RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania mexicana

UniProt:

E9AT71_LEIMU

TriTrypDb:

LmxM.36.2930

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AT71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.460
CLV_NRD_NRD_1	427	429	PF00675	0.582
CLV_NRD_NRD_1	442	444	PF00675	0.435
CLV_NRD_NRD_1	496	498	PF00675	0.544
CLV_NRD_NRD_1	532	534	PF00675	0.587
CLV_PCSK_FUR_1	496	500	PF00082	0.531
CLV_PCSK_KEX2_1	427	429	PF00082	0.582
CLV_PCSK_KEX2_1	441	443	PF00082	0.451
CLV_PCSK_KEX2_1	496	498	PF00082	0.542
CLV_PCSK_KEX2_1	531	533	PF00082	0.507
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.527
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.542
CLV_PCSK_PC7_1	437	443	PF00082	0.519
CLV_PCSK_SKI1_1	114	118	PF00082	0.415
CLV_PCSK_SKI1_1	208	212	PF00082	0.388
CLV_PCSK_SKI1_1	287	291	PF00082	0.464
CLV_PCSK_SKI1_1	33	37	PF00082	0.331
DEG_APCC_DBOX_1	113	121	PF00400	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SPOP_SBC_1	482	486	PF00917	0.612
DOC_CDC14_PxL_1	2	10	PF14671	0.477
DOC_MAPK_gen_1	363	372	PF00069	0.721
DOC_MAPK_gen_1	441	447	PF00069	0.719
DOC_MAPK_MEF2A_6	363	372	PF00069	0.721
DOC_PP1_RVXF_1	270	276	PF00149	0.631
DOC_PP4_FxxP_1	71	74	PF00568	0.531
DOC_USP7_MATH_1	348	352	PF00917	0.674
DOC_USP7_MATH_1	368	372	PF00917	0.790
DOC_USP7_MATH_1	401	405	PF00917	0.779
DOC_USP7_MATH_1	481	485	PF00917	0.796
DOC_USP7_MATH_1	74	78	PF00917	0.458
DOC_USP7_MATH_2	481	487	PF00917	0.665
DOC_WW_Pin1_4	258	263	PF00397	0.641
DOC_WW_Pin1_4	416	421	PF00397	0.807
DOC_WW_Pin1_4	474	479	PF00397	0.762
DOC_WW_Pin1_4	70	75	PF00397	0.476
LIG_14-3-3_CanoR_1	192	198	PF00244	0.393
LIG_14-3-3_CanoR_1	208	214	PF00244	0.634
LIG_14-3-3_CanoR_1	33	42	PF00244	0.490
LIG_14-3-3_CanoR_1	402	408	PF00244	0.749
LIG_14-3-3_CanoR_1	442	446	PF00244	0.697
LIG_14-3-3_CanoR_1	60	65	PF00244	0.493
LIG_14-3-3_CanoR_1	67	72	PF00244	0.540
LIG_Actin_WH2_2	179	194	PF00022	0.480
LIG_APCC_ABBA_1	230	235	PF00400	0.641
LIG_BRCT_BRCA1_1	76	80	PF00533	0.479
LIG_CSL_BTD_1	71	74	PF09270	0.476
LIG_CtBP_PxDLS_1	423	427	PF00389	0.796
LIG_EH_1	230	234	PF12763	0.661
LIG_EH1_1	58	66	PF00400	0.438
LIG_eIF4E_1	24	30	PF01652	0.447
LIG_FHA_1	106	112	PF00498	0.480
LIG_FHA_1	171	177	PF00498	0.413
LIG_FHA_1	179	185	PF00498	0.291
LIG_FHA_1	2	8	PF00498	0.453
LIG_FHA_1	25	31	PF00498	0.454
LIG_FHA_1	301	307	PF00498	0.530
LIG_FHA_1	34	40	PF00498	0.365
LIG_FHA_1	382	388	PF00498	0.730
LIG_FHA_1	475	481	PF00498	0.804
LIG_FHA_1	523	529	PF00498	0.805
LIG_FHA_2	120	126	PF00498	0.585
LIG_LIR_Apic_2	70	74	PF02991	0.532
LIG_LIR_Gen_1	48	55	PF02991	0.365
LIG_LIR_Nem_3	238	243	PF02991	0.647
LIG_LIR_Nem_3	291	296	PF02991	0.604
LIG_LIR_Nem_3	48	54	PF02991	0.409
LIG_LIR_Nem_3	85	90	PF02991	0.508
LIG_NRBOX	143	149	PF00104	0.402
LIG_Pex14_1	264	268	PF04695	0.664
LIG_Pex14_2	51	55	PF04695	0.480
LIG_Pex14_2	68	72	PF04695	0.332
LIG_SH2_CRK	160	164	PF00017	0.465
LIG_SH2_CRK	180	184	PF00017	0.150
LIG_SH2_CRK	2	6	PF00017	0.481
LIG_SH2_CRK	207	211	PF00017	0.622
LIG_SH2_CRK	286	290	PF00017	0.651
LIG_SH2_GRB2like	24	27	PF00017	0.378
LIG_SH2_NCK_1	2	6	PF00017	0.506
LIG_SH2_NCK_1	88	92	PF00017	0.508
LIG_SH2_SRC	243	246	PF00017	0.637
LIG_SH2_STAP1	13	17	PF00017	0.447
LIG_SH2_STAP1	180	184	PF00017	0.335
LIG_SH2_STAT3	285	288	PF00017	0.490
LIG_SH2_STAT5	160	163	PF00017	0.411
LIG_SH2_STAT5	180	183	PF00017	0.150
LIG_SH2_STAT5	185	188	PF00017	0.335
LIG_SH2_STAT5	243	246	PF00017	0.600
LIG_SH2_STAT5	256	259	PF00017	0.533
LIG_SH2_STAT5	274	277	PF00017	0.525
LIG_SH2_STAT5	407	410	PF00017	0.600
LIG_SH3_3	386	392	PF00018	0.730
LIG_SH3_3	417	423	PF00018	0.780
LIG_SH3_3	475	481	PF00018	0.740
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.434
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.447
LIG_TRAF2_1	164	167	PF00917	0.468
LIG_TRFH_1	160	164	PF08558	0.441
LIG_UBA3_1	42	46	PF00899	0.480
LIG_WRC_WIRS_1	68	73	PF05994	0.532
MOD_CK1_1	133	139	PF00069	0.466
MOD_CK1_1	193	199	PF00069	0.402
MOD_CK1_1	212	218	PF00069	0.431
MOD_CK1_1	258	264	PF00069	0.677
MOD_CK1_1	455	461	PF00069	0.656
MOD_CK1_1	510	516	PF00069	0.762
MOD_CK2_1	119	125	PF00069	0.559
MOD_CK2_1	132	138	PF00069	0.605
MOD_CK2_1	408	414	PF00069	0.746
MOD_Cter_Amidation	494	497	PF01082	0.621
MOD_GlcNHglycan	117	120	PF01048	0.420
MOD_GlcNHglycan	192	195	PF01048	0.434
MOD_GlcNHglycan	226	230	PF01048	0.461
MOD_GlcNHglycan	279	282	PF01048	0.473
MOD_GlcNHglycan	410	413	PF01048	0.554
MOD_GlcNHglycan	464	468	PF01048	0.542
MOD_GlcNHglycan	493	496	PF01048	0.634
MOD_GlcNHglycan	512	515	PF01048	0.401
MOD_GlcNHglycan	519	522	PF01048	0.526
MOD_GSK3_1	115	122	PF00069	0.470
MOD_GSK3_1	158	165	PF00069	0.384
MOD_GSK3_1	166	173	PF00069	0.432
MOD_GSK3_1	193	200	PF00069	0.389
MOD_GSK3_1	25	32	PF00069	0.424
MOD_GSK3_1	254	261	PF00069	0.646
MOD_GSK3_1	294	301	PF00069	0.553
MOD_GSK3_1	402	409	PF00069	0.726
MOD_GSK3_1	412	419	PF00069	0.656
MOD_GSK3_1	503	510	PF00069	0.763
MOD_GSK3_1	522	529	PF00069	0.665
MOD_GSK3_1	70	77	PF00069	0.479
MOD_GSK3_1	82	89	PF00069	0.484
MOD_N-GLC_1	25	30	PF02516	0.447
MOD_N-GLC_1	74	79	PF02516	0.595
MOD_NEK2_1	1	6	PF00069	0.486
MOD_NEK2_1	148	153	PF00069	0.389
MOD_NEK2_1	178	183	PF00069	0.400
MOD_NEK2_1	197	202	PF00069	0.271
MOD_NEK2_1	225	230	PF00069	0.613
MOD_NEK2_1	29	34	PF00069	0.523
MOD_NEK2_1	38	43	PF00069	0.323
MOD_NEK2_1	383	388	PF00069	0.701
MOD_NEK2_1	53	58	PF00069	0.430
MOD_NEK2_1	80	85	PF00069	0.502
MOD_NEK2_2	322	327	PF00069	0.562
MOD_PIKK_1	130	136	PF00454	0.665
MOD_PIKK_1	166	172	PF00454	0.494
MOD_PIKK_1	212	218	PF00454	0.603
MOD_PIKK_1	402	408	PF00454	0.648
MOD_PIKK_1	412	418	PF00454	0.697
MOD_PIKK_1	80	86	PF00454	0.493
MOD_PK_1	292	298	PF00069	0.632
MOD_PKA_1	441	447	PF00069	0.719
MOD_PKA_2	362	368	PF00069	0.741
MOD_PKA_2	401	407	PF00069	0.759
MOD_PKA_2	441	447	PF00069	0.695
MOD_PKB_1	461	469	PF00069	0.603
MOD_Plk_1	124	130	PF00069	0.683
MOD_Plk_1	25	31	PF00069	0.398
MOD_Plk_1	482	488	PF00069	0.647
MOD_Plk_1	74	80	PF00069	0.382
MOD_Plk_4	143	149	PF00069	0.472
MOD_Plk_4	158	164	PF00069	0.376
MOD_Plk_4	172	178	PF00069	0.217
MOD_Plk_4	179	185	PF00069	0.341
MOD_Plk_4	197	203	PF00069	0.506
MOD_Plk_4	25	31	PF00069	0.398
MOD_Plk_4	38	44	PF00069	0.326
MOD_Plk_4	60	66	PF00069	0.509
MOD_ProDKin_1	258	264	PF00069	0.642
MOD_ProDKin_1	416	422	PF00069	0.806
MOD_ProDKin_1	474	480	PF00069	0.764
MOD_ProDKin_1	70	76	PF00069	0.472
TRG_DiLeu_BaEn_2	137	143	PF01217	0.460
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.778
TRG_ENDOCYTIC_2	159	162	PF00928	0.445
TRG_ENDOCYTIC_2	180	183	PF00928	0.358
TRG_ENDOCYTIC_2	2	5	PF00928	0.484
TRG_ENDOCYTIC_2	207	210	PF00928	0.635
TRG_ENDOCYTIC_2	286	289	PF00928	0.644
TRG_ENDOCYTIC_2	432	435	PF00928	0.729
TRG_ER_diArg_1	426	428	PF00400	0.788
TRG_ER_diArg_1	496	499	PF00400	0.757
TRG_ER_diArg_1	531	533	PF00400	0.736
TRG_NLS_Bipartite_1	427	445	PF00514	0.734
TRG_NLS_MonoExtC_3	496	501	PF00514	0.782
TRG_NLS_MonoExtN_4	496	502	PF00514	0.741
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B9	Leptomonas seymouri	55%	99%
A0A1X0NKB6	Trypanosomatidae	25%	100%
A0A1X0NKU5	Trypanosomatidae	25%	100%
A0A3Q8IJ86	Leishmania donovani	91%	98%
A0A3R7NH33	Trypanosoma rangeli	24%	100%
A4HPF9	Leishmania braziliensis	76%	100%
A4ID81	Leishmania infantum	91%	98%
Q4Q1C6	Leishmania major	89%	100%
V5BKC4	Trypanosoma cruzi	23%	97%