Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT57_LEIMU

TriTrypDb:

LmxM.36.2800

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.671
CLV_C14_Caspase3-7	279	283	PF00656	0.650
CLV_C14_Caspase3-7	352	356	PF00656	0.652
CLV_C14_Caspase3-7	566	570	PF00656	0.513
CLV_NRD_NRD_1	116	118	PF00675	0.540
CLV_NRD_NRD_1	127	129	PF00675	0.616
CLV_NRD_NRD_1	17	19	PF00675	0.583
CLV_NRD_NRD_1	284	286	PF00675	0.630
CLV_NRD_NRD_1	64	66	PF00675	0.711
CLV_NRD_NRD_1	640	642	PF00675	0.429
CLV_NRD_NRD_1	707	709	PF00675	0.439
CLV_NRD_NRD_1	73	75	PF00675	0.476
CLV_PCSK_KEX2_1	116	118	PF00082	0.540
CLV_PCSK_KEX2_1	127	129	PF00082	0.616
CLV_PCSK_KEX2_1	17	19	PF00082	0.583
CLV_PCSK_KEX2_1	284	286	PF00082	0.630
CLV_PCSK_KEX2_1	294	296	PF00082	0.638
CLV_PCSK_KEX2_1	331	333	PF00082	0.635
CLV_PCSK_KEX2_1	64	66	PF00082	0.609
CLV_PCSK_KEX2_1	640	642	PF00082	0.464
CLV_PCSK_KEX2_1	707	709	PF00082	0.439
CLV_PCSK_KEX2_1	73	75	PF00082	0.552
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.632
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.549
CLV_PCSK_SKI1_1	342	346	PF00082	0.527
CLV_PCSK_SKI1_1	36	40	PF00082	0.432
CLV_PCSK_SKI1_1	384	388	PF00082	0.615
CLV_PCSK_SKI1_1	641	645	PF00082	0.407
CLV_PCSK_SKI1_1	695	699	PF00082	0.360
CLV_PCSK_SKI1_1	74	78	PF00082	0.511
CLV_PCSK_SKI1_1	801	805	PF00082	0.417
DEG_APCC_KENBOX_2	119	123	PF00400	0.462
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DEG_SPOP_SBC_1	57	61	PF00917	0.562
DOC_CKS1_1	343	348	PF01111	0.625
DOC_CYCLIN_RxL_1	381	391	PF00134	0.613
DOC_CYCLIN_RxL_1	845	856	PF00134	0.365
DOC_CYCLIN_yClb5_NLxxxL_5	845	854	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	669	675	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	811	817	PF00134	0.578
DOC_MAPK_DCC_7	342	351	PF00069	0.597
DOC_MAPK_gen_1	124	133	PF00069	0.611
DOC_MAPK_gen_1	331	339	PF00069	0.537
DOC_MAPK_gen_1	640	648	PF00069	0.401
DOC_MAPK_gen_1	95	104	PF00069	0.576
DOC_MAPK_MEF2A_6	342	351	PF00069	0.593
DOC_MAPK_MEF2A_6	640	648	PF00069	0.398
DOC_MAPK_MEF2A_6	95	104	PF00069	0.576
DOC_MAPK_NFAT4_5	641	649	PF00069	0.397
DOC_PP1_RVXF_1	307	313	PF00149	0.636
DOC_PP1_RVXF_1	474	481	PF00149	0.410
DOC_PP1_RVXF_1	766	773	PF00149	0.485
DOC_PP2B_LxvP_1	337	340	PF13499	0.694
DOC_PP2B_LxvP_1	648	651	PF13499	0.379
DOC_PP2B_LxvP_1	669	672	PF13499	0.429
DOC_PP2B_LxvP_1	852	855	PF13499	0.378
DOC_PP4_FxxP_1	344	347	PF00568	0.526
DOC_USP7_MATH_1	138	142	PF00917	0.593
DOC_USP7_MATH_1	196	200	PF00917	0.793
DOC_USP7_MATH_1	210	214	PF00917	0.690
DOC_USP7_MATH_1	242	246	PF00917	0.784
DOC_USP7_MATH_1	289	293	PF00917	0.539
DOC_USP7_MATH_1	403	407	PF00917	0.555
DOC_USP7_MATH_1	410	414	PF00917	0.467
DOC_USP7_MATH_1	522	526	PF00917	0.597
DOC_USP7_MATH_1	57	61	PF00917	0.636
DOC_USP7_MATH_1	725	729	PF00917	0.446
DOC_USP7_MATH_1	76	80	PF00917	0.518
DOC_WW_Pin1_4	342	347	PF00397	0.629
DOC_WW_Pin1_4	36	41	PF00397	0.543
DOC_WW_Pin1_4	401	406	PF00397	0.647
DOC_WW_Pin1_4	456	461	PF00397	0.514
DOC_WW_Pin1_4	498	503	PF00397	0.659
DOC_WW_Pin1_4	505	510	PF00397	0.640
DOC_WW_Pin1_4	53	58	PF00397	0.669
LIG_14-3-3_CanoR_1	132	139	PF00244	0.628
LIG_14-3-3_CanoR_1	148	153	PF00244	0.630
LIG_14-3-3_CanoR_1	265	270	PF00244	0.636
LIG_14-3-3_CanoR_1	284	290	PF00244	0.704
LIG_14-3-3_CanoR_1	491	495	PF00244	0.547
LIG_14-3-3_CanoR_1	521	529	PF00244	0.522
LIG_14-3-3_CanoR_1	626	632	PF00244	0.524
LIG_14-3-3_CanoR_1	64	70	PF00244	0.748
LIG_14-3-3_CanoR_1	707	711	PF00244	0.447
LIG_14-3-3_CanoR_1	74	84	PF00244	0.480
LIG_APCC_ABBA_1	215	220	PF00400	0.608
LIG_APCC_ABBA_1	772	777	PF00400	0.439
LIG_APCC_ABBA_1	807	812	PF00400	0.389
LIG_BIR_III_4	280	284	PF00653	0.656
LIG_Clathr_ClatBox_1	184	188	PF01394	0.675
LIG_CtBP_PxDLS_1	684	688	PF00389	0.383
LIG_deltaCOP1_diTrp_1	767	775	PF00928	0.422
LIG_EVH1_1	337	341	PF00568	0.657
LIG_EVH1_2	340	344	PF00568	0.523
LIG_FHA_1	11	17	PF00498	0.497
LIG_FHA_1	165	171	PF00498	0.692
LIG_FHA_1	37	43	PF00498	0.635
LIG_FHA_1	381	387	PF00498	0.613
LIG_FHA_1	457	463	PF00498	0.461
LIG_FHA_1	581	587	PF00498	0.514
LIG_FHA_1	856	862	PF00498	0.398
LIG_FHA_2	163	169	PF00498	0.689
LIG_FHA_2	360	366	PF00498	0.641
LIG_FHA_2	452	458	PF00498	0.569
LIG_FHA_2	514	520	PF00498	0.639
LIG_FHA_2	542	548	PF00498	0.645
LIG_FHA_2	854	860	PF00498	0.476
LIG_Integrin_isoDGR_2	122	124	PF01839	0.474
LIG_LIR_Apic_2	404	410	PF02991	0.530
LIG_LIR_Gen_1	213	220	PF02991	0.648
LIG_LIR_Gen_1	3	9	PF02991	0.569
LIG_LIR_Gen_1	485	495	PF02991	0.408
LIG_LIR_Gen_1	689	698	PF02991	0.340
LIG_LIR_Gen_1	767	776	PF02991	0.467
LIG_LIR_Gen_1	821	832	PF02991	0.382
LIG_LIR_Nem_3	192	198	PF02991	0.672
LIG_LIR_Nem_3	213	218	PF02991	0.647
LIG_LIR_Nem_3	3	8	PF02991	0.569
LIG_LIR_Nem_3	472	478	PF02991	0.389
LIG_LIR_Nem_3	485	490	PF02991	0.367
LIG_LIR_Nem_3	619	625	PF02991	0.531
LIG_LIR_Nem_3	689	693	PF02991	0.334
LIG_LIR_Nem_3	767	772	PF02991	0.389
LIG_LIR_Nem_3	821	827	PF02991	0.378
LIG_LIR_Nem_3	88	93	PF02991	0.529
LIG_LYPXL_yS_3	195	198	PF13949	0.591
LIG_NRP_CendR_1	871	874	PF00754	0.452
LIG_Pex14_2	623	627	PF04695	0.402
LIG_Pex14_2	760	764	PF04695	0.345
LIG_REV1ctd_RIR_1	84	90	PF16727	0.598
LIG_SH2_CRK	407	411	PF00017	0.654
LIG_SH2_CRK	475	479	PF00017	0.378
LIG_SH2_CRK	5	9	PF00017	0.569
LIG_SH2_CRK	675	679	PF00017	0.431
LIG_SH2_CRK	690	694	PF00017	0.333
LIG_SH2_CRK	93	97	PF00017	0.478
LIG_SH2_NCK_1	5	9	PF00017	0.569
LIG_SH2_PTP2	487	490	PF00017	0.446
LIG_SH2_PTP2	824	827	PF00017	0.370
LIG_SH2_SRC	660	663	PF00017	0.418
LIG_SH2_STAP1	5	9	PF00017	0.576
LIG_SH2_STAP1	690	694	PF00017	0.333
LIG_SH2_STAT3	843	846	PF00017	0.464
LIG_SH2_STAT5	15	18	PF00017	0.541
LIG_SH2_STAT5	24	27	PF00017	0.493
LIG_SH2_STAT5	487	490	PF00017	0.446
LIG_SH2_STAT5	593	596	PF00017	0.717
LIG_SH2_STAT5	622	625	PF00017	0.419
LIG_SH2_STAT5	690	693	PF00017	0.367
LIG_SH2_STAT5	824	827	PF00017	0.370
LIG_SH2_STAT5	843	846	PF00017	0.464
LIG_SH3_3	170	176	PF00018	0.662
LIG_SH3_3	272	278	PF00018	0.739
LIG_SH3_3	335	341	PF00018	0.644
LIG_SH3_3	344	350	PF00018	0.665
LIG_SH3_3	556	562	PF00018	0.691
LIG_SH3_3	579	585	PF00018	0.639
LIG_SH3_CIN85_PxpxPR_1	271	276	PF14604	0.605
LIG_SUMO_SIM_par_1	683	689	PF11976	0.373
LIG_SUMO_SIM_par_1	829	836	PF11976	0.550
LIG_SUMO_SIM_par_1	850	859	PF11976	0.372
LIG_TRAF2_1	247	250	PF00917	0.642
LIG_TRAF2_1	449	452	PF00917	0.471
LIG_TRAF2_1	618	621	PF00917	0.595
LIG_TYR_ITIM	673	678	PF00017	0.478
LIG_UBA3_1	844	848	PF00899	0.393
LIG_WW_3	339	343	PF00397	0.627
MOD_CDK_SPxK_1	58	64	PF00069	0.627
MOD_CDK_SPxxK_3	401	408	PF00069	0.635
MOD_CDK_SPxxK_3	58	65	PF00069	0.624
MOD_CK1_1	126	132	PF00069	0.615
MOD_CK1_1	141	147	PF00069	0.618
MOD_CK1_1	155	161	PF00069	0.621
MOD_CK1_1	190	196	PF00069	0.618
MOD_CK1_1	213	219	PF00069	0.798
MOD_CK1_1	221	227	PF00069	0.646
MOD_CK1_1	298	304	PF00069	0.643
MOD_CK1_1	374	380	PF00069	0.602
MOD_CK1_1	396	402	PF00069	0.700
MOD_CK1_1	49	55	PF00069	0.586
MOD_CK1_1	508	514	PF00069	0.675
MOD_CK1_1	686	692	PF00069	0.384
MOD_CK1_1	728	734	PF00069	0.550
MOD_CK1_1	795	801	PF00069	0.625
MOD_CK1_1	853	859	PF00069	0.476
MOD_CK2_1	162	168	PF00069	0.749
MOD_CK2_1	242	248	PF00069	0.614
MOD_CK2_1	359	365	PF00069	0.641
MOD_CK2_1	446	452	PF00069	0.428
MOD_CK2_1	455	461	PF00069	0.418
MOD_CK2_1	498	504	PF00069	0.552
MOD_CK2_1	513	519	PF00069	0.595
MOD_CK2_1	541	547	PF00069	0.611
MOD_CK2_1	615	621	PF00069	0.650
MOD_CK2_1	853	859	PF00069	0.478
MOD_CMANNOS	766	769	PF00535	0.404
MOD_Cter_Amidation	282	285	PF01082	0.611
MOD_GlcNHglycan	128	131	PF01048	0.618
MOD_GlcNHglycan	133	136	PF01048	0.627
MOD_GlcNHglycan	154	157	PF01048	0.624
MOD_GlcNHglycan	188	192	PF01048	0.596
MOD_GlcNHglycan	198	201	PF01048	0.679
MOD_GlcNHglycan	208	211	PF01048	0.549
MOD_GlcNHglycan	300	303	PF01048	0.756
MOD_GlcNHglycan	315	320	PF01048	0.635
MOD_GlcNHglycan	376	379	PF01048	0.637
MOD_GlcNHglycan	413	416	PF01048	0.481
MOD_GlcNHglycan	418	421	PF01048	0.538
MOD_GlcNHglycan	471	474	PF01048	0.527
MOD_GlcNHglycan	492	495	PF01048	0.486
MOD_GlcNHglycan	53	56	PF01048	0.613
MOD_GlcNHglycan	607	610	PF01048	0.527
MOD_GlcNHglycan	680	683	PF01048	0.396
MOD_GlcNHglycan	714	717	PF01048	0.546
MOD_GSK3_1	140	147	PF00069	0.653
MOD_GSK3_1	148	155	PF00069	0.701
MOD_GSK3_1	164	171	PF00069	0.704
MOD_GSK3_1	190	197	PF00069	0.607
MOD_GSK3_1	202	209	PF00069	0.671
MOD_GSK3_1	370	377	PF00069	0.637
MOD_GSK3_1	386	393	PF00069	0.532
MOD_GSK3_1	399	406	PF00069	0.541
MOD_GSK3_1	451	458	PF00069	0.644
MOD_GSK3_1	49	56	PF00069	0.622
MOD_GSK3_1	498	505	PF00069	0.781
MOD_GSK3_1	513	520	PF00069	0.543
MOD_GSK3_1	576	583	PF00069	0.588
MOD_GSK3_1	725	732	PF00069	0.455
MOD_N-GLC_1	393	398	PF02516	0.587
MOD_N-GLC_1	712	717	PF02516	0.507
MOD_N-GLC_2	611	613	PF02516	0.550
MOD_NEK2_1	218	223	PF00069	0.604
MOD_NEK2_1	234	239	PF00069	0.600
MOD_NEK2_1	386	391	PF00069	0.637
MOD_NEK2_1	418	423	PF00069	0.647
MOD_NEK2_1	644	649	PF00069	0.415
MOD_NEK2_1	75	80	PF00069	0.716
MOD_NEK2_1	803	808	PF00069	0.504
MOD_NEK2_1	850	855	PF00069	0.375
MOD_NEK2_2	706	711	PF00069	0.418
MOD_OFUCOSY	596	603	PF10250	0.630
MOD_PIKK_1	162	168	PF00454	0.696
MOD_PIKK_1	283	289	PF00454	0.701
MOD_PIKK_1	616	622	PF00454	0.521
MOD_PIKK_1	835	841	PF00454	0.510
MOD_PK_1	148	154	PF00069	0.701
MOD_PKA_1	64	70	PF00069	0.590
MOD_PKA_2	123	129	PF00069	0.608
MOD_PKA_2	131	137	PF00069	0.608
MOD_PKA_2	152	158	PF00069	0.676
MOD_PKA_2	174	180	PF00069	0.588
MOD_PKA_2	210	216	PF00069	0.757
MOD_PKA_2	218	224	PF00069	0.609
MOD_PKA_2	283	289	PF00069	0.616
MOD_PKA_2	298	304	PF00069	0.708
MOD_PKA_2	305	311	PF00069	0.682
MOD_PKA_2	368	374	PF00069	0.620
MOD_PKA_2	380	386	PF00069	0.607
MOD_PKA_2	387	393	PF00069	0.620
MOD_PKA_2	490	496	PF00069	0.559
MOD_PKA_2	520	526	PF00069	0.532
MOD_PKA_2	627	633	PF00069	0.516
MOD_PKA_2	63	69	PF00069	0.769
MOD_PKA_2	706	712	PF00069	0.437
MOD_PKB_1	295	303	PF00069	0.637
MOD_Plk_1	11	17	PF00069	0.551
MOD_Plk_1	168	174	PF00069	0.646
MOD_Plk_1	213	219	PF00069	0.606
MOD_Plk_1	359	365	PF00069	0.645
MOD_Plk_1	550	556	PF00069	0.700
MOD_Plk_1	712	718	PF00069	0.509
MOD_Plk_1	770	776	PF00069	0.598
MOD_Plk_2-3	451	457	PF00069	0.467
MOD_Plk_2-3	541	547	PF00069	0.648
MOD_Plk_4	11	17	PF00069	0.532
MOD_Plk_4	180	186	PF00069	0.700
MOD_Plk_4	463	469	PF00069	0.409
MOD_Plk_4	627	633	PF00069	0.569
MOD_Plk_4	689	695	PF00069	0.363
MOD_Plk_4	700	706	PF00069	0.419
MOD_ProDKin_1	342	348	PF00069	0.625
MOD_ProDKin_1	36	42	PF00069	0.549
MOD_ProDKin_1	401	407	PF00069	0.635
MOD_ProDKin_1	456	462	PF00069	0.504
MOD_ProDKin_1	498	504	PF00069	0.663
MOD_ProDKin_1	505	511	PF00069	0.643
MOD_ProDKin_1	53	59	PF00069	0.671
MOD_SUMO_for_1	28	31	PF00179	0.544
TRG_DiLeu_BaEn_1	249	254	PF01217	0.588
TRG_DiLeu_BaEn_1	822	827	PF01217	0.403
TRG_ENDOCYTIC_2	195	198	PF00928	0.591
TRG_ENDOCYTIC_2	475	478	PF00928	0.372
TRG_ENDOCYTIC_2	487	490	PF00928	0.373
TRG_ENDOCYTIC_2	5	8	PF00928	0.571
TRG_ENDOCYTIC_2	675	678	PF00928	0.458
TRG_ENDOCYTIC_2	690	693	PF00928	0.366
TRG_ENDOCYTIC_2	824	827	PF00928	0.370
TRG_ENDOCYTIC_2	93	96	PF00928	0.479
TRG_ER_diArg_1	115	117	PF00400	0.534
TRG_ER_diArg_1	16	18	PF00400	0.598
TRG_ER_diArg_1	309	312	PF00400	0.742
TRG_ER_diArg_1	73	75	PF00400	0.544
TRG_NES_CRM1_1	94	108	PF08389	0.584
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P794	Leptomonas seymouri	53%	100%
A0A3Q8INY8	Leishmania donovani	92%	100%
A4HPE6	Leishmania braziliensis	80%	100%
A4ICI7	Leishmania infantum	92%	100%
Q4Q1E0	Leishmania major	89%	99%