C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin binding cofactor c, putative

Species:

Leishmania mexicana

UniProt:

E9AT94_LEIMU

TriTrypDb:

LmxM.36.3160

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AT94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT94

PDB structure(s): 5aj8_A , 5aj8_B

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0007023	post-chaperonin tubulin folding pathway	3	12
GO:0009987	cellular process	1	12
GO:0007021	tubulin complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.636
CLV_PCSK_KEX2_1	16	18	PF00082	0.608
CLV_PCSK_KEX2_1	98	100	PF00082	0.347
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.338
CLV_PCSK_PC7_1	12	18	PF00082	0.592
CLV_PCSK_SKI1_1	105	109	PF00082	0.556
CLV_PCSK_SKI1_1	137	141	PF00082	0.454
CLV_PCSK_SKI1_1	175	179	PF00082	0.285
CLV_PCSK_SKI1_1	4	8	PF00082	0.524
DEG_APCC_DBOX_1	244	252	PF00400	0.188
DEG_Nend_UBRbox_2	1	3	PF02207	0.555
DEG_SCF_FBW7_1	318	324	PF00400	0.322
DEG_SPOP_SBC_1	123	127	PF00917	0.614
DOC_CKS1_1	318	323	PF01111	0.306
DOC_MAPK_gen_1	19	28	PF00069	0.614
DOC_MAPK_gen_1	214	223	PF00069	0.290
DOC_MAPK_HePTP_8	213	225	PF00069	0.256
DOC_MAPK_MEF2A_6	216	225	PF00069	0.294
DOC_MAPK_RevD_3	84	99	PF00069	0.266
DOC_USP7_MATH_1	123	127	PF00917	0.606
DOC_USP7_MATH_1	143	147	PF00917	0.485
DOC_WW_Pin1_4	126	131	PF00397	0.656
DOC_WW_Pin1_4	227	232	PF00397	0.272
DOC_WW_Pin1_4	295	300	PF00397	0.381
DOC_WW_Pin1_4	317	322	PF00397	0.512
LIG_14-3-3_CanoR_1	310	316	PF00244	0.564
LIG_BIR_III_2	120	124	PF00653	0.642
LIG_FHA_1	123	129	PF00498	0.709
LIG_FHA_1	140	146	PF00498	0.740
LIG_FHA_1	21	27	PF00498	0.584
LIG_FHA_1	228	234	PF00498	0.272
LIG_FHA_1	43	49	PF00498	0.455
LIG_FHA_2	163	169	PF00498	0.489
LIG_FHA_2	217	223	PF00498	0.309
LIG_FHA_2	261	267	PF00498	0.398
LIG_FHA_2	75	81	PF00498	0.450
LIG_LIR_Apic_2	186	191	PF02991	0.277
LIG_LIR_Gen_1	2	11	PF02991	0.526
LIG_LIR_Gen_1	281	290	PF02991	0.388
LIG_LIR_Nem_3	154	160	PF02991	0.661
LIG_LIR_Nem_3	2	8	PF02991	0.595
LIG_LIR_Nem_3	281	287	PF02991	0.363
LIG_LIR_Nem_3	288	293	PF02991	0.361
LIG_LIR_Nem_3	298	304	PF02991	0.310
LIG_SH2_CRK	188	192	PF00017	0.390
LIG_SH2_PTP2	284	287	PF00017	0.467
LIG_SH2_STAP1	261	265	PF00017	0.470
LIG_SH2_STAP1	33	37	PF00017	0.496
LIG_SH2_STAT5	188	191	PF00017	0.448
LIG_SH2_STAT5	207	210	PF00017	0.133
LIG_SH2_STAT5	224	227	PF00017	0.272
LIG_SH2_STAT5	284	287	PF00017	0.467
LIG_SH3_3	157	163	PF00018	0.563
LIG_SH3_3	312	318	PF00018	0.458
LIG_TRAF2_1	305	308	PF00917	0.471
MOD_CDK_SPxxK_3	295	302	PF00069	0.489
MOD_CK1_1	126	132	PF00069	0.602
MOD_CK1_1	164	170	PF00069	0.503
MOD_CK1_1	199	205	PF00069	0.332
MOD_CK1_1	20	26	PF00069	0.573
MOD_CK1_1	252	258	PF00069	0.435
MOD_CK2_1	116	122	PF00069	0.719
MOD_CK2_1	250	256	PF00069	0.350
MOD_CK2_1	260	266	PF00069	0.268
MOD_CK2_1	74	80	PF00069	0.499
MOD_GlcNHglycan	194	197	PF01048	0.416
MOD_GlcNHglycan	295	298	PF01048	0.550
MOD_GlcNHglycan	99	102	PF01048	0.528
MOD_GSK3_1	122	129	PF00069	0.701
MOD_GSK3_1	133	140	PF00069	0.499
MOD_GSK3_1	143	150	PF00069	0.581
MOD_GSK3_1	169	176	PF00069	0.151
MOD_GSK3_1	192	199	PF00069	0.289
MOD_GSK3_1	20	27	PF00069	0.573
MOD_GSK3_1	317	324	PF00069	0.573
MOD_GSK3_1	68	75	PF00069	0.499
MOD_N-GLC_1	199	204	PF02516	0.418
MOD_N-GLC_1	51	56	PF02516	0.539
MOD_N-GLC_2	180	182	PF02516	0.393
MOD_NEK2_1	107	112	PF00069	0.576
MOD_NEK2_1	169	174	PF00069	0.396
MOD_NEK2_1	250	255	PF00069	0.319
MOD_NEK2_2	311	316	PF00069	0.441
MOD_PIKK_1	42	48	PF00454	0.487
MOD_PIKK_1	53	59	PF00454	0.479
MOD_PKA_2	309	315	PF00069	0.563
MOD_Plk_1	42	48	PF00069	0.367
MOD_Plk_4	173	179	PF00069	0.177
MOD_Plk_4	311	317	PF00069	0.510
MOD_ProDKin_1	126	132	PF00069	0.654
MOD_ProDKin_1	227	233	PF00069	0.272
MOD_ProDKin_1	295	301	PF00069	0.377
MOD_ProDKin_1	317	323	PF00069	0.512
MOD_SUMO_rev_2	129	139	PF00179	0.461
MOD_SUMO_rev_2	252	260	PF00179	0.469
TRG_AP2beta_CARGO_1	2	12	PF09066	0.590
TRG_DiLeu_BaEn_1	43	48	PF01217	0.501
TRG_ENDOCYTIC_2	284	287	PF00928	0.365
TRG_ER_diArg_1	16	19	PF00400	0.660
TRG_NLS_MonoExtN_4	104	109	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J8	Leptomonas seymouri	67%	97%
A0A0S4JHW0	Bodo saltans	33%	97%
A0A1X0P3G4	Trypanosomatidae	45%	100%
A0A3Q8IG96	Leishmania donovani	93%	97%
A0A3R7L226	Trypanosoma rangeli	45%	100%
A4HPI2	Leishmania braziliensis	82%	100%
A4IDA4	Leishmania infantum	93%	97%
D0A8E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q15814	Homo sapiens	26%	94%
Q3SZE9	Bos taurus	25%	94%
Q4Q1A3	Leishmania major	93%	100%
Q5R5J7	Pongo abelii	26%	94%
Q8VCN9	Mus musculus	26%	95%
V5B9L2	Trypanosoma cruzi	46%	100%