Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AT42_LEIMU

TriTrypDb:

LmxM.36.2650

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT42

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	12
GO:0002098	tRNA wobble uridine modification	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008175	tRNA methyltransferase activity	5	12
GO:0016300	tRNA (uracil) methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0000049	tRNA binding	5	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.519
CLV_NRD_NRD_1	171	173	PF00675	0.445
CLV_NRD_NRD_1	232	234	PF00675	0.338
CLV_PCSK_FUR_1	169	173	PF00082	0.432
CLV_PCSK_FUR_1	229	233	PF00082	0.448
CLV_PCSK_KEX2_1	169	171	PF00082	0.436
CLV_PCSK_KEX2_1	176	178	PF00082	0.400
CLV_PCSK_KEX2_1	231	233	PF00082	0.336
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.417
CLV_PCSK_PC7_1	172	178	PF00082	0.370
CLV_PCSK_SKI1_1	176	180	PF00082	0.448
CLV_PCSK_SKI1_1	237	241	PF00082	0.278
CLV_PCSK_SKI1_1	92	96	PF00082	0.451
CLV_Separin_Metazoa	150	154	PF03568	0.421
CLV_Separin_Metazoa	193	197	PF03568	0.422
CLV_Separin_Metazoa	238	242	PF03568	0.278
DEG_APCC_DBOX_1	236	244	PF00400	0.237
DEG_SPOP_SBC_1	108	112	PF00917	0.662
DOC_CKS1_1	185	190	PF01111	0.401
DOC_MAPK_gen_1	229	236	PF00069	0.388
DOC_USP7_MATH_1	131	135	PF00917	0.645
DOC_USP7_MATH_1	208	212	PF00917	0.349
DOC_USP7_MATH_1	68	72	PF00917	0.531
DOC_WW_Pin1_4	126	131	PF00397	0.507
DOC_WW_Pin1_4	184	189	PF00397	0.401
LIG_14-3-3_CanoR_1	153	160	PF00244	0.450
LIG_14-3-3_CanoR_1	177	185	PF00244	0.318
LIG_14-3-3_CanoR_1	99	105	PF00244	0.566
LIG_Actin_WH2_2	138	155	PF00022	0.336
LIG_BIR_II_1	1	5	PF00653	0.779
LIG_BRCT_BRCA1_1	210	214	PF00533	0.337
LIG_FHA_1	195	201	PF00498	0.301
LIG_FHA_1	314	320	PF00498	0.568
LIG_FHA_2	23	29	PF00498	0.593
LIG_FHA_2	99	105	PF00498	0.496
LIG_LIR_Gen_1	330	337	PF02991	0.334
LIG_LIR_Gen_1	50	59	PF02991	0.299
LIG_LIR_Nem_3	50	55	PF02991	0.298
LIG_PDZ_Class_3	335	340	PF00595	0.480
LIG_SH2_CRK	52	56	PF00017	0.392
LIG_SH2_NCK_1	52	56	PF00017	0.338
LIG_SH2_STAP1	147	151	PF00017	0.369
LIG_SH2_STAP1	52	56	PF00017	0.337
LIG_SH2_STAT5	141	144	PF00017	0.336
LIG_SH2_STAT5	253	256	PF00017	0.395
LIG_SH2_STAT5	93	96	PF00017	0.391
LIG_SH3_3	102	108	PF00018	0.587
LIG_SH3_3	182	188	PF00018	0.448
LIG_SH3_3	28	34	PF00018	0.526
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.301
LIG_TRAF2_1	190	193	PF00917	0.370
LIG_WRC_WIRS_1	132	137	PF05994	0.559
MOD_CK1_1	112	118	PF00069	0.680
MOD_CK2_1	177	183	PF00069	0.460
MOD_CK2_1	187	193	PF00069	0.308
MOD_CK2_1	296	302	PF00069	0.480
MOD_Cter_Amidation	174	177	PF01082	0.370
MOD_GlcNHglycan	1	4	PF01048	0.758
MOD_GlcNHglycan	111	114	PF01048	0.673
MOD_GlcNHglycan	173	176	PF01048	0.461
MOD_GlcNHglycan	189	192	PF01048	0.412
MOD_GlcNHglycan	210	213	PF01048	0.337
MOD_GlcNHglycan	52	55	PF01048	0.441
MOD_GlcNHglycan	70	73	PF01048	0.383
MOD_GSK3_1	103	110	PF00069	0.677
MOD_GSK3_1	309	316	PF00069	0.512
MOD_GSK3_1	323	330	PF00069	0.387
MOD_N-GLC_2	332	334	PF02516	0.320
MOD_NEK2_1	109	114	PF00069	0.554
MOD_NEK2_1	151	156	PF00069	0.374
MOD_NEK2_1	59	64	PF00069	0.410
MOD_NEK2_1	73	78	PF00069	0.229
MOD_PIKK_1	152	158	PF00454	0.421
MOD_PKA_1	171	177	PF00069	0.442
MOD_PKA_2	152	158	PF00069	0.450
MOD_PKA_2	171	177	PF00069	0.421
MOD_PKA_2	323	329	PF00069	0.381
MOD_PKA_2	98	104	PF00069	0.326
MOD_PKB_1	169	177	PF00069	0.442
MOD_Plk_2-3	22	28	PF00069	0.670
MOD_Plk_2-3	309	315	PF00069	0.565
MOD_Plk_4	323	329	PF00069	0.359
MOD_ProDKin_1	126	132	PF00069	0.509
MOD_ProDKin_1	184	190	PF00069	0.401
MOD_SUMO_for_1	178	181	PF00179	0.370
MOD_SUMO_rev_2	12	17	PF00179	0.601
TRG_DiLeu_BaEn_1	238	243	PF01217	0.306
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.286
TRG_ENDOCYTIC_2	294	297	PF00928	0.316
TRG_ENDOCYTIC_2	52	55	PF00928	0.380
TRG_ER_diArg_1	169	172	PF00400	0.462
TRG_ER_diArg_1	231	233	PF00400	0.336
TRG_NLS_MonoExtC_3	14	20	PF00514	0.717
TRG_NLS_MonoExtC_3	175	181	PF00514	0.409
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I4	Leptomonas seymouri	62%	100%
A0A0S4J705	Bodo saltans	37%	100%
A0A1X0NKG3	Trypanosomatidae	45%	100%
A0A3S7XB23	Leishmania donovani	88%	100%
A0A422ND22	Trypanosoma rangeli	40%	100%
A4HPD1	Leishmania braziliensis	78%	100%
A4ICH1	Leishmania infantum	88%	100%
C4V9L5	Nosema ceranae (strain BRL01)	30%	100%
D0A3J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
P49957	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q4Q1F6	Leishmania major	89%	100%
V5DGL8	Trypanosoma cruzi	43%	100%