Nucleic acid binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleic acid binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AT97_LEIMU

TriTrypDb:

LmxM.36.3190

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT97

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0045727	positive regulation of translation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000765	regulation of cytoplasmic translation	7	1
GO:2000767	positive regulation of cytoplasmic translation	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0045182	translation regulator activity	1	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	350	352	PF00675	0.529
CLV_NRD_NRD_1	405	407	PF00675	0.504
CLV_NRD_NRD_1	415	417	PF00675	0.453
CLV_NRD_NRD_1	476	478	PF00675	0.449
CLV_NRD_NRD_1	502	504	PF00675	0.411
CLV_NRD_NRD_1	55	57	PF00675	0.289
CLV_NRD_NRD_1	73	75	PF00675	0.217
CLV_PCSK_KEX2_1	329	331	PF00082	0.487
CLV_PCSK_KEX2_1	350	352	PF00082	0.520
CLV_PCSK_KEX2_1	417	419	PF00082	0.472
CLV_PCSK_KEX2_1	442	444	PF00082	0.595
CLV_PCSK_KEX2_1	476	478	PF00082	0.449
CLV_PCSK_KEX2_1	502	504	PF00082	0.411
CLV_PCSK_KEX2_1	55	57	PF00082	0.289
CLV_PCSK_KEX2_1	73	75	PF00082	0.223
CLV_PCSK_KEX2_1	82	84	PF00082	0.448
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.474
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.472
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.595
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.449
CLV_PCSK_PC7_1	51	57	PF00082	0.487
CLV_PCSK_SKI1_1	360	364	PF00082	0.421
CLV_PCSK_SKI1_1	407	411	PF00082	0.570
CLV_PCSK_SKI1_1	418	422	PF00082	0.494
CLV_PCSK_SKI1_1	445	449	PF00082	0.712
CLV_PCSK_SKI1_1	539	543	PF00082	0.409
DOC_CYCLIN_RxL_1	536	546	PF00134	0.435
DOC_CYCLIN_yClb5_NLxxxL_5	62	69	PF00134	0.335
DOC_MAPK_gen_1	329	338	PF00069	0.394
DOC_MAPK_gen_1	476	484	PF00069	0.395
DOC_MAPK_MEF2A_6	329	338	PF00069	0.412
DOC_PP1_RVXF_1	550	557	PF00149	0.427
DOC_USP7_MATH_1	179	183	PF00917	0.637
DOC_USP7_MATH_1	284	288	PF00917	0.677
DOC_USP7_MATH_1	293	297	PF00917	0.701
DOC_USP7_MATH_1	311	315	PF00917	0.553
DOC_WW_Pin1_4	12	17	PF00397	0.489
DOC_WW_Pin1_4	289	294	PF00397	0.671
LIG_14-3-3_CanoR_1	102	106	PF00244	0.375
LIG_14-3-3_CanoR_1	174	180	PF00244	0.394
LIG_14-3-3_CanoR_1	310	320	PF00244	0.507
LIG_14-3-3_CanoR_1	350	356	PF00244	0.611
LIG_14-3-3_CanoR_1	360	368	PF00244	0.516
LIG_14-3-3_CanoR_1	445	452	PF00244	0.701
LIG_14-3-3_CanoR_1	544	554	PF00244	0.502
LIG_14-3-3_CanoR_1	83	88	PF00244	0.774
LIG_APCC_ABBA_1	470	475	PF00400	0.494
LIG_BRCT_BRCA1_1	558	562	PF00533	0.468
LIG_Clathr_ClatBox_1	9	13	PF01394	0.659
LIG_eIF4E_1	361	367	PF01652	0.247
LIG_FHA_1	231	237	PF00498	0.530
LIG_FHA_1	24	30	PF00498	0.587
LIG_FHA_1	361	367	PF00498	0.425
LIG_FHA_1	392	398	PF00498	0.446
LIG_FHA_1	465	471	PF00498	0.372
LIG_FHA_1	532	538	PF00498	0.592
LIG_FHA_1	556	562	PF00498	0.403
LIG_FHA_2	457	463	PF00498	0.440
LIG_GBD_Chelix_1	433	441	PF00786	0.495
LIG_LIR_Gen_1	390	401	PF02991	0.567
LIG_LIR_Nem_3	355	361	PF02991	0.556
LIG_LIR_Nem_3	390	396	PF02991	0.536
LIG_LIR_Nem_3	490	495	PF02991	0.395
LIG_LIR_Nem_3	559	565	PF02991	0.563
LIG_LYPXL_S_1	491	495	PF13949	0.350
LIG_LYPXL_yS_3	492	495	PF13949	0.355
LIG_MYND_1	7	11	PF01753	0.653
LIG_PCNA_PIPBox_1	530	539	PF02747	0.548
LIG_PCNA_yPIPBox_3	525	537	PF02747	0.553
LIG_Pex14_2	382	386	PF04695	0.452
LIG_SH2_CRK	258	262	PF00017	0.703
LIG_SH2_CRK	359	363	PF00017	0.273
LIG_SH2_STAP1	368	372	PF00017	0.389
LIG_SH2_STAT3	322	325	PF00017	0.388
LIG_SH2_STAT3	527	530	PF00017	0.566
LIG_SH2_STAT5	24	27	PF00017	0.484
LIG_SH2_STAT5	322	325	PF00017	0.593
LIG_SH2_STAT5	342	345	PF00017	0.237
LIG_SH2_STAT5	361	364	PF00017	0.496
LIG_SH2_STAT5	368	371	PF00017	0.334
LIG_SH2_STAT5	372	375	PF00017	0.299
LIG_SH2_STAT5	419	422	PF00017	0.567
LIG_SH2_STAT5	497	500	PF00017	0.397
LIG_SH3_3	314	320	PF00018	0.568
LIG_SUMO_SIM_par_1	481	486	PF11976	0.281
LIG_TRAF2_1	11	14	PF00917	0.655
LIG_TRAF2_1	91	94	PF00917	0.599
LIG_TYR_ITIM	121	126	PF00017	0.482
MOD_CDK_SPK_2	289	294	PF00069	0.531
MOD_CK1_1	27	33	PF00069	0.789
MOD_CK1_1	274	280	PF00069	0.670
MOD_CK1_1	287	293	PF00069	0.510
MOD_CK1_1	301	307	PF00069	0.749
MOD_CK1_1	35	41	PF00069	0.634
MOD_CK1_1	426	432	PF00069	0.564
MOD_CK2_1	338	344	PF00069	0.473
MOD_CK2_1	543	549	PF00069	0.401
MOD_GlcNHglycan	170	173	PF01048	0.529
MOD_GlcNHglycan	26	29	PF01048	0.700
MOD_GlcNHglycan	269	274	PF01048	0.627
MOD_GlcNHglycan	282	285	PF01048	0.476
MOD_GlcNHglycan	289	292	PF01048	0.557
MOD_GlcNHglycan	425	428	PF01048	0.558
MOD_GlcNHglycan	485	488	PF01048	0.303
MOD_GSK3_1	12	19	PF00069	0.541
MOD_GSK3_1	137	144	PF00069	0.387
MOD_GSK3_1	148	155	PF00069	0.381
MOD_GSK3_1	168	175	PF00069	0.266
MOD_GSK3_1	20	27	PF00069	0.760
MOD_GSK3_1	265	272	PF00069	0.690
MOD_GSK3_1	280	287	PF00069	0.440
MOD_GSK3_1	289	296	PF00069	0.545
MOD_GSK3_1	31	38	PF00069	0.609
MOD_GSK3_1	387	394	PF00069	0.565
MOD_GSK3_1	497	504	PF00069	0.484
MOD_GSK3_1	517	524	PF00069	0.274
MOD_LATS_1	228	234	PF00433	0.431
MOD_N-GLC_1	287	292	PF02516	0.603
MOD_N-GLC_1	301	306	PF02516	0.660
MOD_N-GLC_1	32	37	PF02516	0.656
MOD_N-GLC_1	351	356	PF02516	0.520
MOD_N-GLC_2	225	227	PF02516	0.422
MOD_N-GLC_2	46	48	PF02516	0.445
MOD_N-GLC_2	64	66	PF02516	0.396
MOD_NEK2_1	152	157	PF00069	0.357
MOD_NEK2_1	166	171	PF00069	0.343
MOD_NEK2_1	396	401	PF00069	0.616
MOD_NEK2_1	410	415	PF00069	0.424
MOD_NEK2_1	501	506	PF00069	0.475
MOD_NEK2_2	497	502	PF00069	0.441
MOD_PIKK_1	153	159	PF00454	0.364
MOD_PIKK_1	16	22	PF00454	0.627
MOD_PK_1	83	89	PF00069	0.572
MOD_PKA_1	502	508	PF00069	0.548
MOD_PKA_2	101	107	PF00069	0.597
MOD_PKA_2	173	179	PF00069	0.390
MOD_PKA_2	265	271	PF00069	0.744
MOD_PKA_2	293	299	PF00069	0.755
MOD_PKA_2	410	416	PF00069	0.411
MOD_PKA_2	501	507	PF00069	0.415
MOD_PKA_2	543	549	PF00069	0.483
MOD_PKB_1	416	424	PF00069	0.586
MOD_PKB_1	443	451	PF00069	0.684
MOD_Plk_1	397	403	PF00069	0.468
MOD_Plk_1	411	417	PF00069	0.487
MOD_Plk_2-3	265	271	PF00069	0.596
MOD_Plk_4	20	26	PF00069	0.759
MOD_Plk_4	338	344	PF00069	0.473
MOD_ProDKin_1	12	18	PF00069	0.488
MOD_ProDKin_1	289	295	PF00069	0.677
TRG_DiLeu_BaLyEn_6	536	541	PF01217	0.470
TRG_ENDOCYTIC_2	123	126	PF00928	0.480
TRG_ENDOCYTIC_2	359	362	PF00928	0.509
TRG_ENDOCYTIC_2	492	495	PF00928	0.443
TRG_ER_diArg_1	307	310	PF00400	0.581
TRG_ER_diArg_1	349	351	PF00400	0.519
TRG_ER_diArg_1	415	418	PF00400	0.469
TRG_ER_diArg_1	501	503	PF00400	0.522
TRG_ER_diArg_1	54	56	PF00400	0.289
TRG_ER_diArg_1	72	74	PF00400	0.223
TRG_NLS_Bipartite_1	406	420	PF00514	0.367
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIN4	Leptomonas seymouri	73%	100%
A0A1X0P496	Trypanosomatidae	54%	100%
A0A3Q8IKH2	Leishmania donovani	92%	100%
A0A3R7MHM2	Trypanosoma rangeli	53%	100%
A4HPI5	Leishmania braziliensis	83%	100%
A4IDA7	Leishmania infantum	92%	100%
D0A8E8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4Q1A0	Leishmania major	91%	100%
V5DA56	Trypanosoma cruzi	54%	100%