Conserved plasma membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT75_LEIMU

TriTrypDb:

LmxM.36.2970

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AT75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.527
CLV_NRD_NRD_1	154	156	PF00675	0.475
CLV_PCSK_FUR_1	155	159	PF00082	0.500
CLV_PCSK_KEX2_1	145	147	PF00082	0.533
CLV_PCSK_KEX2_1	157	159	PF00082	0.466
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.533
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.756
DOC_MAPK_gen_1	145	153	PF00069	0.663
DOC_MAPK_MEF2A_6	52	61	PF00069	0.407
DOC_PP4_FxxP_1	20	23	PF00568	0.376
DOC_USP7_UBL2_3	165	169	PF12436	0.621
LIG_14-3-3_CanoR_1	79	85	PF00244	0.471
LIG_Actin_RPEL_3	62	81	PF02755	0.376
LIG_EH1_1	111	119	PF00400	0.359
LIG_eIF4E_1	112	118	PF01652	0.382
LIG_FHA_1	114	120	PF00498	0.309
LIG_FHA_1	81	87	PF00498	0.242
LIG_FHA_2	135	141	PF00498	0.746
LIG_GBD_Chelix_1	25	33	PF00786	0.637
LIG_LIR_Gen_1	83	91	PF02991	0.355
LIG_LIR_LC3C_4	83	87	PF02991	0.210
LIG_LIR_Nem_3	7	13	PF02991	0.558
LIG_LIR_Nem_3	83	87	PF02991	0.269
LIG_SH2_GRB2like	48	51	PF00017	0.448
LIG_SH2_PTP2	56	59	PF00017	0.430
LIG_SH2_STAT5	112	115	PF00017	0.357
LIG_SH2_STAT5	13	16	PF00017	0.487
LIG_SH2_STAT5	48	51	PF00017	0.482
LIG_SH2_STAT5	56	59	PF00017	0.338
LIG_SH2_STAT5	84	87	PF00017	0.444
LIG_SH2_STAT5	96	99	PF00017	0.301
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.503
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.688
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.476
LIG_SUMO_SIM_par_1	83	90	PF11976	0.487
LIG_TYR_ITIM	54	59	PF00017	0.387
LIG_TYR_ITIM	82	87	PF00017	0.335
LIG_WRC_WIRS_1	88	93	PF05994	0.501
MOD_CK2_1	134	140	PF00069	0.698
MOD_CK2_1	98	104	PF00069	0.543
MOD_GlcNHglycan	29	32	PF01048	0.651
MOD_NEK2_1	4	9	PF00069	0.708
MOD_NEK2_1	65	70	PF00069	0.430
MOD_PIKK_1	131	137	PF00454	0.583
MOD_Plk_1	2	8	PF00069	0.560
MOD_Plk_4	113	119	PF00069	0.312
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.424
TRG_ENDOCYTIC_2	56	59	PF00928	0.352
TRG_ENDOCYTIC_2	84	87	PF00928	0.292
TRG_ER_diLys_1	168	171	PF00400	0.709
TRG_NLS_Bipartite_1	145	159	PF00514	0.690
TRG_NLS_MonoCore_2	154	159	PF00514	0.749
TRG_NLS_MonoExtC_3	154	160	PF00514	0.750
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P795	Leptomonas seymouri	54%	100%
A0A1X0NL06	Trypanosomatidae	26%	100%
A0A3Q8IJG9	Leishmania donovani	90%	100%
A4HPG3	Leishmania braziliensis	81%	100%
A4ID85	Leishmania infantum	90%	100%
Q4Q1C2	Leishmania major	92%	100%