ATPase_AAA_core domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT68_LEIMU

TriTrypDb:

LmxM.36.2900

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AT68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT68

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0032392	DNA geometric change	7	2
GO:0032508	DNA duplex unwinding	8	2
GO:0051276	chromosome organization	5	2
GO:0071103	DNA conformation change	6	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.522
CLV_NRD_NRD_1	170	172	PF00675	0.559
CLV_NRD_NRD_1	310	312	PF00675	0.489
CLV_NRD_NRD_1	406	408	PF00675	0.623
CLV_NRD_NRD_1	579	581	PF00675	0.570
CLV_NRD_NRD_1	704	706	PF00675	0.542
CLV_NRD_NRD_1	847	849	PF00675	0.516
CLV_PCSK_KEX2_1	170	172	PF00082	0.559
CLV_PCSK_KEX2_1	310	312	PF00082	0.489
CLV_PCSK_KEX2_1	406	408	PF00082	0.692
CLV_PCSK_KEX2_1	579	581	PF00082	0.570
CLV_PCSK_KEX2_1	704	706	PF00082	0.538
CLV_PCSK_KEX2_1	786	788	PF00082	0.469
CLV_PCSK_KEX2_1	847	849	PF00082	0.516
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.503
CLV_PCSK_PC7_1	575	581	PF00082	0.456
CLV_PCSK_SKI1_1	139	143	PF00082	0.582
CLV_PCSK_SKI1_1	274	278	PF00082	0.530
CLV_PCSK_SKI1_1	288	292	PF00082	0.355
CLV_PCSK_SKI1_1	323	327	PF00082	0.370
CLV_PCSK_SKI1_1	362	366	PF00082	0.390
CLV_PCSK_SKI1_1	665	669	PF00082	0.485
CLV_PCSK_SKI1_1	789	793	PF00082	0.501
CLV_Separin_Metazoa	719	723	PF03568	0.567
DEG_APCC_DBOX_1	346	354	PF00400	0.433
DEG_APCC_DBOX_1	786	794	PF00400	0.514
DEG_Nend_Nbox_1	1	3	PF02207	0.420
DEG_SPOP_SBC_1	261	265	PF00917	0.430
DEG_SPOP_SBC_1	553	557	PF00917	0.519
DOC_CKS1_1	780	785	PF01111	0.495
DOC_CYCLIN_RxL_1	133	144	PF00134	0.594
DOC_CYCLIN_RxL_1	223	233	PF00134	0.373
DOC_CYCLIN_RxL_1	662	672	PF00134	0.546
DOC_MAPK_gen_1	579	587	PF00069	0.449
DOC_MAPK_gen_1	785	793	PF00069	0.420
DOC_MAPK_MEF2A_6	126	134	PF00069	0.532
DOC_MAPK_MEF2A_6	226	234	PF00069	0.422
DOC_MAPK_MEF2A_6	323	331	PF00069	0.358
DOC_MAPK_MEF2A_6	347	354	PF00069	0.432
DOC_MAPK_NFAT4_5	323	331	PF00069	0.356
DOC_MAPK_RevD_3	834	848	PF00069	0.420
DOC_PP1_RVXF_1	119	125	PF00149	0.463
DOC_PP1_RVXF_1	787	793	PF00149	0.508
DOC_PP2B_LxvP_1	622	625	PF13499	0.738
DOC_PP4_FxxP_1	828	831	PF00568	0.446
DOC_PP4_FxxP_1	92	95	PF00568	0.477
DOC_USP7_MATH_1	260	264	PF00917	0.610
DOC_USP7_MATH_1	342	346	PF00917	0.622
DOC_USP7_MATH_1	394	398	PF00917	0.639
DOC_USP7_MATH_1	500	504	PF00917	0.583
DOC_USP7_MATH_1	520	524	PF00917	0.390
DOC_USP7_MATH_1	543	547	PF00917	0.687
DOC_USP7_MATH_1	640	644	PF00917	0.636
DOC_USP7_MATH_1	745	749	PF00917	0.662
DOC_USP7_MATH_1	767	771	PF00917	0.741
DOC_USP7_MATH_1	80	84	PF00917	0.502
DOC_USP7_UBL2_3	781	785	PF12436	0.464
DOC_WW_Pin1_4	539	544	PF00397	0.663
DOC_WW_Pin1_4	737	742	PF00397	0.454
DOC_WW_Pin1_4	743	748	PF00397	0.493
DOC_WW_Pin1_4	779	784	PF00397	0.519
DOC_WW_Pin1_4	86	91	PF00397	0.505
LIG_14-3-3_CanoR_1	170	174	PF00244	0.490
LIG_14-3-3_CanoR_1	406	412	PF00244	0.576
LIG_14-3-3_CanoR_1	530	538	PF00244	0.645
LIG_14-3-3_CanoR_1	568	576	PF00244	0.709
LIG_14-3-3_CanoR_1	704	712	PF00244	0.537
LIG_14-3-3_CanoR_1	722	727	PF00244	0.425
LIG_BRCT_BRCA1_1	119	123	PF00533	0.430
LIG_BRCT_BRCA1_1	727	731	PF00533	0.545
LIG_BRCT_BRCA1_1	824	828	PF00533	0.465
LIG_BRCT_BRCA1_1	88	92	PF00533	0.452
LIG_BRCT_BRCA1_1	95	99	PF00533	0.531
LIG_Clathr_ClatBox_1	372	376	PF01394	0.420
LIG_Clathr_ClatBox_1	790	794	PF01394	0.507
LIG_CSL_BTD_1	776	779	PF09270	0.592
LIG_deltaCOP1_diTrp_1	57	64	PF00928	0.542
LIG_eIF4E_1	321	327	PF01652	0.503
LIG_eIF4E_1	348	354	PF01652	0.291
LIG_FAT_LD_1	38	46	PF03623	0.357
LIG_FHA_1	136	142	PF00498	0.515
LIG_FHA_1	198	204	PF00498	0.410
LIG_FHA_1	419	425	PF00498	0.504
LIG_FHA_1	499	505	PF00498	0.518
LIG_FHA_1	533	539	PF00498	0.568
LIG_FHA_2	142	148	PF00498	0.522
LIG_FHA_2	182	188	PF00498	0.392
LIG_FHA_2	476	482	PF00498	0.318
LIG_FHA_2	52	58	PF00498	0.484
LIG_FHA_2	568	574	PF00498	0.593
LIG_FHA_2	95	101	PF00498	0.489
LIG_LIR_Apic_2	466	471	PF02991	0.391
LIG_LIR_Apic_2	825	831	PF02991	0.452
LIG_LIR_Apic_2	89	95	PF02991	0.469
LIG_LIR_Gen_1	198	207	PF02991	0.476
LIG_LIR_Nem_3	15	21	PF02991	0.401
LIG_LIR_Nem_3	198	202	PF02991	0.489
LIG_LIR_Nem_3	685	691	PF02991	0.452
LIG_LIR_Nem_3	69	74	PF02991	0.444
LIG_LIR_Nem_3	816	822	PF02991	0.482
LIG_MLH1_MIPbox_1	727	731	PF16413	0.548
LIG_NRBOX	37	43	PF00104	0.407
LIG_NRBOX	71	77	PF00104	0.349
LIG_NRBOX	817	823	PF00104	0.415
LIG_Rb_LxCxE_1	263	284	PF01857	0.502
LIG_SH2_CRK	468	472	PF00017	0.363
LIG_SH2_NCK_1	239	243	PF00017	0.390
LIG_SH2_STAP1	597	601	PF00017	0.457
LIG_SH2_STAT5	2	5	PF00017	0.380
LIG_SH2_STAT5	204	207	PF00017	0.443
LIG_SH2_STAT5	239	242	PF00017	0.480
LIG_SH2_STAT5	332	335	PF00017	0.478
LIG_SH2_STAT5	491	494	PF00017	0.470
LIG_SH2_STAT5	576	579	PF00017	0.576
LIG_SH2_STAT5	71	74	PF00017	0.348
LIG_SH3_3	191	197	PF00018	0.527
LIG_SH3_3	547	553	PF00018	0.574
LIG_SH3_3	711	717	PF00018	0.549
LIG_Sin3_3	664	671	PF02671	0.416
LIG_SUMO_SIM_anti_2	39	47	PF11976	0.466
LIG_SUMO_SIM_anti_2	830	837	PF11976	0.531
LIG_SUMO_SIM_par_1	420	425	PF11976	0.499
LIG_SUMO_SIM_par_1	583	589	PF11976	0.437
LIG_SUMO_SIM_par_1	647	653	PF11976	0.568
LIG_TRAF2_1	478	481	PF00917	0.564
LIG_TYR_ITIM	202	207	PF00017	0.420
LIG_TYR_ITIM	489	494	PF00017	0.303
MOD_CDC14_SPxK_1	746	749	PF00782	0.515
MOD_CDK_SPxK_1	743	749	PF00069	0.519
MOD_CDK_SPxK_1	779	785	PF00069	0.508
MOD_CDK_SPxxK_3	779	786	PF00069	0.502
MOD_CK1_1	263	269	PF00069	0.492
MOD_CK1_1	397	403	PF00069	0.573
MOD_CK1_1	415	421	PF00069	0.583
MOD_CK1_1	522	528	PF00069	0.589
MOD_CK1_1	529	535	PF00069	0.601
MOD_CK1_1	539	545	PF00069	0.546
MOD_CK1_1	557	563	PF00069	0.670
MOD_CK1_1	589	595	PF00069	0.589
MOD_CK1_1	706	712	PF00069	0.660
MOD_CK1_1	725	731	PF00069	0.535
MOD_CK1_1	737	743	PF00069	0.599
MOD_CK1_1	748	754	PF00069	0.744
MOD_CK1_1	83	89	PF00069	0.472
MOD_CK2_1	141	147	PF00069	0.547
MOD_CK2_1	238	244	PF00069	0.402
MOD_CK2_1	475	481	PF00069	0.314
MOD_CK2_1	766	772	PF00069	0.569
MOD_CK2_1	810	816	PF00069	0.532
MOD_Cter_Amidation	168	171	PF01082	0.446
MOD_GlcNHglycan	240	243	PF01048	0.402
MOD_GlcNHglycan	299	302	PF01048	0.602
MOD_GlcNHglycan	362	365	PF01048	0.380
MOD_GlcNHglycan	389	392	PF01048	0.592
MOD_GlcNHglycan	399	402	PF01048	0.517
MOD_GlcNHglycan	407	410	PF01048	0.643
MOD_GlcNHglycan	414	417	PF01048	0.552
MOD_GlcNHglycan	46	49	PF01048	0.501
MOD_GlcNHglycan	480	484	PF01048	0.592
MOD_GlcNHglycan	538	541	PF01048	0.684
MOD_GlcNHglycan	561	565	PF01048	0.573
MOD_GlcNHglycan	625	628	PF01048	0.653
MOD_GlcNHglycan	637	640	PF01048	0.574
MOD_GlcNHglycan	708	711	PF01048	0.678
MOD_GlcNHglycan	750	753	PF01048	0.654
MOD_GlcNHglycan	802	805	PF01048	0.597
MOD_GlcNHglycan	807	810	PF01048	0.513
MOD_GlcNHglycan	82	85	PF01048	0.524
MOD_GlcNHglycan	825	828	PF01048	0.429
MOD_GSK3_1	141	148	PF00069	0.479
MOD_GSK3_1	2	9	PF00069	0.466
MOD_GSK3_1	380	387	PF00069	0.492
MOD_GSK3_1	475	482	PF00069	0.408
MOD_GSK3_1	500	507	PF00069	0.533
MOD_GSK3_1	515	522	PF00069	0.580
MOD_GSK3_1	525	532	PF00069	0.611
MOD_GSK3_1	539	546	PF00069	0.671
MOD_GSK3_1	548	555	PF00069	0.719
MOD_GSK3_1	563	570	PF00069	0.702
MOD_GSK3_1	722	729	PF00069	0.586
MOD_GSK3_1	94	101	PF00069	0.518
MOD_LATS_1	524	530	PF00433	0.635
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	141	146	PF00069	0.497
MOD_NEK2_1	210	215	PF00069	0.370
MOD_NEK2_1	237	242	PF00069	0.471
MOD_NEK2_1	380	385	PF00069	0.526
MOD_NEK2_1	405	410	PF00069	0.666
MOD_NEK2_1	412	417	PF00069	0.619
MOD_NEK2_1	44	49	PF00069	0.446
MOD_NEK2_1	504	509	PF00069	0.573
MOD_NEK2_1	538	543	PF00069	0.670
MOD_NEK2_1	586	591	PF00069	0.533
MOD_NEK2_1	611	616	PF00069	0.510
MOD_NEK2_1	822	827	PF00069	0.515
MOD_NEK2_2	640	645	PF00069	0.651
MOD_PIKK_1	145	151	PF00454	0.562
MOD_PIKK_1	169	175	PF00454	0.521
MOD_PIKK_1	181	187	PF00454	0.477
MOD_PIKK_1	508	514	PF00454	0.500
MOD_PIKK_1	533	539	PF00454	0.713
MOD_PIKK_1	543	549	PF00454	0.691
MOD_PIKK_1	58	64	PF00454	0.439
MOD_PIKK_1	611	617	PF00454	0.728
MOD_PIKK_1	83	89	PF00454	0.536
MOD_PIKK_1	834	840	PF00454	0.584
MOD_PK_1	548	554	PF00069	0.588
MOD_PKA_2	169	175	PF00069	0.552
MOD_PKA_2	284	290	PF00069	0.396
MOD_PKA_2	405	411	PF00069	0.583
MOD_PKA_2	520	526	PF00069	0.608
MOD_PKA_2	529	535	PF00069	0.636
MOD_PKA_2	567	573	PF00069	0.692
MOD_PKA_2	703	709	PF00069	0.552
MOD_PKA_2	748	754	PF00069	0.639
MOD_PKA_2	800	806	PF00069	0.540
MOD_Plk_1	380	386	PF00069	0.552
MOD_Plk_1	504	510	PF00069	0.596
MOD_Plk_4	380	386	PF00069	0.481
MOD_Plk_4	418	424	PF00069	0.511
MOD_Plk_4	470	476	PF00069	0.573
MOD_Plk_4	586	592	PF00069	0.506
MOD_Plk_4	726	732	PF00069	0.622
MOD_ProDKin_1	539	545	PF00069	0.665
MOD_ProDKin_1	737	743	PF00069	0.457
MOD_ProDKin_1	779	785	PF00069	0.508
MOD_ProDKin_1	86	92	PF00069	0.502
TRG_DiLeu_BaEn_1	368	373	PF01217	0.523
TRG_DiLeu_BaEn_1	40	45	PF01217	0.451
TRG_DiLeu_BaEn_1	669	674	PF01217	0.432
TRG_DiLeu_BaEn_1	841	846	PF01217	0.484
TRG_DiLeu_BaEn_4	841	847	PF01217	0.536
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.578
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.501
TRG_ENDOCYTIC_2	204	207	PF00928	0.460
TRG_ENDOCYTIC_2	491	494	PF00928	0.470
TRG_ENDOCYTIC_2	597	600	PF00928	0.509
TRG_ER_diArg_1	310	312	PF00400	0.489
TRG_ER_diArg_1	405	407	PF00400	0.626
TRG_ER_diArg_1	787	790	PF00400	0.519
TRG_ER_diArg_1	796	799	PF00400	0.509
TRG_ER_diArg_1	846	848	PF00400	0.488
TRG_NLS_MonoExtC_3	784	789	PF00514	0.527
TRG_NLS_MonoExtN_4	783	790	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P797	Leptomonas seymouri	46%	100%
A0A1X0NKL2	Trypanosomatidae	26%	100%
A0A3R7LZS8	Trypanosoma rangeli	27%	100%
A0A3S5H829	Leishmania donovani	90%	95%
A4HPF6	Leishmania braziliensis	76%	100%
A4ID78	Leishmania infantum	89%	95%
Q4Q1C9	Leishmania major	89%	100%
V5B0C2	Trypanosoma cruzi	26%	100%