TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT74_LEIMU

TriTrypDb:

LmxM.36.2960

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AT74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	28	32	PF00082	0.499
CLV_PCSK_SKI1_1	71	75	PF00082	0.509
CLV_PCSK_SKI1_1	84	88	PF00082	0.491
DEG_APCC_DBOX_1	83	91	PF00400	0.320
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DOC_CYCLIN_RxL_1	68	78	PF00134	0.352
DOC_MAPK_HePTP_8	37	49	PF00069	0.463
DOC_MAPK_MEF2A_6	40	49	PF00069	0.379
LIG_BRCT_BRCA1_1	59	63	PF00533	0.319
LIG_BRCT_BRCA1_1	88	92	PF00533	0.311
LIG_DCNL_PONY_1	1	4	PF03556	0.545
LIG_EH1_1	6	14	PF00400	0.464
LIG_FHA_1	101	107	PF00498	0.291
LIG_FHA_1	32	38	PF00498	0.581
LIG_FHA_1	6	12	PF00498	0.578
LIG_FHA_2	76	82	PF00498	0.353
LIG_GBD_Chelix_1	45	53	PF00786	0.367
LIG_LIR_Gen_1	15	25	PF02991	0.565
LIG_LIR_Gen_1	60	69	PF02991	0.372
LIG_LIR_Nem_3	15	20	PF02991	0.581
LIG_LIR_Nem_3	60	66	PF02991	0.419
LIG_NRBOX	61	67	PF00104	0.307
LIG_NRBOX	86	92	PF00104	0.325
LIG_SH2_CRK	50	54	PF00017	0.367
LIG_SH2_CRK	88	92	PF00017	0.386
LIG_SH2_STAP1	32	36	PF00017	0.466
LIG_SH2_STAP1	7	11	PF00017	0.521
LIG_SH2_STAP1	88	92	PF00017	0.354
LIG_SH2_STAT3	116	119	PF00017	0.422
LIG_SH2_STAT5	121	124	PF00017	0.546
LIG_SH2_STAT5	7	10	PF00017	0.566
LIG_Sin3_3	51	58	PF02671	0.234
LIG_SUMO_SIM_anti_2	8	13	PF11976	0.518
LIG_SUMO_SIM_par_1	102	107	PF11976	0.325
LIG_SUMO_SIM_par_1	72	78	PF11976	0.358
LIG_TYR_ITIM	86	91	PF00017	0.373
MOD_CK1_1	96	102	PF00069	0.374
MOD_CK2_1	75	81	PF00069	0.390
MOD_GlcNHglycan	95	98	PF01048	0.607
MOD_GSK3_1	86	93	PF00069	0.343
MOD_GSK3_1	96	103	PF00069	0.338
MOD_NEK2_1	110	115	PF00069	0.415
MOD_NEK2_1	57	62	PF00069	0.398
MOD_NEK2_1	75	80	PF00069	0.244
MOD_NEK2_1	90	95	PF00069	0.403
MOD_PIKK_1	90	96	PF00454	0.388
MOD_Plk_4	100	106	PF00069	0.258
MOD_Plk_4	110	116	PF00069	0.281
MOD_Plk_4	31	37	PF00069	0.569
MOD_Plk_4	86	92	PF00069	0.412
TRG_DiLeu_BaEn_1	81	86	PF01217	0.345
TRG_ENDOCYTIC_2	121	124	PF00928	0.515
TRG_ENDOCYTIC_2	17	20	PF00928	0.617
TRG_ENDOCYTIC_2	50	53	PF00928	0.357
TRG_ENDOCYTIC_2	88	91	PF00928	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Z5	Leptomonas seymouri	55%	100%
A0A1X0NKL9	Trypanosomatidae	39%	99%
A0A3Q8IP15	Leishmania donovani	89%	100%
A0A3R7KH99	Trypanosoma rangeli	40%	100%
A4HPG2	Leishmania braziliensis	83%	100%
A4ID84	Leishmania infantum	88%	100%
Q4Q1C3	Leishmania major	90%	100%