Cyclin-e binding protein 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin-e binding protein 1-like protein

Species:

Leishmania mexicana

UniProt:

E9AT37_LEIMU

TriTrypDb:

LmxM.36.2600

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT37

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.661
CLV_C14_Caspase3-7	19	23	PF00656	0.662
CLV_C14_Caspase3-7	408	412	PF00656	0.696
CLV_NRD_NRD_1	162	164	PF00675	0.608
CLV_NRD_NRD_1	333	335	PF00675	0.347
CLV_PCSK_KEX2_1	162	164	PF00082	0.507
CLV_PCSK_KEX2_1	333	335	PF00082	0.535
CLV_PCSK_SKI1_1	241	245	PF00082	0.404
CLV_PCSK_SKI1_1	278	282	PF00082	0.537
CLV_PCSK_SKI1_1	287	291	PF00082	0.454
CLV_PCSK_SKI1_1	32	36	PF00082	0.653
CLV_PCSK_SKI1_1	489	493	PF00082	0.684
CLV_PCSK_SKI1_1	53	57	PF00082	0.493
CLV_PCSK_SKI1_1	580	584	PF00082	0.520
CLV_PCSK_SKI1_1	615	619	PF00082	0.703
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SPOP_SBC_1	669	673	PF00917	0.668
DOC_MAPK_gen_1	194	202	PF00069	0.667
DOC_MAPK_MEF2A_6	194	202	PF00069	0.727
DOC_MAPK_MEF2A_6	66	74	PF00069	0.557
DOC_PP1_RVXF_1	51	57	PF00149	0.299
DOC_PP2B_LxvP_1	158	161	PF13499	0.545
DOC_PP2B_LxvP_1	376	379	PF13499	0.669
DOC_PP2B_LxvP_1	390	393	PF13499	0.648
DOC_PP2B_LxvP_1	524	527	PF13499	0.696
DOC_PP2B_LxvP_1	554	557	PF13499	0.702
DOC_USP7_MATH_1	189	193	PF00917	0.665
DOC_USP7_MATH_1	204	208	PF00917	0.645
DOC_USP7_MATH_1	219	223	PF00917	0.607
DOC_USP7_MATH_1	379	383	PF00917	0.618
DOC_USP7_MATH_1	41	45	PF00917	0.633
DOC_USP7_MATH_1	540	544	PF00917	0.825
DOC_USP7_MATH_1	669	673	PF00917	0.590
DOC_USP7_MATH_1	693	697	PF00917	0.769
DOC_USP7_MATH_1	712	716	PF00917	0.500
DOC_USP7_MATH_1	86	90	PF00917	0.591
DOC_USP7_UBL2_3	611	615	PF12436	0.694
DOC_WW_Pin1_4	185	190	PF00397	0.724
DOC_WW_Pin1_4	212	217	PF00397	0.732
DOC_WW_Pin1_4	220	225	PF00397	0.637
DOC_WW_Pin1_4	35	40	PF00397	0.618
DOC_WW_Pin1_4	656	661	PF00397	0.700
DOC_WW_Pin1_4	678	683	PF00397	0.809
DOC_WW_Pin1_4	8	13	PF00397	0.423
LIG_14-3-3_CanoR_1	287	292	PF00244	0.377
LIG_14-3-3_CanoR_1	333	338	PF00244	0.547
LIG_14-3-3_CanoR_1	580	586	PF00244	0.516
LIG_14-3-3_CanoR_1	597	606	PF00244	0.727
LIG_14-3-3_CanoR_1	619	625	PF00244	0.686
LIG_Actin_WH2_2	606	621	PF00022	0.499
LIG_APCC_ABBA_1	31	36	PF00400	0.647
LIG_Clathr_ClatBox_1	292	296	PF01394	0.505
LIG_eIF4E_1	628	634	PF01652	0.708
LIG_FHA_1	251	257	PF00498	0.376
LIG_FHA_1	330	336	PF00498	0.550
LIG_FHA_1	338	344	PF00498	0.561
LIG_FHA_1	464	470	PF00498	0.648
LIG_FHA_1	519	525	PF00498	0.701
LIG_FHA_1	577	583	PF00498	0.713
LIG_FHA_1	628	634	PF00498	0.689
LIG_FHA_1	649	655	PF00498	0.730
LIG_FHA_1	696	702	PF00498	0.802
LIG_FHA_2	342	348	PF00498	0.629
LIG_FHA_2	403	409	PF00498	0.722
LIG_FHA_2	446	452	PF00498	0.528
LIG_LIR_Gen_1	119	129	PF02991	0.259
LIG_LIR_Gen_1	307	316	PF02991	0.376
LIG_LIR_Gen_1	446	455	PF02991	0.522
LIG_LIR_Gen_1	715	720	PF02991	0.687
LIG_LIR_Nem_3	123	129	PF02991	0.476
LIG_LIR_Nem_3	231	235	PF02991	0.812
LIG_LIR_Nem_3	284	289	PF02991	0.439
LIG_LIR_Nem_3	307	311	PF02991	0.376
LIG_LIR_Nem_3	384	390	PF02991	0.582
LIG_LIR_Nem_3	42	48	PF02991	0.416
LIG_LIR_Nem_3	446	450	PF02991	0.488
LIG_LIR_Nem_3	715	719	PF02991	0.686
LIG_SH2_CRK	110	114	PF00017	0.530
LIG_SH2_CRK	126	130	PF00017	0.411
LIG_SH2_CRK	373	377	PF00017	0.738
LIG_SH2_CRK	442	446	PF00017	0.627
LIG_SH2_CRK	61	65	PF00017	0.473
LIG_SH2_GRB2like	122	125	PF00017	0.436
LIG_SH2_NCK_1	18	22	PF00017	0.523
LIG_SH2_PTP2	558	561	PF00017	0.498
LIG_SH2_PTP2	716	719	PF00017	0.761
LIG_SH2_STAP1	122	126	PF00017	0.494
LIG_SH2_STAP1	349	353	PF00017	0.549
LIG_SH2_STAP1	61	65	PF00017	0.473
LIG_SH2_STAT3	388	391	PF00017	0.398
LIG_SH2_STAT3	499	502	PF00017	0.715
LIG_SH2_STAT5	110	113	PF00017	0.466
LIG_SH2_STAT5	442	445	PF00017	0.571
LIG_SH2_STAT5	499	502	PF00017	0.715
LIG_SH2_STAT5	558	561	PF00017	0.498
LIG_SH2_STAT5	716	719	PF00017	0.761
LIG_SH3_3	232	238	PF00018	0.731
LIG_SH3_3	332	338	PF00018	0.445
LIG_SH3_3	497	503	PF00018	0.713
LIG_SUMO_SIM_anti_2	67	75	PF11976	0.499
LIG_SUMO_SIM_par_1	252	257	PF11976	0.376
LIG_SUMO_SIM_par_1	277	285	PF11976	0.514
LIG_SUMO_SIM_par_1	661	666	PF11976	0.702
LIG_SUMO_SIM_par_1	67	75	PF11976	0.488
LIG_TYR_ITIM	108	113	PF00017	0.455
LIG_TYR_ITIM	556	561	PF00017	0.499
LIG_WRC_WIRS_1	633	638	PF05994	0.495
MOD_CK1_1	133	139	PF00069	0.587
MOD_CK1_1	222	228	PF00069	0.717
MOD_CK1_1	336	342	PF00069	0.525
MOD_CK1_1	382	388	PF00069	0.555
MOD_CK1_1	431	437	PF00069	0.642
MOD_CK1_1	576	582	PF00069	0.803
MOD_CK1_1	596	602	PF00069	0.759
MOD_CK1_1	692	698	PF00069	0.741
MOD_CK2_1	341	347	PF00069	0.569
MOD_CK2_1	445	451	PF00069	0.538
MOD_CK2_1	683	689	PF00069	0.574
MOD_CK2_1	86	92	PF00069	0.541
MOD_GlcNHglycan	113	116	PF01048	0.475
MOD_GlcNHglycan	158	161	PF01048	0.616
MOD_GlcNHglycan	22	25	PF01048	0.660
MOD_GlcNHglycan	224	227	PF01048	0.730
MOD_GlcNHglycan	258	261	PF01048	0.478
MOD_GlcNHglycan	268	271	PF01048	0.385
MOD_GlcNHglycan	411	414	PF01048	0.689
MOD_GlcNHglycan	524	527	PF01048	0.546
MOD_GlcNHglycan	538	541	PF01048	0.822
MOD_GlcNHglycan	569	572	PF01048	0.626
MOD_GlcNHglycan	625	628	PF01048	0.772
MOD_GlcNHglycan	637	640	PF01048	0.587
MOD_GlcNHglycan	656	659	PF01048	0.700
MOD_GlcNHglycan	691	694	PF01048	0.627
MOD_GlcNHglycan	695	698	PF01048	0.716
MOD_GlcNHglycan	92	95	PF01048	0.531
MOD_GSK3_1	130	137	PF00069	0.536
MOD_GSK3_1	16	23	PF00069	0.635
MOD_GSK3_1	179	186	PF00069	0.707
MOD_GSK3_1	210	217	PF00069	0.675
MOD_GSK3_1	250	257	PF00069	0.376
MOD_GSK3_1	329	336	PF00069	0.542
MOD_GSK3_1	337	344	PF00069	0.541
MOD_GSK3_1	35	42	PF00069	0.398
MOD_GSK3_1	379	386	PF00069	0.599
MOD_GSK3_1	4	11	PF00069	0.678
MOD_GSK3_1	428	435	PF00069	0.607
MOD_GSK3_1	445	452	PF00069	0.443
MOD_GSK3_1	518	525	PF00069	0.633
MOD_GSK3_1	536	543	PF00069	0.719
MOD_GSK3_1	563	570	PF00069	0.713
MOD_GSK3_1	572	579	PF00069	0.711
MOD_GSK3_1	593	600	PF00069	0.754
MOD_GSK3_1	623	630	PF00069	0.742
MOD_GSK3_1	689	696	PF00069	0.740
MOD_GSK3_1	86	93	PF00069	0.610
MOD_LATS_1	331	337	PF00433	0.545
MOD_N-GLC_1	432	437	PF02516	0.623
MOD_N-GLC_1	703	708	PF02516	0.700
MOD_N-GLC_2	322	324	PF02516	0.376
MOD_NEK2_1	20	25	PF00069	0.618
MOD_NEK2_1	254	259	PF00069	0.376
MOD_NEK2_1	274	279	PF00069	0.313
MOD_NEK2_1	281	286	PF00069	0.531
MOD_NEK2_1	329	334	PF00069	0.548
MOD_NEK2_1	429	434	PF00069	0.707
MOD_NEK2_1	449	454	PF00069	0.362
MOD_NEK2_1	632	637	PF00069	0.497
MOD_NEK2_1	654	659	PF00069	0.703
MOD_NEK2_1	72	77	PF00069	0.462
MOD_NEK2_2	189	194	PF00069	0.707
MOD_NEK2_2	372	377	PF00069	0.682
MOD_PIKK_1	10	16	PF00454	0.430
MOD_PIKK_1	254	260	PF00454	0.465
MOD_PKA_1	333	339	PF00069	0.483
MOD_PKA_2	333	339	PF00069	0.547
MOD_PKA_2	409	415	PF00069	0.690
MOD_PKA_2	563	569	PF00069	0.733
MOD_PKA_2	596	602	PF00069	0.801
MOD_PKA_2	604	610	PF00069	0.675
MOD_PKA_2	618	624	PF00069	0.562
MOD_Plk_1	349	355	PF00069	0.557
MOD_Plk_1	383	389	PF00069	0.592
MOD_Plk_1	432	438	PF00069	0.686
MOD_Plk_4	130	136	PF00069	0.452
MOD_Plk_4	250	256	PF00069	0.357
MOD_Plk_4	304	310	PF00069	0.420
MOD_Plk_4	383	389	PF00069	0.592
MOD_Plk_4	41	47	PF00069	0.730
MOD_Plk_4	506	512	PF00069	0.588
MOD_Plk_4	526	532	PF00069	0.663
MOD_Plk_4	59	65	PF00069	0.389
MOD_Plk_4	620	626	PF00069	0.776
MOD_Plk_4	628	634	PF00069	0.647
MOD_Plk_4	649	655	PF00069	0.783
MOD_Plk_4	696	702	PF00069	0.728
MOD_Plk_4	712	718	PF00069	0.687
MOD_Plk_4	86	92	PF00069	0.501
MOD_ProDKin_1	185	191	PF00069	0.721
MOD_ProDKin_1	212	218	PF00069	0.734
MOD_ProDKin_1	220	226	PF00069	0.637
MOD_ProDKin_1	35	41	PF00069	0.626
MOD_ProDKin_1	656	662	PF00069	0.702
MOD_ProDKin_1	678	684	PF00069	0.809
MOD_ProDKin_1	8	14	PF00069	0.425
TRG_ENDOCYTIC_2	110	113	PF00928	0.529
TRG_ENDOCYTIC_2	122	125	PF00928	0.453
TRG_ENDOCYTIC_2	126	129	PF00928	0.410
TRG_ENDOCYTIC_2	373	376	PF00928	0.664
TRG_ENDOCYTIC_2	387	390	PF00928	0.486
TRG_ENDOCYTIC_2	442	445	PF00928	0.559
TRG_ENDOCYTIC_2	558	561	PF00928	0.498
TRG_ENDOCYTIC_2	61	64	PF00928	0.423
TRG_ENDOCYTIC_2	716	719	PF00928	0.689
TRG_ER_diArg_1	161	163	PF00400	0.615
TRG_ER_diArg_1	333	335	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB4	Leptomonas seymouri	42%	100%
A0A3S7XAY5	Leishmania donovani	89%	100%
A4HPC6	Leishmania braziliensis	71%	100%
A4ICG6	Leishmania infantum	89%	100%
Q4Q1G1	Leishmania major	90%	100%
V5BPT3	Trypanosoma cruzi	34%	100%