Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT29_LEIMU

TriTrypDb:

LmxM.36.2520

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.586
CLV_NRD_NRD_1	342	344	PF00675	0.654
CLV_PCSK_KEX2_1	256	258	PF00082	0.586
CLV_PCSK_KEX2_1	341	343	PF00082	0.635
CLV_PCSK_SKI1_1	202	206	PF00082	0.520
CLV_PCSK_SKI1_1	250	254	PF00082	0.487
CLV_PCSK_SKI1_1	296	300	PF00082	0.671
CLV_PCSK_SKI1_1	306	310	PF00082	0.709
CLV_PCSK_SKI1_1	342	346	PF00082	0.612
CLV_PCSK_SKI1_1	61	65	PF00082	0.561
DEG_APCC_DBOX_1	201	209	PF00400	0.523
DOC_CYCLIN_RxL_1	199	209	PF00134	0.521
DOC_CYCLIN_RxL_1	290	302	PF00134	0.634
DOC_CYCLIN_RxL_1	339	348	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.685
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.505
DOC_MAPK_DCC_7	188	198	PF00069	0.649
DOC_MAPK_gen_1	88	97	PF00069	0.371
DOC_MAPK_MEF2A_6	91	99	PF00069	0.374
DOC_PP2B_LxvP_1	187	190	PF13499	0.701
DOC_PP2B_LxvP_1	79	82	PF13499	0.426
DOC_PP4_FxxP_1	28	31	PF00568	0.478
DOC_PP4_FxxP_1	325	328	PF00568	0.553
DOC_USP7_MATH_1	12	16	PF00917	0.277
DOC_USP7_MATH_1	182	186	PF00917	0.692
DOC_USP7_MATH_1	66	70	PF00917	0.432
DOC_WW_Pin1_4	177	182	PF00397	0.687
DOC_WW_Pin1_4	289	294	PF00397	0.594
LIG_14-3-3_CanoR_1	148	152	PF00244	0.527
LIG_14-3-3_CanoR_1	23	31	PF00244	0.317
LIG_14-3-3_CanoR_1	88	94	PF00244	0.370
LIG_14-3-3_CanoR_1	9	17	PF00244	0.390
LIG_CtBP_PxDLS_1	315	319	PF00389	0.535
LIG_FHA_1	66	72	PF00498	0.412
LIG_FHA_1	90	96	PF00498	0.370
LIG_FHA_2	3	9	PF00498	0.548
LIG_FHA_2	55	61	PF00498	0.511
LIG_LIR_Apic_2	26	31	PF02991	0.355
LIG_LIR_Apic_2	322	328	PF02991	0.560
LIG_LIR_Gen_1	15	25	PF02991	0.365
LIG_LIR_Gen_1	327	337	PF02991	0.528
LIG_LIR_Gen_1	37	45	PF02991	0.504
LIG_LIR_Gen_1	75	86	PF02991	0.432
LIG_LIR_Nem_3	15	20	PF02991	0.361
LIG_LIR_Nem_3	327	333	PF02991	0.603
LIG_LIR_Nem_3	37	42	PF02991	0.506
LIG_LIR_Nem_3	49	53	PF02991	0.505
LIG_LIR_Nem_3	75	81	PF02991	0.392
LIG_LIR_Nem_3	92	96	PF02991	0.364
LIG_NRP_CendR_1	349	350	PF00754	0.633
LIG_Pex14_2	24	28	PF04695	0.457
LIG_Pex14_2	39	43	PF04695	0.408
LIG_SH2_CRK	17	21	PF00017	0.420
LIG_SH2_STAP1	17	21	PF00017	0.420
LIG_SH2_STAT3	102	105	PF00017	0.462
LIG_SH2_STAT3	266	269	PF00017	0.586
LIG_SH2_STAT5	266	269	PF00017	0.586
LIG_SH2_STAT5	50	53	PF00017	0.455
LIG_SH2_STAT5	78	81	PF00017	0.404
LIG_SH3_1	108	114	PF00018	0.620
LIG_SH3_3	108	114	PF00018	0.701
LIG_SH3_3	175	181	PF00018	0.635
LIG_SH3_3	187	193	PF00018	0.634
LIG_SH3_3	59	65	PF00018	0.505
LIG_SUMO_SIM_par_1	194	199	PF11976	0.542
LIG_SUMO_SIM_par_1	68	76	PF11976	0.462
LIG_TRAF2_1	314	317	PF00917	0.665
LIG_WRC_WIRS_1	90	95	PF05994	0.347
LIG_WW_3	137	141	PF00397	0.503
MOD_CDK_SPxxK_3	289	296	PF00069	0.596
MOD_CK1_1	155	161	PF00069	0.647
MOD_CK1_1	206	212	PF00069	0.520
MOD_CK1_1	26	32	PF00069	0.312
MOD_CK2_1	165	171	PF00069	0.671
MOD_CK2_1	2	8	PF00069	0.492
MOD_CK2_1	242	248	PF00069	0.491
MOD_CK2_1	26	32	PF00069	0.508
MOD_CK2_1	43	49	PF00069	0.406
MOD_CK2_1	54	60	PF00069	0.499
MOD_CK2_1	77	83	PF00069	0.416
MOD_GlcNHglycan	135	138	PF01048	0.712
MOD_GlcNHglycan	167	170	PF01048	0.714
MOD_GlcNHglycan	213	216	PF01048	0.634
MOD_GlcNHglycan	217	220	PF01048	0.688
MOD_GlcNHglycan	237	240	PF01048	0.715
MOD_GlcNHglycan	258	261	PF01048	0.464
MOD_GlcNHglycan	273	276	PF01048	0.584
MOD_GlcNHglycan	277	280	PF01048	0.516
MOD_GlcNHglycan	311	314	PF01048	0.625
MOD_GlcNHglycan	75	78	PF01048	0.385
MOD_GSK3_1	129	136	PF00069	0.644
MOD_GSK3_1	152	159	PF00069	0.630
MOD_GSK3_1	173	180	PF00069	0.704
MOD_GSK3_1	211	218	PF00069	0.653
MOD_GSK3_1	271	278	PF00069	0.496
MOD_GSK3_1	73	80	PF00069	0.504
MOD_GSK3_1	8	15	PF00069	0.370
MOD_N-GLC_1	309	314	PF02516	0.601
MOD_NEK2_1	101	106	PF00069	0.473
MOD_NEK2_1	133	138	PF00069	0.673
MOD_NEK2_1	156	161	PF00069	0.649
MOD_NEK2_1	203	208	PF00069	0.633
MOD_NEK2_1	299	304	PF00069	0.528
MOD_NEK2_1	309	314	PF00069	0.601
MOD_NEK2_1	43	48	PF00069	0.424
MOD_NEK2_1	72	77	PF00069	0.384
MOD_NEK2_1	95	100	PF00069	0.386
MOD_NEK2_2	320	325	PF00069	0.547
MOD_PIKK_1	101	107	PF00454	0.472
MOD_PIKK_1	158	164	PF00454	0.634
MOD_PKA_1	256	262	PF00069	0.579
MOD_PKA_2	144	150	PF00069	0.634
MOD_PKA_2	2	8	PF00069	0.492
MOD_PKA_2	206	212	PF00069	0.500
MOD_PKA_2	256	262	PF00069	0.579
MOD_PKA_2	32	38	PF00069	0.481
MOD_Plk_1	43	49	PF00069	0.508
MOD_Plk_2-3	32	38	PF00069	0.433
MOD_Plk_4	129	135	PF00069	0.652
MOD_Plk_4	320	326	PF00069	0.576
MOD_Plk_4	95	101	PF00069	0.386
MOD_ProDKin_1	177	183	PF00069	0.689
MOD_ProDKin_1	289	295	PF00069	0.592
MOD_SUMO_rev_2	245	252	PF00179	0.544
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.592
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.605
TRG_ENDOCYTIC_2	17	20	PF00928	0.368
TRG_ENDOCYTIC_2	21	24	PF00928	0.345
TRG_ENDOCYTIC_2	78	81	PF00928	0.507
TRG_ER_diArg_1	108	111	PF00400	0.548
TRG_ER_diArg_1	255	257	PF00400	0.575
TRG_ER_diArg_1	331	334	PF00400	0.528
TRG_ER_diArg_1	341	343	PF00400	0.598
TRG_NES_CRM1_1	19	32	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y4	Leptomonas seymouri	47%	100%
A0A3S7XB07	Leishmania donovani	90%	100%
A4HPB8	Leishmania braziliensis	79%	100%
A4ICF8	Leishmania infantum	90%	100%
Q4Q1G9	Leishmania major	90%	100%