DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase III, putative

Species:

Leishmania mexicana

UniProt:

E9AT98_LEIMU

TriTrypDb:

LmxM.36.3200

Length:

948

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0005694	chromosome	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AT98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT98

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.266
CLV_C14_Caspase3-7	492	496	PF00656	0.355
CLV_NRD_NRD_1	216	218	PF00675	0.345
CLV_NRD_NRD_1	284	286	PF00675	0.297
CLV_NRD_NRD_1	519	521	PF00675	0.186
CLV_NRD_NRD_1	882	884	PF00675	0.649
CLV_NRD_NRD_1	923	925	PF00675	0.454
CLV_PCSK_FUR_1	929	933	PF00082	0.534
CLV_PCSK_KEX2_1	131	133	PF00082	0.268
CLV_PCSK_KEX2_1	138	140	PF00082	0.229
CLV_PCSK_KEX2_1	162	164	PF00082	0.333
CLV_PCSK_KEX2_1	216	218	PF00082	0.345
CLV_PCSK_KEX2_1	284	286	PF00082	0.280
CLV_PCSK_KEX2_1	519	521	PF00082	0.266
CLV_PCSK_KEX2_1	599	601	PF00082	0.501
CLV_PCSK_KEX2_1	882	884	PF00082	0.647
CLV_PCSK_KEX2_1	931	933	PF00082	0.396
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.275
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.225
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.356
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.501
CLV_PCSK_PC1ET2_1	931	933	PF00082	0.449
CLV_PCSK_PC7_1	280	286	PF00082	0.287
CLV_PCSK_PC7_1	515	521	PF00082	0.266
CLV_PCSK_SKI1_1	148	152	PF00082	0.346
CLV_PCSK_SKI1_1	191	195	PF00082	0.420
CLV_PCSK_SKI1_1	309	313	PF00082	0.358
CLV_PCSK_SKI1_1	406	410	PF00082	0.300
CLV_PCSK_SKI1_1	46	50	PF00082	0.297
CLV_PCSK_SKI1_1	510	514	PF00082	0.285
CLV_PCSK_SKI1_1	770	774	PF00082	0.256
CLV_PCSK_SKI1_1	931	935	PF00082	0.366
CLV_Separin_Metazoa	342	346	PF03568	0.286
DEG_APCC_DBOX_1	147	155	PF00400	0.385
DEG_APCC_DBOX_1	396	404	PF00400	0.263
DEG_APCC_DBOX_1	405	413	PF00400	0.203
DEG_APCC_DBOX_1	86	94	PF00400	0.482
DOC_ANK_TNKS_1	816	823	PF00023	0.458
DOC_MAPK_DCC_7	817	825	PF00069	0.454
DOC_MAPK_gen_1	131	137	PF00069	0.509
DOC_MAPK_gen_1	284	290	PF00069	0.321
DOC_MAPK_gen_1	397	405	PF00069	0.328
DOC_MAPK_gen_1	836	843	PF00069	0.452
DOC_MAPK_MEF2A_6	103	111	PF00069	0.428
DOC_MAPK_MEF2A_6	171	178	PF00069	0.266
DOC_MAPK_MEF2A_6	552	559	PF00069	0.251
DOC_MAPK_MEF2A_6	817	825	PF00069	0.454
DOC_MAPK_NFAT4_5	171	179	PF00069	0.266
DOC_MAPK_NFAT4_5	552	560	PF00069	0.251
DOC_PP2B_LxvP_1	157	160	PF13499	0.351
DOC_PP4_FxxP_1	702	705	PF00568	0.349
DOC_PP4_FxxP_1	78	81	PF00568	0.517
DOC_USP7_MATH_1	533	537	PF00917	0.252
DOC_USP7_MATH_1	790	794	PF00917	0.542
DOC_USP7_MATH_1	796	800	PF00917	0.522
DOC_USP7_MATH_1	803	807	PF00917	0.422
DOC_USP7_MATH_1	851	855	PF00917	0.639
DOC_USP7_MATH_1	881	885	PF00917	0.715
DOC_USP7_MATH_1	99	103	PF00917	0.480
DOC_USP7_UBL2_3	158	162	PF12436	0.488
DOC_USP7_UBL2_3	42	46	PF12436	0.466
DOC_WW_Pin1_4	410	415	PF00397	0.269
DOC_WW_Pin1_4	668	673	PF00397	0.498
DOC_WW_Pin1_4	701	706	PF00397	0.374
DOC_WW_Pin1_4	794	799	PF00397	0.480
LIG_14-3-3_CanoR_1	184	189	PF00244	0.308
LIG_14-3-3_CanoR_1	27	37	PF00244	0.369
LIG_14-3-3_CanoR_1	304	313	PF00244	0.247
LIG_14-3-3_CanoR_1	345	353	PF00244	0.229
LIG_14-3-3_CanoR_1	452	461	PF00244	0.240
LIG_14-3-3_CanoR_1	663	668	PF00244	0.550
LIG_14-3-3_CanoR_1	785	789	PF00244	0.381
LIG_14-3-3_CanoR_1	882	886	PF00244	0.722
LIG_14-3-3_CanoR_1	939	944	PF00244	0.438
LIG_Actin_WH2_2	161	179	PF00022	0.266
LIG_Actin_WH2_2	291	306	PF00022	0.216
LIG_Actin_WH2_2	357	375	PF00022	0.311
LIG_Actin_WH2_2	459	477	PF00022	0.149
LIG_APCC_ABBA_1	577	582	PF00400	0.329
LIG_BRCT_BRCA1_1	331	335	PF00533	0.266
LIG_BRCT_BRCA1_1	423	427	PF00533	0.395
LIG_CaM_IQ_9	756	772	PF13499	0.240
LIG_Clathr_ClatBox_1	809	813	PF01394	0.449
LIG_CtBP_PxDLS_1	631	635	PF00389	0.298
LIG_eIF4E_1	72	78	PF01652	0.457
LIG_FHA_1	104	110	PF00498	0.427
LIG_FHA_1	229	235	PF00498	0.285
LIG_FHA_1	356	362	PF00498	0.362
LIG_FHA_1	418	424	PF00498	0.297
LIG_FHA_1	435	441	PF00498	0.402
LIG_FHA_1	45	51	PF00498	0.467
LIG_FHA_1	486	492	PF00498	0.294
LIG_FHA_1	527	533	PF00498	0.327
LIG_FHA_1	673	679	PF00498	0.489
LIG_FHA_1	751	757	PF00498	0.397
LIG_FHA_1	81	87	PF00498	0.466
LIG_FHA_1	868	874	PF00498	0.542
LIG_FHA_2	144	150	PF00498	0.331
LIG_FHA_2	310	316	PF00498	0.229
LIG_FHA_2	326	332	PF00498	0.321
LIG_FHA_2	391	397	PF00498	0.345
LIG_FHA_2	509	515	PF00498	0.265
LIG_GBD_Chelix_1	505	513	PF00786	0.285
LIG_Integrin_isoDGR_2	661	663	PF01839	0.427
LIG_LIR_Apic_2	868	874	PF02991	0.490
LIG_LIR_Gen_1	183	193	PF02991	0.288
LIG_LIR_Gen_1	247	257	PF02991	0.302
LIG_LIR_Gen_1	3	11	PF02991	0.316
LIG_LIR_Gen_1	536	546	PF02991	0.285
LIG_LIR_Gen_1	581	589	PF02991	0.354
LIG_LIR_Gen_1	839	847	PF02991	0.416
LIG_LIR_Gen_1	942	948	PF02991	0.441
LIG_LIR_Nem_3	183	188	PF02991	0.288
LIG_LIR_Nem_3	227	232	PF02991	0.307
LIG_LIR_Nem_3	247	252	PF02991	0.302
LIG_LIR_Nem_3	3	7	PF02991	0.316
LIG_LIR_Nem_3	33	38	PF02991	0.425
LIG_LIR_Nem_3	536	541	PF02991	0.285
LIG_LIR_Nem_3	581	587	PF02991	0.357
LIG_LIR_Nem_3	66	72	PF02991	0.443
LIG_LIR_Nem_3	731	735	PF02991	0.395
LIG_LIR_Nem_3	839	843	PF02991	0.388
LIG_LIR_Nem_3	942	947	PF02991	0.460
LIG_NRBOX	542	548	PF00104	0.266
LIG_PCNA_yPIPBox_3	397	409	PF02747	0.266
LIG_Pex14_1	444	448	PF04695	0.251
LIG_Pex14_2	190	194	PF04695	0.266
LIG_Pex14_2	74	78	PF04695	0.519
LIG_PTB_Apo_2	33	40	PF02174	0.425
LIG_PTB_Phospho_1	33	39	PF10480	0.440
LIG_SH2_CRK	185	189	PF00017	0.420
LIG_SH2_CRK	249	253	PF00017	0.345
LIG_SH2_CRK	401	405	PF00017	0.308
LIG_SH2_CRK	871	875	PF00017	0.378
LIG_SH2_NCK_1	249	253	PF00017	0.316
LIG_SH2_NCK_1	580	584	PF00017	0.355
LIG_SH2_NCK_1	871	875	PF00017	0.393
LIG_SH2_PTP2	840	843	PF00017	0.399
LIG_SH2_SRC	318	321	PF00017	0.266
LIG_SH2_SRC	461	464	PF00017	0.395
LIG_SH2_SRC	580	583	PF00017	0.446
LIG_SH2_STAP1	249	253	PF00017	0.316
LIG_SH2_STAP1	258	262	PF00017	0.322
LIG_SH2_STAP1	356	360	PF00017	0.362
LIG_SH2_STAP1	39	43	PF00017	0.440
LIG_SH2_STAP1	580	584	PF00017	0.355
LIG_SH2_STAT3	218	221	PF00017	0.395
LIG_SH2_STAT3	333	336	PF00017	0.395
LIG_SH2_STAT3	72	75	PF00017	0.467
LIG_SH2_STAT5	333	336	PF00017	0.349
LIG_SH2_STAT5	517	520	PF00017	0.251
LIG_SH2_STAT5	601	604	PF00017	0.384
LIG_SH2_STAT5	840	843	PF00017	0.380
LIG_SH2_STAT5	85	88	PF00017	0.531
LIG_SH2_STAT5	871	874	PF00017	0.399
LIG_SH3_2	383	388	PF14604	0.292
LIG_SH3_3	283	289	PF00018	0.263
LIG_SH3_3	365	371	PF00018	0.372
LIG_SH3_3	380	386	PF00018	0.238
LIG_SH3_3	666	672	PF00018	0.504
LIG_SH3_3	783	789	PF00018	0.390
LIG_SUMO_SIM_anti_2	337	345	PF11976	0.353
LIG_SUMO_SIM_par_1	486	496	PF11976	0.271
LIG_SxIP_EBH_1	452	464	PF03271	0.381
LIG_TRAF2_1	170	173	PF00917	0.285
LIG_TRAF2_1	334	337	PF00917	0.401
LIG_TYR_ITSM	181	188	PF00017	0.395
LIG_WRC_WIRS_1	200	205	PF05994	0.266
LIG_WRC_WIRS_1	809	814	PF05994	0.378
MOD_CDC14_SPxK_1	704	707	PF00782	0.451
MOD_CDK_SPxK_1	701	707	PF00069	0.427
MOD_CDK_SPxxK_3	794	801	PF00069	0.484
MOD_CK1_1	143	149	PF00069	0.487
MOD_CK1_1	244	250	PF00069	0.374
MOD_CK1_1	859	865	PF00069	0.636
MOD_CK2_1	309	315	PF00069	0.223
MOD_CK2_1	331	337	PF00069	0.275
MOD_CK2_1	390	396	PF00069	0.324
MOD_CK2_1	533	539	PF00069	0.266
MOD_CK2_1	920	926	PF00069	0.439
MOD_CK2_1	99	105	PF00069	0.469
MOD_Cter_Amidation	929	932	PF01082	0.421
MOD_GlcNHglycan	142	145	PF01048	0.240
MOD_GlcNHglycan	21	24	PF01048	0.282
MOD_GlcNHglycan	423	426	PF01048	0.350
MOD_GlcNHglycan	432	435	PF01048	0.260
MOD_GlcNHglycan	479	482	PF01048	0.380
MOD_GlcNHglycan	535	538	PF01048	0.256
MOD_GlcNHglycan	711	714	PF01048	0.558
MOD_GlcNHglycan	717	720	PF01048	0.646
MOD_GlcNHglycan	766	769	PF01048	0.504
MOD_GlcNHglycan	78	81	PF01048	0.289
MOD_GlcNHglycan	805	808	PF01048	0.463
MOD_GlcNHglycan	813	817	PF01048	0.516
MOD_GlcNHglycan	853	856	PF01048	0.626
MOD_GlcNHglycan	858	861	PF01048	0.618
MOD_GlcNHglycan	867	870	PF01048	0.593
MOD_GlcNHglycan	879	882	PF01048	0.639
MOD_GlcNHglycan	904	907	PF01048	0.635
MOD_GSK3_1	180	187	PF00069	0.277
MOD_GSK3_1	236	243	PF00069	0.324
MOD_GSK3_1	309	316	PF00069	0.240
MOD_GSK3_1	321	328	PF00069	0.290
MOD_GSK3_1	331	338	PF00069	0.251
MOD_GSK3_1	417	424	PF00069	0.276
MOD_GSK3_1	430	437	PF00069	0.203
MOD_GSK3_1	44	51	PF00069	0.489
MOD_GSK3_1	485	492	PF00069	0.442
MOD_GSK3_1	521	528	PF00069	0.329
MOD_GSK3_1	533	540	PF00069	0.313
MOD_GSK3_1	63	70	PF00069	0.494
MOD_GSK3_1	668	675	PF00069	0.493
MOD_GSK3_1	76	83	PF00069	0.424
MOD_GSK3_1	790	797	PF00069	0.472
MOD_GSK3_1	808	815	PF00069	0.513
MOD_GSK3_1	859	866	PF00069	0.589
MOD_GSK3_1	872	879	PF00069	0.563
MOD_GSK3_1	898	905	PF00069	0.540
MOD_GSK3_1	99	106	PF00069	0.342
MOD_LATS_1	302	308	PF00433	0.310
MOD_N-GLC_1	390	395	PF02516	0.326
MOD_N-GLC_1	453	458	PF02516	0.330
MOD_N-GLC_1	67	72	PF02516	0.317
MOD_N-GLC_1	851	856	PF02516	0.625
MOD_N-GLC_1	901	906	PF02516	0.671
MOD_N-GLC_2	119	121	PF02516	0.228
MOD_N-GLC_2	455	457	PF02516	0.224
MOD_NEK2_1	17	22	PF00069	0.488
MOD_NEK2_1	241	246	PF00069	0.393
MOD_NEK2_1	298	303	PF00069	0.288
MOD_NEK2_1	313	318	PF00069	0.285
MOD_NEK2_1	408	413	PF00069	0.352
MOD_NEK2_1	48	53	PF00069	0.444
MOD_NEK2_1	485	490	PF00069	0.319
MOD_NEK2_1	493	498	PF00069	0.338
MOD_NEK2_1	588	593	PF00069	0.485
MOD_NEK2_1	772	777	PF00069	0.409
MOD_NEK2_1	784	789	PF00069	0.386
MOD_NEK2_1	812	817	PF00069	0.526
MOD_NEK2_2	790	795	PF00069	0.505
MOD_NEK2_2	881	886	PF00069	0.607
MOD_OFUCOSY	776	782	PF10250	0.447
MOD_PIKK_1	28	34	PF00454	0.522
MOD_PIKK_1	390	396	PF00454	0.381
MOD_PIKK_1	418	424	PF00454	0.355
MOD_PIKK_1	796	802	PF00454	0.510
MOD_PK_1	707	713	PF00069	0.483
MOD_PKA_1	162	168	PF00069	0.395
MOD_PKA_2	162	168	PF00069	0.395
MOD_PKA_2	244	250	PF00069	0.354
MOD_PKA_2	272	278	PF00069	0.305
MOD_PKA_2	279	285	PF00069	0.267
MOD_PKA_2	303	309	PF00069	0.216
MOD_PKA_2	784	790	PF00069	0.470
MOD_PKA_2	881	887	PF00069	0.665
MOD_Plk_1	453	459	PF00069	0.368
MOD_Plk_1	501	507	PF00069	0.251
MOD_Plk_1	613	619	PF00069	0.277
MOD_Plk_1	67	73	PF00069	0.467
MOD_Plk_2-3	331	337	PF00069	0.266
MOD_Plk_4	103	109	PF00069	0.445
MOD_Plk_4	244	250	PF00069	0.330
MOD_Plk_4	252	258	PF00069	0.370
MOD_Plk_4	289	295	PF00069	0.345
MOD_Plk_4	313	319	PF00069	0.251
MOD_Plk_4	435	441	PF00069	0.302
MOD_Plk_4	44	50	PF00069	0.507
MOD_Plk_4	508	514	PF00069	0.269
MOD_Plk_4	521	527	PF00069	0.336
MOD_Plk_4	542	548	PF00069	0.269
MOD_Plk_4	613	619	PF00069	0.523
MOD_Plk_4	939	945	PF00069	0.445
MOD_ProDKin_1	410	416	PF00069	0.269
MOD_ProDKin_1	668	674	PF00069	0.491
MOD_ProDKin_1	701	707	PF00069	0.388
MOD_ProDKin_1	794	800	PF00069	0.483
MOD_SUMO_for_1	41	44	PF00179	0.440
MOD_SUMO_rev_2	40	48	PF00179	0.459
TRG_DiLeu_BaEn_1	339	344	PF01217	0.395
TRG_DiLeu_BaEn_1	521	526	PF01217	0.266
TRG_ENDOCYTIC_2	185	188	PF00928	0.420
TRG_ENDOCYTIC_2	249	252	PF00928	0.316
TRG_ENDOCYTIC_2	258	261	PF00928	0.322
TRG_ENDOCYTIC_2	401	404	PF00928	0.251
TRG_ENDOCYTIC_2	538	541	PF00928	0.285
TRG_ENDOCYTIC_2	580	583	PF00928	0.317
TRG_ENDOCYTIC_2	595	598	PF00928	0.330
TRG_ENDOCYTIC_2	840	843	PF00928	0.380
TRG_ER_diArg_1	215	217	PF00400	0.345
TRG_ER_diArg_1	284	286	PF00400	0.295
TRG_ER_diArg_1	397	400	PF00400	0.286
TRG_ER_diArg_1	518	520	PF00400	0.186
TRG_ER_diArg_1	763	766	PF00400	0.343
TRG_NES_CRM1_1	149	161	PF08389	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P1	Leptomonas seymouri	33%	100%
A0A0N1PAL1	Leptomonas seymouri	76%	98%
A0A0S4J933	Bodo saltans	31%	100%
A0A0S4JI21	Bodo saltans	48%	97%
A0A1X0NSK9	Trypanosomatidae	32%	100%
A0A1X0P3I0	Trypanosomatidae	58%	100%
A0A3R7KDV1	Trypanosoma rangeli	59%	100%
A0A3S7WW83	Leishmania donovani	22%	100%
A0A3S7X1K1	Leishmania donovani	33%	100%
A0A3S7XB89	Leishmania donovani	96%	100%
A0A422NYW0	Trypanosoma rangeli	32%	100%
A0R979	Bacillus thuringiensis (strain Al Hakam)	22%	100%
A4HGN1	Leishmania braziliensis	36%	100%
A4HPI6	Leishmania braziliensis	88%	100%
A4I3Q5	Leishmania infantum	33%	100%
A4IDA8	Leishmania infantum	95%	100%
D0A8A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A8E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AZZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
F4ISQ7	Arabidopsis thaliana	32%	100%
O27661	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	24%	100%
O28469	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O58356	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	29%	100%
O67226	Aquifex aeolicus (strain VF5)	22%	82%
O95985	Homo sapiens	32%	100%
O96651	Drosophila melanogaster	33%	100%
P13099	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P34184	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	23%	100%
P43012	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
P43704	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P55991	Helicobacter pylori (strain ATCC 700392 / 26695)	22%	100%
P78032	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	23%	100%
Q06AK7	Staphylococcus aureus	23%	100%
Q08582	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	21%	76%
Q0J0S6	Oryza sativa subsp. japonica	33%	100%
Q2FHI8	Staphylococcus aureus (strain USA300)	23%	100%
Q2FZ32	Staphylococcus aureus (strain NCTC 8325 / PS 47)	23%	100%
Q2YXL8	Staphylococcus aureus (strain bovine RF122 / ET3-1)	23%	100%
Q49ZH2	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	22%	100%
Q4L8B8	Staphylococcus haemolyticus (strain JCSC1435)	21%	100%
Q4Q199	Leishmania major	95%	100%
Q4Q888	Leishmania major	35%	100%
Q4QCK3	Leishmania major	22%	100%
Q59046	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5HGI2	Staphylococcus aureus (strain COL)	23%	100%
Q5HLZ4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	22%	100%
Q5WAX6	Alkalihalobacillus clausii (strain KSM-K16)	26%	100%
Q63GK5	Bacillus cereus (strain ZK / E33L)	22%	100%
Q65N90	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	24%	100%
Q6G9W3	Staphylococcus aureus (strain MSSA476)	23%	100%
Q6GHI5	Staphylococcus aureus (strain MRSA252)	23%	100%
Q6HP19	Bacillus thuringiensis subsp. konkukian (strain 97-27)	22%	100%
Q73E74	Bacillus cereus (strain ATCC 10987 / NRS 248)	22%	100%
Q7A5Y5	Staphylococcus aureus (strain N315)	23%	100%
Q81IH1	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	22%	100%
Q81Z97	Bacillus anthracis	22%	100%
Q8CRF7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	22%	100%
Q8NWZ9	Staphylococcus aureus (strain MW2)	23%	100%
Q8T2T7	Dictyostelium discoideum	38%	100%
Q8ZXT5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	23%	77%
Q99UM1	Staphylococcus aureus (strain Mu50 / ATCC 700699)	23%	100%
Q9CN30	Pasteurella multocida (strain Pm70)	24%	100%
Q9CP53	Pasteurella multocida (strain Pm70)	25%	100%
Q9HM08	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	100%
Q9KRB2	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	23%	100%
Q9NG98	Drosophila melanogaster	37%	76%
Q9UYS8	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
Q9YB01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	27%	100%
Q9Z321	Mus musculus	32%	100%
Q9ZMV7	Helicobacter pylori (strain J99 / ATCC 700824)	22%	100%
V5AV88	Trypanosoma cruzi	32%	100%
V5BE78	Trypanosoma cruzi	55%	100%