Centrosomal protein POC5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT47_LEIMU

TriTrypDb:

LmxM.36.2690

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005814	centriole	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1

Expansion

Sequence features

E9AT47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT47

Function

Biological processes
Term	Name	Level	Count
GO:0007049	cell cycle	2	10
GO:0009987	cellular process	1	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.541
CLV_NRD_NRD_1	110	112	PF00675	0.432
CLV_NRD_NRD_1	116	118	PF00675	0.461
CLV_NRD_NRD_1	120	122	PF00675	0.420
CLV_NRD_NRD_1	41	43	PF00675	0.476
CLV_NRD_NRD_1	63	65	PF00675	0.456
CLV_PCSK_FUR_1	117	121	PF00082	0.525
CLV_PCSK_FUR_1	150	154	PF00082	0.426
CLV_PCSK_KEX2_1	110	112	PF00082	0.421
CLV_PCSK_KEX2_1	116	118	PF00082	0.428
CLV_PCSK_KEX2_1	119	121	PF00082	0.405
CLV_PCSK_KEX2_1	152	154	PF00082	0.459
CLV_PCSK_KEX2_1	161	163	PF00082	0.485
CLV_PCSK_KEX2_1	40	42	PF00082	0.490
CLV_PCSK_KEX2_1	63	65	PF00082	0.433
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.432
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.535
CLV_PCSK_PC7_1	116	122	PF00082	0.585
CLV_PCSK_SKI1_1	195	199	PF00082	0.452
CLV_PCSK_SKI1_1	240	244	PF00082	0.684
DOC_MAPK_MEF2A_6	26	35	PF00069	0.500
DOC_PP4_FxxP_1	272	275	PF00568	0.655
DOC_USP7_MATH_1	300	304	PF00917	0.631
DOC_USP7_UBL2_3	157	161	PF12436	0.493
DOC_WW_Pin1_4	240	245	PF00397	0.603
DOC_WW_Pin1_4	248	253	PF00397	0.670
DOC_WW_Pin1_4	275	280	PF00397	0.634
DOC_WW_Pin1_4	318	323	PF00397	0.621
LIG_14-3-3_CanoR_1	132	136	PF00244	0.544
LIG_14-3-3_CanoR_1	238	243	PF00244	0.684
LIG_14-3-3_CanoR_1	291	300	PF00244	0.716
LIG_BIR_III_4	267	271	PF00653	0.545
LIG_BRCT_BRCA1_1	302	306	PF00533	0.631
LIG_eIF4E_1	139	145	PF01652	0.365
LIG_EVH1_2	322	326	PF00568	0.713
LIG_FHA_1	41	47	PF00498	0.432
LIG_LIR_Nem_3	134	139	PF02991	0.364
LIG_SH2_STAT3	176	179	PF00017	0.491
LIG_SH2_STAT5	129	132	PF00017	0.337
LIG_SH2_STAT5	38	41	PF00017	0.497
LIG_SH3_2	322	327	PF14604	0.633
LIG_SH3_3	319	325	PF00018	0.686
LIG_SUMO_SIM_anti_2	29	37	PF11976	0.494
LIG_TRAF2_1	50	53	PF00917	0.433
LIG_TRAF2_1	73	76	PF00917	0.527
MOD_CK1_1	232	238	PF00069	0.714
MOD_CK1_1	250	256	PF00069	0.648
MOD_CK1_1	314	320	PF00069	0.650
MOD_CK1_1	330	336	PF00069	0.685
MOD_CK2_1	186	192	PF00069	0.446
MOD_DYRK1A_RPxSP_1	240	244	PF00069	0.617
MOD_GlcNHglycan	287	290	PF01048	0.663
MOD_GlcNHglycan	294	297	PF01048	0.779
MOD_GlcNHglycan	300	303	PF01048	0.731
MOD_GlcNHglycan	313	316	PF01048	0.592
MOD_GSK3_1	234	241	PF00069	0.603
MOD_GSK3_1	246	253	PF00069	0.645
MOD_GSK3_1	314	321	PF00069	0.668
MOD_LATS_1	236	242	PF00433	0.606
MOD_NEK2_1	247	252	PF00069	0.695
MOD_NEK2_1	329	334	PF00069	0.620
MOD_NEK2_2	131	136	PF00069	0.322
MOD_PIKK_1	332	338	PF00454	0.627
MOD_PIKK_1	40	46	PF00454	0.430
MOD_PK_1	238	244	PF00069	0.704
MOD_PKA_1	40	46	PF00069	0.430
MOD_PKA_2	131	137	PF00069	0.541
MOD_PKA_2	232	238	PF00069	0.661
MOD_PKA_2	285	291	PF00069	0.564
MOD_PKA_2	40	46	PF00069	0.525
MOD_Plk_1	186	192	PF00069	0.444
MOD_Plk_1	8	14	PF00069	0.509
MOD_Plk_4	131	137	PF00069	0.322
MOD_Plk_4	8	14	PF00069	0.577
MOD_ProDKin_1	240	246	PF00069	0.603
MOD_ProDKin_1	248	254	PF00069	0.666
MOD_ProDKin_1	275	281	PF00069	0.636
MOD_ProDKin_1	318	324	PF00069	0.621
MOD_SUMO_for_1	4	7	PF00179	0.635
MOD_SUMO_for_1	50	53	PF00179	0.488
TRG_ER_diArg_1	109	111	PF00400	0.477
TRG_ER_diArg_1	115	117	PF00400	0.458
TRG_ER_diArg_1	119	121	PF00400	0.427
TRG_ER_diArg_1	39	42	PF00400	0.515
TRG_ER_diArg_1	63	65	PF00400	0.529
TRG_NES_CRM1_1	92	103	PF08389	0.415
TRG_NLS_Bipartite_1	63	85	PF00514	0.530
TRG_NLS_MonoExtN_4	78	85	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V9	Leptomonas seymouri	49%	99%
A0A1X0NKY4	Trypanosomatidae	27%	82%
A0A3Q8IKC6	Leishmania donovani	94%	100%
A4HPD7	Leishmania braziliensis	81%	100%
A4ICH6	Leishmania infantum	94%	100%
D0A3J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	93%
Q4Q1F1	Leishmania major	91%	100%
V5BK99	Trypanosoma cruzi	28%	90%