G protein-coupled receptor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT59_LEIMU

TriTrypDb:

LmxM.36.2820

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AT59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.638
CLV_C14_Caspase3-7	322	326	PF00656	0.685
CLV_C14_Caspase3-7	328	332	PF00656	0.648
CLV_C14_Caspase3-7	417	421	PF00656	0.618
CLV_C14_Caspase3-7	428	432	PF00656	0.662
CLV_C14_Caspase3-7	435	439	PF00656	0.712
CLV_C14_Caspase3-7	512	516	PF00656	0.721
CLV_C14_Caspase3-7	589	593	PF00656	0.605
CLV_NRD_NRD_1	12	14	PF00675	0.385
CLV_NRD_NRD_1	181	183	PF00675	0.545
CLV_NRD_NRD_1	480	482	PF00675	0.534
CLV_PCSK_FUR_1	476	480	PF00082	0.551
CLV_PCSK_KEX2_1	12	14	PF00082	0.426
CLV_PCSK_KEX2_1	320	322	PF00082	0.565
CLV_PCSK_KEX2_1	478	480	PF00082	0.542
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.480
CLV_PCSK_PC7_1	474	480	PF00082	0.546
CLV_PCSK_SKI1_1	12	16	PF00082	0.438
CLV_PCSK_SKI1_1	167	171	PF00082	0.560
CLV_PCSK_SKI1_1	247	251	PF00082	0.420
CLV_PCSK_SKI1_1	255	259	PF00082	0.383
CLV_PCSK_SKI1_1	309	313	PF00082	0.452
DEG_APCC_DBOX_1	11	19	PF00400	0.607
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DOC_CKS1_1	5	10	PF01111	0.638
DOC_CYCLIN_RxL_1	10	21	PF00134	0.619
DOC_CYCLIN_RxL_1	252	262	PF00134	0.626
DOC_MAPK_FxFP_2	3	6	PF00069	0.621
DOC_MAPK_gen_1	130	139	PF00069	0.594
DOC_MAPK_MEF2A_6	133	141	PF00069	0.595
DOC_PP1_RVXF_1	11	18	PF00149	0.624
DOC_PP4_FxxP_1	3	6	PF00568	0.647
DOC_PP4_FxxP_1	371	374	PF00568	0.679
DOC_USP7_MATH_1	243	247	PF00917	0.628
DOC_USP7_MATH_1	519	523	PF00917	0.667
DOC_USP7_MATH_1	546	550	PF00917	0.636
DOC_USP7_MATH_2	345	351	PF00917	0.601
DOC_USP7_MATH_2	442	448	PF00917	0.615
DOC_USP7_UBL2_3	277	281	PF12436	0.662
DOC_WW_Pin1_4	341	346	PF00397	0.602
DOC_WW_Pin1_4	4	9	PF00397	0.642
DOC_WW_Pin1_4	438	443	PF00397	0.739
LIG_14-3-3_CanoR_1	259	268	PF00244	0.540
LIG_14-3-3_CanoR_1	283	289	PF00244	0.679
LIG_14-3-3_CanoR_1	44	50	PF00244	0.300
LIG_AP2alpha_1	375	379	PF02296	0.677
LIG_APCC_ABBA_1	234	239	PF00400	0.624
LIG_BRCT_BRCA1_1	245	249	PF00533	0.587
LIG_Clathr_ClatBox_1	107	111	PF01394	0.352
LIG_Clathr_ClatBox_1	65	69	PF01394	0.353
LIG_CSL_BTD_1	439	442	PF09270	0.739
LIG_deltaCOP1_diTrp_1	241	249	PF00928	0.585
LIG_EH1_1	141	149	PF00400	0.506
LIG_eIF4E_1	53	59	PF01652	0.392
LIG_FHA_1	26	32	PF00498	0.424
LIG_FHA_1	408	414	PF00498	0.619
LIG_FHA_1	463	469	PF00498	0.631
LIG_FHA_1	83	89	PF00498	0.358
LIG_FHA_2	182	188	PF00498	0.480
LIG_FHA_2	320	326	PF00498	0.668
LIG_FHA_2	449	455	PF00498	0.850
LIG_FHA_2	52	58	PF00498	0.404
LIG_GBD_Chelix_1	590	598	PF00786	0.501
LIG_Integrin_RGD_1	481	483	PF01839	0.520
LIG_LIR_Apic_2	368	374	PF02991	0.680
LIG_LIR_Apic_2	454	459	PF02991	0.718
LIG_LIR_Gen_1	111	120	PF02991	0.360
LIG_LIR_Gen_1	184	194	PF02991	0.378
LIG_LIR_Gen_1	195	205	PF02991	0.262
LIG_LIR_Gen_1	287	296	PF02991	0.606
LIG_LIR_Gen_1	313	323	PF02991	0.613
LIG_LIR_LC3C_4	33	36	PF02991	0.336
LIG_LIR_Nem_3	111	115	PF02991	0.360
LIG_LIR_Nem_3	16	22	PF02991	0.546
LIG_LIR_Nem_3	184	189	PF02991	0.357
LIG_LIR_Nem_3	192	197	PF02991	0.298
LIG_LIR_Nem_3	202	208	PF02991	0.237
LIG_LIR_Nem_3	287	291	PF02991	0.704
LIG_LIR_Nem_3	293	299	PF02991	0.636
LIG_LIR_Nem_3	368	373	PF02991	0.660
LIG_NRBOX	109	115	PF00104	0.384
LIG_NRBOX	33	39	PF00104	0.213
LIG_Pex14_2	108	112	PF04695	0.360
LIG_Pex14_2	220	224	PF04695	0.243
LIG_Pex14_2	371	375	PF04695	0.676
LIG_PTB_Apo_2	329	336	PF02174	0.655
LIG_PTB_Apo_2	369	376	PF02174	0.656
LIG_SH2_CRK	288	292	PF00017	0.691
LIG_SH2_CRK	456	460	PF00017	0.792
LIG_SH2_GRB2like	53	56	PF00017	0.385
LIG_SH2_NCK_1	456	460	PF00017	0.792
LIG_SH2_SRC	456	459	PF00017	0.751
LIG_SH2_STAP1	152	156	PF00017	0.398
LIG_SH2_STAP1	186	190	PF00017	0.384
LIG_SH2_STAT3	520	523	PF00017	0.625
LIG_SH2_STAT5	103	106	PF00017	0.360
LIG_SH2_STAT5	125	128	PF00017	0.608
LIG_SH2_STAT5	197	200	PF00017	0.317
LIG_SH2_STAT5	218	221	PF00017	0.390
LIG_SH2_STAT5	227	230	PF00017	0.647
LIG_SH2_STAT5	378	381	PF00017	0.685
LIG_SH2_STAT5	520	523	PF00017	0.755
LIG_SH2_STAT5	526	529	PF00017	0.698
LIG_SH2_STAT5	53	56	PF00017	0.383
LIG_SH2_STAT5	535	538	PF00017	0.631
LIG_SH3_1	5	11	PF00018	0.636
LIG_SH3_2	8	13	PF14604	0.626
LIG_SH3_3	134	140	PF00018	0.600
LIG_SH3_3	201	207	PF00018	0.346
LIG_SH3_3	455	461	PF00018	0.717
LIG_SH3_3	495	501	PF00018	0.744
LIG_SH3_3	5	11	PF00018	0.593
LIG_SH3_5	374	378	PF00018	0.674
LIG_Sin3_3	296	303	PF02671	0.630
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.343
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.376
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.327
LIG_SUMO_SIM_anti_2	61	70	PF11976	0.348
LIG_SUMO_SIM_par_1	33	40	PF11976	0.327
LIG_SUMO_SIM_par_1	396	402	PF11976	0.720
LIG_SUMO_SIM_par_1	61	70	PF11976	0.360
LIG_SUMO_SIM_par_1	84	89	PF11976	0.376
LIG_TRAF2_1	399	402	PF00917	0.753
LIG_TRAF2_1	441	444	PF00917	0.783
LIG_Vh1_VBS_1	17	35	PF01044	0.483
MOD_CK1_1	48	54	PF00069	0.371
MOD_CK2_1	181	187	PF00069	0.472
MOD_CK2_1	226	232	PF00069	0.521
MOD_CK2_1	341	347	PF00069	0.674
MOD_CK2_1	396	402	PF00069	0.751
MOD_CK2_1	438	444	PF00069	0.773
MOD_CK2_1	448	454	PF00069	0.840
MOD_CK2_1	564	570	PF00069	0.755
MOD_GlcNHglycan	349	352	PF01048	0.589
MOD_GlcNHglycan	541	544	PF01048	0.565
MOD_GlcNHglycan	548	551	PF01048	0.612
MOD_GSK3_1	142	149	PF00069	0.519
MOD_GSK3_1	195	202	PF00069	0.352
MOD_GSK3_1	444	451	PF00069	0.828
MOD_GSK3_1	462	469	PF00069	0.776
MOD_GSK3_1	564	571	PF00069	0.754
MOD_GSK3_1	69	76	PF00069	0.411
MOD_GSK3_1	82	89	PF00069	0.337
MOD_LATS_1	470	476	PF00433	0.671
MOD_N-GLC_1	123	128	PF02516	0.348
MOD_N-GLC_1	251	256	PF02516	0.431
MOD_N-GLC_1	325	330	PF02516	0.481
MOD_N-GLC_1	73	78	PF02516	0.541
MOD_NEK2_1	123	128	PF00069	0.548
MOD_NEK2_1	181	186	PF00069	0.392
MOD_NEK2_1	208	213	PF00069	0.384
MOD_NEK2_1	25	30	PF00069	0.376
MOD_NEK2_1	250	255	PF00069	0.635
MOD_NEK2_1	319	324	PF00069	0.718
MOD_NEK2_1	448	453	PF00069	0.756
MOD_NEK2_1	45	50	PF00069	0.360
MOD_NEK2_1	557	562	PF00069	0.701
MOD_NEK2_1	97	102	PF00069	0.320
MOD_NEK2_2	73	78	PF00069	0.293
MOD_PIKK_1	146	152	PF00454	0.360
MOD_PIKK_1	325	331	PF00454	0.679
MOD_PIKK_1	462	468	PF00454	0.734
MOD_PIKK_1	519	525	PF00454	0.623
MOD_PKA_2	181	187	PF00069	0.385
MOD_PKA_2	43	49	PF00069	0.300
MOD_PKA_2	568	574	PF00069	0.749
MOD_PKA_2	82	88	PF00069	0.347
MOD_PKB_1	572	580	PF00069	0.716
MOD_Plk_1	325	331	PF00069	0.682
MOD_Plk_1	444	450	PF00069	0.667
MOD_Plk_1	69	75	PF00069	0.398
MOD_Plk_2-3	396	402	PF00069	0.730
MOD_Plk_2-3	414	420	PF00069	0.607
MOD_Plk_2-3	592	598	PF00069	0.737
MOD_Plk_4	18	24	PF00069	0.506
MOD_Plk_4	195	201	PF00069	0.326
MOD_Plk_4	30	36	PF00069	0.324
MOD_Plk_4	444	450	PF00069	0.634
MOD_Plk_4	48	54	PF00069	0.299
MOD_ProDKin_1	341	347	PF00069	0.605
MOD_ProDKin_1	4	10	PF00069	0.641
MOD_ProDKin_1	438	444	PF00069	0.738
TRG_DiLeu_BaEn_1	111	116	PF01217	0.343
TRG_DiLeu_BaEn_2	244	250	PF01217	0.579
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.621
TRG_ENDOCYTIC_2	186	189	PF00928	0.377
TRG_ENDOCYTIC_2	197	200	PF00928	0.249
TRG_ENDOCYTIC_2	205	208	PF00928	0.234
TRG_ENDOCYTIC_2	288	291	PF00928	0.630
TRG_ENDOCYTIC_2	95	98	PF00928	0.346
TRG_ER_diArg_1	11	13	PF00400	0.625
TRG_ER_diArg_1	476	479	PF00400	0.733
TRG_NLS_MonoExtC_3	181	187	PF00514	0.299
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M6	Leptomonas seymouri	58%	99%
A0A3Q8IW35	Leishmania donovani	89%	100%
A4HPE8	Leishmania braziliensis	73%	98%
A4ICI9	Leishmania infantum	89%	100%
Q4Q1D8	Leishmania major	89%	99%
V5BFT0	Trypanosoma cruzi	36%	100%