Serine/arginine repetitive matrix protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT54_LEIMU

TriTrypDb:

LmxM.36.2770

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.876
CLV_C14_Caspase3-7	346	350	PF00656	0.645
CLV_C14_Caspase3-7	386	390	PF00656	0.674
CLV_C14_Caspase3-7	494	498	PF00656	0.681
CLV_C14_Caspase3-7	531	535	PF00656	0.655
CLV_C14_Caspase3-7	615	619	PF00656	0.686
CLV_NRD_NRD_1	119	121	PF00675	0.586
CLV_NRD_NRD_1	129	131	PF00675	0.709
CLV_NRD_NRD_1	136	138	PF00675	0.600
CLV_NRD_NRD_1	166	168	PF00675	0.875
CLV_NRD_NRD_1	178	180	PF00675	0.686
CLV_NRD_NRD_1	181	183	PF00675	0.620
CLV_NRD_NRD_1	20	22	PF00675	0.775
CLV_NRD_NRD_1	224	226	PF00675	0.800
CLV_NRD_NRD_1	230	232	PF00675	0.720
CLV_NRD_NRD_1	250	252	PF00675	0.705
CLV_NRD_NRD_1	298	300	PF00675	0.860
CLV_NRD_NRD_1	317	319	PF00675	0.622
CLV_NRD_NRD_1	340	342	PF00675	0.766
CLV_NRD_NRD_1	356	358	PF00675	0.554
CLV_NRD_NRD_1	430	432	PF00675	0.853
CLV_NRD_NRD_1	49	51	PF00675	0.698
CLV_NRD_NRD_1	491	493	PF00675	0.758
CLV_NRD_NRD_1	61	63	PF00675	0.659
CLV_NRD_NRD_1	695	697	PF00675	0.613
CLV_NRD_NRD_1	700	702	PF00675	0.647
CLV_NRD_NRD_1	90	92	PF00675	0.876
CLV_PCSK_FUR_1	179	183	PF00082	0.796
CLV_PCSK_FUR_1	296	300	PF00082	0.797
CLV_PCSK_FUR_1	338	342	PF00082	0.575
CLV_PCSK_FUR_1	560	564	PF00082	0.687
CLV_PCSK_KEX2_1	119	121	PF00082	0.877
CLV_PCSK_KEX2_1	128	130	PF00082	0.732
CLV_PCSK_KEX2_1	135	137	PF00082	0.616
CLV_PCSK_KEX2_1	161	163	PF00082	0.847
CLV_PCSK_KEX2_1	166	168	PF00082	0.811
CLV_PCSK_KEX2_1	178	180	PF00082	0.623
CLV_PCSK_KEX2_1	181	183	PF00082	0.556
CLV_PCSK_KEX2_1	19	21	PF00082	0.783
CLV_PCSK_KEX2_1	224	226	PF00082	0.800
CLV_PCSK_KEX2_1	250	252	PF00082	0.744
CLV_PCSK_KEX2_1	289	291	PF00082	0.833
CLV_PCSK_KEX2_1	298	300	PF00082	0.746
CLV_PCSK_KEX2_1	317	319	PF00082	0.622
CLV_PCSK_KEX2_1	338	340	PF00082	0.855
CLV_PCSK_KEX2_1	356	358	PF00082	0.547
CLV_PCSK_KEX2_1	430	432	PF00082	0.853
CLV_PCSK_KEX2_1	562	564	PF00082	0.814
CLV_PCSK_KEX2_1	700	702	PF00082	0.657
CLV_PCSK_KEX2_1	90	92	PF00082	0.876
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.789
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.778
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.864
CLV_PCSK_PC7_1	115	121	PF00082	0.690
CLV_PCSK_PC7_1	15	21	PF00082	0.580
CLV_PCSK_PC7_1	162	168	PF00082	0.783
CLV_PCSK_PC7_1	696	702	PF00082	0.484
CLV_PCSK_SKI1_1	290	294	PF00082	0.777
CLV_PCSK_SKI1_1	705	709	PF00082	0.498
CLV_PCSK_SKI1_1	711	715	PF00082	0.485
DEG_APCC_DBOX_1	456	464	PF00400	0.669
DEG_APCC_DBOX_1	61	69	PF00400	0.769
DEG_SPOP_SBC_1	122	126	PF00917	0.673
DEG_SPOP_SBC_1	14	18	PF00917	0.827
DEG_SPOP_SBC_1	169	173	PF00917	0.875
DEG_SPOP_SBC_1	226	230	PF00917	0.775
DEG_SPOP_SBC_1	541	545	PF00917	0.561
DOC_CKS1_1	574	579	PF01111	0.621
DOC_CKS1_1	581	586	PF01111	0.619
DOC_CYCLIN_RxL_1	705	717	PF00134	0.539
DOC_MAPK_gen_1	394	404	PF00069	0.761
DOC_MAPK_gen_1	705	715	PF00069	0.359
DOC_PP2B_LxvP_1	578	581	PF13499	0.574
DOC_USP7_MATH_1	121	125	PF00917	0.750
DOC_USP7_MATH_1	14	18	PF00917	0.827
DOC_USP7_MATH_1	165	169	PF00917	0.860
DOC_USP7_MATH_1	177	181	PF00917	0.672
DOC_USP7_MATH_1	209	213	PF00917	0.864
DOC_USP7_MATH_1	227	231	PF00917	0.565
DOC_USP7_MATH_1	242	246	PF00917	0.680
DOC_USP7_MATH_1	294	298	PF00917	0.788
DOC_USP7_MATH_1	305	309	PF00917	0.672
DOC_USP7_MATH_1	322	326	PF00917	0.742
DOC_USP7_MATH_1	541	545	PF00917	0.841
DOC_USP7_MATH_1	738	742	PF00917	0.685
DOC_USP7_UBL2_3	464	468	PF12436	0.750
DOC_WW_Pin1_4	123	128	PF00397	0.842
DOC_WW_Pin1_4	129	134	PF00397	0.794
DOC_WW_Pin1_4	161	166	PF00397	0.856
DOC_WW_Pin1_4	173	178	PF00397	0.671
DOC_WW_Pin1_4	194	199	PF00397	0.860
DOC_WW_Pin1_4	205	210	PF00397	0.682
DOC_WW_Pin1_4	215	220	PF00397	0.697
DOC_WW_Pin1_4	290	295	PF00397	0.807
DOC_WW_Pin1_4	312	317	PF00397	0.866
DOC_WW_Pin1_4	344	349	PF00397	0.853
DOC_WW_Pin1_4	36	41	PF00397	0.702
DOC_WW_Pin1_4	44	49	PF00397	0.768
DOC_WW_Pin1_4	440	445	PF00397	0.626
DOC_WW_Pin1_4	507	512	PF00397	0.609
DOC_WW_Pin1_4	573	578	PF00397	0.617
DOC_WW_Pin1_4	580	585	PF00397	0.710
DOC_WW_Pin1_4	99	104	PF00397	0.789
LIG_14-3-3_CanoR_1	128	133	PF00244	0.853
LIG_14-3-3_CanoR_1	141	147	PF00244	0.638
LIG_14-3-3_CanoR_1	15	23	PF00244	0.729
LIG_14-3-3_CanoR_1	167	177	PF00244	0.871
LIG_14-3-3_CanoR_1	203	209	PF00244	0.837
LIG_14-3-3_CanoR_1	225	233	PF00244	0.732
LIG_14-3-3_CanoR_1	234	240	PF00244	0.812
LIG_14-3-3_CanoR_1	277	286	PF00244	0.861
LIG_14-3-3_CanoR_1	341	351	PF00244	0.783
LIG_14-3-3_CanoR_1	357	367	PF00244	0.656
LIG_14-3-3_CanoR_1	44	48	PF00244	0.740
LIG_14-3-3_CanoR_1	488	495	PF00244	0.791
LIG_14-3-3_CanoR_1	5	14	PF00244	0.827
LIG_14-3-3_CanoR_1	520	529	PF00244	0.604
LIG_14-3-3_CanoR_1	550	558	PF00244	0.721
LIG_14-3-3_CanoR_1	563	571	PF00244	0.711
LIG_14-3-3_CanoR_1	62	72	PF00244	0.686
LIG_14-3-3_CanoR_1	90	96	PF00244	0.832
LIG_14-3-3_CanoR_1	98	103	PF00244	0.773
LIG_Actin_WH2_2	632	650	PF00022	0.673
LIG_AP_GAE_1	656	662	PF02883	0.695
LIG_BIR_II_1	1	5	PF00653	0.869
LIG_BRCT_BRCA1_1	740	744	PF00533	0.503
LIG_FHA_1	150	156	PF00498	0.796
LIG_FHA_1	573	579	PF00498	0.579
LIG_FHA_1	623	629	PF00498	0.542
LIG_FHA_2	169	175	PF00498	0.876
LIG_FHA_2	541	547	PF00498	0.568
LIG_LIR_Apic_2	25	31	PF02991	0.851
LIG_LIR_Apic_2	369	375	PF02991	0.798
LIG_LIR_Gen_1	612	617	PF02991	0.664
LIG_LIR_Gen_1	656	664	PF02991	0.696
LIG_LIR_LC3C_4	690	693	PF02991	0.614
LIG_LIR_Nem_3	145	150	PF02991	0.762
LIG_LIR_Nem_3	361	367	PF02991	0.761
LIG_LIR_Nem_3	607	611	PF02991	0.636
LIG_LIR_Nem_3	612	616	PF02991	0.626
LIG_LIR_Nem_3	656	662	PF02991	0.630
LIG_LYPXL_S_1	146	150	PF13949	0.759
LIG_LYPXL_yS_3	147	150	PF13949	0.755
LIG_LYPXL_yS_3	608	611	PF13949	0.546
LIG_NRBOX	709	715	PF00104	0.652
LIG_SH2_CRK	191	195	PF00017	0.791
LIG_SH2_CRK	372	376	PF00017	0.723
LIG_SH2_NCK_1	372	376	PF00017	0.723
LIG_SH2_PTP2	28	31	PF00017	0.560
LIG_SH2_STAT3	243	246	PF00017	0.579
LIG_SH2_STAT5	28	31	PF00017	0.560
LIG_SH2_STAT5	383	386	PF00017	0.741
LIG_SH2_STAT5	75	78	PF00017	0.760
LIG_SH3_2	219	224	PF14604	0.859
LIG_SH3_3	216	222	PF00018	0.863
LIG_SH3_3	436	442	PF00018	0.643
LIG_SH3_3	552	558	PF00018	0.787
LIG_SH3_3	571	577	PF00018	0.609
LIG_SH3_3	578	584	PF00018	0.715
LIG_SH3_3	740	746	PF00018	0.784
LIG_SH3_CIN85_PxpxPR_1	577	582	PF14604	0.787
LIG_SUMO_SIM_anti_2	400	406	PF11976	0.848
LIG_SUMO_SIM_anti_2	640	648	PF11976	0.565
LIG_SUMO_SIM_anti_2	690	695	PF11976	0.689
LIG_SUMO_SIM_par_1	151	159	PF11976	0.833
LIG_SUMO_SIM_par_1	403	409	PF11976	0.847
LIG_SUMO_SIM_par_1	437	443	PF11976	0.792
LIG_TRAF2_1	601	604	PF00917	0.714
LIG_TRAF2_2	475	480	PF00917	0.497
LIG_TYR_ITIM	189	194	PF00017	0.696
LIG_TYR_ITIM	606	611	PF00017	0.555
LIG_WRC_WIRS_1	610	615	PF05994	0.679
LIG_WW_3	95	99	PF00397	0.862
MOD_CDC14_SPxK_1	126	129	PF00782	0.791
MOD_CDC14_SPxK_1	164	167	PF00782	0.855
MOD_CDC14_SPxK_1	208	211	PF00782	0.864
MOD_CDC14_SPxK_1	315	318	PF00782	0.861
MOD_CDC14_SPxK_1	47	50	PF00782	0.572
MOD_CDK_SPK_2	123	128	PF00069	0.788
MOD_CDK_SPK_2	161	166	PF00069	0.856
MOD_CDK_SPK_2	173	178	PF00069	0.671
MOD_CDK_SPK_2	312	317	PF00069	0.866
MOD_CDK_SPK_2	440	445	PF00069	0.626
MOD_CDK_SPxK_1	123	129	PF00069	0.843
MOD_CDK_SPxK_1	161	167	PF00069	0.860
MOD_CDK_SPxK_1	173	179	PF00069	0.673
MOD_CDK_SPxK_1	205	211	PF00069	0.867
MOD_CDK_SPxK_1	290	296	PF00069	0.862
MOD_CDK_SPxK_1	312	318	PF00069	0.866
MOD_CDK_SPxK_1	44	50	PF00069	0.573
MOD_CDK_SPxxK_3	123	130	PF00069	0.846
MOD_CDK_SPxxK_3	44	51	PF00069	0.788
MOD_CK1_1	101	107	PF00069	0.864
MOD_CK1_1	168	174	PF00069	0.875
MOD_CK1_1	205	211	PF00069	0.867
MOD_CK1_1	245	251	PF00069	0.703
MOD_CK1_1	255	261	PF00069	0.723
MOD_CK1_1	325	331	PF00069	0.873
MOD_CK1_1	390	396	PF00069	0.788
MOD_CK1_1	406	412	PF00069	0.646
MOD_CK1_1	421	427	PF00069	0.599
MOD_CK1_1	484	490	PF00069	0.598
MOD_CK1_1	512	518	PF00069	0.852
MOD_CK1_1	56	62	PF00069	0.576
MOD_CK1_1	597	603	PF00069	0.614
MOD_CK1_1	612	618	PF00069	0.674
MOD_CK1_1	624	630	PF00069	0.405
MOD_CK1_1	66	72	PF00069	0.682
MOD_CK2_1	325	331	PF00069	0.873
MOD_CK2_1	347	353	PF00069	0.864
MOD_CK2_1	397	403	PF00069	0.848
MOD_CK2_1	597	603	PF00069	0.789
MOD_CK2_1	726	732	PF00069	0.549
MOD_Cter_Amidation	159	162	PF01082	0.781
MOD_DYRK1A_RPxSP_1	573	577	PF00069	0.616
MOD_GlcNHglycan	1	4	PF01048	0.789
MOD_GlcNHglycan	167	170	PF01048	0.876
MOD_GlcNHglycan	247	250	PF01048	0.583
MOD_GlcNHglycan	307	310	PF01048	0.867
MOD_GlcNHglycan	320	323	PF01048	0.650
MOD_GlcNHglycan	385	388	PF01048	0.810
MOD_GlcNHglycan	397	400	PF01048	0.698
MOD_GlcNHglycan	408	411	PF01048	0.665
MOD_GlcNHglycan	489	492	PF01048	0.786
MOD_GlcNHglycan	503	506	PF01048	0.594
MOD_GlcNHglycan	56	59	PF01048	0.859
MOD_GlcNHglycan	591	594	PF01048	0.513
MOD_GSK3_1	161	168	PF00069	0.845
MOD_GSK3_1	169	176	PF00069	0.728
MOD_GSK3_1	190	197	PF00069	0.870
MOD_GSK3_1	205	212	PF00069	0.617
MOD_GSK3_1	241	248	PF00069	0.710
MOD_GSK3_1	252	259	PF00069	0.685
MOD_GSK3_1	290	297	PF00069	0.793
MOD_GSK3_1	318	325	PF00069	0.868
MOD_GSK3_1	329	336	PF00069	0.686
MOD_GSK3_1	343	350	PF00069	0.632
MOD_GSK3_1	379	386	PF00069	0.772
MOD_GSK3_1	418	425	PF00069	0.766
MOD_GSK3_1	497	504	PF00069	0.782
MOD_GSK3_1	512	519	PF00069	0.595
MOD_GSK3_1	52	59	PF00069	0.583
MOD_GSK3_1	594	601	PF00069	0.724
MOD_GSK3_1	618	625	PF00069	0.560
MOD_GSK3_1	679	686	PF00069	0.716
MOD_LATS_1	134	140	PF00433	0.842
MOD_LATS_1	201	207	PF00433	0.574
MOD_LATS_1	518	524	PF00433	0.861
MOD_N-GLC_1	598	603	PF02516	0.515
MOD_NEK2_1	378	383	PF00069	0.772
MOD_NEK2_1	594	599	PF00069	0.645
MOD_NEK2_1	622	627	PF00069	0.580
MOD_NEK2_1	635	640	PF00069	0.438
MOD_PIKK_1	242	248	PF00454	0.831
MOD_PIKK_1	5	11	PF00454	0.788
MOD_PIKK_1	564	570	PF00454	0.783
MOD_PIKK_1	57	63	PF00454	0.561
MOD_PIKK_1	726	732	PF00454	0.568
MOD_PIKK_1	91	97	PF00454	0.866
MOD_PKA_1	128	134	PF00069	0.845
MOD_PKA_1	135	141	PF00069	0.780
MOD_PKA_1	298	304	PF00069	0.799
MOD_PKA_1	317	323	PF00069	0.549
MOD_PKA_1	90	96	PF00069	0.871
MOD_PKA_2	128	134	PF00069	0.845
MOD_PKA_2	135	141	PF00069	0.780
MOD_PKA_2	14	20	PF00069	0.705
MOD_PKA_2	165	171	PF00069	0.866
MOD_PKA_2	177	183	PF00069	0.670
MOD_PKA_2	202	208	PF00069	0.796
MOD_PKA_2	213	219	PF00069	0.686
MOD_PKA_2	252	258	PF00069	0.739
MOD_PKA_2	278	284	PF00069	0.851
MOD_PKA_2	298	304	PF00069	0.608
MOD_PKA_2	317	323	PF00069	0.595
MOD_PKA_2	325	331	PF00069	0.772
MOD_PKA_2	34	40	PF00069	0.807
MOD_PKA_2	343	349	PF00069	0.566
MOD_PKA_2	358	364	PF00069	0.667
MOD_PKA_2	4	10	PF00069	0.863
MOD_PKA_2	43	49	PF00069	0.725
MOD_PKA_2	484	490	PF00069	0.762
MOD_PKA_2	495	501	PF00069	0.630
MOD_PKA_2	516	522	PF00069	0.773
MOD_PKA_2	53	59	PF00069	0.563
MOD_PKA_2	549	555	PF00069	0.770
MOD_PKA_2	564	570	PF00069	0.720
MOD_PKA_2	572	578	PF00069	0.708
MOD_PKA_2	90	96	PF00069	0.871
MOD_PKB_1	11	19	PF00069	0.791
MOD_PKB_1	135	143	PF00069	0.789
MOD_PKB_1	296	304	PF00069	0.799
MOD_PKB_1	357	365	PF00069	0.652
MOD_PKB_1	507	515	PF00069	0.846
MOD_Plk_2-3	618	624	PF00069	0.700
MOD_Plk_2-3	637	643	PF00069	0.354
MOD_Plk_4	142	148	PF00069	0.768
MOD_Plk_4	359	365	PF00069	0.766
MOD_Plk_4	379	385	PF00069	0.601
MOD_Plk_4	609	615	PF00069	0.612
MOD_Plk_4	739	745	PF00069	0.594
MOD_ProDKin_1	123	129	PF00069	0.843
MOD_ProDKin_1	161	167	PF00069	0.860
MOD_ProDKin_1	173	179	PF00069	0.673
MOD_ProDKin_1	194	200	PF00069	0.854
MOD_ProDKin_1	205	211	PF00069	0.685
MOD_ProDKin_1	215	221	PF00069	0.695
MOD_ProDKin_1	290	296	PF00069	0.811
MOD_ProDKin_1	312	318	PF00069	0.866
MOD_ProDKin_1	344	350	PF00069	0.853
MOD_ProDKin_1	36	42	PF00069	0.701
MOD_ProDKin_1	44	50	PF00069	0.771
MOD_ProDKin_1	440	446	PF00069	0.619
MOD_ProDKin_1	507	513	PF00069	0.610
MOD_ProDKin_1	573	579	PF00069	0.617
MOD_ProDKin_1	580	586	PF00069	0.706
MOD_ProDKin_1	99	105	PF00069	0.791
MOD_SUMO_for_1	467	470	PF00179	0.696
TRG_ENDOCYTIC_2	147	150	PF00928	0.755
TRG_ENDOCYTIC_2	191	194	PF00928	0.796
TRG_ENDOCYTIC_2	608	611	PF00928	0.539
TRG_ER_diArg_1	127	130	PF00400	0.794
TRG_ER_diArg_1	135	137	PF00400	0.701
TRG_ER_diArg_1	165	167	PF00400	0.854
TRG_ER_diArg_1	177	179	PF00400	0.668
TRG_ER_diArg_1	19	21	PF00400	0.870
TRG_ER_diArg_1	250	253	PF00400	0.736
TRG_ER_diArg_1	296	299	PF00400	0.868
TRG_ER_diArg_1	316	318	PF00400	0.607
TRG_ER_diArg_1	338	341	PF00400	0.789
TRG_ER_diArg_1	356	359	PF00400	0.548
TRG_ER_diArg_1	429	431	PF00400	0.779
TRG_ER_diArg_1	506	509	PF00400	0.640
TRG_ER_diArg_1	699	701	PF00400	0.661
TRG_ER_diArg_1	89	91	PF00400	0.874
TRG_ER_diArg_1	97	100	PF00400	0.732
TRG_NLS_MonoCore_2	230	235	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XB19	Leishmania donovani	86%	100%
A4HPE3	Leishmania braziliensis	66%	100%
A4ICI4	Leishmania infantum	86%	100%
Q4Q1E3	Leishmania major	83%	100%