Intu_longin_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATA4_LEIMU

TriTrypDb:

LmxM.36.3250

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATA4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.691
CLV_MEL_PAP_1	61	67	PF00089	0.296
CLV_NRD_NRD_1	138	140	PF00675	0.672
CLV_NRD_NRD_1	75	77	PF00675	0.390
CLV_PCSK_SKI1_1	168	172	PF00082	0.461
CLV_PCSK_SKI1_1	177	181	PF00082	0.416
CLV_PCSK_SKI1_1	247	251	PF00082	0.671
CLV_PCSK_SKI1_1	372	376	PF00082	0.665
CLV_PCSK_SKI1_1	509	513	PF00082	0.489
CLV_Separin_Metazoa	244	248	PF03568	0.642
DEG_SPOP_SBC_1	2	6	PF00917	0.596
DEG_SPOP_SBC_1	458	462	PF00917	0.581
DOC_ANK_TNKS_1	435	442	PF00023	0.606
DOC_CKS1_1	152	157	PF01111	0.683
DOC_CYCLIN_RxL_1	369	376	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.586
DOC_MAPK_FxFP_2	37	40	PF00069	0.421
DOC_MAPK_gen_1	76	84	PF00069	0.329
DOC_MAPK_MEF2A_6	232	239	PF00069	0.611
DOC_PP1_RVXF_1	245	252	PF00149	0.567
DOC_PP2B_LxvP_1	130	133	PF13499	0.564
DOC_PP2B_LxvP_1	307	310	PF13499	0.524
DOC_PP2B_LxvP_1	409	412	PF13499	0.585
DOC_PP2B_LxvP_1	455	458	PF13499	0.619
DOC_PP2B_LxvP_1	512	515	PF13499	0.736
DOC_PP4_FxxP_1	222	225	PF00568	0.656
DOC_PP4_FxxP_1	279	282	PF00568	0.560
DOC_PP4_FxxP_1	37	40	PF00568	0.421
DOC_PP4_FxxP_1	481	484	PF00568	0.425
DOC_SPAK_OSR1_1	64	68	PF12202	0.296
DOC_USP7_MATH_1	144	148	PF00917	0.582
DOC_USP7_MATH_1	160	164	PF00917	0.673
DOC_USP7_MATH_1	170	174	PF00917	0.421
DOC_USP7_MATH_1	205	209	PF00917	0.574
DOC_USP7_MATH_1	218	222	PF00917	0.547
DOC_USP7_MATH_1	312	316	PF00917	0.501
DOC_USP7_MATH_1	414	418	PF00917	0.668
DOC_USP7_MATH_1	57	61	PF00917	0.324
DOC_USP7_UBL2_3	406	410	PF12436	0.658
DOC_WW_Pin1_4	151	156	PF00397	0.696
DOC_WW_Pin1_4	354	359	PF00397	0.597
DOC_WW_Pin1_4	430	435	PF00397	0.606
DOC_WW_Pin1_4	459	464	PF00397	0.426
DOC_WW_Pin1_4	83	88	PF00397	0.324
LIG_14-3-3_CanoR_1	177	182	PF00244	0.530
LIG_14-3-3_CanoR_1	227	235	PF00244	0.604
LIG_14-3-3_CanoR_1	365	374	PF00244	0.629
LIG_14-3-3_CanoR_1	471	476	PF00244	0.504
LIG_14-3-3_CanoR_1	76	85	PF00244	0.364
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.478
LIG_eIF4E_1	122	128	PF01652	0.347
LIG_eIF4E_1	505	511	PF01652	0.592
LIG_FHA_1	105	111	PF00498	0.334
LIG_FHA_1	393	399	PF00498	0.534
LIG_FHA_1	505	511	PF00498	0.432
LIG_FHA_2	3	9	PF00498	0.658
LIG_FHA_2	381	387	PF00498	0.565
LIG_FHA_2	426	432	PF00498	0.580
LIG_GBD_Chelix_1	297	305	PF00786	0.593
LIG_LIR_Apic_2	219	225	PF02991	0.717
LIG_LIR_Gen_1	470	479	PF02991	0.460
LIG_LIR_Nem_3	211	215	PF02991	0.421
LIG_LIR_Nem_3	300	306	PF02991	0.594
LIG_LIR_Nem_3	433	438	PF02991	0.560
LIG_LIR_Nem_3	470	475	PF02991	0.477
LIG_NRBOX	116	122	PF00104	0.324
LIG_REV1ctd_RIR_1	172	181	PF16727	0.436
LIG_RPA_C_Fungi	360	372	PF08784	0.432
LIG_SH2_CRK	19	23	PF00017	0.421
LIG_SH2_CRK	308	312	PF00017	0.505
LIG_SH2_NCK_1	308	312	PF00017	0.505
LIG_SH2_SRC	308	311	PF00017	0.502
LIG_SH2_STAP1	451	455	PF00017	0.465
LIG_SH2_STAT3	505	508	PF00017	0.586
LIG_SH2_STAT5	19	22	PF00017	0.421
LIG_SH2_STAT5	215	218	PF00017	0.445
LIG_SH2_STAT5	304	307	PF00017	0.517
LIG_SH2_STAT5	38	41	PF00017	0.475
LIG_SH2_STAT5	445	448	PF00017	0.621
LIG_SH2_STAT5	478	481	PF00017	0.428
LIG_SH3_3	15	21	PF00018	0.230
LIG_SH3_3	319	325	PF00018	0.425
LIG_SH3_3	6	12	PF00018	0.588
LIG_SUMO_SIM_par_1	336	342	PF11976	0.497
LIG_TYR_ITIM	301	306	PF00017	0.598
LIG_WRC_WIRS_1	171	176	PF05994	0.424
MOD_CDK_SPxK_1	430	436	PF00069	0.605
MOD_CK1_1	123	129	PF00069	0.615
MOD_CK1_1	147	153	PF00069	0.656
MOD_CK1_1	162	168	PF00069	0.524
MOD_CK1_1	173	179	PF00069	0.400
MOD_CK1_1	255	261	PF00069	0.522
MOD_CK2_1	227	233	PF00069	0.661
MOD_CK2_1	356	362	PF00069	0.604
MOD_CK2_1	380	386	PF00069	0.565
MOD_CK2_1	425	431	PF00069	0.640
MOD_CK2_1	461	467	PF00069	0.610
MOD_CK2_1	83	89	PF00069	0.421
MOD_CMANNOS	469	472	PF00535	0.473
MOD_Cter_Amidation	137	140	PF01082	0.668
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.630
MOD_GlcNHglycan	122	125	PF01048	0.574
MOD_GlcNHglycan	146	149	PF01048	0.600
MOD_GlcNHglycan	207	210	PF01048	0.609
MOD_GlcNHglycan	216	219	PF01048	0.420
MOD_GlcNHglycan	254	257	PF01048	0.468
MOD_GlcNHglycan	416	419	PF01048	0.680
MOD_GlcNHglycan	93	96	PF01048	0.324
MOD_GSK3_1	142	149	PF00069	0.647
MOD_GSK3_1	173	180	PF00069	0.492
MOD_GSK3_1	214	221	PF00069	0.594
MOD_GSK3_1	457	464	PF00069	0.614
MOD_GSK3_1	467	474	PF00069	0.495
MOD_GSK3_1	67	74	PF00069	0.342
MOD_LATS_1	363	369	PF00433	0.582
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	111	116	PF00069	0.183
MOD_NEK2_1	128	133	PF00069	0.468
MOD_NEK2_1	181	186	PF00069	0.550
MOD_NEK2_1	288	293	PF00069	0.656
MOD_NEK2_1	425	430	PF00069	0.588
MOD_NEK2_1	449	454	PF00069	0.511
MOD_NEK2_1	91	96	PF00069	0.338
MOD_NEK2_2	170	175	PF00069	0.520
MOD_NEK2_2	270	275	PF00069	0.606
MOD_NEK2_2	312	317	PF00069	0.484
MOD_NEK2_2	405	410	PF00069	0.599
MOD_NEK2_2	71	76	PF00069	0.295
MOD_PIKK_1	504	510	PF00454	0.382
MOD_PKA_2	270	276	PF00069	0.603
MOD_PKA_2	425	431	PF00069	0.653
MOD_PKA_2	78	84	PF00069	0.371
MOD_Plk_1	218	224	PF00069	0.501
MOD_Plk_4	123	129	PF00069	0.473
MOD_Plk_4	177	183	PF00069	0.528
MOD_Plk_4	356	362	PF00069	0.568
MOD_Plk_4	425	431	PF00069	0.577
MOD_Plk_4	461	467	PF00069	0.638
MOD_Plk_4	471	477	PF00069	0.489
MOD_ProDKin_1	151	157	PF00069	0.692
MOD_ProDKin_1	354	360	PF00069	0.593
MOD_ProDKin_1	430	436	PF00069	0.610
MOD_ProDKin_1	459	465	PF00069	0.419
MOD_ProDKin_1	83	89	PF00069	0.324
TRG_DiLeu_BaEn_1	506	511	PF01217	0.582
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.290
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.517
TRG_DiLeu_LyEn_5	506	511	PF01217	0.512
TRG_ENDOCYTIC_2	19	22	PF00928	0.471
TRG_ENDOCYTIC_2	303	306	PF00928	0.509
TRG_ENDOCYTIC_2	308	311	PF00928	0.523
TRG_ENDOCYTIC_2	404	407	PF00928	0.641
TRG_ENDOCYTIC_2	478	481	PF00928	0.447
TRG_ER_diArg_1	423	426	PF00400	0.557
TRG_ER_diArg_1	498	501	PF00400	0.416
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW11	Leptomonas seymouri	44%	100%
A0A3Q8IR86	Leishmania donovani	90%	100%
A4HPJ2	Leishmania braziliensis	77%	100%
A4ID71	Leishmania infantum	90%	100%
Q4Q193	Leishmania major	91%	100%