LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Membrane-bound acid phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-bound acid phosphatase
Gene product:
membrane-bound acid phosphatase precursor
Species:
Leishmania mexicana
UniProt:
E9AT34_LEIMU
TriTrypDb:
LmxM.36.2570
Length:
516

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 42, no: 5
NetGPI no yes: 0, no: 47
Cellular components
Term Name Level Count
GO:0016020 membrane 2 35
GO:0110165 cellular anatomical entity 1 35

Expansion

Sequence features

E9AT34
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT34

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016311 dephosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0003993 acid phosphatase activity 6 3
GO:0016787 hydrolase activity 2 8
GO:0016788 hydrolase activity, acting on ester bonds 3 8
GO:0016791 phosphatase activity 5 8
GO:0042578 phosphoric ester hydrolase activity 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 308 312 PF00656 0.340
CLV_C14_Caspase3-7 331 335 PF00656 0.484
CLV_NRD_NRD_1 144 146 PF00675 0.695
CLV_NRD_NRD_1 501 503 PF00675 0.453
CLV_PCSK_KEX2_1 211 213 PF00082 0.617
CLV_PCSK_KEX2_1 501 503 PF00082 0.425
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.591
CLV_PCSK_SKI1_1 208 212 PF00082 0.593
CLV_PCSK_SKI1_1 502 506 PF00082 0.427
DEG_Nend_Nbox_1 1 3 PF02207 0.595
DOC_CDC14_PxL_1 226 234 PF14671 0.488
DOC_MAPK_gen_1 145 151 PF00069 0.269
DOC_MAPK_gen_1 507 516 PF00069 0.695
DOC_MAPK_MEF2A_6 10 19 PF00069 0.638
DOC_PP1_RVXF_1 1 8 PF00149 0.754
DOC_PP4_MxPP_1 317 320 PF00568 0.429
DOC_USP7_MATH_1 131 135 PF00917 0.425
DOC_USP7_MATH_1 24 28 PF00917 0.647
DOC_USP7_MATH_1 244 248 PF00917 0.396
DOC_USP7_MATH_1 337 341 PF00917 0.500
DOC_USP7_MATH_1 463 467 PF00917 0.533
DOC_USP7_MATH_1 472 476 PF00917 0.550
DOC_USP7_UBL2_3 505 509 PF12436 0.652
DOC_WW_Pin1_4 300 305 PF00397 0.349
DOC_WW_Pin1_4 398 403 PF00397 0.380
DOC_WW_Pin1_4 44 49 PF00397 0.323
DOC_WW_Pin1_4 468 473 PF00397 0.605
LIG_14-3-3_CanoR_1 111 119 PF00244 0.384
LIG_14-3-3_CanoR_1 180 185 PF00244 0.356
LIG_14-3-3_CanoR_1 392 402 PF00244 0.379
LIG_14-3-3_CanoR_1 427 436 PF00244 0.417
LIG_14-3-3_CanoR_1 85 93 PF00244 0.437
LIG_APCC_ABBA_1 384 389 PF00400 0.382
LIG_BIR_III_4 372 376 PF00653 0.497
LIG_BRCT_BRCA1_1 133 137 PF00533 0.364
LIG_BRCT_BRCA1_1 195 199 PF00533 0.415
LIG_BRCT_BRCA1_1 245 249 PF00533 0.369
LIG_Clathr_ClatBox_1 181 185 PF01394 0.282
LIG_Clathr_ClatBox_1 413 417 PF01394 0.305
LIG_deltaCOP1_diTrp_1 498 506 PF00928 0.537
LIG_DLG_GKlike_1 180 187 PF00625 0.266
LIG_eIF4E_1 268 274 PF01652 0.426
LIG_eIF4E_1 407 413 PF01652 0.281
LIG_FHA_1 111 117 PF00498 0.413
LIG_FHA_1 221 227 PF00498 0.444
LIG_FHA_1 321 327 PF00498 0.386
LIG_FHA_1 358 364 PF00498 0.426
LIG_FHA_1 379 385 PF00498 0.459
LIG_FHA_1 403 409 PF00498 0.419
LIG_FHA_1 482 488 PF00498 0.415
LIG_GBD_Chelix_1 270 278 PF00786 0.535
LIG_LIR_Apic_2 153 157 PF02991 0.404
LIG_LIR_Apic_2 405 410 PF02991 0.402
LIG_LIR_Gen_1 183 192 PF02991 0.442
LIG_LIR_Gen_1 340 347 PF02991 0.399
LIG_LIR_Gen_1 389 398 PF02991 0.340
LIG_LIR_Nem_3 101 105 PF02991 0.412
LIG_LIR_Nem_3 134 140 PF02991 0.395
LIG_LIR_Nem_3 183 187 PF02991 0.440
LIG_LIR_Nem_3 246 251 PF02991 0.298
LIG_LIR_Nem_3 340 346 PF02991 0.392
LIG_LIR_Nem_3 389 393 PF02991 0.349
LIG_LIR_Nem_3 498 503 PF02991 0.643
LIG_LIR_Nem_3 94 100 PF02991 0.456
LIG_MLH1_MIPbox_1 133 137 PF16413 0.407
LIG_MLH1_MIPbox_1 245 249 PF16413 0.232
LIG_NRBOX 269 275 PF00104 0.424
LIG_PCNA_yPIPBox_3 117 130 PF02747 0.287
LIG_PDZ_Class_2 511 516 PF00595 0.601
LIG_Pex14_2 321 325 PF04695 0.343
LIG_Pex14_2 62 66 PF04695 0.286
LIG_Pex14_2 98 102 PF04695 0.288
LIG_SH2_CRK 154 158 PF00017 0.257
LIG_SH2_CRK 9 13 PF00017 0.555
LIG_SH2_PTP2 343 346 PF00017 0.451
LIG_SH2_SRC 293 296 PF00017 0.393
LIG_SH2_SRC 407 410 PF00017 0.365
LIG_SH2_SRC 450 453 PF00017 0.462
LIG_SH2_SRC 81 84 PF00017 0.331
LIG_SH2_STAP1 293 297 PF00017 0.373
LIG_SH2_STAT3 69 72 PF00017 0.428
LIG_SH2_STAT5 109 112 PF00017 0.345
LIG_SH2_STAT5 203 206 PF00017 0.436
LIG_SH2_STAT5 248 251 PF00017 0.369
LIG_SH2_STAT5 343 346 PF00017 0.389
LIG_SH2_STAT5 378 381 PF00017 0.370
LIG_SH2_STAT5 407 410 PF00017 0.359
LIG_SH2_STAT5 450 453 PF00017 0.422
LIG_SH2_STAT5 81 84 PF00017 0.353
LIG_SH2_STAT5 86 89 PF00017 0.339
LIG_SH2_STAT5 97 100 PF00017 0.454
LIG_SH3_3 333 339 PF00018 0.308
LIG_SH3_3 396 402 PF00018 0.345
LIG_SH3_3 90 96 PF00018 0.446
LIG_Sin3_3 271 278 PF02671 0.268
LIG_SUMO_SIM_par_1 303 308 PF11976 0.421
LIG_SUMO_SIM_par_1 325 331 PF11976 0.372
LIG_SUMO_SIM_par_1 417 425 PF11976 0.287
LIG_SUMO_SIM_par_1 479 484 PF11976 0.329
LIG_TRAF2_1 166 169 PF00917 0.418
LIG_UBA3_1 74 80 PF00899 0.258
LIG_WRC_WIRS_1 133 138 PF05994 0.420
LIG_WRC_WIRS_1 181 186 PF05994 0.267
MOD_CK1_1 357 363 PF00069 0.425
MOD_CK1_1 441 447 PF00069 0.390
MOD_CK1_1 471 477 PF00069 0.537
MOD_CK1_1 91 97 PF00069 0.466
MOD_CK2_1 425 431 PF00069 0.505
MOD_Cter_Amidation 143 146 PF01082 0.674
MOD_GlcNHglycan 120 123 PF01048 0.583
MOD_GlcNHglycan 21 24 PF01048 0.686
MOD_GlcNHglycan 26 29 PF01048 0.646
MOD_GlcNHglycan 294 298 PF01048 0.594
MOD_GlcNHglycan 350 353 PF01048 0.594
MOD_GlcNHglycan 474 477 PF01048 0.754
MOD_GSK3_1 103 110 PF00069 0.352
MOD_GSK3_1 240 247 PF00069 0.378
MOD_GSK3_1 293 300 PF00069 0.369
MOD_GSK3_1 357 364 PF00069 0.430
MOD_GSK3_1 374 381 PF00069 0.301
MOD_GSK3_1 393 400 PF00069 0.311
MOD_GSK3_1 421 428 PF00069 0.368
MOD_GSK3_1 463 470 PF00069 0.531
MOD_GSK3_1 84 91 PF00069 0.431
MOD_N-GLC_1 103 108 PF02516 0.604
MOD_N-GLC_1 131 136 PF02516 0.611
MOD_N-GLC_1 201 206 PF02516 0.638
MOD_N-GLC_1 253 258 PF02516 0.608
MOD_N-GLC_1 357 362 PF02516 0.580
MOD_N-GLC_1 394 399 PF02516 0.499
MOD_N-GLC_1 425 430 PF02516 0.592
MOD_N-GLC_1 441 446 PF02516 0.664
MOD_N-GLC_1 463 468 PF02516 0.768
MOD_N-GLC_1 52 57 PF02516 0.618
MOD_N-GLC_2 383 385 PF02516 0.597
MOD_NEK2_1 105 110 PF00069 0.382
MOD_NEK2_1 150 155 PF00069 0.419
MOD_NEK2_1 273 278 PF00069 0.417
MOD_NEK2_1 305 310 PF00069 0.348
MOD_NEK2_1 361 366 PF00069 0.439
MOD_NEK2_1 393 398 PF00069 0.303
MOD_NEK2_1 481 486 PF00069 0.318
MOD_NEK2_2 201 206 PF00069 0.454
MOD_NEK2_2 402 407 PF00069 0.403
MOD_OFUCOSY 440 445 PF10250 0.585
MOD_PIKK_1 193 199 PF00454 0.470
MOD_PKA_2 110 116 PF00069 0.397
MOD_PKA_2 283 289 PF00069 0.512
MOD_PKA_2 84 90 PF00069 0.399
MOD_Plk_1 103 109 PF00069 0.367
MOD_Plk_1 131 137 PF00069 0.478
MOD_Plk_1 201 207 PF00069 0.436
MOD_Plk_1 298 304 PF00069 0.369
MOD_Plk_1 310 316 PF00069 0.389
MOD_Plk_1 357 363 PF00069 0.389
MOD_Plk_1 425 431 PF00069 0.454
MOD_Plk_1 52 58 PF00069 0.406
MOD_Plk_2-3 328 334 PF00069 0.292
MOD_Plk_2-3 425 431 PF00069 0.310
MOD_Plk_4 132 138 PF00069 0.425
MOD_Plk_4 150 156 PF00069 0.361
MOD_Plk_4 244 250 PF00069 0.327
MOD_Plk_4 338 344 PF00069 0.436
MOD_Plk_4 374 380 PF00069 0.395
MOD_Plk_4 52 58 PF00069 0.407
MOD_Plk_4 88 94 PF00069 0.437
MOD_Plk_4 98 104 PF00069 0.407
MOD_ProDKin_1 300 306 PF00069 0.349
MOD_ProDKin_1 398 404 PF00069 0.376
MOD_ProDKin_1 44 50 PF00069 0.323
MOD_ProDKin_1 468 474 PF00069 0.601
MOD_SUMO_for_1 166 169 PF00179 0.289
TRG_DiLeu_BaLyEn_6 342 347 PF01217 0.455
TRG_DiLeu_LyEn_5 227 232 PF01217 0.429
TRG_ENDOCYTIC_2 248 251 PF00928 0.346
TRG_ENDOCYTIC_2 343 346 PF00928 0.431
TRG_ENDOCYTIC_2 503 506 PF00928 0.744
TRG_ENDOCYTIC_2 9 12 PF00928 0.524
TRG_ER_diArg_1 159 162 PF00400 0.394
TRG_ER_diArg_1 205 208 PF00400 0.439
TRG_ER_diArg_1 500 502 PF00400 0.621
TRG_NES_CRM1_1 315 328 PF08389 0.437
TRG_Pf-PMV_PEXEL_1 234 238 PF00026 0.645
TRG_Pf-PMV_PEXEL_1 427 431 PF00026 0.679

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 34% 90%
A0A0N1I756 Leptomonas seymouri 65% 100%
A0A0N1PEH4 Leptomonas seymouri 38% 100%
A0A0S4IRF5 Bodo saltans 24% 77%
A0A0S4IUV8 Bodo saltans 24% 100%
A0A0S4IV77 Bodo saltans 34% 99%
A0A0S4JEA9 Bodo saltans 25% 100%
A0A0S4JJK3 Bodo saltans 29% 100%
A0A0S4JW09 Bodo saltans 28% 100%
A0A1X0NNY4 Trypanosomatidae 36% 93%
A0A1X0NQL4 Trypanosomatidae 27% 94%
A0A1X0NY34 Trypanosomatidae 28% 100%
A0A1X0P7V5 Trypanosomatidae 39% 99%
A0A3Q8IR23 Leishmania donovani 39% 90%
A0A3R7KSH4 Trypanosoma rangeli 26% 100%
A0A3R7MEN7 Trypanosoma rangeli 38% 100%
A0A3R7MHJ7 Trypanosoma rangeli 25% 100%
A0A3S5H827 Leishmania donovani 89% 100%
A0A3S7WXU0 Leishmania donovani 38% 97%
A0A3S7X1W4 Leishmania donovani 34% 94%
A4HCZ0 Leishmania braziliensis 37% 100%
A4HGW8 Leishmania braziliensis 35% 100%
A4HPC1 Leishmania braziliensis 68% 100%
A4HPC5 Leishmania braziliensis 37% 100%
A4HQG6 Leishmania braziliensis 39% 100%
A4HQG9 Leishmania braziliensis 38% 100%
A4I0H5 Leishmania infantum 38% 97%
A4I3Z8 Leishmania infantum 34% 94%
A4ICA5 Leishmania infantum 36% 77%
A4ICG3 Leishmania infantum 89% 100%
A4ICG5 Leishmania infantum 39% 90%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 98%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 98%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 90%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 97%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 94%
Q4Q0A9 Leishmania major 30% 96%
Q4Q1G2 Leishmania major 37% 100%
Q4Q1G4 Leishmania major 86% 100%
Q4Q7Z7 Leishmania major 34% 100%
Q4QB35 Leishmania major 38% 100%
V5BCI2 Trypanosoma cruzi 26% 100%
V5BK91 Trypanosoma cruzi 37% 100%
V5BL75 Trypanosoma cruzi 27% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS