Clathrin coat assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

clathrin coat assembly protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AT81_LEIMU

TriTrypDb:

LmxM.36.3030

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	11
GO:0030131	clathrin adaptor complex	4	11
GO:0032991	protein-containing complex	1	11
GO:0098796	membrane protein complex	2	11
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AT81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT81

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006897	endocytosis	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.607
CLV_NRD_NRD_1	263	265	PF00675	0.381
CLV_PCSK_KEX2_1	100	102	PF00082	0.457
CLV_PCSK_KEX2_1	263	265	PF00082	0.381
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.457
CLV_PCSK_SKI1_1	100	104	PF00082	0.513
CLV_PCSK_SKI1_1	263	267	PF00082	0.470
CLV_PCSK_SKI1_1	318	322	PF00082	0.416
CLV_PCSK_SKI1_1	392	396	PF00082	0.459
DEG_APCC_KENBOX_2	102	106	PF00400	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.366
DOC_MAPK_FxFP_2	119	122	PF00069	0.395
DOC_MAPK_gen_1	100	109	PF00069	0.504
DOC_MAPK_gen_1	301	308	PF00069	0.315
DOC_MAPK_gen_1	318	327	PF00069	0.315
DOC_MAPK_MEF2A_6	171	179	PF00069	0.357
DOC_MAPK_MEF2A_6	318	327	PF00069	0.363
DOC_MAPK_MEF2A_6	388	395	PF00069	0.327
DOC_MAPK_MEF2A_6	52	61	PF00069	0.416
DOC_PP1_RVXF_1	261	268	PF00149	0.363
DOC_PP1_RVXF_1	390	396	PF00149	0.357
DOC_PP4_FxxP_1	119	122	PF00568	0.395
DOC_PP4_FxxP_1	267	270	PF00568	0.386
DOC_USP7_MATH_1	22	26	PF00917	0.483
DOC_USP7_MATH_1	230	234	PF00917	0.381
DOC_USP7_MATH_1	244	248	PF00917	0.403
DOC_WW_Pin1_4	158	163	PF00397	0.556
DOC_WW_Pin1_4	311	316	PF00397	0.264
LIG_14-3-3_CanoR_1	21	27	PF00244	0.548
LIG_14-3-3_CanoR_1	263	268	PF00244	0.359
LIG_14-3-3_CanoR_1	280	284	PF00244	0.327
LIG_14-3-3_CanoR_1	426	430	PF00244	0.330
LIG_Actin_WH2_2	241	259	PF00022	0.459
LIG_Actin_WH2_2	44	62	PF00022	0.493
LIG_AP2alpha_1	176	180	PF02296	0.426
LIG_APCC_ABBA_1	177	182	PF00400	0.459
LIG_BRCT_BRCA1_1	115	119	PF00533	0.456
LIG_BRCT_BRCA1_1	16	20	PF00533	0.373
LIG_BRCT_BRCA1_1	246	250	PF00533	0.381
LIG_CaM_IQ_9	77	93	PF13499	0.522
LIG_deltaCOP1_diTrp_1	160	170	PF00928	0.427
LIG_FHA_1	333	339	PF00498	0.344
LIG_FHA_1	38	44	PF00498	0.397
LIG_FHA_1	380	386	PF00498	0.394
LIG_FHA_2	123	129	PF00498	0.484
LIG_FHA_2	300	306	PF00498	0.304
LIG_Integrin_RGD_1	11	13	PF01839	0.413
LIG_LIR_Apic_2	116	122	PF02991	0.380
LIG_LIR_Apic_2	266	270	PF02991	0.387
LIG_LIR_Apic_2	383	389	PF02991	0.315
LIG_LIR_Gen_1	104	113	PF02991	0.403
LIG_LIR_Gen_1	174	183	PF02991	0.304
LIG_LIR_Gen_1	271	279	PF02991	0.315
LIG_LIR_Gen_1	62	69	PF02991	0.397
LIG_LIR_LC3C_4	409	412	PF02991	0.459
LIG_LIR_Nem_3	104	109	PF02991	0.389
LIG_LIR_Nem_3	118	124	PF02991	0.403
LIG_LIR_Nem_3	174	179	PF02991	0.317
LIG_LIR_Nem_3	93	97	PF02991	0.434
LIG_LYPXL_yS_3	121	124	PF13949	0.480
LIG_Pex14_2	176	180	PF04695	0.426
LIG_SH2_CRK	347	351	PF00017	0.426
LIG_SH2_NCK_1	347	351	PF00017	0.426
LIG_SH2_SRC	347	350	PF00017	0.413
LIG_SH2_STAP1	427	431	PF00017	0.368
LIG_SH2_STAT5	427	430	PF00017	0.292
LIG_SH2_STAT5	65	68	PF00017	0.357
LIG_SH3_3	282	288	PF00018	0.426
LIG_SH3_3	324	330	PF00018	0.340
LIG_SH3_3	409	415	PF00018	0.357
LIG_SUMO_SIM_par_1	65	72	PF11976	0.417
LIG_TRAF2_1	259	262	PF00917	0.381
LIG_TRAF2_1	363	366	PF00917	0.413
MOD_CDK_SPxK_1	158	164	PF00069	0.545
MOD_CDK_SPxxK_3	311	318	PF00069	0.264
MOD_CK1_1	246	252	PF00069	0.381
MOD_CK1_1	25	31	PF00069	0.449
MOD_CK2_1	122	128	PF00069	0.485
MOD_CK2_1	25	31	PF00069	0.439
MOD_CK2_1	256	262	PF00069	0.459
MOD_CK2_1	299	305	PF00069	0.304
MOD_CK2_1	360	366	PF00069	0.377
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.264
MOD_GlcNHglycan	208	211	PF01048	0.309
MOD_GlcNHglycan	258	261	PF01048	0.459
MOD_GlcNHglycan	292	295	PF01048	0.407
MOD_GSK3_1	122	129	PF00069	0.261
MOD_GSK3_1	190	197	PF00069	0.427
MOD_GSK3_1	221	228	PF00069	0.238
MOD_GSK3_1	25	32	PF00069	0.491
MOD_GSK3_1	275	282	PF00069	0.363
MOD_GSK3_1	297	304	PF00069	0.355
MOD_GSK3_1	396	403	PF00069	0.318
MOD_NEK2_1	16	21	PF00069	0.376
MOD_NEK2_1	185	190	PF00069	0.379
MOD_NEK2_1	194	199	PF00069	0.298
MOD_NEK2_1	29	34	PF00069	0.345
MOD_NEK2_1	384	389	PF00069	0.475
MOD_NEK2_1	400	405	PF00069	0.322
MOD_NEK2_1	7	12	PF00069	0.374
MOD_NEK2_2	22	27	PF00069	0.562
MOD_PIKK_1	185	191	PF00454	0.303
MOD_PKA_1	263	269	PF00069	0.381
MOD_PKA_2	155	161	PF00069	0.433
MOD_PKA_2	263	269	PF00069	0.413
MOD_PKA_2	279	285	PF00069	0.314
MOD_PKA_2	425	431	PF00069	0.381
MOD_Plk_1	113	119	PF00069	0.427
MOD_Plk_1	306	312	PF00069	0.426
MOD_Plk_2-3	126	132	PF00069	0.262
MOD_Plk_2-3	360	366	PF00069	0.168
MOD_Plk_4	194	200	PF00069	0.398
MOD_Plk_4	263	269	PF00069	0.387
MOD_Plk_4	413	419	PF00069	0.428
MOD_Plk_4	425	431	PF00069	0.432
MOD_ProDKin_1	158	164	PF00069	0.545
MOD_ProDKin_1	311	317	PF00069	0.264
MOD_SUMO_for_1	361	364	PF00179	0.168
MOD_SUMO_rev_2	93	102	PF00179	0.498
TRG_DiLeu_BaEn_1	181	186	PF01217	0.336
TRG_DiLeu_BaEn_1	380	385	PF01217	0.381
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.469
TRG_ENDOCYTIC_2	121	124	PF00928	0.480
TRG_ENDOCYTIC_2	347	350	PF00928	0.426
TRG_ENDOCYTIC_2	427	430	PF00928	0.461
TRG_ENDOCYTIC_2	65	68	PF00928	0.357
TRG_ENDOCYTIC_2	94	97	PF00928	0.553
TRG_ER_diArg_1	263	265	PF00400	0.381
TRG_NES_CRM1_1	166	181	PF08389	0.394
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.402
TRG_PTS1	435	438	PF00515	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F2	Leptomonas seymouri	25%	92%
A0A0N1I7F0	Leptomonas seymouri	28%	100%
A0A0N1ILY9	Leptomonas seymouri	71%	100%
A0A0N1PAY6	Leptomonas seymouri	24%	97%
A0A0S4INT9	Bodo saltans	25%	96%
A0A0S4JHW9	Bodo saltans	42%	95%
A0A0S4JX54	Bodo saltans	22%	90%
A0A1X0NJW3	Trypanosomatidae	27%	97%
A0A1X0NL86	Trypanosomatidae	46%	100%
A0A1X0NTD3	Trypanosomatidae	30%	100%
A0A1X0P9U6	Trypanosomatidae	26%	100%
A0A3Q8IB94	Leishmania donovani	28%	100%
A0A3Q8IKF7	Leishmania donovani	94%	100%
A0A3R7NKK1	Trypanosoma rangeli	27%	97%
A0A3S7X806	Leishmania donovani	24%	94%
A0A422NHS3	Trypanosoma rangeli	29%	100%
A0A422NLU9	Trypanosoma rangeli	46%	90%
A4HAX6	Leishmania braziliensis	25%	100%
A4HCF3	Leishmania braziliensis	28%	98%
A4HPG9	Leishmania braziliensis	84%	100%
A4HZY5	Leishmania infantum	30%	100%
A4IA35	Leishmania infantum	24%	94%
A4ID91	Leishmania infantum	95%	100%
C9ZM64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZSM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZWJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	96%
D3ZRP6	Rattus norvegicus	28%	100%
E2RED8	Canis lupus familiaris	24%	97%
E9AVU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B550	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	94%
F4I562	Arabidopsis thaliana	23%	100%
O00189	Homo sapiens	23%	97%
O22715	Arabidopsis thaliana	31%	100%
O23140	Arabidopsis thaliana	35%	100%
P35585	Mus musculus	31%	100%
P35602	Caenorhabditis elegans	28%	100%
P35603	Caenorhabditis elegans	33%	99%
P38700	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	72%
P47795	Diplobatis ommata	23%	100%
P53676	Rattus norvegicus	25%	100%
P53677	Homo sapiens	25%	100%
P53678	Rattus norvegicus	25%	100%
P54672	Dictyostelium discoideum	34%	100%
P84091	Mus musculus	33%	100%
P84092	Rattus norvegicus	33%	100%
Q00776	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	92%
Q09718	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	98%
Q24K11	Bos taurus	24%	100%
Q29RY8	Bos taurus	23%	97%
Q2KJ81	Bos taurus	31%	100%
Q2PWT8	Rattus norvegicus	23%	97%
Q32Q06	Rattus norvegicus	31%	100%
Q3SYW1	Bos taurus	28%	100%
Q3ZC13	Bos taurus	33%	100%
Q4Q1B6	Leishmania major	95%	100%
Q4Q2T6	Leishmania major	25%	100%
Q4QBN3	Leishmania major	29%	97%
Q4R706	Macaca fascicularis	33%	100%
Q54HS9	Dictyostelium discoideum	30%	100%
Q5NVF7	Pongo abelii	32%	100%
Q5R478	Pongo abelii	25%	100%
Q5ZMP6	Gallus gallus	33%	100%
Q5ZMP7	Gallus gallus	24%	100%
Q6NWK2	Danio rerio	33%	100%
Q6P856	Xenopus tropicalis	33%	100%
Q750L8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	97%
Q7ZW98	Danio rerio	33%	100%
Q801Q8	Xenopus laevis	33%	100%
Q8R2R9	Mus musculus	25%	100%
Q96CW1	Homo sapiens	33%	100%
Q99186	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	89%
Q9BXS5	Homo sapiens	31%	100%
Q9GPF0	Dictyostelium discoideum	24%	83%
Q9GPF1	Dictyostelium discoideum	24%	100%
Q9HFE5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9JKC7	Mus musculus	23%	98%
Q9JKC8	Mus musculus	25%	100%
Q9SAC9	Arabidopsis thaliana	32%	100%
Q9SB50	Arabidopsis thaliana	25%	97%
Q9WVP1	Mus musculus	28%	100%
Q9Y2T2	Homo sapiens	25%	100%
Q9Y6Q5	Homo sapiens	28%	100%
V5BKQ8	Trypanosoma cruzi	23%	100%
V5BLL2	Trypanosoma cruzi	28%	100%
V5D569	Trypanosoma cruzi	24%	88%
V5DGM7	Trypanosoma cruzi	45%	100%