ATP pyrophosphate-lyase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ATA3_LEIMU

TriTrypDb:

LmxM.36.3240

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ATA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	506	510	PF00656	0.448
CLV_C14_Caspase3-7	811	815	PF00656	0.483
CLV_NRD_NRD_1	200	202	PF00675	0.517
CLV_NRD_NRD_1	31	33	PF00675	0.787
CLV_NRD_NRD_1	545	547	PF00675	0.667
CLV_NRD_NRD_1	721	723	PF00675	0.701
CLV_PCSK_FUR_1	29	33	PF00082	0.798
CLV_PCSK_KEX2_1	200	202	PF00082	0.517
CLV_PCSK_KEX2_1	29	31	PF00082	0.808
CLV_PCSK_KEX2_1	545	547	PF00082	0.667
CLV_PCSK_KEX2_1	721	723	PF00082	0.701
CLV_PCSK_SKI1_1	354	358	PF00082	0.542
DEG_Nend_UBRbox_2	1	3	PF02207	0.614
DEG_SCF_FBW7_1	537	543	PF00400	0.571
DEG_SCF_FBW7_1	804	810	PF00400	0.572
DEG_SCF_FBW7_2	325	331	PF00400	0.408
DEG_SCF_FBW7_2	744	750	PF00400	0.514
DEG_SPOP_SBC_1	518	522	PF00917	0.437
DOC_ANK_TNKS_1	816	823	PF00023	0.490
DOC_CKS1_1	325	330	PF01111	0.339
DOC_CKS1_1	358	363	PF01111	0.422
DOC_CKS1_1	537	542	PF01111	0.571
DOC_CKS1_1	744	749	PF01111	0.514
DOC_CKS1_1	804	809	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	818	821	PF00134	0.488
DOC_MAPK_DCC_7	289	299	PF00069	0.461
DOC_PP1_RVXF_1	352	359	PF00149	0.346
DOC_PP1_RVXF_1	766	773	PF00149	0.338
DOC_PP2B_LxvP_1	365	368	PF13499	0.510
DOC_PP2B_LxvP_1	818	821	PF13499	0.488
DOC_USP7_MATH_1	126	130	PF00917	0.512
DOC_USP7_MATH_1	191	195	PF00917	0.486
DOC_USP7_MATH_1	196	200	PF00917	0.423
DOC_USP7_MATH_1	22	26	PF00917	0.417
DOC_USP7_MATH_1	240	244	PF00917	0.437
DOC_USP7_MATH_1	518	522	PF00917	0.610
DOC_USP7_MATH_1	524	528	PF00917	0.579
DOC_USP7_MATH_1	540	544	PF00917	0.460
DOC_USP7_MATH_1	564	568	PF00917	0.458
DOC_USP7_MATH_1	808	812	PF00917	0.486
DOC_WW_Pin1_4	324	329	PF00397	0.528
DOC_WW_Pin1_4	357	362	PF00397	0.462
DOC_WW_Pin1_4	412	417	PF00397	0.499
DOC_WW_Pin1_4	536	541	PF00397	0.568
DOC_WW_Pin1_4	629	634	PF00397	0.357
DOC_WW_Pin1_4	743	748	PF00397	0.505
DOC_WW_Pin1_4	803	808	PF00397	0.569
LIG_14-3-3_CanoR_1	124	134	PF00244	0.438
LIG_14-3-3_CanoR_1	289	294	PF00244	0.404
LIG_14-3-3_CanoR_1	492	499	PF00244	0.571
LIG_14-3-3_CanoR_1	768	773	PF00244	0.536
LIG_APCC_ABBAyCdc20_2	41	47	PF00400	0.580
LIG_BRCT_BRCA1_1	214	218	PF00533	0.490
LIG_BRCT_BRCA1_1	634	638	PF00533	0.338
LIG_BRCT_BRCA1_1	69	73	PF00533	0.469
LIG_BRCT_BRCA1_1	768	772	PF00533	0.340
LIG_BRCT_BRCA1_1	832	836	PF00533	0.415
LIG_Clathr_ClatBox_1	332	336	PF01394	0.484
LIG_deltaCOP1_diTrp_1	585	596	PF00928	0.311
LIG_eIF4E_1	830	836	PF01652	0.523
LIG_FHA_1	118	124	PF00498	0.508
LIG_FHA_1	129	135	PF00498	0.420
LIG_FHA_1	181	187	PF00498	0.415
LIG_FHA_1	267	273	PF00498	0.371
LIG_FHA_1	325	331	PF00498	0.453
LIG_FHA_1	384	390	PF00498	0.516
LIG_FHA_1	425	431	PF00498	0.314
LIG_FHA_1	512	518	PF00498	0.447
LIG_FHA_1	558	564	PF00498	0.603
LIG_FHA_1	610	616	PF00498	0.433
LIG_FHA_1	711	717	PF00498	0.467
LIG_FHA_1	735	741	PF00498	0.455
LIG_FHA_1	774	780	PF00498	0.424
LIG_FHA_1	804	810	PF00498	0.572
LIG_FHA_1	811	817	PF00498	0.485
LIG_FHA_1	822	828	PF00498	0.341
LIG_FHA_1	86	92	PF00498	0.544
LIG_FHA_2	55	61	PF00498	0.495
LIG_FHA_2	690	696	PF00498	0.392
LIG_IRF3_LxIS_1	564	571	PF10401	0.437
LIG_LIR_Apic_2	270	276	PF02991	0.286
LIG_LIR_Apic_2	290	296	PF02991	0.457
LIG_LIR_Apic_2	355	361	PF02991	0.428
LIG_LIR_Apic_2	654	660	PF02991	0.424
LIG_LIR_Apic_2	675	679	PF02991	0.482
LIG_LIR_Gen_1	143	153	PF02991	0.499
LIG_LIR_Gen_1	164	173	PF02991	0.502
LIG_LIR_Gen_1	302	311	PF02991	0.272
LIG_LIR_Gen_1	407	417	PF02991	0.491
LIG_LIR_Gen_1	70	80	PF02991	0.473
LIG_LIR_Gen_1	738	747	PF02991	0.474
LIG_LIR_Gen_1	750	759	PF02991	0.389
LIG_LIR_LC3C_4	331	334	PF02991	0.374
LIG_LIR_Nem_3	164	169	PF02991	0.500
LIG_LIR_Nem_3	183	187	PF02991	0.224
LIG_LIR_Nem_3	199	205	PF02991	0.316
LIG_LIR_Nem_3	302	307	PF02991	0.283
LIG_LIR_Nem_3	359	365	PF02991	0.516
LIG_LIR_Nem_3	407	412	PF02991	0.478
LIG_LIR_Nem_3	478	483	PF02991	0.330
LIG_LIR_Nem_3	595	599	PF02991	0.441
LIG_LIR_Nem_3	635	641	PF02991	0.330
LIG_LIR_Nem_3	70	76	PF02991	0.517
LIG_LIR_Nem_3	738	744	PF02991	0.475
LIG_LIR_Nem_3	750	754	PF02991	0.388
LIG_LIR_Nem_3	785	791	PF02991	0.482
LIG_LIR_Nem_3	833	839	PF02991	0.415
LIG_LYPXL_S_1	36	40	PF13949	0.776
LIG_LYPXL_yS_3	37	40	PF13949	0.580
LIG_MYND_1	115	119	PF01753	0.572
LIG_Pex14_1	273	277	PF04695	0.402
LIG_Pex14_1	358	362	PF04695	0.476
LIG_Pex14_1	657	661	PF04695	0.491
LIG_Pex14_2	173	177	PF04695	0.500
LIG_Pex14_2	638	642	PF04695	0.308
LIG_PTB_Apo_2	39	46	PF02174	0.581
LIG_PTB_Phospho_1	39	45	PF10480	0.583
LIG_REV1ctd_RIR_1	93	101	PF16727	0.555
LIG_SH2_CRK	187	191	PF00017	0.500
LIG_SH2_CRK	304	308	PF00017	0.271
LIG_SH2_CRK	400	404	PF00017	0.476
LIG_SH2_CRK	741	745	PF00017	0.508
LIG_SH2_GRB2like	394	397	PF00017	0.430
LIG_SH2_NCK_1	483	487	PF00017	0.453
LIG_SH2_NCK_1	759	763	PF00017	0.516
LIG_SH2_PTP2	676	679	PF00017	0.482
LIG_SH2_SRC	156	159	PF00017	0.314
LIG_SH2_SRC	394	397	PF00017	0.430
LIG_SH2_SRC	676	679	PF00017	0.482
LIG_SH2_STAP1	304	308	PF00017	0.464
LIG_SH2_STAP1	519	523	PF00017	0.553
LIG_SH2_STAP1	703	707	PF00017	0.310
LIG_SH2_STAP1	98	102	PF00017	0.558
LIG_SH2_STAT3	246	249	PF00017	0.435
LIG_SH2_STAT3	98	101	PF00017	0.556
LIG_SH2_STAT5	184	187	PF00017	0.447
LIG_SH2_STAT5	219	222	PF00017	0.481
LIG_SH2_STAT5	246	249	PF00017	0.512
LIG_SH2_STAT5	293	296	PF00017	0.388
LIG_SH2_STAT5	480	483	PF00017	0.374
LIG_SH2_STAT5	661	664	PF00017	0.367
LIG_SH2_STAT5	676	679	PF00017	0.309
LIG_SH2_STAT5	68	71	PF00017	0.549
LIG_SH2_STAT5	687	690	PF00017	0.365
LIG_SH2_STAT5	703	706	PF00017	0.313
LIG_SH2_STAT5	717	720	PF00017	0.362
LIG_SH2_STAT5	741	744	PF00017	0.387
LIG_SH2_STAT5	75	78	PF00017	0.470
LIG_SH2_STAT5	803	806	PF00017	0.564
LIG_SH2_STAT5	830	833	PF00017	0.523
LIG_SH3_3	74	80	PF00018	0.436
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.412
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.487
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.587
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.548
LIG_SUMO_SIM_par_1	253	259	PF11976	0.490
LIG_SUMO_SIM_par_1	331	336	PF11976	0.487
LIG_SUMO_SIM_par_1	414	420	PF11976	0.516
LIG_SUMO_SIM_par_1	51	58	PF11976	0.587
LIG_TRAF2_1	46	49	PF00917	0.577
LIG_TRAF2_1	747	750	PF00917	0.329
LIG_TYR_ITIM	398	403	PF00017	0.490
LIG_TYR_ITIM	779	784	PF00017	0.476
LIG_UBA3_1	91	97	PF00899	0.553
LIG_WRC_WIRS_1	127	132	PF05994	0.513
LIG_WRC_WIRS_1	349	354	PF05994	0.515
MOD_CK1_1	125	131	PF00069	0.437
MOD_CK1_1	209	215	PF00069	0.445
MOD_CK1_1	221	227	PF00069	0.332
MOD_CK1_1	256	262	PF00069	0.489
MOD_CK1_1	378	384	PF00069	0.445
MOD_CK1_1	407	413	PF00069	0.477
MOD_CK1_1	478	484	PF00069	0.479
MOD_CK1_1	494	500	PF00069	0.466
MOD_CK1_1	503	509	PF00069	0.515
MOD_CK1_1	527	533	PF00069	0.555
MOD_CK1_1	578	584	PF00069	0.594
MOD_CK1_1	609	615	PF00069	0.402
MOD_CK1_1	632	638	PF00069	0.484
MOD_CK1_1	649	655	PF00069	0.311
MOD_CK1_1	664	670	PF00069	0.448
MOD_CK2_1	126	132	PF00069	0.512
MOD_CK2_1	417	423	PF00069	0.515
MOD_CK2_1	43	49	PF00069	0.578
MOD_CK2_1	546	552	PF00069	0.528
MOD_CK2_1	607	613	PF00069	0.377
MOD_CK2_1	689	695	PF00069	0.320
MOD_GlcNHglycan	124	127	PF01048	0.729
MOD_GlcNHglycan	264	267	PF01048	0.669
MOD_GlcNHglycan	269	272	PF01048	0.615
MOD_GlcNHglycan	442	445	PF01048	0.668
MOD_GlcNHglycan	450	453	PF01048	0.632
MOD_GlcNHglycan	494	497	PF01048	0.771
MOD_GlcNHglycan	526	529	PF01048	0.729
MOD_GlcNHglycan	530	533	PF01048	0.730
MOD_GlcNHglycan	548	551	PF01048	0.637
MOD_GlcNHglycan	570	573	PF01048	0.771
MOD_GlcNHglycan	577	580	PF01048	0.804
MOD_GlcNHglycan	623	626	PF01048	0.788
MOD_GlcNHglycan	634	637	PF01048	0.609
MOD_GlcNHglycan	664	667	PF01048	0.683
MOD_GlcNHglycan	69	72	PF01048	0.667
MOD_GlcNHglycan	755	758	PF01048	0.689
MOD_GlcNHglycan	810	813	PF01048	0.691
MOD_GSK3_1	122	129	PF00069	0.527
MOD_GSK3_1	157	164	PF00069	0.520
MOD_GSK3_1	191	198	PF00069	0.555
MOD_GSK3_1	218	225	PF00069	0.437
MOD_GSK3_1	228	235	PF00069	0.423
MOD_GSK3_1	262	269	PF00069	0.425
MOD_GSK3_1	348	355	PF00069	0.407
MOD_GSK3_1	407	414	PF00069	0.478
MOD_GSK3_1	471	478	PF00069	0.465
MOD_GSK3_1	481	488	PF00069	0.412
MOD_GSK3_1	490	497	PF00069	0.487
MOD_GSK3_1	499	506	PF00069	0.472
MOD_GSK3_1	507	514	PF00069	0.544
MOD_GSK3_1	519	526	PF00069	0.531
MOD_GSK3_1	536	543	PF00069	0.488
MOD_GSK3_1	564	571	PF00069	0.518
MOD_GSK3_1	574	581	PF00069	0.524
MOD_GSK3_1	600	607	PF00069	0.442
MOD_GSK3_1	646	653	PF00069	0.332
MOD_GSK3_1	664	671	PF00069	0.411
MOD_GSK3_1	723	730	PF00069	0.484
MOD_GSK3_1	739	746	PF00069	0.321
MOD_GSK3_1	753	760	PF00069	0.412
MOD_GSK3_1	762	769	PF00069	0.426
MOD_GSK3_1	803	810	PF00069	0.568
MOD_N-GLC_1	209	214	PF02516	0.733
MOD_N-GLC_1	221	226	PF02516	0.558
MOD_N-GLC_1	23	28	PF02516	0.695
MOD_N-GLC_1	339	344	PF02516	0.673
MOD_N-GLC_1	389	394	PF02516	0.718
MOD_N-GLC_1	600	605	PF02516	0.586
MOD_N-GLC_1	621	626	PF02516	0.643
MOD_N-GLC_1	668	673	PF02516	0.719
MOD_N-GLC_1	710	715	PF02516	0.635
MOD_NEK2_1	149	154	PF00069	0.391
MOD_NEK2_1	173	178	PF00069	0.489
MOD_NEK2_1	267	272	PF00069	0.499
MOD_NEK2_1	352	357	PF00069	0.524
MOD_NEK2_1	375	380	PF00069	0.420
MOD_NEK2_1	40	45	PF00069	0.581
MOD_NEK2_1	411	416	PF00069	0.469
MOD_NEK2_1	417	422	PF00069	0.431
MOD_NEK2_1	479	484	PF00069	0.402
MOD_NEK2_1	485	490	PF00069	0.449
MOD_NEK2_1	568	573	PF00069	0.449
MOD_NEK2_1	606	611	PF00069	0.472
MOD_NEK2_1	616	621	PF00069	0.475
MOD_NEK2_1	641	646	PF00069	0.435
MOD_NEK2_1	662	667	PF00069	0.465
MOD_NEK2_1	689	694	PF00069	0.380
MOD_NEK2_1	701	706	PF00069	0.438
MOD_NEK2_1	727	732	PF00069	0.477
MOD_NEK2_1	774	779	PF00069	0.390
MOD_NEK2_1	845	850	PF00069	0.705
MOD_NEK2_1	85	90	PF00069	0.546
MOD_NEK2_2	119	124	PF00069	0.543
MOD_NEK2_2	284	289	PF00069	0.442
MOD_PIKK_1	607	613	PF00454	0.354
MOD_PIKK_1	641	647	PF00454	0.344
MOD_PKA_2	149	155	PF00069	0.501
MOD_PKA_2	491	497	PF00069	0.566
MOD_PKA_2	524	530	PF00069	0.437
MOD_PKA_2	574	580	PF00069	0.560
MOD_PKA_2	662	668	PF00069	0.469
MOD_PKA_2	689	695	PF00069	0.351
MOD_Plk_1	212	218	PF00069	0.507
MOD_Plk_1	221	227	PF00069	0.383
MOD_Plk_1	23	29	PF00069	0.418
MOD_Plk_1	311	317	PF00069	0.472
MOD_Plk_1	352	358	PF00069	0.428
MOD_Plk_1	600	606	PF00069	0.319
MOD_Plk_1	668	674	PF00069	0.514
MOD_Plk_1	766	772	PF00069	0.528
MOD_Plk_1	774	780	PF00069	0.408
MOD_Plk_4	165	171	PF00069	0.429
MOD_Plk_4	173	179	PF00069	0.404
MOD_Plk_4	180	186	PF00069	0.278
MOD_Plk_4	303	309	PF00069	0.270
MOD_Plk_4	352	358	PF00069	0.533
MOD_Plk_4	375	381	PF00069	0.448
MOD_Plk_4	389	395	PF00069	0.411
MOD_Plk_4	40	46	PF00069	0.578
MOD_Plk_4	401	407	PF00069	0.474
MOD_Plk_4	475	481	PF00069	0.491
MOD_Plk_4	616	622	PF00069	0.539
MOD_Plk_4	634	640	PF00069	0.305
MOD_Plk_4	672	678	PF00069	0.445
MOD_Plk_4	689	695	PF00069	0.272
MOD_Plk_4	723	729	PF00069	0.486
MOD_Plk_4	774	780	PF00069	0.501
MOD_Plk_4	830	836	PF00069	0.523
MOD_ProDKin_1	324	330	PF00069	0.533
MOD_ProDKin_1	357	363	PF00069	0.453
MOD_ProDKin_1	412	418	PF00069	0.506
MOD_ProDKin_1	536	542	PF00069	0.569
MOD_ProDKin_1	629	635	PF00069	0.360
MOD_ProDKin_1	743	749	PF00069	0.509
MOD_ProDKin_1	803	809	PF00069	0.564
MOD_SUMO_for_1	583	586	PF00179	0.409
MOD_SUMO_rev_2	10	16	PF00179	0.415
TRG_DiLeu_BaEn_4	132	138	PF01217	0.500
TRG_DiLeu_BaEn_4	51	57	PF01217	0.398
TRG_DiLeu_BaLyEn_6	814	819	PF01217	0.568
TRG_ENDOCYTIC_2	304	307	PF00928	0.314
TRG_ENDOCYTIC_2	349	352	PF00928	0.473
TRG_ENDOCYTIC_2	362	365	PF00928	0.428
TRG_ENDOCYTIC_2	37	40	PF00928	0.580
TRG_ENDOCYTIC_2	400	403	PF00928	0.473
TRG_ENDOCYTIC_2	639	642	PF00928	0.307
TRG_ENDOCYTIC_2	741	744	PF00928	0.502
TRG_ENDOCYTIC_2	781	784	PF00928	0.478
TRG_ER_diArg_1	200	202	PF00400	0.317
TRG_ER_diArg_1	28	31	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XB55	Leishmania donovani	88%	100%
A4HPJ1	Leishmania braziliensis	68%	100%
A4ID72	Leishmania infantum	89%	100%