RTP1_C1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT33_LEIMU

TriTrypDb:

LmxM.36.2560

Length:

926

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.275
CLV_C14_Caspase3-7	395	399	PF00656	0.689
CLV_C14_Caspase3-7	40	44	PF00656	0.423
CLV_C14_Caspase3-7	729	733	PF00656	0.591
CLV_NRD_NRD_1	260	262	PF00675	0.424
CLV_NRD_NRD_1	539	541	PF00675	0.326
CLV_NRD_NRD_1	667	669	PF00675	0.565
CLV_PCSK_KEX2_1	260	262	PF00082	0.544
CLV_PCSK_KEX2_1	539	541	PF00082	0.326
CLV_PCSK_KEX2_1	667	669	PF00082	0.565
CLV_PCSK_KEX2_1	783	785	PF00082	0.505
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.353
CLV_PCSK_SKI1_1	157	161	PF00082	0.709
CLV_PCSK_SKI1_1	228	232	PF00082	0.417
CLV_PCSK_SKI1_1	99	103	PF00082	0.545
DEG_APCC_DBOX_1	227	235	PF00400	0.378
DEG_APCC_DBOX_1	916	924	PF00400	0.307
DEG_SCF_FBW7_1	13	18	PF00400	0.411
DEG_SCF_FBW7_1	285	291	PF00400	0.353
DEG_SPOP_SBC_1	146	150	PF00917	0.625
DOC_CKS1_1	285	290	PF01111	0.578
DOC_CKS1_1	439	444	PF01111	0.439
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.383
DOC_MAPK_DCC_7	465	475	PF00069	0.396
DOC_MAPK_gen_1	801	810	PF00069	0.535
DOC_MAPK_gen_1	887	896	PF00069	0.480
DOC_MAPK_gen_1	915	923	PF00069	0.360
DOC_MAPK_MEF2A_6	247	256	PF00069	0.395
DOC_MAPK_MEF2A_6	480	487	PF00069	0.447
DOC_MAPK_MEF2A_6	887	896	PF00069	0.358
DOC_MAPK_MEF2A_6	915	922	PF00069	0.335
DOC_MAPK_RevD_3	527	540	PF00069	0.341
DOC_PP1_RVXF_1	226	233	PF00149	0.460
DOC_PP2B_LxvP_1	111	114	PF13499	0.396
DOC_PP2B_LxvP_1	352	355	PF13499	0.488
DOC_PP4_FxxP_1	481	484	PF00568	0.468
DOC_PP4_FxxP_1	527	530	PF00568	0.469
DOC_SPAK_OSR1_1	460	464	PF12202	0.438
DOC_USP7_MATH_1	146	150	PF00917	0.734
DOC_USP7_MATH_1	169	173	PF00917	0.551
DOC_USP7_MATH_1	269	273	PF00917	0.473
DOC_USP7_MATH_1	288	292	PF00917	0.411
DOC_USP7_MATH_1	340	344	PF00917	0.389
DOC_USP7_MATH_1	54	58	PF00917	0.403
DOC_USP7_MATH_1	584	588	PF00917	0.420
DOC_USP7_MATH_1	590	594	PF00917	0.535
DOC_USP7_MATH_1	811	815	PF00917	0.611
DOC_USP7_MATH_1	854	858	PF00917	0.619
DOC_USP7_UBL2_3	160	164	PF12436	0.720
DOC_WW_Pin1_4	11	16	PF00397	0.586
DOC_WW_Pin1_4	142	147	PF00397	0.612
DOC_WW_Pin1_4	152	157	PF00397	0.784
DOC_WW_Pin1_4	211	216	PF00397	0.542
DOC_WW_Pin1_4	264	269	PF00397	0.528
DOC_WW_Pin1_4	284	289	PF00397	0.479
DOC_WW_Pin1_4	290	295	PF00397	0.624
DOC_WW_Pin1_4	438	443	PF00397	0.555
DOC_WW_Pin1_4	455	460	PF00397	0.396
DOC_WW_Pin1_4	549	554	PF00397	0.563
DOC_WW_Pin1_4	56	61	PF00397	0.553
DOC_WW_Pin1_4	789	794	PF00397	0.436
LIG_14-3-3_CanoR_1	107	112	PF00244	0.509
LIG_14-3-3_CanoR_1	140	146	PF00244	0.725
LIG_14-3-3_CanoR_1	190	195	PF00244	0.495
LIG_14-3-3_CanoR_1	260	270	PF00244	0.450
LIG_14-3-3_CanoR_1	335	340	PF00244	0.398
LIG_14-3-3_CanoR_1	570	576	PF00244	0.514
LIG_14-3-3_CanoR_1	591	597	PF00244	0.441
LIG_14-3-3_CanoR_1	99	104	PF00244	0.556
LIG_AP2alpha_2	103	105	PF02296	0.405
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BRCT_BRCA1_1	449	453	PF00533	0.381
LIG_BRCT_BRCA1_1	457	461	PF00533	0.450
LIG_BRCT_BRCA1_1	477	481	PF00533	0.199
LIG_BRCT_BRCA1_1	774	778	PF00533	0.489
LIG_CaM_NSCaTE_8	163	170	PF13499	0.567
LIG_Clathr_ClatBox_1	119	123	PF01394	0.237
LIG_Clathr_ClatBox_1	20	24	PF01394	0.373
LIG_Clathr_ClatBox_1	297	301	PF01394	0.452
LIG_deltaCOP1_diTrp_1	183	189	PF00928	0.398
LIG_deltaCOP1_diTrp_1	864	869	PF00928	0.631
LIG_eIF4E_1	722	728	PF01652	0.490
LIG_FAT_LD_1	405	413	PF03623	0.326
LIG_FHA_1	12	18	PF00498	0.525
LIG_FHA_1	134	140	PF00498	0.444
LIG_FHA_1	269	275	PF00498	0.441
LIG_FHA_1	301	307	PF00498	0.434
LIG_FHA_1	434	440	PF00498	0.599
LIG_FHA_1	524	530	PF00498	0.388
LIG_FHA_1	600	606	PF00498	0.439
LIG_FHA_1	675	681	PF00498	0.518
LIG_FHA_1	704	710	PF00498	0.486
LIG_FHA_1	751	757	PF00498	0.440
LIG_FHA_1	793	799	PF00498	0.590
LIG_FHA_1	851	857	PF00498	0.433
LIG_FHA_2	166	172	PF00498	0.558
LIG_FHA_2	612	618	PF00498	0.355
LIG_FHA_2	660	666	PF00498	0.523
LIG_LIR_Apic_2	478	484	PF02991	0.337
LIG_LIR_Apic_2	526	530	PF02991	0.477
LIG_LIR_Apic_2	720	725	PF02991	0.446
LIG_LIR_Apic_2	788	793	PF02991	0.404
LIG_LIR_Gen_1	102	113	PF02991	0.358
LIG_LIR_Gen_1	401	410	PF02991	0.457
LIG_LIR_Gen_1	610	618	PF02991	0.384
LIG_LIR_Gen_1	775	786	PF02991	0.422
LIG_LIR_LC3C_4	18	23	PF02991	0.279
LIG_LIR_Nem_3	102	108	PF02991	0.367
LIG_LIR_Nem_3	401	405	PF02991	0.386
LIG_LIR_Nem_3	610	615	PF02991	0.372
LIG_LIR_Nem_3	632	637	PF02991	0.446
LIG_LIR_Nem_3	775	781	PF02991	0.384
LIG_NRBOX	16	22	PF00104	0.473
LIG_NRBOX	226	232	PF00104	0.455
LIG_PCNA_PIPBox_1	409	418	PF02747	0.412
LIG_PCNA_yPIPBox_3	198	211	PF02747	0.383
LIG_PCNA_yPIPBox_3	688	696	PF02747	0.470
LIG_Pex14_1	740	744	PF04695	0.427
LIG_Pex14_2	232	236	PF04695	0.452
LIG_PTB_Apo_2	230	237	PF02174	0.375
LIG_RPA_C_Fungi	502	514	PF08784	0.330
LIG_RPA_C_Fungi	885	897	PF08784	0.403
LIG_SH2_CRK	722	726	PF00017	0.593
LIG_SH2_CRK	790	794	PF00017	0.422
LIG_SH2_NCK_1	722	726	PF00017	0.597
LIG_SH2_STAP1	823	827	PF00017	0.439
LIG_SH2_STAT3	32	35	PF00017	0.497
LIG_SH2_STAT3	347	350	PF00017	0.456
LIG_SH2_STAT3	362	365	PF00017	0.463
LIG_SH2_STAT5	184	187	PF00017	0.420
LIG_SH2_STAT5	32	35	PF00017	0.475
LIG_SH2_STAT5	347	350	PF00017	0.456
LIG_SH2_STAT5	362	365	PF00017	0.463
LIG_SH2_STAT5	418	421	PF00017	0.449
LIG_SH2_STAT5	523	526	PF00017	0.432
LIG_SH2_STAT5	611	614	PF00017	0.320
LIG_SH3_2	242	247	PF14604	0.375
LIG_SH3_3	175	181	PF00018	0.574
LIG_SH3_3	231	237	PF00018	0.331
LIG_SH3_3	239	245	PF00018	0.323
LIG_SH3_3	282	288	PF00018	0.487
LIG_SH3_3	36	42	PF00018	0.383
LIG_SH3_3	482	488	PF00018	0.396
LIG_SH3_3	612	618	PF00018	0.539
LIG_SH3_3	757	763	PF00018	0.452
LIG_SH3_3	98	104	PF00018	0.369
LIG_SH3_CIN85_PxpxPR_1	484	489	PF14604	0.361
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.501
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.273
LIG_SUMO_SIM_anti_2	447	453	PF11976	0.436
LIG_SUMO_SIM_anti_2	766	773	PF11976	0.412
LIG_SUMO_SIM_par_1	18	25	PF11976	0.378
LIG_SUMO_SIM_par_1	296	303	PF11976	0.598
LIG_SUMO_SIM_par_1	309	315	PF11976	0.335
LIG_SUMO_SIM_par_1	705	711	PF11976	0.471
LIG_SUMO_SIM_par_1	766	773	PF11976	0.574
LIG_SUMO_SIM_par_1	795	802	PF11976	0.588
LIG_SUMO_SIM_par_1	892	898	PF11976	0.537
LIG_TRAF2_1	642	645	PF00917	0.549
LIG_TRAF2_1	708	711	PF00917	0.537
LIG_TRAF2_1	746	749	PF00917	0.528
LIG_TRAF2_1	882	885	PF00917	0.395
LIG_UBA3_1	310	314	PF00899	0.281
LIG_WRC_WIRS_1	270	275	PF05994	0.352
LIG_WRC_WIRS_1	524	529	PF05994	0.371
LIG_WW_3	761	765	PF00397	0.384
MOD_CDK_SPK_2	152	157	PF00069	0.549
MOD_CDK_SPK_2	455	460	PF00069	0.487
MOD_CDK_SPK_2	56	61	PF00069	0.453
MOD_CDK_SPxK_1	284	290	PF00069	0.493
MOD_CK1_1	133	139	PF00069	0.633
MOD_CK1_1	141	147	PF00069	0.791
MOD_CK1_1	25	31	PF00069	0.443
MOD_CK1_1	262	268	PF00069	0.547
MOD_CK1_1	293	299	PF00069	0.559
MOD_CK1_1	433	439	PF00069	0.645
MOD_CK1_1	552	558	PF00069	0.585
MOD_CK1_1	59	65	PF00069	0.691
MOD_CK1_1	77	83	PF00069	0.597
MOD_CK1_1	773	779	PF00069	0.469
MOD_CK1_1	792	798	PF00069	0.391
MOD_CK2_1	165	171	PF00069	0.561
MOD_CK2_1	659	665	PF00069	0.514
MOD_CMANNOS	186	189	PF00535	0.464
MOD_CMANNOS	866	869	PF00535	0.619
MOD_DYRK1A_RPxSP_1	211	215	PF00069	0.470
MOD_DYRK1A_RPxSP_1	290	294	PF00069	0.601
MOD_GlcNHglycan	157	160	PF01048	0.775
MOD_GlcNHglycan	2	5	PF01048	0.587
MOD_GlcNHglycan	211	214	PF01048	0.465
MOD_GlcNHglycan	215	218	PF01048	0.404
MOD_GlcNHglycan	248	251	PF01048	0.434
MOD_GlcNHglycan	422	425	PF01048	0.426
MOD_GlcNHglycan	586	589	PF01048	0.599
MOD_GlcNHglycan	592	595	PF01048	0.660
MOD_GlcNHglycan	63	66	PF01048	0.718
MOD_GlcNHglycan	79	82	PF01048	0.546
MOD_GlcNHglycan	815	818	PF01048	0.591
MOD_GlcNHglycan	856	859	PF01048	0.598
MOD_GSK3_1	11	18	PF00069	0.560
MOD_GSK3_1	130	137	PF00069	0.669
MOD_GSK3_1	138	145	PF00069	0.745
MOD_GSK3_1	165	172	PF00069	0.706
MOD_GSK3_1	207	214	PF00069	0.525
MOD_GSK3_1	260	267	PF00069	0.513
MOD_GSK3_1	284	291	PF00069	0.601
MOD_GSK3_1	296	303	PF00069	0.539
MOD_GSK3_1	335	342	PF00069	0.308
MOD_GSK3_1	519	526	PF00069	0.336
MOD_GSK3_1	55	62	PF00069	0.576
MOD_GSK3_1	607	614	PF00069	0.540
MOD_GSK3_1	73	80	PF00069	0.520
MOD_GSK3_1	811	818	PF00069	0.567
MOD_GSK3_1	850	857	PF00069	0.563
MOD_GSK3_1	99	106	PF00069	0.405
MOD_N-GLC_1	142	147	PF02516	0.566
MOD_N-GLC_1	773	778	PF02516	0.549
MOD_N-GLC_2	863	865	PF02516	0.544
MOD_NEK2_1	139	144	PF00069	0.791
MOD_NEK2_1	334	339	PF00069	0.514
MOD_NEK2_1	419	424	PF00069	0.477
MOD_NEK2_1	445	450	PF00069	0.411
MOD_NEK2_1	453	458	PF00069	0.397
MOD_NEK2_1	475	480	PF00069	0.346
MOD_NEK2_1	579	584	PF00069	0.391
MOD_NEK2_1	770	775	PF00069	0.632
MOD_NEK2_1	806	811	PF00069	0.575
MOD_NEK2_1	815	820	PF00069	0.585
MOD_NEK2_2	340	345	PF00069	0.418
MOD_NEK2_2	534	539	PF00069	0.443
MOD_PIKK_1	15	21	PF00454	0.590
MOD_PIKK_1	579	585	PF00454	0.481
MOD_PIKK_1	744	750	PF00454	0.464
MOD_PK_1	764	770	PF00069	0.613
MOD_PKA_1	260	266	PF00069	0.414
MOD_PKA_2	139	145	PF00069	0.729
MOD_PKA_2	189	195	PF00069	0.293
MOD_PKA_2	246	252	PF00069	0.448
MOD_PKA_2	259	265	PF00069	0.539
MOD_PKA_2	334	340	PF00069	0.398
MOD_PKA_2	590	596	PF00069	0.657
MOD_Plk_1	170	176	PF00069	0.532
MOD_Plk_1	300	306	PF00069	0.498
MOD_Plk_1	773	779	PF00069	0.575
MOD_Plk_4	190	196	PF00069	0.446
MOD_Plk_4	25	31	PF00069	0.473
MOD_Plk_4	269	275	PF00069	0.394
MOD_Plk_4	293	299	PF00069	0.505
MOD_Plk_4	404	410	PF00069	0.355
MOD_Plk_4	447	453	PF00069	0.346
MOD_Plk_4	519	525	PF00069	0.415
MOD_Plk_4	607	613	PF00069	0.360
MOD_Plk_4	629	635	PF00069	0.444
MOD_Plk_4	712	718	PF00069	0.505
MOD_Plk_4	764	770	PF00069	0.693
MOD_Plk_4	773	779	PF00069	0.445
MOD_ProDKin_1	11	17	PF00069	0.570
MOD_ProDKin_1	142	148	PF00069	0.613
MOD_ProDKin_1	152	158	PF00069	0.783
MOD_ProDKin_1	211	217	PF00069	0.535
MOD_ProDKin_1	264	270	PF00069	0.520
MOD_ProDKin_1	284	290	PF00069	0.489
MOD_ProDKin_1	438	444	PF00069	0.547
MOD_ProDKin_1	455	461	PF00069	0.403
MOD_ProDKin_1	549	555	PF00069	0.564
MOD_ProDKin_1	56	62	PF00069	0.565
MOD_ProDKin_1	789	795	PF00069	0.433
TRG_DiLeu_BaEn_1	248	253	PF01217	0.467
TRG_DiLeu_BaEn_1	766	771	PF01217	0.356
TRG_DiLeu_BaEn_1	802	807	PF01217	0.472
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.426
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.328
TRG_ENDOCYTIC_2	572	575	PF00928	0.456
TRG_ENDOCYTIC_2	786	789	PF00928	0.360
TRG_ER_diArg_1	538	540	PF00400	0.328
TRG_ER_diArg_1	666	668	PF00400	0.589
TRG_NES_CRM1_1	118	132	PF08389	0.306
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G2	Leptomonas seymouri	48%	93%
A0A1X0P8G4	Trypanosomatidae	22%	100%
A0A3Q8IHB1	Leishmania donovani	91%	100%
A0A422NCC8	Trypanosoma rangeli	26%	100%
A4HPC2	Leishmania braziliensis	76%	97%
A4ICG2	Leishmania infantum	91%	100%
D0A3D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q1G5	Leishmania major	90%	100%
V5BCJ8	Trypanosoma cruzi	27%	100%