SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT63_LEIMU

TriTrypDb:

LmxM.36.2850

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	85	89	PF00082	0.523
DEG_Nend_Nbox_1	1	3	PF02207	0.734
DOC_CKS1_1	149	154	PF01111	0.433
DOC_CKS1_1	33	38	PF01111	0.595
DOC_CYCLIN_RxL_1	80	89	PF00134	0.355
DOC_PP1_RVXF_1	96	102	PF00149	0.513
DOC_PP2B_LxvP_1	181	184	PF13499	0.435
DOC_PP4_FxxP_1	2	5	PF00568	0.653
DOC_PP4_FxxP_1	249	252	PF00568	0.452
DOC_USP7_MATH_1	10	14	PF00917	0.755
DOC_USP7_MATH_1	126	130	PF00917	0.641
DOC_USP7_MATH_1	138	142	PF00917	0.650
DOC_USP7_MATH_1	237	241	PF00917	0.607
DOC_WW_Pin1_4	148	153	PF00397	0.442
DOC_WW_Pin1_4	26	31	PF00397	0.669
DOC_WW_Pin1_4	32	37	PF00397	0.530
LIG_14-3-3_CanoR_1	15	23	PF00244	0.596
LIG_14-3-3_CanoR_1	91	99	PF00244	0.444
LIG_BRCT_BRCA1_1	165	169	PF00533	0.532
LIG_BRCT_BRCA1_1	40	44	PF00533	0.448
LIG_FHA_1	101	107	PF00498	0.447
LIG_FHA_1	163	169	PF00498	0.379
LIG_FHA_2	106	112	PF00498	0.418
LIG_LIR_Gen_1	158	168	PF02991	0.501
LIG_LIR_Nem_3	154	160	PF02991	0.529
LIG_LIR_Nem_3	177	182	PF02991	0.472
LIG_LIR_Nem_3	224	229	PF02991	0.442
LIG_LIR_Nem_3	67	73	PF02991	0.475
LIG_LYPXL_S_1	225	229	PF13949	0.432
LIG_LYPXL_SIV_4	69	77	PF13949	0.478
LIG_LYPXL_yS_3	226	229	PF13949	0.432
LIG_Pex14_2	178	182	PF04695	0.486
LIG_PTB_Apo_2	112	119	PF02174	0.551
LIG_PTB_Apo_2	203	210	PF02174	0.333
LIG_PTB_Phospho_1	203	209	PF10480	0.359
LIG_SH2_CRK	70	74	PF00017	0.440
LIG_SH2_GRB2like	107	110	PF00017	0.378
LIG_SH2_SRC	31	34	PF00017	0.552
LIG_SH2_STAT5	107	110	PF00017	0.563
LIG_SH2_STAT5	209	212	PF00017	0.453
LIG_SH2_STAT5	31	34	PF00017	0.565
LIG_SH2_STAT5	53	56	PF00017	0.450
LIG_SH2_STAT5	86	89	PF00017	0.421
LIG_SH3_2	150	155	PF14604	0.593
LIG_SH3_3	146	152	PF00018	0.558
LIG_SH3_3	27	33	PF00018	0.636
LIG_SH3_3	4	10	PF00018	0.660
LIG_SH3_3	66	72	PF00018	0.495
LIG_TYR_ITIM	68	73	PF00017	0.523
LIG_TYR_ITSM	222	229	PF00017	0.445
LIG_UBA3_1	1	9	PF00899	0.728
LIG_WRC_WIRS_1	189	194	PF05994	0.414
MOD_CDK_SPxxK_3	148	155	PF00069	0.430
MOD_CK1_1	240	246	PF00069	0.569
MOD_CK1_1	38	44	PF00069	0.469
MOD_CK2_1	105	111	PF00069	0.473
MOD_GlcNHglycan	185	188	PF01048	0.429
MOD_GlcNHglycan	215	220	PF01048	0.570
MOD_GlcNHglycan	231	234	PF01048	0.397
MOD_GlcNHglycan	242	245	PF01048	0.497
MOD_GSK3_1	10	17	PF00069	0.755
MOD_GSK3_1	101	108	PF00069	0.360
MOD_GSK3_1	34	41	PF00069	0.540
MOD_N-GLC_1	237	242	PF02516	0.581
MOD_NEK2_1	101	106	PF00069	0.463
MOD_NEK2_1	16	21	PF00069	0.470
MOD_NEK2_1	163	168	PF00069	0.507
MOD_NEK2_2	51	56	PF00069	0.554
MOD_PIKK_1	16	22	PF00454	0.598
MOD_PK_1	56	62	PF00069	0.508
MOD_PKA_2	14	20	PF00069	0.717
MOD_Plk_1	237	243	PF00069	0.629
MOD_Plk_1	94	100	PF00069	0.473
MOD_Plk_4	138	144	PF00069	0.573
MOD_Plk_4	174	180	PF00069	0.528
MOD_Plk_4	188	194	PF00069	0.444
MOD_Plk_4	221	227	PF00069	0.416
MOD_Plk_4	56	62	PF00069	0.531
MOD_ProDKin_1	148	154	PF00069	0.433
MOD_ProDKin_1	26	32	PF00069	0.661
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.418
TRG_ENDOCYTIC_2	160	163	PF00928	0.491
TRG_ENDOCYTIC_2	209	212	PF00928	0.408
TRG_ENDOCYTIC_2	226	229	PF00928	0.385
TRG_ENDOCYTIC_2	70	73	PF00928	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH2	Leptomonas seymouri	67%	100%
A0A0S4IV73	Bodo saltans	35%	100%
A0A1X0NKA4	Trypanosomatidae	44%	100%
A0A3R7L2T5	Trypanosoma rangeli	37%	100%
A0A3S7XB21	Leishmania donovani	91%	100%
A4HPF2	Leishmania braziliensis	75%	100%
A4ICJ3	Leishmania infantum	91%	100%
D0A3G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q1D4	Leishmania major	88%	100%