LeishMANIAdb
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Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
Nodulin-like, putative
Species:
Leishmania mexicana
UniProt:
E9AT53_LEIMU
TriTrypDb:
LmxM.36.2760
Length:
592

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 122
NetGPI no yes: 0, no: 122
Cellular components
Term Name Level Count
GO:0016020 membrane 2 115
GO:0110165 cellular anatomical entity 1 115
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

E9AT53
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT53

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 55
GO:0022857 transmembrane transporter activity 2 55

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 248 250 PF00675 0.271
CLV_NRD_NRD_1 339 341 PF00675 0.436
CLV_NRD_NRD_1 443 445 PF00675 0.360
CLV_NRD_NRD_1 584 586 PF00675 0.328
CLV_PCSK_KEX2_1 248 250 PF00082 0.265
CLV_PCSK_KEX2_1 30 32 PF00082 0.284
CLV_PCSK_PC1ET2_1 30 32 PF00082 0.322
CLV_PCSK_SKI1_1 166 170 PF00082 0.379
CLV_PCSK_SKI1_1 181 185 PF00082 0.498
CLV_PCSK_SKI1_1 444 448 PF00082 0.361
CLV_PCSK_SKI1_1 524 528 PF00082 0.317
CLV_PCSK_SKI1_1 585 589 PF00082 0.361
DEG_APCC_DBOX_1 443 451 PF00400 0.551
DEG_Nend_Nbox_1 1 3 PF02207 0.699
DOC_ANK_TNKS_1 157 164 PF00023 0.549
DOC_CDC14_PxL_1 93 101 PF14671 0.479
DOC_CKS1_1 552 557 PF01111 0.384
DOC_CYCLIN_RxL_1 521 530 PF00134 0.308
DOC_CYCLIN_yCln2_LP_2 474 480 PF00134 0.248
DOC_MAPK_gen_1 30 40 PF00069 0.454
DOC_MAPK_gen_1 340 347 PF00069 0.490
DOC_MAPK_gen_1 442 452 PF00069 0.511
DOC_MAPK_MEF2A_6 156 164 PF00069 0.468
DOC_MAPK_MEF2A_6 31 40 PF00069 0.486
DOC_MAPK_MEF2A_6 370 377 PF00069 0.521
DOC_MAPK_MEF2A_6 442 450 PF00069 0.528
DOC_PP1_RVXF_1 490 497 PF00149 0.393
DOC_PP2B_LxvP_1 300 303 PF13499 0.291
DOC_PP2B_LxvP_1 467 470 PF13499 0.413
DOC_PP2B_LxvP_1 474 477 PF13499 0.265
DOC_PP2B_PxIxI_1 476 482 PF00149 0.351
DOC_PP2B_PxIxI_1 554 560 PF00149 0.383
DOC_PP4_FxxP_1 82 85 PF00568 0.311
DOC_USP7_MATH_1 232 236 PF00917 0.483
DOC_USP7_UBL2_3 533 537 PF12436 0.409
DOC_WW_Pin1_4 551 556 PF00397 0.409
LIG_14-3-3_CanoR_1 223 230 PF00244 0.478
LIG_14-3-3_CanoR_1 316 320 PF00244 0.642
LIG_14-3-3_CanoR_1 340 345 PF00244 0.629
LIG_14-3-3_CanoR_1 404 413 PF00244 0.369
LIG_14-3-3_CanoR_1 426 430 PF00244 0.304
LIG_14-3-3_CanoR_1 61 69 PF00244 0.337
LIG_Actin_RPEL_3 271 290 PF02755 0.156
LIG_Actin_WH2_2 232 250 PF00022 0.551
LIG_Actin_WH2_2 561 578 PF00022 0.373
LIG_AP2alpha_1 54 58 PF02296 0.264
LIG_APCC_ABBA_1 479 484 PF00400 0.338
LIG_APCC_ABBA_1 51 56 PF00400 0.357
LIG_BRCT_BRCA1_1 138 142 PF00533 0.419
LIG_BRCT_BRCA1_1 45 49 PF00533 0.318
LIG_BRCT_BRCA1_1 54 58 PF00533 0.265
LIG_Clathr_ClatBox_1 344 348 PF01394 0.688
LIG_Clathr_ClatBox_1 480 484 PF01394 0.374
LIG_deltaCOP1_diTrp_1 372 380 PF00928 0.503
LIG_FHA_1 10 16 PF00498 0.565
LIG_FHA_1 123 129 PF00498 0.300
LIG_FHA_1 183 189 PF00498 0.217
LIG_FHA_1 197 203 PF00498 0.374
LIG_FHA_1 265 271 PF00498 0.332
LIG_FHA_1 286 292 PF00498 0.369
LIG_FHA_1 328 334 PF00498 0.747
LIG_FHA_1 394 400 PF00498 0.322
LIG_FHA_1 405 411 PF00498 0.348
LIG_FHA_1 413 419 PF00498 0.329
LIG_FHA_1 447 453 PF00498 0.462
LIG_FHA_1 512 518 PF00498 0.302
LIG_FHA_1 552 558 PF00498 0.305
LIG_FHA_1 72 78 PF00498 0.341
LIG_FHA_2 147 153 PF00498 0.351
LIG_FHA_2 316 322 PF00498 0.634
LIG_FHA_2 361 367 PF00498 0.555
LIG_GBD_Chelix_1 200 208 PF00786 0.431
LIG_GBD_Chelix_1 461 469 PF00786 0.218
LIG_LIR_Gen_1 189 198 PF02991 0.284
LIG_LIR_Gen_1 363 373 PF02991 0.509
LIG_LIR_Gen_1 412 420 PF02991 0.293
LIG_LIR_Gen_1 511 520 PF02991 0.291
LIG_LIR_Gen_1 562 573 PF02991 0.331
LIG_LIR_Nem_3 129 134 PF02991 0.337
LIG_LIR_Nem_3 189 194 PF02991 0.263
LIG_LIR_Nem_3 363 368 PF02991 0.526
LIG_LIR_Nem_3 372 377 PF02991 0.463
LIG_LIR_Nem_3 412 417 PF02991 0.327
LIG_LIR_Nem_3 485 491 PF02991 0.382
LIG_LIR_Nem_3 511 516 PF02991 0.256
LIG_LIR_Nem_3 562 568 PF02991 0.340
LIG_MAD2 445 453 PF02301 0.571
LIG_Pex14_2 216 220 PF04695 0.402
LIG_Pex14_2 496 500 PF04695 0.534
LIG_Pex14_2 5 9 PF04695 0.636
LIG_Pex14_2 54 58 PF04695 0.316
LIG_PTB_Apo_2 506 513 PF02174 0.520
LIG_SH2_CRK 252 256 PF00017 0.374
LIG_SH2_CRK 273 277 PF00017 0.310
LIG_SH2_CRK 414 418 PF00017 0.371
LIG_SH2_CRK 86 90 PF00017 0.308
LIG_SH2_NCK_1 273 277 PF00017 0.310
LIG_SH2_NCK_1 90 94 PF00017 0.371
LIG_SH2_PTP2 254 257 PF00017 0.298
LIG_SH2_PTP2 478 481 PF00017 0.323
LIG_SH2_SRC 254 257 PF00017 0.320
LIG_SH2_SRC 90 93 PF00017 0.527
LIG_SH2_STAP1 240 244 PF00017 0.565
LIG_SH2_STAP1 414 418 PF00017 0.358
LIG_SH2_STAP1 577 581 PF00017 0.534
LIG_SH2_STAT5 14 17 PF00017 0.617
LIG_SH2_STAT5 193 196 PF00017 0.310
LIG_SH2_STAT5 215 218 PF00017 0.458
LIG_SH2_STAT5 254 257 PF00017 0.352
LIG_SH2_STAT5 273 276 PF00017 0.259
LIG_SH2_STAT5 398 401 PF00017 0.292
LIG_SH2_STAT5 414 417 PF00017 0.263
LIG_SH2_STAT5 435 438 PF00017 0.537
LIG_SH2_STAT5 478 481 PF00017 0.306
LIG_SH2_STAT5 482 485 PF00017 0.307
LIG_SH2_STAT5 81 84 PF00017 0.310
LIG_SH3_3 305 311 PF00018 0.583
LIG_SH3_3 352 358 PF00018 0.544
LIG_SH3_3 450 456 PF00018 0.296
LIG_SH3_3 549 555 PF00018 0.310
LIG_Sin3_3 258 265 PF02671 0.434
LIG_SUMO_SIM_anti_2 146 152 PF11976 0.357
LIG_SUMO_SIM_anti_2 554 560 PF11976 0.368
LIG_SUMO_SIM_par_1 146 152 PF11976 0.240
LIG_SUMO_SIM_par_1 193 199 PF11976 0.354
LIG_SUMO_SIM_par_1 554 560 PF11976 0.315
LIG_TYR_ITIM 250 255 PF00017 0.359
LIG_TYR_ITIM 271 276 PF00017 0.284
LIG_TYR_ITIM 476 481 PF00017 0.391
LIG_TYR_ITIM 84 89 PF00017 0.323
LIG_UBA3_1 526 533 PF00899 0.449
LIG_WRC_WIRS_1 2 7 PF05994 0.481
MOD_CK1_1 146 152 PF00069 0.358
MOD_CK1_1 174 180 PF00069 0.364
MOD_CK1_1 412 418 PF00069 0.353
MOD_CK1_1 511 517 PF00069 0.355
MOD_CK1_1 70 76 PF00069 0.333
MOD_CK2_1 146 152 PF00069 0.408
MOD_CK2_1 221 227 PF00069 0.426
MOD_CK2_1 360 366 PF00069 0.526
MOD_GlcNHglycan 138 141 PF01048 0.373
MOD_GlcNHglycan 188 191 PF01048 0.458
MOD_GlcNHglycan 421 424 PF01048 0.311
MOD_GSK3_1 1 8 PF00069 0.598
MOD_GSK3_1 122 129 PF00069 0.293
MOD_GSK3_1 166 173 PF00069 0.332
MOD_GSK3_1 182 189 PF00069 0.247
MOD_GSK3_1 315 322 PF00069 0.692
MOD_GSK3_1 327 334 PF00069 0.745
MOD_GSK3_1 360 367 PF00069 0.580
MOD_GSK3_1 381 388 PF00069 0.392
MOD_GSK3_1 39 46 PF00069 0.332
MOD_GSK3_1 67 74 PF00069 0.273
MOD_N-GLC_1 186 191 PF02516 0.444
MOD_N-GLC_1 392 397 PF02516 0.548
MOD_N-GLC_1 508 513 PF02516 0.436
MOD_N-GLC_2 136 138 PF02516 0.355
MOD_NEK2_1 1 6 PF00069 0.665
MOD_NEK2_1 134 139 PF00069 0.340
MOD_NEK2_1 171 176 PF00069 0.381
MOD_NEK2_1 196 201 PF00069 0.289
MOD_NEK2_1 264 269 PF00069 0.345
MOD_NEK2_1 271 276 PF00069 0.286
MOD_NEK2_1 291 296 PF00069 0.343
MOD_NEK2_1 39 44 PF00069 0.301
MOD_NEK2_1 457 462 PF00069 0.295
MOD_NEK2_1 9 14 PF00069 0.551
MOD_NEK2_2 126 131 PF00069 0.293
MOD_NEK2_2 232 237 PF00069 0.512
MOD_NEK2_2 508 513 PF00069 0.461
MOD_PIKK_1 7 13 PF00454 0.599
MOD_PKA_1 340 346 PF00069 0.667
MOD_PKA_2 315 321 PF00069 0.647
MOD_PKA_2 425 431 PF00069 0.342
MOD_PKB_1 221 229 PF00069 0.487
MOD_Plk_1 508 514 PF00069 0.436
MOD_Plk_1 67 73 PF00069 0.259
MOD_Plk_2-3 52 58 PF00069 0.172
MOD_Plk_4 143 149 PF00069 0.333
MOD_Plk_4 171 177 PF00069 0.382
MOD_Plk_4 196 202 PF00069 0.256
MOD_Plk_4 291 297 PF00069 0.368
MOD_Plk_4 340 346 PF00069 0.686
MOD_Plk_4 360 366 PF00069 0.550
MOD_Plk_4 381 387 PF00069 0.358
MOD_Plk_4 393 399 PF00069 0.312
MOD_Plk_4 409 415 PF00069 0.257
MOD_Plk_4 43 49 PF00069 0.314
MOD_Plk_4 508 514 PF00069 0.310
MOD_ProDKin_1 551 557 PF00069 0.387
MOD_SUMO_rev_2 27 32 PF00179 0.508
TRG_DiLeu_BaLyEn_6 94 99 PF01217 0.549
TRG_ENDOCYTIC_2 132 135 PF00928 0.279
TRG_ENDOCYTIC_2 193 196 PF00928 0.309
TRG_ENDOCYTIC_2 252 255 PF00928 0.350
TRG_ENDOCYTIC_2 273 276 PF00928 0.241
TRG_ENDOCYTIC_2 414 417 PF00928 0.295
TRG_ENDOCYTIC_2 478 481 PF00928 0.337
TRG_ENDOCYTIC_2 577 580 PF00928 0.518
TRG_ENDOCYTIC_2 81 84 PF00928 0.311
TRG_ENDOCYTIC_2 86 89 PF00928 0.327
TRG_ENDOCYTIC_2 90 93 PF00928 0.494
TRG_ER_diArg_1 155 158 PF00400 0.525
TRG_ER_diArg_1 220 223 PF00400 0.502
TRG_ER_diArg_1 247 249 PF00400 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 28% 93%
A0A0N1HT40 Leptomonas seymouri 31% 100%
A0A0N1HZC2 Leptomonas seymouri 72% 94%
A0A0N1IKC5 Leptomonas seymouri 31% 97%
A0A0N1PAX2 Leptomonas seymouri 40% 100%
A0A0N1PB63 Leptomonas seymouri 46% 90%
A0A0N1PFR4 Leptomonas seymouri 28% 90%
A0A0S4JR45 Bodo saltans 25% 100%
A0A1X0NKK0 Trypanosomatidae 54% 98%
A0A1X0NL32 Trypanosomatidae 30% 95%
A0A1X0NM09 Trypanosomatidae 54% 97%
A0A1X0NRW5 Trypanosomatidae 25% 85%
A0A1X0NV13 Trypanosomatidae 30% 91%
A0A1X0NV19 Trypanosomatidae 32% 99%
A0A1X0NV27 Trypanosomatidae 32% 99%
A0A1X0NVH8 Trypanosomatidae 31% 90%
A0A1X0NVM7 Trypanosomatidae 30% 92%
A0A1X0NWQ1 Trypanosomatidae 30% 92%
A0A1X0NZE6 Trypanosomatidae 31% 99%
A0A1X0NZU2 Trypanosomatidae 27% 92%
A0A1X0NZU5 Trypanosomatidae 32% 100%
A0A1X0NZW1 Trypanosomatidae 29% 98%
A0A1X0P0M7 Trypanosomatidae 31% 100%
A0A381MMW5 Leishmania infantum 28% 90%
A0A3Q8I7Y9 Leishmania donovani 30% 100%
A0A3Q8IEC4 Leishmania donovani 28% 91%
A0A3Q8IF95 Leishmania donovani 44% 94%
A0A3Q8IIT5 Leishmania donovani 28% 88%
A0A3Q8ISY9 Leishmania donovani 27% 93%
A0A3R7JPZ0 Trypanosoma rangeli 47% 100%
A0A3R7JSQ9 Trypanosoma rangeli 27% 100%
A0A3R7KKN8 Trypanosoma rangeli 30% 99%
A0A3R7MAQ7 Trypanosoma rangeli 26% 84%
A0A3R7N415 Trypanosoma rangeli 30% 99%
A0A3R7N921 Trypanosoma rangeli 30% 100%
A0A3R7R443 Trypanosoma rangeli 29% 99%
A0A3R7R6N6 Trypanosoma rangeli 44% 100%
A0A3S7WRJ4 Leishmania donovani 31% 92%
A0A3S7WRJ5 Leishmania donovani 30% 85%
A0A3S7WRL4 Leishmania donovani 29% 95%
A0A3S7WRS3 Leishmania donovani 26% 94%
A0A3S7WSR4 Leishmania donovani 31% 98%
A0A3S7WWU1 Leishmania donovani 47% 89%
A0A3S7X2G0 Leishmania donovani 28% 90%
A0A3S7X2K5 Leishmania donovani 28% 100%
A0A3S7XB11 Leishmania donovani 93% 98%
A0A422MSE4 Trypanosoma rangeli 31% 100%
A0A422MSP6 Trypanosoma rangeli 29% 100%
A0A422MST9 Trypanosoma rangeli 29% 99%
A0A422MU68 Trypanosoma rangeli 49% 100%
A4H6J0 Leishmania braziliensis 30% 100%
A4H6J1 Leishmania braziliensis 31% 100%
A4H6J3 Leishmania braziliensis 30% 100%
A4H6Q5 Leishmania braziliensis 24% 100%
A4HC19 Leishmania braziliensis 47% 100%
A4HHG2 Leishmania braziliensis 27% 100%
A4HHG3 Leishmania braziliensis 29% 100%
A4HHG4 Leishmania braziliensis 29% 100%
A4HJW3 Leishmania braziliensis 28% 100%
A4HPE2 Leishmania braziliensis 84% 100%
A4HUX5 Leishmania infantum 31% 92%
A4HUX6 Leishmania infantum 30% 85%
A4HUX7 Leishmania infantum 29% 95%
A4HUX8 Leishmania infantum 29% 100%
A4HV40 Leishmania infantum 26% 94%
A4HZF5 Leishmania infantum 44% 94%
A4HZJ4 Leishmania infantum 47% 89%
A4I4L2 Leishmania infantum 27% 88%
A4I7C5 Leishmania infantum 27% 93%
A4ICI3 Leishmania infantum 94% 98%
C9ZL97 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 99%
C9ZL98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZL99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 99%
C9ZLA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZLA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 99%
C9ZTR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 99%
C9ZTR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 98%
C9ZTR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZTR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 99%
C9ZTR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZTS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 99%
C9ZUT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0A7H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0AAQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 87%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AE01 Leishmania major 29% 100%
E9AE09 Leishmania major 28% 100%
E9AE10 Leishmania major 27% 100%
E9AE11 Leishmania major 30% 100%
E9AGK5 Leishmania infantum 31% 98%
E9AHJ0 Leishmania infantum 28% 91%
E9AHJ1 Leishmania infantum 28% 100%
E9ALS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ALS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ANL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ANS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AVF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 96%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 90%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 93%
Q4Q1E4 Leishmania major 92% 100%
Q4Q5T8 Leishmania major 27% 100%
Q4QC27 Leishmania major 47% 100%
Q4QC28 Leishmania major 45% 100%
Q4QFY5 Leishmania major 32% 100%
Q4QGU8 Leishmania major 27% 100%
Q4QH10 Leishmania major 29% 100%
Q4QH11 Leishmania major 29% 98%
Q4QH12 Leishmania major 29% 98%
Q4QH13 Leishmania major 30% 98%
Q4QH14 Leishmania major 29% 100%
Q4QH15 Leishmania major 31% 100%
V5B647 Trypanosoma cruzi 32% 94%
V5B983 Trypanosoma cruzi 30% 100%
V5BBB1 Trypanosoma cruzi 31% 100%
V5BFV8 Trypanosoma cruzi 29% 88%
V5BQY6 Trypanosoma cruzi 27% 84%
V5BVP0 Trypanosoma cruzi 29% 100%
V5DT25 Trypanosoma cruzi 30% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS