Glycerophosphocholine phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

related to multifunctional cyclin-dependent kinase pho85-like protein

Species:

Leishmania mexicana

UniProt:

E9AT35_LEIMU

TriTrypDb:

LmxM.36.2580

Length:

991

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AT35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT35

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009395	phospholipid catabolic process	5	7
GO:0009987	cellular process	1	7
GO:0016042	lipid catabolic process	4	7
GO:0016310	phosphorylation	5	5
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044242	cellular lipid catabolic process	4	7
GO:0044248	cellular catabolic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046475	glycerophospholipid catabolic process	6	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046503	glycerolipid catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0047389	glycerophosphocholine phosphodiesterase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.739
CLV_C14_Caspase3-7	269	273	PF00656	0.600
CLV_C14_Caspase3-7	333	337	PF00656	0.789
CLV_C14_Caspase3-7	735	739	PF00656	0.222
CLV_C14_Caspase3-7	817	821	PF00656	0.436
CLV_NRD_NRD_1	193	195	PF00675	0.627
CLV_NRD_NRD_1	329	331	PF00675	0.620
CLV_NRD_NRD_1	380	382	PF00675	0.605
CLV_NRD_NRD_1	427	429	PF00675	0.743
CLV_NRD_NRD_1	629	631	PF00675	0.513
CLV_NRD_NRD_1	822	824	PF00675	0.436
CLV_NRD_NRD_1	950	952	PF00675	0.334
CLV_PCSK_FUR_1	378	382	PF00082	0.644
CLV_PCSK_KEX2_1	193	195	PF00082	0.627
CLV_PCSK_KEX2_1	328	330	PF00082	0.632
CLV_PCSK_KEX2_1	380	382	PF00082	0.671
CLV_PCSK_KEX2_1	427	429	PF00082	0.743
CLV_PCSK_KEX2_1	661	663	PF00082	0.355
CLV_PCSK_KEX2_1	950	952	PF00082	0.336
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.355
CLV_PCSK_SKI1_1	173	177	PF00082	0.676
CLV_PCSK_SKI1_1	455	459	PF00082	0.586
CLV_PCSK_SKI1_1	707	711	PF00082	0.411
CLV_PCSK_SKI1_1	747	751	PF00082	0.222
CLV_PCSK_SKI1_1	767	771	PF00082	0.411
CLV_PCSK_SKI1_1	813	817	PF00082	0.411
CLV_PCSK_SKI1_1	823	827	PF00082	0.411
CLV_PCSK_SKI1_1	857	861	PF00082	0.411
CLV_PCSK_SKI1_1	950	954	PF00082	0.411
CLV_Separin_Metazoa	325	329	PF03568	0.744
CLV_Separin_Metazoa	574	578	PF03568	0.504
DEG_SCF_FBW7_1	135	142	PF00400	0.589
DEG_SPOP_SBC_1	32	36	PF00917	0.389
DEG_SPOP_SBC_1	338	342	PF00917	0.655
DEG_SPOP_SBC_1	401	405	PF00917	0.743
DEG_SPOP_SBC_1	986	990	PF00917	0.646
DOC_ANK_TNKS_1	331	338	PF00023	0.705
DOC_CDC14_PxL_1	232	240	PF14671	0.764
DOC_CKS1_1	136	141	PF01111	0.694
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	364	370	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.557
DOC_MAPK_DCC_7	212	222	PF00069	0.486
DOC_MAPK_DCC_7	241	250	PF00069	0.707
DOC_MAPK_gen_1	193	202	PF00069	0.650
DOC_MAPK_gen_1	630	637	PF00069	0.513
DOC_MAPK_gen_1	643	650	PF00069	0.298
DOC_MAPK_gen_1	747	756	PF00069	0.222
DOC_MAPK_gen_1	841	850	PF00069	0.411
DOC_MAPK_MEF2A_6	241	250	PF00069	0.707
DOC_MAPK_MEF2A_6	643	650	PF00069	0.464
DOC_PP1_RVXF_1	811	817	PF00149	0.411
DOC_PP1_RVXF_1	821	828	PF00149	0.411
DOC_PP2B_LxvP_1	244	247	PF13499	0.496
DOC_PP2B_LxvP_1	364	367	PF13499	0.580
DOC_PP2B_LxvP_1	585	588	PF13499	0.508
DOC_PP2B_LxvP_1	78	81	PF13499	0.539
DOC_PP4_FxxP_1	133	136	PF00568	0.691
DOC_USP7_MATH_1	139	143	PF00917	0.677
DOC_USP7_MATH_1	240	244	PF00917	0.545
DOC_USP7_MATH_1	263	267	PF00917	0.730
DOC_USP7_MATH_1	270	274	PF00917	0.741
DOC_USP7_MATH_1	314	318	PF00917	0.716
DOC_USP7_MATH_1	33	37	PF00917	0.668
DOC_USP7_MATH_1	385	389	PF00917	0.641
DOC_USP7_MATH_1	400	404	PF00917	0.627
DOC_USP7_MATH_1	604	608	PF00917	0.436
DOC_USP7_MATH_1	880	884	PF00917	0.411
DOC_WW_Pin1_4	135	140	PF00397	0.682
DOC_WW_Pin1_4	143	148	PF00397	0.598
DOC_WW_Pin1_4	164	169	PF00397	0.625
DOC_WW_Pin1_4	331	336	PF00397	0.707
DOC_WW_Pin1_4	396	401	PF00397	0.721
DOC_WW_Pin1_4	433	438	PF00397	0.478
DOC_WW_Pin1_4	545	550	PF00397	0.368
DOC_WW_Pin1_4	600	605	PF00397	0.506
DOC_WW_Pin1_4	672	677	PF00397	0.430
DOC_WW_Pin1_4	770	775	PF00397	0.397
DOC_WW_Pin1_4	888	893	PF00397	0.513
LIG_14-3-3_CanoR_1	100	109	PF00244	0.648
LIG_14-3-3_CanoR_1	110	119	PF00244	0.567
LIG_14-3-3_CanoR_1	157	161	PF00244	0.728
LIG_14-3-3_CanoR_1	396	400	PF00244	0.655
LIG_14-3-3_CanoR_1	431	437	PF00244	0.720
LIG_14-3-3_CanoR_1	524	533	PF00244	0.563
LIG_14-3-3_CanoR_1	577	585	PF00244	0.448
LIG_14-3-3_CanoR_1	730	740	PF00244	0.450
LIG_14-3-3_CanoR_1	747	756	PF00244	0.221
LIG_14-3-3_CanoR_1	823	828	PF00244	0.436
LIG_14-3-3_CanoR_1	912	920	PF00244	0.521
LIG_APCC_ABBA_1	274	279	PF00400	0.787
LIG_BRCT_BRCA1_1	297	301	PF00533	0.607
LIG_BRCT_BRCA1_1	437	441	PF00533	0.709
LIG_BRCT_BRCA1_1	578	582	PF00533	0.515
LIG_BRCT_BRCA1_1	775	779	PF00533	0.411
LIG_BRCT_BRCA1_1	792	796	PF00533	0.411
LIG_Clathr_ClatBox_1	125	129	PF01394	0.560
LIG_Clathr_ClatBox_1	753	757	PF01394	0.436
LIG_eIF4E_1	555	561	PF01652	0.446
LIG_eIF4E_1	785	791	PF01652	0.513
LIG_FHA_1	403	409	PF00498	0.684
LIG_FHA_1	459	465	PF00498	0.641
LIG_FHA_1	475	481	PF00498	0.368
LIG_FHA_1	496	502	PF00498	0.507
LIG_FHA_1	528	534	PF00498	0.617
LIG_FHA_1	704	710	PF00498	0.524
LIG_FHA_1	914	920	PF00498	0.436
LIG_FHA_2	100	106	PF00498	0.690
LIG_FHA_2	165	171	PF00498	0.660
LIG_FHA_2	954	960	PF00498	0.513
LIG_Integrin_isoDGR_2	821	823	PF01839	0.436
LIG_LIR_Apic_2	130	136	PF02991	0.655
LIG_LIR_Apic_2	155	161	PF02991	0.729
LIG_LIR_Gen_1	227	237	PF02991	0.656
LIG_LIR_Gen_1	548	559	PF02991	0.454
LIG_LIR_Gen_1	579	590	PF02991	0.502
LIG_LIR_Gen_1	636	641	PF02991	0.513
LIG_LIR_Gen_1	826	834	PF02991	0.402
LIG_LIR_Gen_1	843	850	PF02991	0.508
LIG_LIR_Gen_1	962	971	PF02991	0.513
LIG_LIR_Nem_3	129	135	PF02991	0.525
LIG_LIR_Nem_3	227	232	PF02991	0.636
LIG_LIR_Nem_3	38	44	PF02991	0.591
LIG_LIR_Nem_3	548	554	PF02991	0.483
LIG_LIR_Nem_3	579	585	PF02991	0.513
LIG_LIR_Nem_3	673	677	PF02991	0.524
LIG_LIR_Nem_3	826	830	PF02991	0.402
LIG_LIR_Nem_3	843	848	PF02991	0.508
LIG_LIR_Nem_3	861	865	PF02991	0.279
LIG_LIR_Nem_3	934	939	PF02991	0.411
LIG_LIR_Nem_3	962	968	PF02991	0.411
LIG_MYND_1	236	240	PF01753	0.675
LIG_PCNA_yPIPBox_3	89	100	PF02747	0.490
LIG_Pex14_1	551	555	PF04695	0.469
LIG_PTB_Apo_2	796	803	PF02174	0.222
LIG_REV1ctd_RIR_1	130	135	PF16727	0.626
LIG_REV1ctd_RIR_1	17	26	PF16727	0.658
LIG_SH2_CRK	158	162	PF00017	0.718
LIG_SH2_CRK	233	237	PF00017	0.782
LIG_SH2_CRK	674	678	PF00017	0.513
LIG_SH2_CRK	686	690	PF00017	0.298
LIG_SH2_CRK	845	849	PF00017	0.436
LIG_SH2_GRB2like	302	305	PF00017	0.545
LIG_SH2_NCK_1	158	162	PF00017	0.718
LIG_SH2_NCK_1	233	237	PF00017	0.782
LIG_SH2_SRC	866	869	PF00017	0.433
LIG_SH2_STAP1	845	849	PF00017	0.411
LIG_SH2_STAT3	785	788	PF00017	0.411
LIG_SH2_STAT3	95	98	PF00017	0.577
LIG_SH2_STAT5	503	506	PF00017	0.578
LIG_SH2_STAT5	536	539	PF00017	0.637
LIG_SH2_STAT5	555	558	PF00017	0.251
LIG_SH2_STAT5	674	677	PF00017	0.459
LIG_SH2_STAT5	686	689	PF00017	0.336
LIG_SH2_STAT5	76	79	PF00017	0.744
LIG_SH2_STAT5	866	869	PF00017	0.513
LIG_SH2_STAT5	95	98	PF00017	0.678
LIG_SH2_STAT5	963	966	PF00017	0.420
LIG_SH2_STAT5	968	971	PF00017	0.402
LIG_SH3_1	233	239	PF00018	0.764
LIG_SH3_2	236	241	PF14604	0.751
LIG_SH3_3	133	139	PF00018	0.670
LIG_SH3_3	233	239	PF00018	0.675
LIG_SH3_3	287	293	PF00018	0.730
LIG_SH3_3	303	309	PF00018	0.509
LIG_SH3_3	453	459	PF00018	0.600
LIG_SH3_3	496	502	PF00018	0.609
LIG_SH3_3	528	534	PF00018	0.546
LIG_SH3_3	69	75	PF00018	0.488
LIG_SH3_3	780	786	PF00018	0.411
LIG_SH3_3	896	902	PF00018	0.356
LIG_SH3_3	927	933	PF00018	0.513
LIG_SH3_4	308	315	PF00018	0.431
LIG_SUMO_SIM_par_1	124	130	PF11976	0.570
LIG_SUMO_SIM_par_1	246	252	PF11976	0.731
LIG_SUMO_SIM_par_1	295	300	PF11976	0.515
LIG_SUMO_SIM_par_1	543	548	PF11976	0.364
LIG_SUMO_SIM_par_1	57	62	PF11976	0.566
LIG_SUMO_SIM_par_1	646	652	PF11976	0.416
LIG_TRAF2_1	102	105	PF00917	0.594
LIG_TYR_ITIM	556	561	PF00017	0.436
LIG_TYR_ITIM	684	689	PF00017	0.513
LIG_UBA3_1	654	661	PF00899	0.424
LIG_WRC_WIRS_1	621	626	PF05994	0.513
LIG_WRC_WIRS_1	827	832	PF05994	0.411
LIG_WRC_WIRS_1	862	867	PF05994	0.411
LIG_WW_3	238	242	PF00397	0.660
MOD_CDK_SPxK_1	672	678	PF00069	0.436
MOD_CK1_1	159	165	PF00069	0.596
MOD_CK1_1	266	272	PF00069	0.730
MOD_CK1_1	321	327	PF00069	0.667
MOD_CK1_1	34	40	PF00069	0.692
MOD_CK1_1	403	409	PF00069	0.662
MOD_CK1_1	413	419	PF00069	0.642
MOD_CK1_1	426	432	PF00069	0.672
MOD_CK1_1	525	531	PF00069	0.510
MOD_CK1_1	578	584	PF00069	0.527
MOD_CK1_1	617	623	PF00069	0.445
MOD_CK1_1	716	722	PF00069	0.451
MOD_CK1_1	732	738	PF00069	0.311
MOD_CK1_1	745	751	PF00069	0.298
MOD_CK2_1	111	117	PF00069	0.651
MOD_CK2_1	134	140	PF00069	0.471
MOD_CK2_1	164	170	PF00069	0.694
MOD_CK2_1	221	227	PF00069	0.622
MOD_CK2_1	32	38	PF00069	0.560
MOD_CK2_1	418	424	PF00069	0.752
MOD_CK2_1	762	768	PF00069	0.513
MOD_CK2_1	87	93	PF00069	0.705
MOD_CK2_1	99	105	PF00069	0.512
MOD_Cter_Amidation	821	824	PF01082	0.436
MOD_DYRK1A_RPxSP_1	396	400	PF00069	0.646
MOD_GlcNHglycan	113	116	PF01048	0.604
MOD_GlcNHglycan	178	182	PF01048	0.707
MOD_GlcNHglycan	209	212	PF01048	0.713
MOD_GlcNHglycan	251	254	PF01048	0.709
MOD_GlcNHglycan	26	29	PF01048	0.706
MOD_GlcNHglycan	268	271	PF01048	0.746
MOD_GlcNHglycan	382	385	PF01048	0.628
MOD_GlcNHglycan	428	431	PF01048	0.602
MOD_GlcNHglycan	437	440	PF01048	0.571
MOD_GlcNHglycan	519	522	PF01048	0.556
MOD_GlcNHglycan	527	530	PF01048	0.512
MOD_GlcNHglycan	565	569	PF01048	0.393
MOD_GlcNHglycan	604	607	PF01048	0.415
MOD_GlcNHglycan	744	747	PF01048	0.398
MOD_GlcNHglycan	874	877	PF01048	0.490
MOD_GlcNHglycan	908	911	PF01048	0.472
MOD_GSK3_1	134	141	PF00069	0.583
MOD_GSK3_1	156	163	PF00069	0.728
MOD_GSK3_1	266	273	PF00069	0.799
MOD_GSK3_1	314	321	PF00069	0.636
MOD_GSK3_1	391	398	PF00069	0.725
MOD_GSK3_1	400	407	PF00069	0.766
MOD_GSK3_1	410	417	PF00069	0.631
MOD_GSK3_1	418	425	PF00069	0.564
MOD_GSK3_1	429	436	PF00069	0.800
MOD_GSK3_1	513	520	PF00069	0.499
MOD_GSK3_1	523	530	PF00069	0.448
MOD_GSK3_1	596	603	PF00069	0.411
MOD_GSK3_1	729	736	PF00069	0.491
MOD_GSK3_1	745	752	PF00069	0.290
MOD_GSK3_1	928	935	PF00069	0.416
MOD_N-GLC_1	411	416	PF02516	0.760
MOD_N-GLC_1	684	689	PF02516	0.513
MOD_N-GLC_2	5	7	PF02516	0.594
MOD_N-GLC_2	833	835	PF02516	0.411
MOD_NEK2_1	207	212	PF00069	0.768
MOD_NEK2_1	249	254	PF00069	0.722
MOD_NEK2_1	297	302	PF00069	0.512
MOD_NEK2_1	31	36	PF00069	0.578
MOD_NEK2_1	379	384	PF00069	0.693
MOD_NEK2_1	402	407	PF00069	0.686
MOD_NEK2_1	411	416	PF00069	0.706
MOD_NEK2_1	522	527	PF00069	0.602
MOD_NEK2_1	564	569	PF00069	0.577
MOD_NEK2_1	596	601	PF00069	0.458
MOD_NEK2_1	684	689	PF00069	0.353
MOD_NEK2_1	729	734	PF00069	0.513
MOD_NEK2_1	790	795	PF00069	0.513
MOD_NEK2_1	840	845	PF00069	0.411
MOD_NEK2_2	450	455	PF00069	0.690
MOD_PIKK_1	10	16	PF00454	0.660
MOD_PIKK_1	100	106	PF00454	0.668
MOD_PIKK_1	156	162	PF00454	0.724
MOD_PIKK_1	474	480	PF00454	0.532
MOD_PIKK_1	733	739	PF00454	0.509
MOD_PKA_1	380	386	PF00069	0.651
MOD_PKA_1	823	829	PF00069	0.436
MOD_PKA_2	156	162	PF00069	0.724
MOD_PKA_2	240	246	PF00069	0.553
MOD_PKA_2	379	385	PF00069	0.648
MOD_PKA_2	391	397	PF00069	0.692
MOD_PKA_2	426	432	PF00069	0.833
MOD_PKA_2	523	529	PF00069	0.565
MOD_PKA_2	576	582	PF00069	0.523
MOD_PKA_2	729	735	PF00069	0.436
MOD_PKA_2	99	105	PF00069	0.646
MOD_PKB_1	194	202	PF00069	0.489
MOD_PKB_1	378	386	PF00069	0.574
MOD_Plk_1	139	145	PF00069	0.670
MOD_Plk_1	196	202	PF00069	0.719
MOD_Plk_1	263	269	PF00069	0.737
MOD_Plk_1	495	501	PF00069	0.467
MOD_Plk_1	508	514	PF00069	0.448
MOD_Plk_1	617	623	PF00069	0.393
MOD_Plk_1	684	690	PF00069	0.462
MOD_Plk_4	146	152	PF00069	0.631
MOD_Plk_4	297	303	PF00069	0.504
MOD_Plk_4	513	519	PF00069	0.523
MOD_Plk_4	527	533	PF00069	0.517
MOD_Plk_4	586	592	PF00069	0.429
MOD_Plk_4	713	719	PF00069	0.513
MOD_Plk_4	749	755	PF00069	0.513
MOD_Plk_4	885	891	PF00069	0.411
MOD_Plk_4	959	965	PF00069	0.465
MOD_ProDKin_1	135	141	PF00069	0.683
MOD_ProDKin_1	143	149	PF00069	0.590
MOD_ProDKin_1	164	170	PF00069	0.634
MOD_ProDKin_1	331	337	PF00069	0.705
MOD_ProDKin_1	396	402	PF00069	0.720
MOD_ProDKin_1	433	439	PF00069	0.472
MOD_ProDKin_1	545	551	PF00069	0.370
MOD_ProDKin_1	600	606	PF00069	0.506
MOD_ProDKin_1	672	678	PF00069	0.430
MOD_ProDKin_1	770	776	PF00069	0.397
MOD_ProDKin_1	888	894	PF00069	0.513
MOD_SUMO_for_1	660	663	PF00179	0.513
MOD_SUMO_rev_2	776	786	PF00179	0.411
MOD_SUMO_rev_2	846	856	PF00179	0.411
TRG_DiLeu_BaEn_1	227	232	PF01217	0.563
TRG_DiLeu_BaEn_2	802	808	PF01217	0.411
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.549
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.459
TRG_ENDOCYTIC_2	558	561	PF00928	0.430
TRG_ENDOCYTIC_2	674	677	PF00928	0.513
TRG_ENDOCYTIC_2	686	689	PF00928	0.298
TRG_ENDOCYTIC_2	845	848	PF00928	0.411
TRG_ENDOCYTIC_2	862	865	PF00928	0.411
TRG_ENDOCYTIC_2	963	966	PF00928	0.513
TRG_ER_diArg_1	192	194	PF00400	0.582
TRG_ER_diArg_1	327	330	PF00400	0.600
TRG_ER_diArg_1	377	380	PF00400	0.575
TRG_ER_diArg_1	950	952	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	690	695	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	857	861	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL19	Leptomonas seymouri	54%	96%
A0A3S7XAZ7	Leishmania donovani	93%	100%
A4HPC4	Leishmania braziliensis	80%	100%
A4ICG4	Leishmania infantum	93%	100%
Q4Q1G3	Leishmania major	91%	100%