.532
LIG_TRAF2_1	815	818	PF00917	0.411
LIG_TYR_ITIM	436	441	PF00017	0.242
LIG_TYR_ITSM	10	17	PF00017	0.561
LIG_UBA3_1	481	489	PF00899	0.451
LIG_WRC_WIRS_1	315	320	PF05994	0.388
LIG_WW_1	304	307	PF00397	0.316
MOD_CDC14_SPxK_1	147	150	PF00782	0.491
MOD_CDK_SPK_2	271	276	PF00069	0.659
MOD_CDK_SPK_2	343	348	PF00069	0.534
MOD_CDK_SPK_2	350	355	PF00069	0.332
MOD_CDK_SPK_2	363	368	PF00069	0.357
MOD_CDK_SPxK_1	144	150	PF00069	0.498
MOD_CDK_SPxK_1	271	277	PF00069	0.781
MOD_CDK_SPxxK_3	116	123	PF00069	0.750
MOD_CK1_1	203	209	PF00069	0.720
MOD_CK1_1	267	273	PF00069	0.609
MOD_CK1_1	353	359	PF00069	0.352
MOD_CK1_1	375	381	PF00069	0.551
MOD_CK1_1	458	464	PF00069	0.543
MOD_CK2_1	34	40	PF00069	0.668
MOD_CK2_1	77	83	PF00069	0.542
MOD_CK2_1	812	818	PF00069	0.551
MOD_Cter_Amidation	237	240	PF01082	0.818
MOD_Cter_Amidation	91	94	PF01082	0.546
MOD_DYRK1A_RPxSP_1	264	268	PF00069	0.770
MOD_GlcNHglycan	105	108	PF01048	0.670
MOD_GlcNHglycan	209	212	PF01048	0.735
MOD_GlcNHglycan	247	250	PF01048	0.767
MOD_GlcNHglycan	324	327	PF01048	0.487
MOD_GlcNHglycan	377	380	PF01048	0.668
MOD_GSK3_1	114	121	PF00069	0.523
MOD_GSK3_1	124	131	PF00069	0.616
MOD_GSK3_1	150	157	PF00069	0.593
MOD_GSK3_1	162	169	PF00069	0.592
MOD_GSK3_1	203	210	PF00069	0.679
MOD_GSK3_1	211	218	PF00069	0.538
MOD_GSK3_1	221	228	PF00069	0.696
MOD_GSK3_1	241	248	PF00069	0.718
MOD_GSK3_1	263	270	PF00069	0.697
MOD_GSK3_1	286	293	PF00069	0.584
MOD_GSK3_1	410	417	PF00069	0.492
MOD_GSK3_1	5	12	PF00069	0.662
MOD_GSK3_1	728	735	PF00069	0.442
MOD_GSK3_1	812	819	PF00069	0.406
MOD_LATS_1	219	225	PF00433	0.503
MOD_N-GLC_1	342	347	PF02516	0.520
MOD_NEK2_1	313	318	PF00069	0.425
MOD_NEK2_1	372	377	PF00069	0.412
MOD_NEK2_1	414	419	PF00069	0.399
MOD_NEK2_1	589	594	PF00069	0.484
MOD_NEK2_1	69	74	PF00069	0.679
MOD_NEK2_2	307	312	PF00069	0.448
MOD_NEK2_2	804	809	PF00069	0.328
MOD_PIKK_1	128	134	PF00454	0.719
MOD_PIKK_1	386	392	PF00454	0.491
MOD_PIKK_1	5	11	PF00454	0.607
MOD_PIKK_1	699	705	PF00454	0.483
MOD_PIKK_1	813	819	PF00454	0.607
MOD_PKA_2	122	128	PF00069	0.687
MOD_PKA_2	149	155	PF00069	0.569
MOD_PKA_2	183	189	PF00069	0.660
MOD_PKA_2	263	269	PF00069	0.744
MOD_PKA_2	372	378	PF00069	0.526
MOD_PKA_2	386	392	PF00069	0.370
MOD_PKA_2	410	416	PF00069	0.577
MOD_PKA_2	590	596	PF00069	0.548
MOD_PKA_2	719	725	PF00069	0.598
MOD_PKA_2	728	734	PF00069	0.532
MOD_PKA_2	804	810	PF00069	0.446
MOD_PKA_2	813	819	PF00069	0.582
MOD_PKA_2	9	15	PF00069	0.521
MOD_PKB_1	3	11	PF00069	0.608
MOD_Plk_1	232	238	PF00069	0.568
MOD_Plk_1	313	319	PF00069	0.502
MOD_Plk_1	495	501	PF00069	0.446
MOD_Plk_1	69	75	PF00069	0.564
MOD_Plk_2-3	314	320	PF00069	0.392
MOD_Plk_4	332	338	PF00069	0.320
MOD_Plk_4	420	426	PF00069	0.461
MOD_Plk_4	72	78	PF00069	0.562
MOD_Plk_4	766	772	PF00069	0.421
MOD_ProDKin_1	114	120	PF00069	0.581
MOD_ProDKin_1	124	130	PF00069	0.636
MOD_ProDKin_1	142	148	PF00069	0.744
MOD_ProDKin_1	154	160	PF00069	0.622
MOD_ProDKin_1	162	168	PF00069	0.621
MOD_ProDKin_1	173	179	PF00069	0.693
MOD_ProDKin_1	212	218	PF00069	0.635
MOD_ProDKin_1	241	247	PF00069	0.618
MOD_ProDKin_1	264	270	PF00069	0.686
MOD_ProDKin_1	271	277	PF00069	0.634
MOD_ProDKin_1	343	349	PF00069	0.588
MOD_ProDKin_1	350	356	PF00069	0.249
MOD_ProDKin_1	363	369	PF00069	0.364
MOD_SUMO_for_1	612	615	PF00179	0.585
MOD_SUMO_for_1	706	709	PF00179	0.490
MOD_SUMO_for_1	808	811	PF00179	0.537
MOD_SUMO_rev_2	592	601	PF00179	0.617
MOD_SUMO_rev_2	746	752	PF00179	0.414
MOD_SUMO_rev_2	85	95	PF00179	0.391
TRG_DiLeu_BaEn_1	627	632	PF01217	0.494
TRG_DiLeu_BaEn_4	170	176	PF01217	0.674
TRG_DiLeu_BaEn_4	454	460	PF01217	0.544
TRG_DiLeu_LyEn_5	627	632	PF01217	0.369
TRG_ENDOCYTIC_2	14	17	PF00928	0.716
TRG_ENDOCYTIC_2	422	425	PF00928	0.363
TRG_ENDOCYTIC_2	438	441	PF00928	0.531
TRG_ENDOCYTIC_2	753	756	PF00928	0.482
TRG_ENDOCYTIC_2	768	771	PF00928	0.343
TRG_ER_diArg_1	220	223	PF00400	0.771
TRG_ER_diArg_1	275	277	PF00400	0.749
TRG_ER_diArg_1	438	440	PF00400	0.441
TRG_ER_diArg_1	46	48	PF00400	0.621
TRG_ER_diArg_1	512	514	PF00400	0.526
TRG_ER_diArg_1	523	525	PF00400	0.502
TRG_ER_diArg_1	538	541	PF00400	0.360
TRG_ER_diArg_1	585	588	PF00400	0.554
TRG_ER_diArg_1	629	631	PF00400	0.399
TRG_ER_diArg_1	739	741	PF00400	0.456
TRG_ER_diArg_1	784	787	PF00400	0.498
TRG_ER_diArg_1	795	798	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	629	634	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	732	736	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	787	792	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ0	Leptomonas seymouri	46%	100%
A0A1X0P4M8	Trypanosomatidae	30%	98%
A0A3Q8IW63	Leishmania donovani	89%	100%
A0A3R7KTP5	Trypanosoma rangeli	31%	100%
A4HPJ7	Leishmania braziliensis	69%	100%
D0A8L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
E9AHX5	Leishmania infantum	89%	100%
Q4Q188	Leishmania major	88%	100%
V5BS35	Trypanosoma cruzi	30%	100%