Putative ADP-ribosylation factor GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein, putative

Species:

Leishmania mexicana

UniProt:

E9AT93_LEIMU

TriTrypDb:

LmxM.36.3150

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT93

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.513
CLV_NRD_NRD_1	15	17	PF00675	0.353
CLV_NRD_NRD_1	5	7	PF00675	0.603
CLV_NRD_NRD_1	85	87	PF00675	0.319
CLV_PCSK_KEX2_1	117	119	PF00082	0.513
CLV_PCSK_SKI1_1	111	115	PF00082	0.416
CLV_PCSK_SKI1_1	12	16	PF00082	0.478
CLV_PCSK_SKI1_1	62	66	PF00082	0.411
CLV_Separin_Metazoa	13	17	PF03568	0.436
DEG_APCC_DBOX_1	32	40	PF00400	0.474
DEG_COP1_1	153	162	PF00400	0.519
DEG_Nend_UBRbox_3	1	3	PF02207	0.700
DEG_SPOP_SBC_1	193	197	PF00917	0.637
DEG_SPOP_SBC_1	211	215	PF00917	0.626
DOC_MAPK_MEF2A_6	107	114	PF00069	0.436
DOC_PP1_RVXF_1	109	115	PF00149	0.338
DOC_PP4_FxxP_1	189	192	PF00568	0.689
DOC_PP4_FxxP_1	329	332	PF00568	0.585
DOC_SPAK_OSR1_1	76	80	PF12202	0.513
DOC_USP7_MATH_1	151	155	PF00917	0.755
DOC_USP7_MATH_1	192	196	PF00917	0.544
DOC_USP7_MATH_1	330	334	PF00917	0.592
DOC_WW_Pin1_4	140	145	PF00397	0.530
DOC_WW_Pin1_4	195	200	PF00397	0.803
LIG_14-3-3_CanoR_1	287	297	PF00244	0.535
LIG_14-3-3_CanoR_1	4	14	PF00244	0.546
LIG_14-3-3_CanoR_1	76	80	PF00244	0.436
LIG_FHA_1	228	234	PF00498	0.794
LIG_FHA_2	63	69	PF00498	0.411
LIG_FHA_2	90	96	PF00498	0.375
LIG_IBAR_NPY_1	338	340	PF08397	0.594
LIG_LIR_Apic_2	186	192	PF02991	0.690
LIG_LIR_Apic_2	326	332	PF02991	0.585
LIG_LIR_Gen_1	124	130	PF02991	0.417
LIG_LIR_Gen_1	153	163	PF02991	0.763
LIG_LIR_Gen_1	182	193	PF02991	0.712
LIG_LIR_Nem_3	124	128	PF02991	0.381
LIG_LIR_Nem_3	153	159	PF02991	0.765
LIG_LIR_Nem_3	182	188	PF02991	0.715
LIG_LIR_Nem_3	235	240	PF02991	0.650
LIG_LIR_Nem_3	40	45	PF02991	0.416
LIG_Pex14_1	89	93	PF04695	0.411
LIG_Pex14_2	185	189	PF04695	0.810
LIG_SH2_CRK	251	255	PF00017	0.798
LIG_SH2_STAT3	296	299	PF00017	0.703
LIG_SH2_STAT3	340	343	PF00017	0.603
LIG_SH2_STAT5	318	321	PF00017	0.464
LIG_SH2_STAT5	340	343	PF00017	0.487
LIG_SH2_STAT5	37	40	PF00017	0.411
LIG_SH3_2	173	178	PF14604	0.751
LIG_SH3_3	145	151	PF00018	0.741
LIG_SH3_3	157	163	PF00018	0.671
LIG_SH3_3	170	176	PF00018	0.682
LIG_SH3_3	203	209	PF00018	0.684
LIG_SH3_3	215	221	PF00018	0.633
LIG_SH3_3	237	243	PF00018	0.656
LIG_SH3_3	333	339	PF00018	0.561
LIG_SUMO_SIM_par_1	143	149	PF11976	0.639
LIG_TRAF2_1	113	116	PF00917	0.280
LIG_TRAF2_1	179	182	PF00917	0.738
LIG_WRC_WIRS_1	90	95	PF05994	0.513
MOD_CK1_1	140	146	PF00069	0.559
MOD_CK1_1	155	161	PF00069	0.733
MOD_CK1_1	171	177	PF00069	0.692
MOD_CK1_1	195	201	PF00069	0.593
MOD_CK1_1	48	54	PF00069	0.443
MOD_CK1_1	67	73	PF00069	0.513
MOD_CK2_1	155	161	PF00069	0.734
MOD_CK2_1	62	68	PF00069	0.411
MOD_GlcNHglycan	124	128	PF01048	0.515
MOD_GlcNHglycan	166	169	PF01048	0.722
MOD_GlcNHglycan	170	173	PF01048	0.754
MOD_GlcNHglycan	189	192	PF01048	0.743
MOD_GlcNHglycan	251	254	PF01048	0.714
MOD_GlcNHglycan	280	283	PF01048	0.504
MOD_GlcNHglycan	309	312	PF01048	0.588
MOD_GlcNHglycan	332	335	PF01048	0.753
MOD_GlcNHglycan	50	53	PF01048	0.328
MOD_GlcNHglycan	79	82	PF01048	0.397
MOD_GlcNHglycan	99	102	PF01048	0.299
MOD_GSK3_1	140	147	PF00069	0.627
MOD_GSK3_1	151	158	PF00069	0.747
MOD_GSK3_1	164	171	PF00069	0.795
MOD_GSK3_1	195	202	PF00069	0.700
MOD_N-GLC_1	273	278	PF02516	0.718
MOD_NEK2_1	146	151	PF00069	0.805
MOD_NEK2_1	212	217	PF00069	0.706
MOD_NEK2_1	289	294	PF00069	0.809
MOD_NEK2_1	45	50	PF00069	0.411
MOD_NEK2_1	77	82	PF00069	0.494
MOD_PIKK_1	137	143	PF00454	0.675
MOD_PIKK_1	16	22	PF00454	0.411
MOD_PIKK_1	273	279	PF00454	0.795
MOD_PIKK_1	289	295	PF00454	0.541
MOD_PIKK_1	318	324	PF00454	0.583
MOD_PKA_1	16	22	PF00069	0.411
MOD_PKA_2	5	11	PF00069	0.615
MOD_PKA_2	75	81	PF00069	0.436
MOD_Plk_1	123	129	PF00069	0.621
MOD_Plk_1	152	158	PF00069	0.633
MOD_Plk_4	228	234	PF00069	0.794
MOD_ProDKin_1	140	146	PF00069	0.533
MOD_ProDKin_1	195	201	PF00069	0.799
TRG_ENDOCYTIC_2	251	254	PF00928	0.589
TRG_ER_diArg_1	117	119	PF00400	0.436
TRG_ER_diArg_1	3	6	PF00400	0.681
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XB38	Leishmania donovani	87%	75%
A4HPI1	Leishmania braziliensis	66%	100%
A4IDA3	Leishmania infantum	87%	75%
D0A8E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	99%
Q4Q1A4	Leishmania major	80%	100%