BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT89_LEIMU

TriTrypDb:

LmxM.36.3110

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AT89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.518
CLV_NRD_NRD_1	343	345	PF00675	0.503
CLV_NRD_NRD_1	45	47	PF00675	0.505
CLV_PCSK_KEX2_1	343	345	PF00082	0.540
CLV_PCSK_SKI1_1	191	195	PF00082	0.556
CLV_PCSK_SKI1_1	313	317	PF00082	0.694
CLV_PCSK_SKI1_1	326	330	PF00082	0.453
CLV_PCSK_SKI1_1	344	348	PF00082	0.339
CLV_PCSK_SKI1_1	37	41	PF00082	0.577
DEG_APCC_DBOX_1	312	320	PF00400	0.633
DEG_SPOP_SBC_1	220	224	PF00917	0.725
DOC_MAPK_gen_1	14	22	PF00069	0.341
DOC_USP7_MATH_1	220	224	PF00917	0.725
DOC_USP7_MATH_1	279	283	PF00917	0.662
DOC_USP7_UBL2_3	110	114	PF12436	0.454
DOC_USP7_UBL2_3	172	176	PF12436	0.649
DOC_WW_Pin1_4	155	160	PF00397	0.574
DOC_WW_Pin1_4	300	305	PF00397	0.754
LIG_14-3-3_CanoR_1	205	215	PF00244	0.703
LIG_Actin_WH2_2	100	116	PF00022	0.617
LIG_Actin_WH2_2	143	158	PF00022	0.603
LIG_BRCT_BRCA1_1	189	193	PF00533	0.543
LIG_BRCT_BRCA1_1	357	361	PF00533	0.413
LIG_FHA_1	138	144	PF00498	0.533
LIG_FHA_1	156	162	PF00498	0.565
LIG_FHA_1	240	246	PF00498	0.501
LIG_FHA_1	38	44	PF00498	0.517
LIG_FHA_2	132	138	PF00498	0.610
LIG_FHA_2	190	196	PF00498	0.541
LIG_LIR_Gen_1	126	136	PF02991	0.615
LIG_LIR_Gen_1	139	146	PF02991	0.626
LIG_LIR_Gen_1	177	187	PF02991	0.614
LIG_LIR_Gen_1	21	32	PF02991	0.546
LIG_LIR_LC3C_4	30	34	PF02991	0.465
LIG_LIR_Nem_3	126	132	PF02991	0.631
LIG_LIR_Nem_3	139	144	PF02991	0.493
LIG_LIR_Nem_3	177	182	PF02991	0.613
LIG_LIR_Nem_3	21	27	PF02991	0.530
LIG_LIR_Nem_3	267	271	PF02991	0.675
LIG_OCRL_FandH_1	309	321	PF00620	0.445
LIG_Pex14_2	189	193	PF04695	0.543
LIG_Pex14_2	268	272	PF04695	0.711
LIG_SH2_PTP2	24	27	PF00017	0.298
LIG_SH2_STAT5	186	189	PF00017	0.504
LIG_SH2_STAT5	24	27	PF00017	0.335
LIG_SH2_STAT5	350	353	PF00017	0.643
LIG_SH2_STAT5	61	64	PF00017	0.521
LIG_SH3_3	209	215	PF00018	0.741
LIG_SH3_3	302	308	PF00018	0.669
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.707
LIG_SUMO_SIM_par_1	30	35	PF11976	0.385
LIG_TRFH_1	141	145	PF08558	0.574
LIG_UBA3_1	254	260	PF00899	0.467
LIG_WRC_WIRS_1	19	24	PF05994	0.549
LIG_WRC_WIRS_1	332	337	PF05994	0.523
MOD_CDK_SPxxK_3	300	307	PF00069	0.678
MOD_CK1_1	219	225	PF00069	0.713
MOD_CK2_1	174	180	PF00069	0.500
MOD_CK2_1	189	195	PF00069	0.470
MOD_CK2_1	86	92	PF00069	0.671
MOD_GlcNHglycan	216	219	PF01048	0.736
MOD_GlcNHglycan	281	284	PF01048	0.713
MOD_GlcNHglycan	337	340	PF01048	0.565
MOD_GlcNHglycan	357	360	PF01048	0.311
MOD_GSK3_1	216	223	PF00069	0.762
MOD_GSK3_1	296	303	PF00069	0.728
MOD_GSK3_1	331	338	PF00069	0.511
MOD_GSK3_1	351	358	PF00069	0.349
MOD_N-GLC_1	228	233	PF02516	0.666
MOD_N-GLC_1	288	293	PF02516	0.464
MOD_N-GLC_1	37	42	PF02516	0.532
MOD_NEK2_1	187	192	PF00069	0.527
MOD_NEK2_1	216	221	PF00069	0.750
MOD_NEK2_1	23	28	PF00069	0.538
MOD_NEK2_1	264	269	PF00069	0.675
MOD_NEK2_1	32	37	PF00069	0.434
MOD_NEK2_1	335	340	PF00069	0.521
MOD_NEK2_1	42	47	PF00069	0.465
MOD_NEK2_1	74	79	PF00069	0.507
MOD_NEK2_2	328	333	PF00069	0.596
MOD_PIKK_1	37	43	PF00454	0.479
MOD_PKA_1	355	361	PF00069	0.367
MOD_PKA_2	137	143	PF00069	0.642
MOD_PKA_2	342	348	PF00069	0.540
MOD_PKA_2	351	357	PF00069	0.597
MOD_Plk_1	228	234	PF00069	0.652
MOD_Plk_1	37	43	PF00069	0.479
MOD_Plk_1	84	90	PF00069	0.387
MOD_Plk_1	9	15	PF00069	0.556
MOD_Plk_4	131	137	PF00069	0.493
MOD_Plk_4	174	180	PF00069	0.587
MOD_Plk_4	223	229	PF00069	0.696
MOD_Plk_4	281	287	PF00069	0.664
MOD_Plk_4	288	294	PF00069	0.550
MOD_Plk_4	57	63	PF00069	0.480
MOD_Plk_4	74	80	PF00069	0.391
MOD_ProDKin_1	155	161	PF00069	0.567
MOD_ProDKin_1	300	306	PF00069	0.757
MOD_SUMO_for_1	63	66	PF00179	0.556
MOD_SUMO_rev_2	109	116	PF00179	0.455
MOD_SUMO_rev_2	171	177	PF00179	0.610
TRG_DiLeu_BaEn_1	139	144	PF01217	0.645
TRG_DiLeu_BaEn_3	111	117	PF01217	0.668
TRG_ENDOCYTIC_2	186	189	PF00928	0.504
TRG_ENDOCYTIC_2	24	27	PF00928	0.545
TRG_ER_diArg_1	306	309	PF00400	0.725
TRG_ER_diArg_1	43	46	PF00400	0.474
TRG_NES_CRM1_1	18	30	PF08389	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M7	Leptomonas seymouri	62%	100%
A0A1X0P3J0	Trypanosomatidae	37%	98%
A0A3S5IRD4	Trypanosoma rangeli	40%	100%
A0A3S7XB77	Leishmania donovani	92%	100%
A4HPH7	Leishmania braziliensis	84%	100%
A4ID99	Leishmania infantum	92%	100%
D0A8D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q1A8	Leishmania major	90%	100%
V5B9K7	Trypanosoma cruzi	38%	87%