Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATA0_LEIMU

TriTrypDb:

LmxM.36.3220

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.599
CLV_C14_Caspase3-7	66	70	PF00656	0.318
CLV_C14_Caspase3-7	97	101	PF00656	0.466
CLV_NRD_NRD_1	136	138	PF00675	0.361
CLV_NRD_NRD_1	200	202	PF00675	0.426
CLV_NRD_NRD_1	239	241	PF00675	0.550
CLV_NRD_NRD_1	291	293	PF00675	0.616
CLV_NRD_NRD_1	317	319	PF00675	0.518
CLV_NRD_NRD_1	40	42	PF00675	0.534
CLV_NRD_NRD_1	457	459	PF00675	0.498
CLV_NRD_NRD_1	478	480	PF00675	0.510
CLV_NRD_NRD_1	56	58	PF00675	0.519
CLV_PCSK_FUR_1	476	480	PF00082	0.526
CLV_PCSK_KEX2_1	121	123	PF00082	0.541
CLV_PCSK_KEX2_1	136	138	PF00082	0.432
CLV_PCSK_KEX2_1	200	202	PF00082	0.426
CLV_PCSK_KEX2_1	238	240	PF00082	0.550
CLV_PCSK_KEX2_1	317	319	PF00082	0.460
CLV_PCSK_KEX2_1	457	459	PF00082	0.473
CLV_PCSK_KEX2_1	478	480	PF00082	0.532
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.519
CLV_PCSK_PC7_1	196	202	PF00082	0.426
CLV_PCSK_SKI1_1	145	149	PF00082	0.544
CLV_PCSK_SKI1_1	458	462	PF00082	0.467
CLV_PCSK_SKI1_1	480	484	PF00082	0.462
CLV_PCSK_SKI1_1	501	505	PF00082	0.655
CLV_PCSK_SKI1_1	58	62	PF00082	0.489
DEG_APCC_DBOX_1	237	245	PF00400	0.504
DEG_APCC_DBOX_1	393	401	PF00400	0.464
DOC_CYCLIN_RxL_1	172	182	PF00134	0.476
DOC_MAPK_gen_1	133	142	PF00069	0.384
DOC_MAPK_gen_1	497	505	PF00069	0.457
DOC_MAPK_gen_1	57	63	PF00069	0.643
DOC_MAPK_MEF2A_6	24	32	PF00069	0.517
DOC_MAPK_RevD_3	28	42	PF00069	0.499
DOC_MIT_MIM_1	539	548	PF04212	0.513
DOC_PP1_RVXF_1	327	333	PF00149	0.535
DOC_USP7_MATH_1	94	98	PF00917	0.448
DOC_USP7_UBL2_3	461	465	PF12436	0.438
LIG_14-3-3_CanoR_1	136	141	PF00244	0.562
LIG_14-3-3_CanoR_1	145	150	PF00244	0.498
LIG_14-3-3_CanoR_1	159	165	PF00244	0.411
LIG_14-3-3_CanoR_1	215	222	PF00244	0.516
LIG_14-3-3_CanoR_1	269	274	PF00244	0.523
LIG_14-3-3_CanoR_1	306	311	PF00244	0.607
LIG_14-3-3_CanoR_1	501	506	PF00244	0.637
LIG_14-3-3_CanoR_1	532	541	PF00244	0.477
LIG_Actin_WH2_2	327	344	PF00022	0.435
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BIR_III_4	69	73	PF00653	0.432
LIG_DLG_GKlike_1	269	277	PF00625	0.384
LIG_FHA_1	137	143	PF00498	0.552
LIG_FHA_1	272	278	PF00498	0.553
LIG_FHA_1	33	39	PF00498	0.442
LIG_FHA_1	416	422	PF00498	0.609
LIG_FHA_1	481	487	PF00498	0.465
LIG_FHA_1	500	506	PF00498	0.591
LIG_FHA_1	541	547	PF00498	0.586
LIG_FHA_2	123	129	PF00498	0.590
LIG_FHA_2	482	488	PF00498	0.494
LIG_FHA_2	8	14	PF00498	0.475
LIG_LIR_Gen_1	16	25	PF02991	0.383
LIG_LIR_Gen_1	3	12	PF02991	0.430
LIG_LIR_Gen_1	521	531	PF02991	0.603
LIG_LIR_Nem_3	16	21	PF02991	0.384
LIG_LIR_Nem_3	22	28	PF02991	0.302
LIG_LIR_Nem_3	3	7	PF02991	0.438
LIG_LIR_Nem_3	521	527	PF02991	0.672
LIG_LYPXL_SIV_4	523	531	PF13949	0.561
LIG_Pex14_2	14	18	PF04695	0.408
LIG_SH2_CRK	25	29	PF00017	0.419
LIG_SH2_NCK_1	216	220	PF00017	0.471
LIG_SH2_STAP1	216	220	PF00017	0.471
LIG_SH2_STAP1	4	8	PF00017	0.438
LIG_SH2_STAP1	524	528	PF00017	0.649
LIG_SH2_STAT3	463	466	PF00017	0.557
LIG_SUMO_SIM_par_1	138	144	PF11976	0.456
LIG_SUMO_SIM_par_1	501	506	PF11976	0.557
LIG_TRAF2_1	297	300	PF00917	0.603
LIG_TRAF2_1	373	376	PF00917	0.529
LIG_TRAF2_1	424	427	PF00917	0.528
LIG_TRAF2_1	51	54	PF00917	0.539
LIG_UBA3_1	481	488	PF00899	0.517
LIG_UBA3_1	60	65	PF00899	0.491
MOD_CK1_1	19	25	PF00069	0.515
MOD_CK1_1	522	528	PF00069	0.530
MOD_CK2_1	294	300	PF00069	0.534
MOD_CK2_1	306	312	PF00069	0.427
MOD_CK2_1	481	487	PF00069	0.650
MOD_CK2_1	7	13	PF00069	0.516
MOD_GlcNHglycan	296	299	PF01048	0.551
MOD_GlcNHglycan	312	316	PF01048	0.378
MOD_GlcNHglycan	446	451	PF01048	0.470
MOD_GlcNHglycan	514	517	PF01048	0.712
MOD_GlcNHglycan	521	524	PF01048	0.649
MOD_GlcNHglycan	92	95	PF01048	0.514
MOD_GlcNHglycan	96	99	PF01048	0.544
MOD_GSK3_1	214	221	PF00069	0.483
MOD_GSK3_1	364	371	PF00069	0.466
MOD_GSK3_1	508	515	PF00069	0.571
MOD_GSK3_1	522	529	PF00069	0.388
MOD_GSK3_1	86	93	PF00069	0.355
MOD_LATS_1	267	273	PF00433	0.499
MOD_N-GLC_1	16	21	PF02516	0.518
MOD_N-GLC_1	306	311	PF02516	0.510
MOD_N-GLC_1	422	427	PF02516	0.495
MOD_NEK2_1	32	37	PF00069	0.499
MOD_NEK2_1	362	367	PF00069	0.555
MOD_NEK2_1	437	442	PF00069	0.468
MOD_NEK2_1	481	486	PF00069	0.403
MOD_NEK2_1	519	524	PF00069	0.683
MOD_NEK2_1	530	535	PF00069	0.502
MOD_NEK2_1	7	12	PF00069	0.517
MOD_PIKK_1	158	164	PF00454	0.446
MOD_PIKK_1	300	306	PF00454	0.422
MOD_PIKK_1	362	368	PF00454	0.461
MOD_PIKK_1	437	443	PF00454	0.468
MOD_PIKK_1	530	536	PF00454	0.583
MOD_PIKK_1	86	92	PF00454	0.635
MOD_PK_1	306	312	PF00069	0.509
MOD_PKA_1	136	142	PF00069	0.327
MOD_PKA_1	200	206	PF00069	0.480
MOD_PKA_2	136	142	PF00069	0.536
MOD_PKA_2	158	164	PF00069	0.446
MOD_PKA_2	199	205	PF00069	0.422
MOD_PKA_2	214	220	PF00069	0.420
MOD_PKA_2	382	388	PF00069	0.349
MOD_PKA_2	493	499	PF00069	0.670
MOD_PKB_1	497	505	PF00069	0.457
MOD_Plk_1	16	22	PF00069	0.516
MOD_Plk_1	286	292	PF00069	0.531
MOD_Plk_1	306	312	PF00069	0.401
MOD_Plk_1	325	331	PF00069	0.373
MOD_Plk_1	446	452	PF00069	0.469
MOD_Plk_1	99	105	PF00069	0.654
MOD_Plk_2-3	382	388	PF00069	0.436
MOD_Plk_4	306	312	PF00069	0.550
MOD_Plk_4	481	487	PF00069	0.405
MOD_Plk_4	514	520	PF00069	0.626
MOD_SUMO_for_1	323	326	PF00179	0.530
MOD_SUMO_for_1	63	66	PF00179	0.426
MOD_SUMO_rev_2	29	35	PF00179	0.613
MOD_SUMO_rev_2	455	462	PF00179	0.546
TRG_DiLeu_BaEn_4	325	331	PF01217	0.530
TRG_DiLeu_BaEn_4	446	452	PF01217	0.490
TRG_ENDOCYTIC_2	25	28	PF00928	0.427
TRG_ENDOCYTIC_2	291	294	PF00928	0.502
TRG_ENDOCYTIC_2	4	7	PF00928	0.440
TRG_ENDOCYTIC_2	524	527	PF00928	0.597
TRG_ER_diArg_1	199	201	PF00400	0.432
TRG_ER_diArg_1	238	240	PF00400	0.504
TRG_ER_diArg_1	316	318	PF00400	0.514
TRG_ER_diArg_1	456	458	PF00400	0.502
TRG_ER_diArg_1	476	479	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	177	182	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z1	Leptomonas seymouri	68%	99%
A0A0S4JEL3	Bodo saltans	33%	99%
A0A3Q8IHG3	Leishmania donovani	92%	100%
A4HPI8	Leishmania braziliensis	84%	100%
A4IDB0	Leishmania infantum	92%	100%
D0A8F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q197	Leishmania major	92%	100%
V5AU66	Trypanosoma cruzi	41%	100%