TP6A_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT55_LEIMU

TriTrypDb:

LmxM.36.2780

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000228	nuclear chromosome	6	1

Expansion

Sequence features

E9AT55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT55

Function

Biological processes
Term	Name	Level	Count
GO:0000706	meiotic DNA double-strand break processing	3	1
GO:0000729	DNA double-strand break processing	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	1
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0061982	meiosis I cell cycle process	3	1
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0003916	DNA topoisomerase activity	3	11
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	11
GO:0005488	binding	1	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016853	isomerase activity	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000166	nucleotide binding	3	5
GO:0005524	ATP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.610
CLV_NRD_NRD_1	71	73	PF00675	0.538
CLV_PCSK_KEX2_1	71	73	PF00082	0.538
CLV_PCSK_SKI1_1	151	155	PF00082	0.584
CLV_PCSK_SKI1_1	183	187	PF00082	0.334
CLV_PCSK_SKI1_1	244	248	PF00082	0.505
CLV_PCSK_SKI1_1	360	364	PF00082	0.424
CLV_PCSK_SKI1_1	448	452	PF00082	0.446
DEG_APCC_DBOX_1	150	158	PF00400	0.339
DEG_APCC_DBOX_1	285	293	PF00400	0.315
DEG_APCC_DBOX_1	442	450	PF00400	0.349
DEG_SCF_FBW7_1	167	172	PF00400	0.367
DEG_SCF_FBW7_1	336	341	PF00400	0.460
DEG_SCF_FBW7_1	421	428	PF00400	0.413
DOC_CKS1_1	335	340	PF01111	0.460
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.455
DOC_MAPK_DCC_7	358	367	PF00069	0.419
DOC_MAPK_gen_1	358	367	PF00069	0.419
DOC_MAPK_gen_1	458	467	PF00069	0.426
DOC_MAPK_MEF2A_6	358	367	PF00069	0.419
DOC_MAPK_NFAT4_5	360	368	PF00069	0.403
DOC_PP2B_LxvP_1	105	108	PF13499	0.463
DOC_PP4_FxxP_1	147	150	PF00568	0.495
DOC_USP7_MATH_1	181	185	PF00917	0.440
DOC_USP7_MATH_1	205	209	PF00917	0.575
DOC_USP7_MATH_1	330	334	PF00917	0.638
DOC_USP7_MATH_1	41	45	PF00917	0.577
DOC_USP7_MATH_1	425	429	PF00917	0.671
DOC_WW_Pin1_4	146	151	PF00397	0.446
DOC_WW_Pin1_4	165	170	PF00397	0.627
DOC_WW_Pin1_4	263	268	PF00397	0.572
DOC_WW_Pin1_4	326	331	PF00397	0.688
DOC_WW_Pin1_4	334	339	PF00397	0.706
DOC_WW_Pin1_4	347	352	PF00397	0.583
DOC_WW_Pin1_4	37	42	PF00397	0.617
DOC_WW_Pin1_4	421	426	PF00397	0.433
DOC_WW_Pin1_4	73	78	PF00397	0.628
LIG_14-3-3_CanoR_1	112	118	PF00244	0.391
LIG_14-3-3_CanoR_1	443	447	PF00244	0.387
LIG_14-3-3_CanoR_1	47	54	PF00244	0.462
LIG_BIR_II_1	1	5	PF00653	0.772
LIG_CaM_IQ_9	404	420	PF13499	0.425
LIG_Clathr_ClatBox_1	245	249	PF01394	0.344
LIG_EH1_1	57	65	PF00400	0.402
LIG_eIF4E_1	100	106	PF01652	0.375
LIG_FHA_1	162	168	PF00498	0.445
LIG_FHA_1	189	195	PF00498	0.385
LIG_FHA_1	212	218	PF00498	0.407
LIG_FHA_1	335	341	PF00498	0.467
LIG_FHA_1	354	360	PF00498	0.457
LIG_FHA_1	55	61	PF00498	0.399
LIG_FHA_2	19	25	PF00498	0.228
LIG_FHA_2	4	10	PF00498	0.689
LIG_FHA_2	401	407	PF00498	0.360
LIG_FHA_2	474	480	PF00498	0.375
LIG_FHA_2	92	98	PF00498	0.346
LIG_GBD_Chelix_1	186	194	PF00786	0.447
LIG_LIR_Apic_2	144	150	PF02991	0.445
LIG_LIR_Apic_2	324	330	PF02991	0.560
LIG_LIR_Apic_2	97	103	PF02991	0.469
LIG_LIR_Gen_1	269	275	PF02991	0.415
LIG_LIR_Gen_1	341	351	PF02991	0.523
LIG_LIR_Nem_3	240	246	PF02991	0.527
LIG_LIR_Nem_3	269	273	PF02991	0.435
LIG_LIR_Nem_3	277	283	PF02991	0.457
LIG_LIR_Nem_3	341	346	PF02991	0.601
LIG_LIR_Nem_3	57	61	PF02991	0.455
LIG_LIR_Nem_3	75	81	PF02991	0.631
LIG_LYPXL_yS_3	280	283	PF13949	0.459
LIG_Pex14_1	376	380	PF04695	0.452
LIG_Pex14_2	30	34	PF04695	0.439
LIG_SH2_CRK	100	104	PF00017	0.491
LIG_SH2_CRK	243	247	PF00017	0.472
LIG_SH2_CRK	270	274	PF00017	0.523
LIG_SH2_NCK_1	215	219	PF00017	0.453
LIG_SH2_PTP2	302	305	PF00017	0.367
LIG_SH2_STAP1	215	219	PF00017	0.296
LIG_SH2_STAP1	270	274	PF00017	0.354
LIG_SH2_STAT3	15	18	PF00017	0.493
LIG_SH2_STAT3	59	62	PF00017	0.476
LIG_SH2_STAT5	171	174	PF00017	0.367
LIG_SH2_STAT5	302	305	PF00017	0.367
LIG_SH2_STAT5	59	62	PF00017	0.405
LIG_SH3_3	468	474	PF00018	0.407
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.471
LIG_SUMO_SIM_par_1	190	196	PF11976	0.408
LIG_SUMO_SIM_par_1	199	204	PF11976	0.341
LIG_SUMO_SIM_par_1	244	249	PF11976	0.307
LIG_UBA3_1	153	159	PF00899	0.382
LIG_WRC_WIRS_1	340	345	PF05994	0.600
MOD_CDC14_SPxK_1	40	43	PF00782	0.561
MOD_CDK_SPK_2	146	151	PF00069	0.446
MOD_CDK_SPxK_1	37	43	PF00069	0.538
MOD_CK1_1	2	8	PF00069	0.581
MOD_CK1_1	209	215	PF00069	0.474
MOD_CK1_1	266	272	PF00069	0.301
MOD_CK1_1	334	340	PF00069	0.577
MOD_CK1_1	341	347	PF00069	0.640
MOD_CK1_1	353	359	PF00069	0.416
MOD_CK1_1	420	426	PF00069	0.401
MOD_CK2_1	18	24	PF00069	0.380
MOD_CK2_1	473	479	PF00069	0.417
MOD_GlcNHglycan	202	206	PF01048	0.478
MOD_GlcNHglycan	208	211	PF01048	0.364
MOD_GlcNHglycan	263	266	PF01048	0.505
MOD_GlcNHglycan	346	349	PF01048	0.680
MOD_GlcNHglycan	352	355	PF01048	0.596
MOD_GlcNHglycan	386	389	PF01048	0.598
MOD_GlcNHglycan	429	432	PF01048	0.642
MOD_GlcNHglycan	43	46	PF01048	0.543
MOD_GlcNHglycan	66	69	PF01048	0.586
MOD_GSK3_1	142	149	PF00069	0.568
MOD_GSK3_1	161	168	PF00069	0.666
MOD_GSK3_1	172	179	PF00069	0.428
MOD_GSK3_1	201	208	PF00069	0.482
MOD_GSK3_1	209	216	PF00069	0.482
MOD_GSK3_1	235	242	PF00069	0.531
MOD_GSK3_1	257	264	PF00069	0.420
MOD_GSK3_1	326	333	PF00069	0.629
MOD_GSK3_1	334	341	PF00069	0.558
MOD_GSK3_1	37	44	PF00069	0.578
MOD_GSK3_1	417	424	PF00069	0.517
MOD_GSK3_1	76	83	PF00069	0.630
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	176	181	PF00069	0.509
MOD_NEK2_1	213	218	PF00069	0.357
MOD_NEK2_1	239	244	PF00069	0.356
MOD_NEK2_1	274	279	PF00069	0.291
MOD_NEK2_1	394	399	PF00069	0.622
MOD_NEK2_1	80	85	PF00069	0.549
MOD_PIKK_1	331	337	PF00454	0.640
MOD_PIKK_1	394	400	PF00454	0.580
MOD_PK_1	412	418	PF00069	0.372
MOD_PKA_2	111	117	PF00069	0.446
MOD_PKA_2	172	178	PF00069	0.450
MOD_PKA_2	205	211	PF00069	0.468
MOD_PKA_2	442	448	PF00069	0.336
MOD_PKA_2	46	52	PF00069	0.482
MOD_Plk_1	382	388	PF00069	0.403
MOD_Plk_2-3	91	97	PF00069	0.413
MOD_Plk_4	142	148	PF00069	0.568
MOD_Plk_4	181	187	PF00069	0.358
MOD_Plk_4	314	320	PF00069	0.331
MOD_Plk_4	370	376	PF00069	0.501
MOD_Plk_4	412	418	PF00069	0.457
MOD_Plk_4	436	442	PF00069	0.329
MOD_Plk_4	473	479	PF00069	0.417
MOD_Plk_4	54	60	PF00069	0.464
MOD_Plk_4	76	82	PF00069	0.587
MOD_ProDKin_1	146	152	PF00069	0.450
MOD_ProDKin_1	165	171	PF00069	0.609
MOD_ProDKin_1	263	269	PF00069	0.577
MOD_ProDKin_1	326	332	PF00069	0.691
MOD_ProDKin_1	334	340	PF00069	0.707
MOD_ProDKin_1	347	353	PF00069	0.581
MOD_ProDKin_1	37	43	PF00069	0.624
MOD_ProDKin_1	421	427	PF00069	0.443
MOD_ProDKin_1	73	79	PF00069	0.630
MOD_SUMO_for_1	461	464	PF00179	0.458
TRG_DiLeu_BaEn_1	24	29	PF01217	0.447
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.402
TRG_ENDOCYTIC_2	243	246	PF00928	0.476
TRG_ENDOCYTIC_2	270	273	PF00928	0.543
TRG_ENDOCYTIC_2	280	283	PF00928	0.410
TRG_ENDOCYTIC_2	302	305	PF00928	0.417
TRG_ENDOCYTIC_2	78	81	PF00928	0.634
TRG_ER_diArg_1	458	461	PF00400	0.533
TRG_ER_diArg_1	70	72	PF00400	0.471
TRG_NES_CRM1_1	17	33	PF08389	0.429
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M4	Leptomonas seymouri	41%	100%
A0A1X0NL58	Trypanosomatidae	30%	100%
A0A3R7LIJ3	Trypanosoma rangeli	31%	100%
A0A3S7XAZ9	Leishmania donovani	89%	100%
A4HPE4	Leishmania braziliensis	77%	100%
A4ICI5	Leishmania infantum	89%	92%
D0A3F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q1E2	Leishmania major	85%	100%
V5BPV6	Trypanosoma cruzi	30%	100%