Lrp/AsnC family transcriptional regulator

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT83_LEIMU

TriTrypDb:

LmxM.36.3050

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AT83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT83

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0007031	peroxisome organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.274
CLV_PCSK_KEX2_1	109	111	PF00082	0.539
CLV_PCSK_SKI1_1	59	63	PF00082	0.418
CLV_PCSK_SKI1_1	75	79	PF00082	0.363
CLV_Separin_Metazoa	35	39	PF03568	0.354
DOC_CYCLIN_RxL_1	72	82	PF00134	0.476
DOC_MAPK_gen_1	109	117	PF00069	0.497
DOC_MAPK_gen_1	58	64	PF00069	0.456
DOC_MAPK_MEF2A_6	90	98	PF00069	0.383
DOC_PP1_RVXF_1	73	79	PF00149	0.420
DOC_USP7_MATH_1	41	45	PF00917	0.461
DOC_USP7_UBL2_3	28	32	PF12436	0.511
LIG_14-3-3_CanoR_1	110	116	PF00244	0.509
LIG_BIR_II_1	1	5	PF00653	0.347
LIG_FHA_1	112	118	PF00498	0.511
LIG_FHA_1	87	93	PF00498	0.495
LIG_LIR_Gen_1	82	92	PF02991	0.487
LIG_LIR_Nem_3	82	88	PF02991	0.488
LIG_SH2_STAT5	47	50	PF00017	0.344
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.434
LIG_SUMO_SIM_par_1	113	119	PF11976	0.290
LIG_UBA3_1	61	66	PF00899	0.518
MOD_Cter_Amidation	10	13	PF01082	0.495
MOD_GlcNHglycan	118	121	PF01048	0.357
MOD_GSK3_1	92	99	PF00069	0.424
MOD_NEK2_1	96	101	PF00069	0.512
MOD_Plk_4	111	117	PF00069	0.229
MOD_Plk_4	92	98	PF00069	0.433
MOD_SUMO_rev_2	54	61	PF00179	0.425
TRG_ENDOCYTIC_2	85	88	PF00928	0.387
TRG_ER_diArg_1	108	110	PF00400	0.251
TRG_ER_diArg_1	73	76	PF00400	0.433
TRG_NES_CRM1_1	106	121	PF08389	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N3	Leptomonas seymouri	73%	68%
A0A0S4JN26	Bodo saltans	29%	73%
A0A1X0NKF5	Trypanosomatidae	47%	72%
A0A3S7XB48	Leishmania donovani	92%	100%
A0A422NM43	Trypanosoma rangeli	42%	71%
A4HPH1	Leishmania braziliensis	90%	100%
A4ID93	Leishmania infantum	92%	100%
D0A3I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	72%
Q4Q1B4	Leishmania major	92%	100%
V5BKE1	Trypanosoma cruzi	42%	71%