Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT32_LEIMU

TriTrypDb:

LmxM.36.2550

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.645
CLV_NRD_NRD_1	218	220	PF00675	0.598
CLV_NRD_NRD_1	258	260	PF00675	0.590
CLV_NRD_NRD_1	311	313	PF00675	0.489
CLV_NRD_NRD_1	322	324	PF00675	0.558
CLV_NRD_NRD_1	348	350	PF00675	0.605
CLV_NRD_NRD_1	42	44	PF00675	0.566
CLV_NRD_NRD_1	79	81	PF00675	0.657
CLV_PCSK_KEX2_1	174	176	PF00082	0.645
CLV_PCSK_KEX2_1	258	260	PF00082	0.590
CLV_PCSK_KEX2_1	311	313	PF00082	0.489
CLV_PCSK_KEX2_1	321	323	PF00082	0.553
CLV_PCSK_KEX2_1	348	350	PF00082	0.635
CLV_PCSK_KEX2_1	42	44	PF00082	0.552
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.562
CLV_PCSK_SKI1_1	175	179	PF00082	0.573
CLV_PCSK_SKI1_1	259	263	PF00082	0.521
CLV_PCSK_SKI1_1	312	316	PF00082	0.547
DEG_APCC_DBOX_1	300	308	PF00400	0.576
DEG_SPOP_SBC_1	35	39	PF00917	0.545
DOC_CKS1_1	270	275	PF01111	0.596
DOC_CYCLIN_RxL_1	257	266	PF00134	0.545
DOC_MAPK_gen_1	112	120	PF00069	0.552
DOC_MAPK_gen_1	308	317	PF00069	0.589
DOC_MAPK_gen_1	40	49	PF00069	0.556
DOC_MAPK_MEF2A_6	190	197	PF00069	0.498
DOC_MAPK_MEF2A_6	40	49	PF00069	0.667
DOC_PP1_RVXF_1	257	264	PF00149	0.688
DOC_PP4_FxxP_1	146	149	PF00568	0.680
DOC_USP7_MATH_1	205	209	PF00917	0.652
DOC_USP7_MATH_1	283	287	PF00917	0.634
DOC_USP7_MATH_1	324	328	PF00917	0.610
DOC_USP7_MATH_1	34	38	PF00917	0.548
DOC_WW_Pin1_4	145	150	PF00397	0.577
DOC_WW_Pin1_4	269	274	PF00397	0.596
DOC_WW_Pin1_4	279	284	PF00397	0.501
DOC_WW_Pin1_4	4	9	PF00397	0.605
LIG_14-3-3_CanoR_1	154	158	PF00244	0.529
LIG_14-3-3_CanoR_1	232	237	PF00244	0.610
LIG_14-3-3_CanoR_1	284	288	PF00244	0.684
LIG_14-3-3_CanoR_1	306	311	PF00244	0.569
LIG_14-3-3_CanoR_1	80	86	PF00244	0.614
LIG_Actin_WH2_2	300	318	PF00022	0.450
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	147	151	PF00533	0.571
LIG_FHA_1	201	207	PF00498	0.669
LIG_FHA_1	332	338	PF00498	0.704
LIG_FHA_2	184	190	PF00498	0.468
LIG_FHA_2	21	27	PF00498	0.643
LIG_FHA_2	225	231	PF00498	0.642
LIG_FHA_2	236	242	PF00498	0.619
LIG_FHA_2	326	332	PF00498	0.638
LIG_FHA_2	92	98	PF00498	0.462
LIG_LIR_Apic_2	144	149	PF02991	0.679
LIG_LIR_Gen_1	356	365	PF02991	0.507
LIG_LIR_Gen_1	70	79	PF02991	0.658
LIG_LIR_Nem_3	230	234	PF02991	0.531
LIG_LIR_Nem_3	246	252	PF02991	0.547
LIG_LIR_Nem_3	345	350	PF02991	0.587
LIG_LIR_Nem_3	356	360	PF02991	0.477
LIG_LIR_Nem_3	50	55	PF02991	0.573
LIG_LIR_Nem_3	70	74	PF02991	0.670
LIG_LYPXL_yS_3	52	55	PF13949	0.626
LIG_PDZ_Class_3	368	373	PF00595	0.617
LIG_SH2_CRK	231	235	PF00017	0.527
LIG_SH2_CRK	347	351	PF00017	0.684
LIG_SH2_PTP2	357	360	PF00017	0.500
LIG_SH2_SRC	247	250	PF00017	0.654
LIG_SH2_STAP1	247	251	PF00017	0.603
LIG_SH2_STAT5	161	164	PF00017	0.548
LIG_SH2_STAT5	201	204	PF00017	0.620
LIG_SH2_STAT5	357	360	PF00017	0.500
LIG_SH2_STAT5	93	96	PF00017	0.464
LIG_SH3_3	334	340	PF00018	0.690
LIG_SH3_3	355	361	PF00018	0.554
LIG_SUMO_SIM_par_1	97	106	PF11976	0.609
LIG_TRAF2_1	300	303	PF00917	0.536
LIG_TYR_ITSM	343	350	PF00017	0.447
MOD_CDK_SPK_2	279	284	PF00069	0.553
MOD_CK1_1	133	139	PF00069	0.560
MOD_CK1_1	2	8	PF00069	0.638
MOD_CK1_1	235	241	PF00069	0.550
MOD_CK1_1	250	256	PF00069	0.448
MOD_CK2_1	147	153	PF00069	0.693
MOD_CK2_1	183	189	PF00069	0.478
MOD_CK2_1	20	26	PF00069	0.652
MOD_CK2_1	235	241	PF00069	0.649
MOD_CK2_1	272	278	PF00069	0.705
MOD_CK2_1	283	289	PF00069	0.562
MOD_CK2_1	89	95	PF00069	0.705
MOD_GlcNHglycan	249	252	PF01048	0.575
MOD_GlcNHglycan	292	295	PF01048	0.678
MOD_GlcNHglycan	297	300	PF01048	0.635
MOD_GlcNHglycan	317	320	PF01048	0.382
MOD_GSK3_1	141	148	PF00069	0.658
MOD_GSK3_1	200	207	PF00069	0.536
MOD_GSK3_1	243	250	PF00069	0.519
MOD_GSK3_1	279	286	PF00069	0.543
MOD_N-GLC_1	353	358	PF02516	0.588
MOD_N-GLC_2	107	109	PF02516	0.529
MOD_NEK2_1	103	108	PF00069	0.598
MOD_NEK2_1	169	174	PF00069	0.593
MOD_NEK2_1	243	248	PF00069	0.542
MOD_NEK2_1	263	268	PF00069	0.387
MOD_NEK2_1	277	282	PF00069	0.479
MOD_NEK2_1	288	293	PF00069	0.560
MOD_NEK2_1	315	320	PF00069	0.554
MOD_NEK2_1	342	347	PF00069	0.454
MOD_PIKK_1	224	230	PF00454	0.589
MOD_PKA_2	111	117	PF00069	0.641
MOD_PKA_2	153	159	PF00069	0.534
MOD_PKA_2	283	289	PF00069	0.553
MOD_PKA_2	315	321	PF00069	0.494
MOD_Plk_1	152	158	PF00069	0.647
MOD_Plk_1	263	269	PF00069	0.593
MOD_Plk_1	277	283	PF00069	0.476
MOD_Plk_1	69	75	PF00069	0.723
MOD_Plk_2-3	183	189	PF00069	0.584
MOD_Plk_2-3	70	76	PF00069	0.663
MOD_Plk_4	213	219	PF00069	0.549
MOD_Plk_4	272	278	PF00069	0.636
MOD_Plk_4	283	289	PF00069	0.580
MOD_Plk_4	333	339	PF00069	0.588
MOD_Plk_4	353	359	PF00069	0.431
MOD_ProDKin_1	145	151	PF00069	0.574
MOD_ProDKin_1	269	275	PF00069	0.597
MOD_ProDKin_1	279	285	PF00069	0.501
MOD_ProDKin_1	4	10	PF00069	0.605
MOD_SUMO_rev_2	183	191	PF00179	0.577
MOD_SUMO_rev_2	326	334	PF00179	0.678
TRG_DiLeu_BaEn_4	302	308	PF01217	0.495
TRG_ENDOCYTIC_2	201	204	PF00928	0.543
TRG_ENDOCYTIC_2	231	234	PF00928	0.530
TRG_ENDOCYTIC_2	347	350	PF00928	0.579
TRG_ENDOCYTIC_2	357	360	PF00928	0.481
TRG_ENDOCYTIC_2	367	370	PF00928	0.497
TRG_ENDOCYTIC_2	52	55	PF00928	0.650
TRG_ER_diArg_1	173	175	PF00400	0.542
TRG_ER_diArg_1	257	259	PF00400	0.582
TRG_ER_diArg_1	310	312	PF00400	0.488
TRG_ER_diArg_1	347	349	PF00400	0.638
TRG_ER_diArg_1	42	44	PF00400	0.552
TRG_NLS_Bipartite_1	311	325	PF00514	0.390
TRG_NLS_MonoExtC_3	320	326	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX6	Leptomonas seymouri	58%	97%
A0A1X0P7K9	Trypanosomatidae	39%	100%
A0A3Q8IKB1	Leishmania donovani	92%	100%
A0A3R7K7R7	Trypanosoma rangeli	41%	100%
A4HPC3	Leishmania braziliensis	79%	100%
A4ICG1	Leishmania infantum	92%	100%
D0A3D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q1G6	Leishmania major	93%	100%
V5BH32	Trypanosoma cruzi	38%	100%