Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT44_LEIMU

TriTrypDb:

LmxM.36.2670

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT44

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.405
CLV_NRD_NRD_1	289	291	PF00675	0.395
CLV_NRD_NRD_1	312	314	PF00675	0.545
CLV_NRD_NRD_1	67	69	PF00675	0.342
CLV_PCSK_KEX2_1	167	169	PF00082	0.405
CLV_PCSK_KEX2_1	289	291	PF00082	0.395
CLV_PCSK_SKI1_1	123	127	PF00082	0.450
CLV_PCSK_SKI1_1	167	171	PF00082	0.361
CLV_PCSK_SKI1_1	289	293	PF00082	0.388
CLV_PCSK_SKI1_1	317	321	PF00082	0.565
CLV_Separin_Metazoa	310	314	PF03568	0.465
DOC_CDC14_PxL_1	12	20	PF14671	0.436
DOC_CDC14_PxL_1	333	341	PF14671	0.433
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	356	359	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.445
DOC_MAPK_MEF2A_6	167	176	PF00069	0.378
DOC_MAPK_MEF2A_6	81	90	PF00069	0.401
DOC_PP2B_LxvP_1	169	172	PF13499	0.338
DOC_PP2B_LxvP_1	306	309	PF13499	0.463
DOC_PP2B_LxvP_1	356	359	PF13499	0.356
DOC_PP4_FxxP_1	59	62	PF00568	0.503
DOC_USP7_MATH_1	229	233	PF00917	0.504
DOC_USP7_MATH_1	270	274	PF00917	0.530
DOC_USP7_MATH_1	32	36	PF00917	0.720
DOC_USP7_MATH_1	40	44	PF00917	0.678
DOC_USP7_MATH_1	53	57	PF00917	0.591
DOC_USP7_UBL2_3	211	215	PF12436	0.507
DOC_WW_Pin1_4	190	195	PF00397	0.327
DOC_WW_Pin1_4	200	205	PF00397	0.426
DOC_WW_Pin1_4	235	240	PF00397	0.463
DOC_WW_Pin1_4	248	253	PF00397	0.440
DOC_WW_Pin1_4	261	266	PF00397	0.290
DOC_WW_Pin1_4	48	53	PF00397	0.606
LIG_14-3-3_CanoR_1	269	275	PF00244	0.523
LIG_14-3-3_CanoR_1	313	317	PF00244	0.507
LIG_Actin_WH2_2	71	89	PF00022	0.416
LIG_BRCT_BRCA1_1	132	136	PF00533	0.334
LIG_BRCT_BRCA1_1	55	59	PF00533	0.512
LIG_EH1_1	143	151	PF00400	0.388
LIG_FHA_1	161	167	PF00498	0.433
LIG_FHA_1	20	26	PF00498	0.562
LIG_FHA_1	281	287	PF00498	0.451
LIG_FHA_1	62	68	PF00498	0.538
LIG_LIR_Apic_2	56	62	PF02991	0.505
LIG_LIR_LC3C_4	257	261	PF02991	0.366
LIG_LIR_Nem_3	10	15	PF02991	0.329
LIG_PDZ_Class_2	361	366	PF00595	0.381
LIG_Pex14_2	132	136	PF04695	0.378
LIG_SH2_CRK	12	16	PF00017	0.414
LIG_SH2_CRK	191	195	PF00017	0.388
LIG_SH2_NCK_1	73	77	PF00017	0.429
LIG_SH2_SRC	73	76	PF00017	0.387
LIG_SH2_STAP1	282	286	PF00017	0.424
LIG_SH2_STAT3	282	285	PF00017	0.426
LIG_SH2_STAT5	14	17	PF00017	0.439
LIG_SH2_STAT5	175	178	PF00017	0.364
LIG_SH2_STAT5	282	285	PF00017	0.362
LIG_SH3_1	236	242	PF00018	0.390
LIG_SH3_2	239	244	PF14604	0.367
LIG_SH3_2	50	55	PF14604	0.602
LIG_SH3_3	179	185	PF00018	0.466
LIG_SH3_3	236	242	PF00018	0.473
LIG_SH3_3	249	255	PF00018	0.336
LIG_SH3_3	262	268	PF00018	0.457
LIG_SH3_3	334	340	PF00018	0.475
LIG_SH3_3	352	358	PF00018	0.332
LIG_SH3_3	47	53	PF00018	0.662
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.398
LIG_SUMO_SIM_par_1	360	365	PF11976	0.317
LIG_SUMO_SIM_par_1	87	94	PF11976	0.364
LIG_TRAF2_1	222	225	PF00917	0.340
LIG_TRAF2_1	273	276	PF00917	0.492
LIG_WRPW_2	214	217	PF00400	0.442
MOD_CDK_SPK_2	190	195	PF00069	0.386
MOD_CDK_SPxxK_3	48	55	PF00069	0.562
MOD_CK1_1	193	199	PF00069	0.365
MOD_CK1_1	200	206	PF00069	0.423
MOD_CK1_1	27	33	PF00069	0.615
MOD_CK1_1	63	69	PF00069	0.478
MOD_CK1_1	82	88	PF00069	0.260
MOD_CK2_1	270	276	PF00069	0.537
MOD_Cter_Amidation	209	212	PF01082	0.384
MOD_GlcNHglycan	131	135	PF01048	0.343
MOD_GlcNHglycan	220	223	PF01048	0.458
MOD_GlcNHglycan	30	33	PF01048	0.689
MOD_GlcNHglycan	55	58	PF01048	0.616
MOD_GSK3_1	130	137	PF00069	0.344
MOD_GSK3_1	193	200	PF00069	0.403
MOD_GSK3_1	24	31	PF00069	0.612
MOD_GSK3_1	32	39	PF00069	0.615
MOD_NEK2_1	218	223	PF00069	0.434
MOD_NEK2_1	41	46	PF00069	0.604
MOD_PIKK_1	280	286	PF00454	0.336
MOD_PK_1	99	105	PF00069	0.399
MOD_PKA_2	19	25	PF00069	0.533
MOD_PKA_2	312	318	PF00069	0.498
MOD_PKB_1	97	105	PF00069	0.393
MOD_Plk_1	130	136	PF00069	0.365
MOD_Plk_1	137	143	PF00069	0.394
MOD_Plk_1	177	183	PF00069	0.359
MOD_Plk_1	99	105	PF00069	0.399
MOD_Plk_4	177	183	PF00069	0.364
MOD_Plk_4	357	363	PF00069	0.428
MOD_Plk_4	41	47	PF00069	0.609
MOD_ProDKin_1	190	196	PF00069	0.328
MOD_ProDKin_1	200	206	PF00069	0.423
MOD_ProDKin_1	235	241	PF00069	0.459
MOD_ProDKin_1	248	254	PF00069	0.434
MOD_ProDKin_1	261	267	PF00069	0.300
MOD_ProDKin_1	48	54	PF00069	0.606
TRG_DiLeu_BaEn_2	116	122	PF01217	0.473
TRG_ENDOCYTIC_2	12	15	PF00928	0.341
TRG_ER_diArg_1	166	168	PF00400	0.397
TRG_ER_diArg_1	243	246	PF00400	0.444
TRG_ER_diArg_1	288	290	PF00400	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I7	Leptomonas seymouri	58%	100%
A0A0S4J6J0	Bodo saltans	29%	100%
A0A3Q8IW24	Leishmania donovani	93%	100%
A4HPD3	Leishmania braziliensis	81%	100%
A4ICH3	Leishmania infantum	93%	100%
O15442	Homo sapiens	24%	100%
Q4Q1F4	Leishmania major	89%	100%
Q91ZG2	Mus musculus	24%	100%