LeishMANIAdb
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Putative membrane-bound acid phosphatase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative membrane-bound acid phosphatase 2
Gene product:
membrane-bound acid phosphatase 2, putative
Species:
Leishmania mexicana
UniProt:
E9AT36_LEIMU
TriTrypDb:
LmxM.36.2590
Length:
571

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 38, no: 4
NetGPI no yes: 0, no: 42
Cellular components
Term Name Level Count
GO:0016020 membrane 2 32
GO:0110165 cellular anatomical entity 1 32

Expansion

Sequence features

E9AT36
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT36

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016311 dephosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0003993 acid phosphatase activity 6 2
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016791 phosphatase activity 5 7
GO:0042578 phosphoric ester hydrolase activity 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 484 488 PF00656 0.448
CLV_NRD_NRD_1 537 539 PF00675 0.452
CLV_PCSK_KEX2_1 251 253 PF00082 0.449
CLV_PCSK_KEX2_1 397 399 PF00082 0.587
CLV_PCSK_KEX2_1 536 538 PF00082 0.444
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.449
CLV_PCSK_PC1ET2_1 397 399 PF00082 0.558
CLV_PCSK_SKI1_1 137 141 PF00082 0.557
CLV_PCSK_SKI1_1 177 181 PF00082 0.628
CLV_PCSK_SKI1_1 222 226 PF00082 0.552
CLV_PCSK_SKI1_1 251 255 PF00082 0.575
CLV_PCSK_SKI1_1 398 402 PF00082 0.624
DOC_CDC14_PxL_1 237 245 PF14671 0.459
DOC_CKS1_1 431 436 PF01111 0.365
DOC_CYCLIN_RxL_1 217 226 PF00134 0.394
DOC_MAPK_gen_1 249 258 PF00069 0.341
DOC_PP1_RVXF_1 396 403 PF00149 0.427
DOC_PP1_RVXF_1 4 10 PF00149 0.689
DOC_PP4_FxxP_1 108 111 PF00568 0.383
DOC_PP4_MxPP_1 326 329 PF00568 0.404
DOC_USP7_MATH_1 141 145 PF00917 0.396
DOC_USP7_MATH_1 510 514 PF00917 0.434
DOC_USP7_MATH_1 564 568 PF00917 0.741
DOC_USP7_UBL2_3 397 401 PF12436 0.272
DOC_WW_Pin1_4 102 107 PF00397 0.424
DOC_WW_Pin1_4 319 324 PF00397 0.370
DOC_WW_Pin1_4 356 361 PF00397 0.368
DOC_WW_Pin1_4 430 435 PF00397 0.419
DOC_WW_Pin1_4 69 74 PF00397 0.433
LIG_14-3-3_CanoR_1 121 129 PF00244 0.368
LIG_14-3-3_CanoR_1 252 257 PF00244 0.301
LIG_14-3-3_CanoR_1 33 43 PF00244 0.440
LIG_14-3-3_CanoR_1 545 551 PF00244 0.709
LIG_14-3-3_CanoR_1 95 100 PF00244 0.429
LIG_APCC_ABBA_1 390 395 PF00400 0.345
LIG_BIR_II_1 1 5 PF00653 0.669
LIG_BIR_III_4 378 382 PF00653 0.455
LIG_BIR_III_4 407 411 PF00653 0.377
LIG_BRCT_BRCA1_1 104 108 PF00533 0.427
LIG_deltaCOP1_diTrp_1 365 372 PF00928 0.338
LIG_FHA_1 121 127 PF00498 0.373
LIG_FHA_1 186 192 PF00498 0.338
LIG_FHA_1 252 258 PF00498 0.385
LIG_FHA_1 434 440 PF00498 0.504
LIG_FHA_1 526 532 PF00498 0.505
LIG_FHA_1 63 69 PF00498 0.450
LIG_FHA_2 150 156 PF00498 0.411
LIG_FHA_2 214 220 PF00498 0.362
LIG_FHA_2 221 227 PF00498 0.337
LIG_FHA_2 285 291 PF00498 0.453
LIG_FHA_2 315 321 PF00498 0.391
LIG_FHA_2 360 366 PF00498 0.483
LIG_FHA_2 478 484 PF00498 0.570
LIG_FHA_2 495 501 PF00498 0.443
LIG_FHA_2 547 553 PF00498 0.555
LIG_LIR_Apic_2 105 111 PF02991 0.390
LIG_LIR_Gen_1 144 154 PF02991 0.431
LIG_LIR_Gen_1 165 173 PF02991 0.392
LIG_LIR_Gen_1 194 203 PF02991 0.417
LIG_LIR_Gen_1 244 253 PF02991 0.347
LIG_LIR_Nem_3 144 150 PF02991 0.386
LIG_LIR_Nem_3 165 171 PF02991 0.355
LIG_LIR_Nem_3 194 198 PF02991 0.419
LIG_LIR_Nem_3 238 243 PF02991 0.363
LIG_LIR_Nem_3 244 250 PF02991 0.367
LIG_LIR_Nem_3 395 399 PF02991 0.328
LIG_LIR_Nem_3 78 82 PF02991 0.448
LIG_LYPXL_yS_3 240 243 PF13949 0.345
LIG_PCNA_yPIPBox_3 332 342 PF02747 0.394
LIG_PDZ_Class_3 566 571 PF00595 0.628
LIG_Pex14_1 168 172 PF04695 0.396
LIG_Pex14_2 135 139 PF04695 0.410
LIG_Pex14_2 364 368 PF04695 0.468
LIG_Rb_pABgroove_1 219 227 PF01858 0.409
LIG_SH2_CRK 147 151 PF00017 0.439
LIG_SH2_CRK 431 435 PF00017 0.484
LIG_SH2_GRB2like 173 176 PF00017 0.423
LIG_SH2_PTP2 348 351 PF00017 0.437
LIG_SH2_SRC 206 209 PF00017 0.282
LIG_SH2_SRC 260 263 PF00017 0.402
LIG_SH2_STAP1 113 117 PF00017 0.378
LIG_SH2_STAP1 260 264 PF00017 0.345
LIG_SH2_STAT3 413 416 PF00017 0.273
LIG_SH2_STAT5 210 213 PF00017 0.401
LIG_SH2_STAT5 348 351 PF00017 0.369
LIG_SH2_STAT5 411 414 PF00017 0.350
LIG_SH2_STAT5 543 546 PF00017 0.643
LIG_SH2_STAT5 76 79 PF00017 0.356
LIG_SH3_3 100 106 PF00018 0.442
LIG_SH3_3 150 156 PF00018 0.368
LIG_SH3_3 180 186 PF00018 0.369
LIG_SH3_3 422 428 PF00018 0.410
LIG_SUMO_SIM_anti_2 155 161 PF11976 0.278
LIG_TRAF2_1 480 483 PF00917 0.417
LIG_TRAF2_2 356 361 PF00917 0.415
LIG_UBA3_1 224 232 PF00899 0.422
LIG_WRC_WIRS_1 514 519 PF05994 0.415
MOD_CDK_SPxxK_3 356 363 PF00069 0.406
MOD_CK1_1 101 107 PF00069 0.460
MOD_CK1_1 120 126 PF00069 0.395
MOD_CK1_1 359 365 PF00069 0.449
MOD_CK1_1 471 477 PF00069 0.463
MOD_CK1_1 481 487 PF00069 0.582
MOD_CK1_1 502 508 PF00069 0.567
MOD_CK1_1 513 519 PF00069 0.510
MOD_CK2_1 149 155 PF00069 0.441
MOD_CK2_1 209 215 PF00069 0.468
MOD_CK2_1 284 290 PF00069 0.261
MOD_CK2_1 477 483 PF00069 0.543
MOD_CK2_1 546 552 PF00069 0.712
MOD_GlcNHglycan 130 133 PF01048 0.543
MOD_GlcNHglycan 304 307 PF01048 0.572
MOD_GlcNHglycan 447 450 PF01048 0.597
MOD_GlcNHglycan 482 487 PF01048 0.740
MOD_GlcNHglycan 500 504 PF01048 0.783
MOD_GlcNHglycan 506 509 PF01048 0.735
MOD_GlcNHglycan 57 60 PF01048 0.597
MOD_GSK3_1 115 122 PF00069 0.322
MOD_GSK3_1 209 216 PF00069 0.391
MOD_GSK3_1 302 309 PF00069 0.335
MOD_GSK3_1 477 484 PF00069 0.517
MOD_GSK3_1 63 70 PF00069 0.422
MOD_GSK3_1 91 98 PF00069 0.406
MOD_N-GLC_1 141 146 PF02516 0.604
MOD_N-GLC_1 264 269 PF02516 0.587
MOD_N-GLC_1 340 345 PF02516 0.578
MOD_N-GLC_1 478 483 PF02516 0.778
MOD_N-GLC_1 564 569 PF02516 0.373
MOD_N-GLC_1 63 68 PF02516 0.614
MOD_N-GLC_2 389 391 PF02516 0.562
MOD_NEK2_1 115 120 PF00069 0.369
MOD_NEK2_1 160 165 PF00069 0.397
MOD_NEK2_1 171 176 PF00069 0.412
MOD_NEK2_1 179 184 PF00069 0.421
MOD_NEK2_1 302 307 PF00069 0.375
MOD_NEK2_1 445 450 PF00069 0.420
MOD_NEK2_1 457 462 PF00069 0.389
MOD_NEK2_1 504 509 PF00069 0.466
MOD_NEK2_1 546 551 PF00069 0.614
MOD_NEK2_1 91 96 PF00069 0.373
MOD_NEK2_2 220 225 PF00069 0.389
MOD_OFUCOSY 468 475 PF10250 0.650
MOD_PIKK_1 162 168 PF00454 0.418
MOD_PIKK_1 235 241 PF00454 0.407
MOD_PKA_1 251 257 PF00069 0.246
MOD_PKA_1 494 500 PF00069 0.436
MOD_PKA_2 120 126 PF00069 0.366
MOD_PKA_2 251 257 PF00069 0.374
MOD_PKB_1 93 101 PF00069 0.463
MOD_Plk_1 115 121 PF00069 0.344
MOD_Plk_1 141 147 PF00069 0.452
MOD_Plk_1 235 241 PF00069 0.372
MOD_Plk_1 307 313 PF00069 0.353
MOD_Plk_2-3 415 421 PF00069 0.284
MOD_Plk_4 142 148 PF00069 0.435
MOD_Plk_4 252 258 PF00069 0.343
MOD_Plk_4 98 104 PF00069 0.426
MOD_ProDKin_1 102 108 PF00069 0.419
MOD_ProDKin_1 319 325 PF00069 0.364
MOD_ProDKin_1 356 362 PF00069 0.370
MOD_ProDKin_1 430 436 PF00069 0.421
MOD_ProDKin_1 69 75 PF00069 0.427
MOD_SUMO_rev_2 359 364 PF00179 0.302
MOD_SUMO_rev_2 487 497 PF00179 0.440
TRG_DiLeu_BaLyEn_6 238 243 PF01217 0.370
TRG_ENDOCYTIC_2 147 150 PF00928 0.408
TRG_ENDOCYTIC_2 240 243 PF00928 0.418
TRG_ENDOCYTIC_2 299 302 PF00928 0.427
TRG_ENDOCYTIC_2 348 351 PF00928 0.414
TRG_ENDOCYTIC_2 411 414 PF00928 0.364
TRG_ENDOCYTIC_2 543 546 PF00928 0.714
TRG_ER_diArg_1 536 538 PF00400 0.618
TRG_ER_diArg_1 92 95 PF00400 0.402
TRG_NES_CRM1_1 324 337 PF08389 0.421
TRG_Pf-PMV_PEXEL_1 222 226 PF00026 0.570

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 63% 100%
A0A0N1I756 Leptomonas seymouri 40% 100%
A0A0N1PEH4 Leptomonas seymouri 38% 100%
A0A0S4IRF5 Bodo saltans 23% 85%
A0A0S4IUV8 Bodo saltans 22% 100%
A0A0S4IV77 Bodo saltans 36% 100%
A0A0S4JEA9 Bodo saltans 27% 100%
A0A0S4JJK3 Bodo saltans 25% 100%
A0A0S4JW09 Bodo saltans 30% 100%
A0A1X0NNY4 Trypanosomatidae 34% 100%
A0A1X0NQL4 Trypanosomatidae 30% 100%
A0A1X0NY34 Trypanosomatidae 25% 100%
A0A1X0P7V5 Trypanosomatidae 46% 100%
A0A3Q8IR23 Leishmania donovani 92% 100%
A0A3R7KSH4 Trypanosoma rangeli 24% 100%
A0A3R7MEN7 Trypanosoma rangeli 42% 100%
A0A3R7MHJ7 Trypanosoma rangeli 30% 100%
A0A3S5H827 Leishmania donovani 38% 100%
A0A3S7WXU0 Leishmania donovani 51% 100%
A0A3S7X1W4 Leishmania donovani 46% 100%
A4HCZ0 Leishmania braziliensis 50% 100%
A4HGW8 Leishmania braziliensis 46% 100%
A4HPC1 Leishmania braziliensis 40% 100%
A4HPC5 Leishmania braziliensis 80% 100%
A4HQG6 Leishmania braziliensis 37% 100%
A4HQG9 Leishmania braziliensis 35% 100%
A4I0H5 Leishmania infantum 50% 100%
A4I3Z8 Leishmania infantum 46% 100%
A4ICA5 Leishmania infantum 39% 86%
A4ICG3 Leishmania infantum 38% 100%
A4ICG5 Leishmania infantum 93% 100%
B1H1P9 Xenopus laevis 26% 100%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
Q4Q0A9 Leishmania major 26% 92%
Q4Q1G2 Leishmania major 91% 100%
Q4Q1G4 Leishmania major 38% 100%
Q4Q7Z7 Leishmania major 47% 100%
Q4QB35 Leishmania major 50% 100%
V5BCI2 Trypanosoma cruzi 27% 100%
V5BIM1 Trypanosoma cruzi 24% 100%
V5BK91 Trypanosoma cruzi 41% 100%
V5BL75 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS