Putative pre-mRNA branch site protein p14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA branch site protein p14, putative

Species:

Leishmania mexicana

UniProt:

E9AT82_LEIMU

TriTrypDb:

LmxM.36.3040

Length:

118

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT82

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.518
CLV_PCSK_FUR_1	91	95	PF00082	0.477
CLV_PCSK_KEX2_1	91	93	PF00082	0.466
CLV_PCSK_KEX2_1	95	97	PF00082	0.456
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.457
CLV_PCSK_PC7_1	91	97	PF00082	0.461
CLV_PCSK_SKI1_1	5	9	PF00082	0.359
CLV_PCSK_SKI1_1	86	90	PF00082	0.454
DOC_MAPK_gen_1	71	79	PF00069	0.424
DOC_MAPK_MEF2A_6	71	79	PF00069	0.409
LIG_14-3-3_CanoR_1	76	80	PF00244	0.376
LIG_APCC_ABBA_1	77	82	PF00400	0.392
LIG_APCC_ABBAyCdc20_2	76	82	PF00400	0.395
LIG_LIR_Gen_1	20	29	PF02991	0.481
LIG_LIR_Nem_3	20	26	PF02991	0.418
LIG_MAD2	5	13	PF02301	0.284
LIG_SH2_CRK	29	33	PF00017	0.430
LIG_SH2_SRC	21	24	PF00017	0.508
LIG_SH2_STAT5	21	24	PF00017	0.508
LIG_SUMO_SIM_anti_2	3	10	PF11976	0.377
LIG_SUMO_SIM_par_1	3	10	PF11976	0.377
LIG_SxIP_EBH_1	5	18	PF03271	0.284
MOD_CK1_1	40	46	PF00069	0.499
MOD_CK2_1	75	81	PF00069	0.541
MOD_GSK3_1	36	43	PF00069	0.460
MOD_GSK3_1	7	14	PF00069	0.284
MOD_NEK2_1	7	12	PF00069	0.284
MOD_NEK2_1	75	80	PF00069	0.377
MOD_NEK2_2	21	26	PF00069	0.508
MOD_PKA_2	75	81	PF00069	0.375
MOD_Plk_4	21	27	PF00069	0.508
MOD_Plk_4	75	81	PF00069	0.375
MOD_SUMO_rev_2	81	89	PF00179	0.512
TRG_DiLeu_BaEn_1	4	9	PF01217	0.367
TRG_ENDOCYTIC_2	23	26	PF00928	0.430
TRG_ENDOCYTIC_2	29	32	PF00928	0.430
TRG_ER_diArg_1	91	94	PF00400	0.463
TRG_NLS_MonoCore_2	91	96	PF00514	0.462
TRG_NLS_MonoExtC_3	91	96	PF00514	0.462
TRG_NLS_MonoExtN_4	91	96	PF00514	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P798	Leptomonas seymouri	90%	98%
A0A1X0NKC5	Trypanosomatidae	66%	100%
A0A3R7KER9	Trypanosoma rangeli	69%	100%
A4HPH0	Leishmania braziliensis	96%	100%
D0A3I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	79%
O59670	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P59708	Mus musculus	36%	94%
Q8ITY4	Caenorhabditis elegans	35%	86%
Q9FMP4	Arabidopsis thaliana	40%	95%
Q9VRV7	Drosophila melanogaster	36%	98%
Q9Y3B4	Homo sapiens	36%	94%
V5BFU0	Trypanosoma cruzi	70%	100%