Lrp/AsnC family transcriptional regulator

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT83_LEIMU

TriTrypDb:

LmxM.36.3050

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9AT83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT83

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0007031	peroxisome organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.274
CLV_PCSK_KEX2_1	109	111	PF00082	0.539
CLV_PCSK_SKI1_1	59	63	PF00082	0.418
CLV_PCSK_SKI1_1	75	79	PF00082	0.363
CLV_Separin_Metazoa	35	39	PF03568	0.354
DOC_CYCLIN_RxL_1	72	82	PF00134	0.476
DOC_MAPK_gen_1	109	117	PF00069	0.497
DOC_MAPK_gen_1	58	64	PF00069	0.456
DOC_MAPK_MEF2A_6	90	98	PF00069	0.383
DOC_PP1_RVXF_1	73	79	PF00149	0.420

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N3	Leptomonas seymouri	73%	68%
A0A0S4JN26	Bodo saltans	29%	73%
A0A1X0NKF5	Trypanosomatidae	47%	72%
A0A3S7XB48	Leishmania donovani	92%	100%
A0A422NM43	Trypanosoma rangeli	42%	71%
A4HPH1	Leishmania braziliensis	90%	100%
A4ID93	Leishmania infantum	92%	100%
D0A3I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	72%
Q4Q1B4	Leishmania major	92%	100%
V5BKE1	Trypanosoma cruzi	42%	71%

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