Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted bromodomain protein

Species:

Leishmania mexicana

UniProt:

E9AT76_LEIMU

TriTrypDb:

LmxM.36.2980

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT76

PDB structure(s): 5c4q_A , 5c4q_B

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.520
CLV_NRD_NRD_1	134	136	PF00675	0.525
CLV_NRD_NRD_1	169	171	PF00675	0.630
CLV_NRD_NRD_1	57	59	PF00675	0.378
CLV_PCSK_KEX2_1	102	104	PF00082	0.455
CLV_PCSK_KEX2_1	169	171	PF00082	0.606
CLV_PCSK_KEX2_1	5	7	PF00082	0.546
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.505
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.546
CLV_PCSK_SKI1_1	103	107	PF00082	0.406
CLV_PCSK_SKI1_1	98	102	PF00082	0.424
DEG_Nend_UBRbox_2	1	3	PF02207	0.684
DEG_SCF_TRCP1_1	205	211	PF00400	0.732
DOC_CKS1_1	48	53	PF01111	0.313
DOC_CYCLIN_RxL_1	98	111	PF00134	0.386
DOC_MAPK_FxFP_2	32	35	PF00069	0.313
DOC_MAPK_gen_1	98	107	PF00069	0.478
DOC_PP4_FxxP_1	32	35	PF00568	0.300
DOC_USP7_MATH_1	108	112	PF00917	0.462
DOC_USP7_UBL2_3	136	140	PF12436	0.595
DOC_USP7_UBL2_3	98	102	PF12436	0.472
DOC_WW_Pin1_4	47	52	PF00397	0.313
LIG_14-3-3_CanoR_1	103	108	PF00244	0.361
LIG_APCC_ABBAyCdc20_2	8	14	PF00400	0.381
LIG_CtBP_PxDLS_1	51	55	PF00389	0.280
LIG_FHA_1	122	128	PF00498	0.599
LIG_FHA_2	48	54	PF00498	0.483
LIG_FHA_2	66	72	PF00498	0.334
LIG_GBD_Chelix_1	76	84	PF00786	0.295
LIG_LIR_Gen_1	91	100	PF02991	0.362
LIG_LIR_Nem_3	91	96	PF02991	0.339
LIG_SH2_NCK_1	45	49	PF00017	0.421
LIG_SH2_STAT5	104	107	PF00017	0.384
LIG_SH3_3	45	51	PF00018	0.365
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.446
LIG_SUMO_SIM_par_1	75	81	PF11976	0.313
LIG_TRAF2_1	198	201	PF00917	0.639
LIG_TRAF2_1	7	10	PF00917	0.511
MOD_CK1_1	111	117	PF00069	0.512
MOD_CK1_1	181	187	PF00069	0.645
MOD_CK1_1	206	212	PF00069	0.588
MOD_CK1_1	223	229	PF00069	0.670
MOD_CK2_1	195	201	PF00069	0.638
MOD_CK2_1	34	40	PF00069	0.295
MOD_CK2_1	65	71	PF00069	0.378
MOD_GlcNHglycan	110	113	PF01048	0.402
MOD_GlcNHglycan	184	187	PF01048	0.694
MOD_GlcNHglycan	205	208	PF01048	0.786
MOD_GlcNHglycan	227	230	PF01048	0.745
MOD_GlcNHglycan	36	39	PF01048	0.293
MOD_GSK3_1	177	184	PF00069	0.667
MOD_GSK3_1	203	210	PF00069	0.659
MOD_GSK3_1	223	230	PF00069	0.671
MOD_N-GLC_1	203	208	PF02516	0.470
MOD_NEK2_1	1	6	PF00069	0.672
MOD_NEK2_1	52	57	PF00069	0.374
MOD_NEK2_1	78	83	PF00069	0.374
MOD_PIKK_1	88	94	PF00454	0.324
MOD_PKA_1	169	175	PF00069	0.644
MOD_PKA_2	108	114	PF00069	0.377
MOD_PKA_2	168	174	PF00069	0.623
MOD_Plk_1	129	135	PF00069	0.522
MOD_Plk_1	220	226	PF00069	0.712
MOD_Plk_1	52	58	PF00069	0.283
MOD_Plk_2-3	195	201	PF00069	0.607
MOD_Plk_2-3	220	226	PF00069	0.725
MOD_Plk_4	15	21	PF00069	0.421
MOD_ProDKin_1	47	53	PF00069	0.313
MOD_SUMO_rev_2	138	145	PF00179	0.526
TRG_DiLeu_BaEn_4	219	225	PF01217	0.515
TRG_ENDOCYTIC_2	104	107	PF00928	0.365
TRG_ENDOCYTIC_2	44	47	PF00928	0.280
TRG_NLS_MonoExtN_4	98	105	PF00514	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A0	Leptomonas seymouri	72%	100%
A0A0S4KPA6	Bodo saltans	41%	93%
A0A1X0NM37	Trypanosomatidae	51%	100%
A0A3Q8IW45	Leishmania donovani	90%	100%
A0A422NLU0	Trypanosoma rangeli	51%	100%
A4HPG4	Leishmania braziliensis	80%	100%
A4ID86	Leishmania infantum	90%	100%
D0A3H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q1C1	Leishmania major	91%	99%
V5BPW0	Trypanosoma cruzi	54%	100%