Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT92_LEIMU

TriTrypDb:

LmxM.36.3140

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.700
CLV_PCSK_KEX2_1	119	121	PF00082	0.670
CLV_PCSK_KEX2_1	73	75	PF00082	0.539
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.610
CLV_PCSK_SKI1_1	11	15	PF00082	0.591
CLV_PCSK_SKI1_1	206	210	PF00082	0.580
DEG_SPOP_SBC_1	25	29	PF00917	0.647
DOC_PP2B_LxvP_1	35	38	PF13499	0.585
DOC_USP7_MATH_1	79	83	PF00917	0.685
DOC_USP7_MATH_1	9	13	PF00917	0.531
DOC_USP7_MATH_1	96	100	PF00917	0.606
DOC_USP7_MATH_2	129	135	PF00917	0.483
DOC_USP7_UBL2_3	44	48	PF12436	0.453
DOC_WW_Pin1_4	122	127	PF00397	0.502
DOC_WW_Pin1_4	133	138	PF00397	0.652
DOC_WW_Pin1_4	161	166	PF00397	0.568
DOC_WW_Pin1_4	37	42	PF00397	0.534
DOC_WW_Pin1_4	97	102	PF00397	0.569
LIG_14-3-3_CanoR_1	111	117	PF00244	0.523
LIG_14-3-3_CanoR_1	133	137	PF00244	0.773
LIG_14-3-3_CanoR_1	60	68	PF00244	0.660
LIG_Actin_WH2_2	6	24	PF00022	0.573
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BIR_III_2	162	166	PF00653	0.613
LIG_BRCT_BRCA1_1	135	139	PF00533	0.770
LIG_BRCT_BRCA1_1	163	167	PF00533	0.567
LIG_BRCT_BRCA1_1	39	43	PF00533	0.611
LIG_deltaCOP1_diTrp_1	201	205	PF00928	0.469
LIG_deltaCOP1_diTrp_1	211	217	PF00928	0.478
LIG_FHA_1	108	114	PF00498	0.563
LIG_FHA_1	123	129	PF00498	0.468
LIG_FHA_1	150	156	PF00498	0.612
LIG_FHA_2	171	177	PF00498	0.522
LIG_FHA_2	234	240	PF00498	0.666
LIG_IRF3_LxIS_1	228	235	PF10401	0.454
LIG_LIR_Gen_1	211	219	PF02991	0.561
LIG_LIR_Gen_1	64	75	PF02991	0.490
LIG_LIR_Nem_3	136	142	PF02991	0.638
LIG_LIR_Nem_3	164	170	PF02991	0.552
LIG_LIR_Nem_3	203	208	PF02991	0.529
LIG_LIR_Nem_3	211	217	PF02991	0.572
LIG_LIR_Nem_3	64	70	PF02991	0.481
LIG_PDZ_Class_3	244	249	PF00595	0.610
LIG_SH2_PTP2	67	70	PF00017	0.457
LIG_SH2_STAP1	170	174	PF00017	0.488
LIG_SH2_STAT5	116	119	PF00017	0.587
LIG_SH2_STAT5	199	202	PF00017	0.564
LIG_SH2_STAT5	67	70	PF00017	0.457
LIG_SH3_3	123	129	PF00018	0.662
LIG_SH3_3	162	168	PF00018	0.595
LIG_SH3_3	35	41	PF00018	0.556
LIG_SH3_3	99	105	PF00018	0.568
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.534
LIG_SUMO_SIM_par_1	145	152	PF11976	0.617
LIG_TRAF2_1	236	239	PF00917	0.497
MOD_CDK_SPxxK_3	133	140	PF00069	0.527
MOD_CDK_SPxxK_3	37	44	PF00069	0.505
MOD_CK1_1	100	106	PF00069	0.660
MOD_CK1_1	107	113	PF00069	0.665
MOD_CK1_1	29	35	PF00069	0.661
MOD_CK1_1	3	9	PF00069	0.648
MOD_CK1_1	42	48	PF00069	0.557
MOD_CK2_1	170	176	PF00069	0.517
MOD_CK2_1	215	221	PF00069	0.476
MOD_CK2_1	232	238	PF00069	0.437
MOD_CMANNOS	202	205	PF00535	0.474
MOD_DYRK1A_RPxSP_1	133	137	PF00069	0.525
MOD_GlcNHglycan	102	105	PF01048	0.567
MOD_GlcNHglycan	217	220	PF01048	0.538
MOD_GlcNHglycan	44	47	PF01048	0.634
MOD_GlcNHglycan	75	78	PF01048	0.699
MOD_GSK3_1	127	134	PF00069	0.674
MOD_GSK3_1	24	31	PF00069	0.701
MOD_GSK3_1	59	66	PF00069	0.701
MOD_GSK3_1	96	103	PF00069	0.636
MOD_NEK2_1	112	117	PF00069	0.546
MOD_NEK2_1	149	154	PF00069	0.653
MOD_NEK2_1	232	237	PF00069	0.499
MOD_NEK2_2	79	84	PF00069	0.550
MOD_PIKK_1	3	9	PF00454	0.563
MOD_PKA_1	73	79	PF00069	0.567
MOD_PKA_2	132	138	PF00069	0.527
MOD_PKA_2	59	65	PF00069	0.713
MOD_PKA_2	73	79	PF00069	0.500
MOD_Plk_4	112	118	PF00069	0.550
MOD_Plk_4	63	69	PF00069	0.545
MOD_Plk_4	9	15	PF00069	0.591
MOD_ProDKin_1	122	128	PF00069	0.506
MOD_ProDKin_1	133	139	PF00069	0.653
MOD_ProDKin_1	161	167	PF00069	0.569
MOD_ProDKin_1	37	43	PF00069	0.532
MOD_ProDKin_1	97	103	PF00069	0.569
TRG_DiLeu_BaEn_4	238	244	PF01217	0.479
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.557
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.607
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.517
TRG_ENDOCYTIC_2	67	70	PF00928	0.457
TRG_NLS_MonoExtN_4	105	112	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D7	Leptomonas seymouri	51%	100%
A0A3Q8IW55	Leishmania donovani	92%	100%
A0A3R7NG27	Trypanosoma rangeli	34%	100%
A4HPI0	Leishmania braziliensis	83%	100%
A4IDA2	Leishmania infantum	92%	100%
Q4Q1A5	Leishmania major	91%	100%
V5DA52	Trypanosoma cruzi	33%	100%